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Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario

NCT ID: NCT00235326

Last Updated: 2009-04-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

4561 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-01-31

Study Completion Date

2008-08-31

Brief Summary

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Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).

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Detailed Description

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This research will study chronic gastrointestinal problems in the residents of Walkerton, Ontario region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals

Conditions

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Irritable Bowel Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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2

Unexposed to gastroenteritis

No interventions assigned to this group

1

Exposed to gastroenteritis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study

Exclusion Criteria

* Non residents of Walkerton Ontario at the time of outbreak
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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McMaster University

OTHER

Sponsor Role lead

Responsible Party

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Mcmaster University

Principal Investigators

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John k Marshall, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

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Walkerton

Walkerton, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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02-026; 05-346

Identifier Type: -

Identifier Source: org_study_id

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