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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04227509 | COMPLETED | PHASE2
53 Participants

Consolidation Pembrolizumab After Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-04
Completion: 2024-08-21
Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG
No Results Yet
NCT04224337 | COMPLETED | PHASE2
16 Participants

Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-11
Completion: 2023-08-14
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT04203160 | TERMINATED | PHASE1/PHASE2
75 Participants

Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-23
Completion: 2024-04-16
Conditions
Biliary Tract Cancer
Interventions
DRUG
Results Available
NCT04192435 | COMPLETED | PHASE4
3300 Participants

Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-18
Completion: 2025-09-13
Conditions
Infection Wound Gastrointestinal Complication Anesthesia Bleeding Healthcare Associated Infection
Interventions
DRUG
No Results Yet
NCT04172922 | TERMINATED | PHASE1
5 Participants

Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-04-01
Completion: 2024-02-15
Conditions
Vascular Anomaly
Interventions
DRUG
No Results Yet
NCT04141449 | ACTIVE_NOT_RECRUITING | PHASE2
874 Participants

A Multilevel Intervention to Improve Timely Cancer Detection and Treatment Initiation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-11-18
Completion: 2026-09-30
Conditions
Neoplasms Hiv Cervical Cancer Breast Cancer HNSCC Vulvar Cancer Anal Cancer Cancer Suspect
Interventions
OTHER
No Results Yet
NCT04124198 | ACTIVE_NOT_RECRUITING | NA
138 Participants

Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-03-01
Completion: 2025-12-16
Conditions
Oropharynx Cancer Oropharynx Squamous Cell Carcinoma Carcinoma, Squamous Cell Carcinoma Oropharyngeal Neoplasms Neoplasms, Squamous Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Pharyngeal Neoplasms Malignant and Unspecified Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Otorhinolaryngologic Diseases Pharyngeal Diseases Papillomavirus Infections Virus Diseases DNA Virus Infections Tumor Virus Infections Quality of Life
Interventions
RADIATION DRUG PROCEDURE
No Results Yet
NCT04116905 | COMPLETED | NA
68 Participants

Intensive Lifestyle Intervention for Remission of Metabolic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-10-01
Completion: 2022-08-31
Conditions
Metabolic Syndrome
Interventions
BEHAVIORAL
No Results Yet
NCT04115319 | COMPLETED | PHASE3
305 Participants

A Study of the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-11-21
Completion: 2022-12-30
Conditions
Schizophrenia
Interventions
DRUG
Results Available
NCT04091009 | WITHDRAWN | PHASE4
0 Participants

Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-10-31
Completion: 2025-12-31
Conditions
Opioid-use Disorder Opioid Use Disorder, Mild
Interventions
DRUG
No Results Yet
NCT04064086 | ACTIVE_NOT_RECRUITING | NA
656 Participants

Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-03-25
Completion: 2025-09-30
Conditions
Chronic Kidney Disease End Stage Renal Disease Hemodialysis Peritoneal Dialysis
Interventions
OTHER
No Results Yet
NCT04034264 | RECRUITING
6500 Participants

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-23
Completion: 2026-07-01
Conditions
Vector-Borne Diseases Emerging Pathogens
No Results Yet
NCT04023552 | ACTIVE_NOT_RECRUITING | PHASE3
8323 Participants

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-12-12
Completion: 2026-02-26
Conditions
Cardiovascular Disease and Lipoprotein(a)
Interventions
DRUG
No Results Yet
NCT04002596 | COMPLETED | NA
10 Participants

Safety and Initial Effectiveness of Transcranial MR Guided Focused Ultrasound for the Treatment of Parkinson's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-02-06
Completion: 2018-12-05
Conditions
Parkinson Disease
Interventions
DEVICE
No Results Yet
NCT03978767 | COMPLETED | PHASE2
287 Participants

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-06-10
Completion: 2025-07-31
Conditions
Preeclampsia Severe Preeclampsia Postpartum
Interventions
DRUG
No Results Yet
NCT03955185 | ACTIVE_NOT_RECRUITING | NA
2000 Participants

Clinical Trial of Minimally Invasive Surgery Versus Abdominal Surgery in Patients With Early Stage Cervical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-05-01
Completion: 2026-05-01
Conditions
Uterine Cervical Neoplasm
Interventions
PROCEDURE
No Results Yet
NCT03952598 | SUSPENDED | PHASE2
42 Participants

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-10-16
Completion: 2025-12-31
Conditions
Glioma Gliomas High Grade Glioma Malignant Glioma Low Grade Glioma
Interventions
DRUG DEVICE
No Results Yet
NCT03942653 | RECRUITING | PHASE2
20 Participants

Androgen Deprivation Therapy (ADT) and Pembrolizumab for Advanced Stage Androgen Receptor-positive Salivary Gland Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-05-30
Completion: 2026-04-30
Conditions
Salivary Gland Carcinoma
Interventions
DRUG
No Results Yet
NCT03937830 | ACTIVE_NOT_RECRUITING | PHASE2
27 Participants

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-03-10
Completion: 2025-12-31
Conditions
Hepatocellular Cancer Hepatocellular Carcinoma Metastatic Hepatocellular Carcinoma
Interventions
DRUG PROCEDURE
No Results Yet
NCT03926117 | COMPLETED | PHASE2
264 Participants

Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-06-03
Completion: 2020-06-26
Conditions
Chronic Kidney Diseases Inflammation
Interventions
BIOLOGICAL
Results Available
NCT03922724 | RECRUITING | PHASE2
330 Participants

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-04-18
Completion: 2026-10-31
Conditions
Peripheral T-cell Lymphomas Lymphoproliferative Disorders Immune System Diseases
Interventions
DRUG PROCEDURE
No Results Yet
NCT03844750 | TERMINATED | PHASE2
6 Participants

Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-22
Completion: 2025-09-30
Conditions
Metastatic Malignant Neoplasm in the Liver Stage IV Colorectal Cancer AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE BIOLOGICAL DRUG
Results Available
NCT03840993 | COMPLETED | PHASE2
76 Participants

Safety and Efficacy Study of MT-2990 in Women With Endometriosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-01-15
Completion: 2021-05-13
Conditions
Endometrial Related Pain
Interventions
DRUG
Results Available
NCT03809039 | TERMINATED | PHASE1
52 Participants

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-01-15
Completion: 2019-07-01
Conditions
Healthy
Interventions
DRUG
Results Available
NCT03783351 | ACTIVE_NOT_RECRUITING | NA
4009 Participants

Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-05-27
Completion: 2026-03-31
Conditions
Angina, Stable Acute Coronary Syndrome Drug-Eluting Stents Genotype
Interventions
GENETIC
No Results Yet
NCT03762733 | ENROLLING_BY_INVITATION
500 Participants

Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-01-04
Completion: 2028-12-29
Conditions
Breast Cancer Ovarian Cancer Uterine Cancer
No Results Yet
NCT03736226 | ACTIVE_NOT_RECRUITING
2000 Participants

A Post-Approval, Single-Arm Study of the SYNERGY Stent System in China

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-30
Completion: 2024-08-01
Conditions
Cardiovascular Diseases
Interventions
DEVICE
No Results Yet
NCT03727490 | COMPLETED | NA
102 Participants

The Role of Subscapularis Repair in Reverse Shoulder Arthroplasty

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-12-01
Completion: 2025-01-01
Conditions
Arthropathy Shoulder
Interventions
OTHER
No Results Yet
NCT03602859 | ACTIVE_NOT_RECRUITING | PHASE3
1400 Participants

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-11
Completion: 2024-10-31
Conditions
Ovarian Neoplasms Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
Interventions
DRUG
Results Available
NCT03599765 | ACTIVE_NOT_RECRUITING | PHASE2
380 Participants

Systemic Therapy With or Without Local Consolidative Therapy in Treating Patients With Oligometastatic Solid Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-07-31
Completion: 2029-12-31
Conditions
Oligometastatic Malignant Solid Neoplasm
Interventions
OTHER PROCEDURE
No Results Yet
NCT03596905 | COMPLETED | PHASE2
218 Participants

Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-06-30
Completion: 2024-11-25
Conditions
Irritable Bowel Syndrome With Constipation
Interventions
DRUG
Results Available
NCT03541200 | COMPLETED | PHASE2
190 Participants

Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-04-18
Completion: 2019-11-15
Conditions
Vasomotor Symptoms (VMS)
Interventions
DRUG
Results Available
NCT03529019 | RECRUITING | EARLY_PHASE1
30 Participants

Nutrition in Patient With Critical Limb Ischemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-02
Completion: 2026-06-30
Conditions
Critical Limb Ischemia Malnutrition Nutritional Supplements
Interventions
DRUG
No Results Yet
NCT03520660 | ACTIVE_NOT_RECRUITING | PHASE4
121 Participants

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-19
Completion: 2032-12-31
Conditions
Diabetes Mellitus Hepatitis C, Chronic Cardiovascular Diseases
Interventions
DRUG
No Results Yet
NCT03520036 | COMPLETED | PHASE2
102 Participants

Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-07-05
Completion: 2019-09-28
Conditions
Erythropoietic Protoporphyria (EPP)
Interventions
DRUG
Results Available
NCT03481829 | RECRUITING
1500 Participants

Early Tracking of Childhood Health Determinants (ETCHED) Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-14
Completion: 2041-12-31
Conditions
Diabetes Mellitus Obesity Fatty Liver
No Results Yet
NCT03481738 | ACTIVE_NOT_RECRUITING
500 Participants

Pyruvate Kinase Deficiency Global Longitudinal Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2018-04-23
Completion: 2027-05-31
Conditions
Pyruvate Kinase Deficiency
No Results Yet
NCT03464994 | COMPLETED | NA
152 Participants

Ophthalmological Abnormalities in Hereditary Ichthyosis (ICHTYO-KERATO)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-07-18
Completion: 2022-06-30
Conditions
Ichthyosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT03464344 | COMPLETED | NA
170 Participants

Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-12
Completion: 2025-02-11
Conditions
Cerebral Amyloid Angiopathy
Interventions
OTHER
No Results Yet
NCT03437486 | RECRUITING
750 Participants

Mechanisms of Familial Pulmonary Fibrosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2009-01-01
Completion: 2030-01-30
Conditions
Familial Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonia
No Results Yet
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