Neurosurgery Patient Outcomes in Treating Spinal Disorders

NCT ID: NCT01220921

Last Updated: 2015-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

198 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-09-30

Brief Summary

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The creation of a multi-center cooperative research group encompassing academic and community-based spinal practices . . .

Detailed Description

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Conditions

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Symptomatic Lumbar Disc Herniation Symptomatic Grade I Lumbar Spondylolisthesis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Lumbar Microdiscectomy

Patients aged 18-80 with symptomatic lumbar disc herniation resulting in single nerve root compression recalcitrant to non-invasive therapies for at least 6 weeks

Group Type EXPERIMENTAL

Lumbar Discectomy

Intervention Type PROCEDURE

Microsurgical removal of disc that is compressing a nerve root

Single-Level Lumbar Fusion

Patients aged 18-80 with symptomatic grade I degenerative or isthmic spondylolisthesis with mechanical back pain with or without radiculopathy recalcitrant to non-invasive therapies for at least 3 months

Group Type EXPERIMENTAL

Single-level lumbar fusion

Intervention Type PROCEDURE

pedicle screws with arthrodesis as directed by surgeon. Fusion can be posterolateral, interbody, or both.

Interventions

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Lumbar Discectomy

Microsurgical removal of disc that is compressing a nerve root

Intervention Type PROCEDURE

Single-level lumbar fusion

pedicle screws with arthrodesis as directed by surgeon. Fusion can be posterolateral, interbody, or both.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Grade I degenerative or isthmic spondylolisthesis recalcitrant to non-invasive therapies for at least 3 months or Lumbar degenerative disc herniation with radiculopathy refractory to non-invasive therapies for at least 6 weeks

Exclusion Criteria

* History of previous lumbar spine surgery
* Significant motor weakness (3/5) (i.e. foot drop)
* Cancer, infection, or fracture
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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American Association of Neurological Surgeons

OTHER

Sponsor Role collaborator

Greenwich Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wallace Clinical Trials Center - Greenwich Hospital - Yale New Haven Health

Principal Investigators

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Zoher Ghogawala, MD FACS

Role: STUDY_DIRECTOR

Yale University

Locations

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University of California - San Francisco

San Francisco, California, United States

Site Status

Greenwich Hospital

Greenwich, Connecticut, United States

Site Status

Yale New Haven Hospital

New Haven, Connecticut, United States

Site Status

Johns Hopkins Hospital

Baltimore, Maryland, United States

Site Status

Lahey Clinic

Burlington, Massachusetts, United States

Site Status

University of Medicine and Dentistry - New Jersey

Newark, New Jersey, United States

Site Status

Columbia University - Neurological Institute

New York, New York, United States

Site Status

Carolina Spine

Charlotte, North Carolina, United States

Site Status

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

University of Wisconsin

Madison, Wisconsin, United States

Site Status

University of Calgary - Alberta Health Sevices

Calgary, Alberta, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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Neuropoint SD

Identifier Type: -

Identifier Source: org_study_id