Enhancing Recovery in Non-Traumatic Spinal Cord Injury

NCT ID: NCT03320759

Last Updated: 2024-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-21

Study Completion Date

2026-07-01

Brief Summary

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The investigators have spent the last decade uncovering unique metabolic and functional abnormalities in the brains of patients with spinal cord compression. Degenerative spinal cord compression represents a unique model of reversible spinal cord injury. In the investigator's previous work, they have demonstrated that cortical reorganization and recruitment is associated with metabolic changes in the brains of patients recovering from spinal cord compression and is correlated with recovery and improved neurological scores.

The goal of this study is to combine a rigorous platform of clinical care that includes preoperative evaluation, surgery, and rehabilitation, with state of the art imaging techniques to demonstrate how rehabilitative therapy can increase brain plasticity and recovery of neurological function in patients with spinal cord injury. Neurological function will be carefully evaluated in two groups of patients, those receiving rehabilitation and those not receiving rehabilitation after spine surgery, and will be correlated with the results of advanced imaging.

Detailed Description

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Conditions

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Spinal Cord Compression Spinal Cord Injuries Cervical Spondylosis Myelopathy Cervical

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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No rehabilitation

Group Type NO_INTERVENTION

No interventions assigned to this group

Rehabilitation

Group Type EXPERIMENTAL

Occupational therapy rehabilitation

Intervention Type BEHAVIORAL

Participants in the experimental arm will receive occupational therapy that is individualized to each participant's needs from week 4 post-decompression surgery until week 12.

Interventions

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Occupational therapy rehabilitation

Participants in the experimental arm will receive occupational therapy that is individualized to each participant's needs from week 4 post-decompression surgery until week 12.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* right-handed
* have a history of progressive neurological deficits \<24 months
* eligible for MRI scanning

Exclusion Criteria

* having any other neurological disorder or systemic disease that can impair neurological function
* not fluent in reading and speaking English
* being claustrophobic
* unable to follow simple task instructions and maintain standardized movements
* being unable to return for all follow-up imaging and rehabilitation sessions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Western University, Canada

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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LHSC - University Hospital

London, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Sarah Detombe, PhD

Role: CONTACT

5196858500 ext. 35456

Facility Contacts

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Sarah Detombe

Role: primary

5196858500 ext. 35456

Other Identifiers

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108706

Identifier Type: -

Identifier Source: org_study_id

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