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fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating

NCT ID: NCT00288314

Last Updated: 2010-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2008-05-31

Brief Summary

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Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.

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Detailed Description

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Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.

Conditions

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Post-Traumatic Stress Disorders Anxiety Amnesia, Dissociative

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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PTSD

Magnetic Resonance Imaging, Functional

Intervention Type PROCEDURE

Structural and functional MRI

CONTROLS

Magnetic Resonance Imaging, Functional

Intervention Type PROCEDURE

Structural and functional MRI

Interventions

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Magnetic Resonance Imaging, Functional

Structural and functional MRI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Right-handed women
* Victim of sexual abuse
* Suffering from PTSD

Exclusion Criteria

* Epilepsy
* Claustrophobia
* MRI contre-indication
* Addictive disorders
* Sightless
* Detection of a brain injury at the MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Tours

OTHER

Sponsor Role lead

Responsible Party

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CHRU TOURS

Principal Investigators

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Wissam EL HAGE, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

UNIVERSITY HOSPITAL OF TOURS

Locations

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University Hospital of Tours

Tours, Centre-Val de Loire, France

Site Status

Countries

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France

References

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El-Hage W, Gaillard P, Isingrini M, Belzung C. Trauma-related deficits in working memory. Cogn Neuropsychiatry. 2006 Jan;11(1):33-46. doi: 10.1080/13546800444000164.

Reference Type BACKGROUND
PMID: 16537232 (View on PubMed)

Other Identifiers

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PHRR04-WEH/METRAPI

Identifier Type: -

Identifier Source: org_study_id

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