White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord
NCT ID: NCT00280306
Last Updated: 2015-06-04
Study Results
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Basic Information
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COMPLETED
35 participants
OBSERVATIONAL
2005-11-30
2008-10-31
Brief Summary
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Detailed Description
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* A better understanding of the relationship between abnormal cervical spinal anatomy and the impact on fiber tracts would be helpful in determining the best treatment for a particular patient. It may be able to define the indication and role of surgical decompression and stabilization based on quantifiable and reproducible data obtained with this new imaging technology.
* It could help the surgeon to determine what type of surgical approach to choose (anterior versus posterior surgery, depending on the degree of compression / impingement on nerve fibers).
* Correlation between quantitative diffusion measures and spinal cord injury may be used in monitoring the response to treatment and may therefore be an important parameter for clinicians to follow.
* White matter fiber tracking may also help to determine the pathophysiology underlying cervical spondylotic myelopathy. Currently, there is a debate as to whether cervical spondylitic myelopathy is caused mainly by compressive narrowing of the spinal canal, which may lead to focal ischemia and tissue injury, or whether excessive motion due to cervical spondylosis results in increased strain and shear of spinal axons resulting in injury (Henderson et al., Neurosurgery 56(5):1101-13, 2005). If the latter is correct one would expect diffusion changes along the course of white matter tracks above and below the spondylotic changes.
We will first study a pool of 15 normal control subjects to refine our data acquisition and postprocessing tools, and to sample quantitative diffusion based data for the normal cervical spine. A second group of subjects will include 10 patients with significant cervical spondylosis and upper extremity radiculopathy without myelopathy. The third group will be 10 patients with cervical spondylosis and signs and symptoms of myelopathy. The two patient groups will allow us to define systematic differences between normal values and values in the injured spine.
The DTI data will be processed using tools for artifact correction first and then tools for rendering T2 weighted images, diffusion weighted images, ADC maps and FA values.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Interventions
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No interventions
No intervention
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
21 Years
ALL
Yes
Sponsors
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Cervical Spine Research Society
OTHER
Weill Medical College of Cornell University
OTHER
Responsible Party
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Henning U. Voss
Associate Professor of Physics in Radiology
Principal Investigators
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Henning U Voss
Role: PRINCIPAL_INVESTIGATOR
Weill Medical College of Cornell
Locations
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Weill Medical College of Cornell
New York, New York, United States
Countries
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Other Identifiers
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1-Voss
Identifier Type: -
Identifier Source: org_study_id
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