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Clinical Trials

Showing trials with last updates posted in 2025.

NCT03926117 | COMPLETED | PHASE2
264 Participants

Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-06-03
Completion: 2020-06-26
Conditions
Chronic Kidney Diseases Inflammation
Interventions
BIOLOGICAL
Results Available
NCT03922724 | RECRUITING | PHASE2
330 Participants

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-04-18
Completion: 2026-10-31
Conditions
Peripheral T-cell Lymphomas Lymphoproliferative Disorders Immune System Diseases
Interventions
DRUG PROCEDURE
No Results Yet
NCT03844750 | TERMINATED | PHASE2
6 Participants

Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-22
Completion: 2025-09-30
Conditions
Metastatic Malignant Neoplasm in the Liver Stage IV Colorectal Cancer AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE BIOLOGICAL DRUG
Results Available
NCT03840993 | COMPLETED | PHASE2
76 Participants

Safety and Efficacy Study of MT-2990 in Women With Endometriosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-01-15
Completion: 2021-05-13
Conditions
Endometrial Related Pain
Interventions
DRUG
Results Available
NCT03809039 | TERMINATED | PHASE1
52 Participants

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-01-15
Completion: 2019-07-01
Conditions
Healthy
Interventions
DRUG
Results Available
NCT03783351 | ACTIVE_NOT_RECRUITING | NA
4009 Participants

Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-05-27
Completion: 2026-03-31
Conditions
Angina, Stable Acute Coronary Syndrome Drug-Eluting Stents Genotype
Interventions
GENETIC
No Results Yet
NCT03762733 | ENROLLING_BY_INVITATION
500 Participants

Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-01-04
Completion: 2028-12-29
Conditions
Breast Cancer Ovarian Cancer Uterine Cancer
No Results Yet
NCT03736226 | ACTIVE_NOT_RECRUITING
2000 Participants

A Post-Approval, Single-Arm Study of the SYNERGY Stent System in China

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-30
Completion: 2024-08-01
Conditions
Cardiovascular Diseases
Interventions
DEVICE
No Results Yet
NCT03733093 | ACTIVE_NOT_RECRUITING
1377 Participants

PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2019-08-22
Completion: 2025-12-31
Conditions
HIV
No Results Yet
NCT03727490 | COMPLETED | NA
102 Participants

The Role of Subscapularis Repair in Reverse Shoulder Arthroplasty

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-12-01
Completion: 2025-01-01
Conditions
Arthropathy Shoulder
Interventions
OTHER
No Results Yet
NCT03602859 | ACTIVE_NOT_RECRUITING | PHASE3
1400 Participants

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-11
Completion: 2024-10-31
Conditions
Ovarian Neoplasms Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
Interventions
DRUG
Results Available
NCT03599765 | ACTIVE_NOT_RECRUITING | PHASE2
380 Participants

Systemic Therapy With or Without Local Consolidative Therapy in Treating Patients With Oligometastatic Solid Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-07-31
Completion: 2029-12-31
Conditions
Oligometastatic Malignant Solid Neoplasm
Interventions
OTHER PROCEDURE
No Results Yet
NCT03596905 | COMPLETED | PHASE2
218 Participants

Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-06-30
Completion: 2024-11-25
Conditions
Irritable Bowel Syndrome With Constipation
Interventions
DRUG
Results Available
NCT03541200 | COMPLETED | PHASE2
190 Participants

Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-04-18
Completion: 2019-11-15
Conditions
Vasomotor Symptoms (VMS)
Interventions
DRUG
Results Available
NCT03529019 | RECRUITING | EARLY_PHASE1
30 Participants

Nutrition in Patient With Critical Limb Ischemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-02
Completion: 2026-06-30
Conditions
Critical Limb Ischemia Malnutrition Nutritional Supplements
Interventions
DRUG
No Results Yet
NCT03520660 | ACTIVE_NOT_RECRUITING | PHASE4
121 Participants

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-19
Completion: 2032-12-31
Conditions
Diabetes Mellitus Hepatitis C, Chronic Cardiovascular Diseases
Interventions
DRUG
No Results Yet
NCT03520036 | COMPLETED | PHASE2
102 Participants

Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-07-05
Completion: 2019-09-28
Conditions
Erythropoietic Protoporphyria (EPP)
Interventions
DRUG
Results Available
NCT03481829 | RECRUITING
1500 Participants

Early Tracking of Childhood Health Determinants (ETCHED) Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-14
Completion: 2041-12-31
Conditions
Diabetes Mellitus Obesity Fatty Liver
No Results Yet
NCT03481738 | ACTIVE_NOT_RECRUITING
500 Participants

Pyruvate Kinase Deficiency Global Longitudinal Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2018-04-23
Completion: 2027-05-31
Conditions
Pyruvate Kinase Deficiency
No Results Yet
NCT03464994 | COMPLETED | NA
152 Participants

Ophthalmological Abnormalities in Hereditary Ichthyosis (ICHTYO-KERATO)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-07-18
Completion: 2022-06-30
Conditions
Ichthyosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT03464344 | COMPLETED | NA
170 Participants

Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-10-12
Completion: 2025-02-11
Conditions
Cerebral Amyloid Angiopathy
Interventions
OTHER
No Results Yet
NCT03437486 | RECRUITING
750 Participants

