Vertebral Osteosynthesis in Degenerative Lumbar Stenosis With Spondylolisthesis

NCT ID: NCT00252551

Last Updated: 2015-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2007-12-31

Brief Summary

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Study to evaluate the superiority of the osteosynthesis associated with a decompressive surgery in comparison with a simple decompressive surgery in the treatment of lumbar degenerative stenosis with spondylolisthesis

Detailed Description

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Randomized, comparative study on 152 patients with degenerative spondylolisthesis L4-L5 confirmed by radiography with radicular pain for whom the antalgic and anti-inflammatory treatment are not efficient for at least 3 months.

Patients randomized in 2 parallel groups (each group with 76 patients)

* one group with decompressive surgery + osteosynthesis
* one group with decompressive surgery Study duration : 18 months, including a selection visit, an inclusion with the surgical intervention, 3, 12, 18 months' follow up visits and a follow up call at 6 months.

Conditions

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Spondylolisthesis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

osteosynthesis

Group Type EXPERIMENTAL

Osteosynthesis

Intervention Type PROCEDURE

2

Simple surgery

Group Type ACTIVE_COMPARATOR

Simple surgery

Intervention Type PROCEDURE

Surgery without device

Interventions

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Osteosynthesis

Intervention Type PROCEDURE

Simple surgery

Surgery without device

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with degenerative spondylolisthesis L4-L5 confirmed by radiography with radicular pain for whom the antalgic and anti-inflammatory treatment are not efficient for at least 3 months;
* Patients who agree to take part in the study and to sign an Informed Consent Form

Exclusion Criteria

* Contre-indications to surgery or to vertebral isolated fixation L4-L5
* Previous lumbar surgery
* Work accidents
* Psychiatric troubles that may interfere with the clinical evaluation
* Pregnant women or women who could be pregnant during the study
* Patient under special supervision or trusteeship
* Refusal to sign the Informed Consent Form
* No Public Health Insurance cover
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jacques Lagarrigue

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

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University Hospital of Besançon - Neurosurgey department

Besançon, , France

Site Status

University Hospital of Caen - Neurosurgery department

Caen, , France

Site Status

University Hospital of Clermont Ferrand

Clermont-Ferrand, , France

Site Status

Clinique Rech - Neurosurgery centre

Montpellier, , France

Site Status

University Hospital of Nice - Neurosurgery department

Nice, , France

Site Status

University Hospital of Saint-Etienne - Neurosurgery department

Saint-Etienne, , France

Site Status

University Hospital of Strasbourg

Strasbourg, , France

Site Status

Toulouse University Hospital - Purpan - Neurosurgery department

Toulouse, , France

Site Status

Toulouse University Hospital - Rangueil- Neuro surgery department

Toulouse, , France

Site Status

Countries

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France

References

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Caputy AJ, Luessenhop AJ. Long-term evaluation of decompressive surgery for degenerative lumbar stenosis. J Neurosurg. 1992 Nov;77(5):669-76. doi: 10.3171/jns.1992.77.5.0669.

Reference Type BACKGROUND
PMID: 1403105 (View on PubMed)

Cherkin DC, Deyo RA, Loeser JD, Bush T, Waddell G. An international comparison of back surgery rates. Spine (Phila Pa 1976). 1994 Jun 1;19(11):1201-6. doi: 10.1097/00007632-199405310-00001.

Reference Type BACKGROUND
PMID: 8073310 (View on PubMed)

Davis H. Increasing rates of cervical and lumbar spine surgery in the United States, 1979-1990. Spine (Phila Pa 1976). 1994 May 15;19(10):1117-23; discussion 1123-4. doi: 10.1097/00007632-199405001-00003.

Reference Type BACKGROUND
PMID: 8059266 (View on PubMed)

Feffer HL, Wiesel SW, Cuckler JM, Rothman RH. Degenerative spondylolisthesis. To fuse or not to fuse. Spine (Phila Pa 1976). 1985 Apr;10(3):287-9.

Reference Type BACKGROUND
PMID: 3992350 (View on PubMed)

Fritzell P, Hagg O, Wessberg P, Nordwall A; Swedish Lumbar Spine Study Group. 2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group. Spine (Phila Pa 1976). 2001 Dec 1;26(23):2521-32; discussion 2532-4. doi: 10.1097/00007632-200112010-00002.

Reference Type BACKGROUND
PMID: 11725230 (View on PubMed)

Gibson JN, Grant IC, Waddell G. The Cochrane review of surgery for lumbar disc prolapse and degenerative lumbar spondylosis. Spine (Phila Pa 1976). 1999 Sep 1;24(17):1820-32. doi: 10.1097/00007632-199909010-00012.

Reference Type BACKGROUND
PMID: 10488513 (View on PubMed)

Other Identifiers

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PHRC0300201

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

0300201

Identifier Type: -

Identifier Source: org_study_id

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