Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

NCT ID: NCT03897855

Last Updated: 2021-07-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-04-01
• Study Completion Date: 2021-03-26

Brief Summary

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Conditions

Post-Traumatic Stress Disorder in Old Age

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Patient (TSPT-R)

Post Traumatic Stress Disorder

Group Type: OTHER

Post Traumatic Stress Disorder

Intervention Type: OTHER

The test "Think / No-Think"

control

No Post Traumatic Stress Disorder

Group Type: EXPERIMENTAL

Post Traumatic Stress Disorder

Intervention Type: OTHER

The test "Think / No-Think"

Interventions

Post Traumatic Stress Disorder

The test "Think / No-Think"

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

-

Regarding the constitution of the group patient (TSPT-R):

• Subjects 65 years of age or older
• Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
• The traumatic event must have taken place at the latest before 65 years
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by research)

Regarding the constitution of the control group:

• Subjects 65 years of age or older
• No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by the research).

Exclusion Criteria

• For both groups:
• Acute or chronic cognitive impairment known
• GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:

• 22 if no diploma
• 23 if certificate of study
• 25 if patent
• 26 if bin or more
• Remove one point at each threshold if age> 80 years
• Sensory or motor disorder preventing the passing of different tests
• Psychotic disorder
• Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
• Disorder of the use of a moderate or severe substance (except tobacco).
• Patients under guardianship or curatorship.

• Minimum Eligible Age: 65 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier de Niort

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dominique LEGER, Doctor

Role: STUDY_DIRECTOR

Centre Hospitalier de Niort

Locations

Centre Hospitalier de Niort

Niort, , France

Countries

France

Other Identifiers

CH-NIORT-2018-02

Identifier Type: -

Identifier Source: org_study_id