Mechanisms of Familial Pulmonary Fibrosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2009-01-01
Completion: 2030-01-30
Conditions
Familial Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonia
No Results Yet
NCT03420482 | ACTIVE_NOT_RECRUITING | PHASE2
30 Participants

Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-04-01
Completion: 2026-12-31
Conditions
Hepatic Encephalopathy
Interventions
DRUG
No Results Yet
NCT03405155 | COMPLETED | PHASE2
26 Participants

Nivolumab in Treating Patients With Stage IIB-IIC Melanoma That Can Be Removed by Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-01-17
Completion: 2025-12-15
Conditions
Melanoma (Skin)
Interventions
BIOLOGICAL
No Results Yet
NCT03404193 | ACTIVE_NOT_RECRUITING | PHASE2
235 Participants

Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-01-18
Completion: 2027-12-31
Conditions
Acute Myeloid Leukemia Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Blastic Plasmacytoid Dendritic Cell Neoplasm Chronic Myelomonocytic Leukemia Mixed Phenotype Acute Leukemia Myelodysplastic Syndrome Recurrent Acute Biphenotypic Leukemia Recurrent Acute Myeloid Leukemia Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm Recurrent Chronic Myelomonocytic Leukemia Recurrent Mixed Phenotype Acute Leukemia Refractory Acute Myeloid Leukemia Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm Refractory Chronic Myelomonocytic Leukemia Refractory Mixed Phenotype Acute Leukemia
Interventions
DRUG OTHER
No Results Yet
NCT03397667 | COMPLETED | NA
236 Participants

The Aging Brain ANSWERS Program

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-08-01
Completion: 2023-05-31
Conditions
Traumatic Brain Injury Alzheimer Disease Veterans Family Caregivers Caregiver Burden Quality of Life
Interventions
OTHER
No Results Yet
NCT03388606 | RECRUITING
4100 Participants

Characterization and Treatment of Adolescent Depression

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2017-12-28
Completion: 2026-07-01
Conditions
Depression
Interventions
BEHAVIORAL
No Results Yet
NCT03274492 | ACTIVE_NOT_RECRUITING | PHASE3
1000 Participants

A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-11-16
Completion: 2026-07-05
Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG
No Results Yet
NCT03250247 | ACTIVE_NOT_RECRUITING | NA
225 Participants

Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-07-02
Completion: 2025-11-11
Conditions
Deep Vein Thrombosis Venous Stasis Venous Insufficiency Venous Leg Ulcer Venous Reflux Post Thrombotic Syndrome
Interventions
DEVICE
No Results Yet
NCT03085433 | COMPLETED | NA
393 Participants

Sperm Selection by Microfluidic Separation Improves Embryo Quality

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-06-20
Completion: 2021-10-30
Conditions
Sperm DNA Fragmentation Embryo Quality Fertility Disorders Infertility Infertility, Male Infertility Unexplained
Interventions
DEVICE PROCEDURE
Results Available
NCT03049462 | RECRUITING | PHASE1
100 Participants

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2017-03-13
Completion: 2026-09-30
Conditions
Polycystic Ovary Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT03029429 | ACTIVE_NOT_RECRUITING | PHASE2
29 Participants

Theophylline Treatment for Pseudohypoparathyroidism

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2018-09-01
Completion: 2026-12-01
Conditions
Pseudohypoparathyroidism Albright Hereditary Osteodystrophy
Interventions
DRUG
No Results Yet
NCT02951052 | ACTIVE_NOT_RECRUITING | PHASE3
618 Participants

Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-10-28
Completion: 2018-05-29
Conditions
Infection, Human Immunodeficiency Virus HIV Infections
Interventions
DRUG
Results Available
NCT02938520 | ACTIVE_NOT_RECRUITING | PHASE3
631 Participants

Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-10-27
Completion: 2018-08-30
Conditions
HIV Infections
Interventions
DRUG
Results Available
NCT02877706 | RECRUITING
1500 Participants

French Registry of Adult Patients With Immune Thrombocytopenia and Autoimmune Hemolytic Anemia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2013-06-30
Completion: 2026-12-31
Conditions
Immune Thrombocytopenia Autoimmune Hemolytic Anemia
Interventions
OTHER
No Results Yet
NCT02756793 | ACTIVE_NOT_RECRUITING | NA
90 Participants

Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-10-31
Completion: 2022-07-31
Conditions
Metastatic Cancer
Interventions
RADIATION OTHER
No Results Yet
NCT02739295 | COMPLETED | PHASE4
10 Participants

G-CSF in the Treatment of Toxic Epidermal Necrolysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-07-31
Completion: 2023-03-07
Conditions
Stevens - Johnson Syndrome
Interventions
DRUG
No Results Yet
NCT02719951 | COMPLETED | PHASE1
27 Participants

Glutaminergic Transmission in Autism : Molecular Imaging Exploration

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-04-30
Completion: 2018-11-15
Conditions
Autism Fragile-X Syndrome (FXS) Healthy Volunteers
Interventions
DRUG OTHER
No Results Yet
NCT02709226 | COMPLETED | PHASE1
17 Participants

Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-06-15
Completion: 2022-12-16
Conditions
Astrocytoma, Grade IV Giant Cell Glioblastoma Glioblastoma Multiforme Gliosarcoma
Interventions
RADIATION
No Results Yet
NCT02669225 | COMPLETED | EARLY_PHASE1
22 Participants

Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2016-05-02
Completion: 2017-01-24
Conditions
Normal Physiology
Interventions
OTHER
No Results Yet
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