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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04626596 | COMPLETED | PHASE3
498 Participants

A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-19
Completion: 2024-12-30
Conditions
Contraception
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04604067 | ACTIVE_NOT_RECRUITING | PHASE2
260 Participants

Assessing a ctDNA and PET-oriented Therapy in Patients With DLBCL A Multicenter, Open-label, Phase II Trial.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-06-25
Completion: 2026-07-30
Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT04597359 | RECRUITING | PHASE2
360 Participants

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-05
Completion: 2032-12-31
Conditions
Prostate Carcinoma
Interventions
DRUG OTHER
No Results Yet
NCT04582201 | COMPLETED | PHASE1
20 Participants

A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-09-21
Completion: 2023-04-23
Conditions
Respiratory Distress Syndrome, Adult
Interventions
DRUG
No Results Yet
NCT04577404 | COMPLETED | PHASE3
124 Participants

Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-29
Completion: 2023-08-09
Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
DRUG
Results Available
NCT04573439 | RECRUITING | NA
30 Participants

Protein Requirements for Active Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-08-16
Completion: 2026-06-30
Conditions
Healthy
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04569084 | TERMINATED | PHASE3
384 Participants

Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-13
Completion: 2023-09-29
Conditions
ALS
Interventions
DRUG
Results Available
NCT04569032 | ACTIVE_NOT_RECRUITING | PHASE2
82 Participants

A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-12
Completion: 2024-05-09
Conditions
Peripheral T-cell Lymphoma
Interventions
DRUG
Results Available
NCT04566328 | RECRUITING | PHASE3
1450 Participants

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-02-24
Completion: 2027-12-31
Conditions
Plasma Cell Myeloma RISS Stage I Plasma Cell Myeloma RISS Stage II Plasma Cell Myeloma
Interventions
DRUG BIOLOGICAL OTHER
No Results Yet
NCT04490564 | COMPLETED
135 Participants

Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-06-25
Completion: 2022-09-07
Conditions
Head and Neck Squamous Cell Carcinoma Non Small Cell Lung Cancer Melanoma
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04484818 | ACTIVE_NOT_RECRUITING | PHASE3
27 Participants

Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-03-01
Completion: 2026-06-30
Conditions
Prostate Carcinoma
Interventions
DRUG OTHER
No Results Yet
NCT04480814 | COMPLETED
30 Participants

Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood & Primary Tumor in ER+/HER2- MBC

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-10-11
Completion: 2022-02-08
Conditions
Breast Cancer
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04474158 | ACTIVE_NOT_RECRUITING | NA
1800 Participants

Creating Peace: Community-based Youth Violence Prevention to Address Racism and Discrimination

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-12-04
Completion: 2026-01-23
Conditions
Adolescent Behavior Group, Peer Violence, Non-accidental Violence, Sexual Violence, Domestic Emotional Abuse Coping Skills Communication, Personal
Interventions
BEHAVIORAL
No Results Yet
NCT04472260 | RECRUITING | NA
32 Participants

Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-15
Completion: 2026-07-14
Conditions
Acute Respiratory Distress Syndrome Prone Position
Interventions
PROCEDURE
No Results Yet
NCT04467021 | ACTIVE_NOT_RECRUITING | NA
61 Participants

Cancer and Blood Pressure Management, CARISMA Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-29
Completion: 2026-08-31
Conditions
Cardiovascular Disorder Chronic Kidney Disease Metastatic Renal Cell Carcinoma Metastatic Thyroid Gland Medullary Carcinoma Stage IV Renal Cell Cancer AJCC v8 Stage IV Thyroid Gland Medullary Carcinoma AJCC v8 Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8 Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8 Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8
Interventions
OTHER
No Results Yet
NCT04461639 | ACTIVE_NOT_RECRUITING
62 Participants

Study to Learn More About the Safety of Drug Jivi Over a Long Period of Time in Previously Treated Patients With Hemophilia A (Bleeding Disorder Resulting From a Lack of FVIII) Who Are Receiving Jivi Regularly at Their Treating Doctors to Prevent Bleeding

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-05-14
Completion: 2028-06-30
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
NCT04451499 | COMPLETED | NA
40 Participants

The Effect of Adding Smartphone-based Platform to the Bariatric Surgery Preparation Process

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-12-28
Completion: 2022-10-01
Conditions
Bariatric Surgery Candidate Nutritional and Metabolic Diseases
Interventions
OTHER
No Results Yet
NCT04446728 | ACTIVE_NOT_RECRUITING | NA
18 Participants

Implementation of Family Psychosocial Risk Assessment in Pediatric Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-01-01
Completion: 2026-12-31
Conditions
Pediatric Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04442048 | COMPLETED | PHASE3
195 Participants

Immunization With IMM-101 vs Observation for Prevention of Respiratory and Severe COVID-19 Related Infections in Cancer Patients at Increased Risk of Exposure

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-01
Completion: 2024-05-07
Conditions
Cancer Covid-19
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT04440592 | COMPLETED | PHASE2
76 Participants

Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Diffuse Cutaneous Systemic Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-02-05
Completion: 2024-01-17
Conditions
Diffuse Cutaneous Systemic Sclerosis
Interventions
DRUG
Results Available
NCT04434768 | ACTIVE_NOT_RECRUITING | PHASE1
10 Participants

Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-12-02
Completion: 2026-02-28
Conditions
Acute Stroke
Interventions
BIOLOGICAL
No Results Yet
NCT04423211 | RECRUITING | PHASE3
804 Participants

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-08
Completion: 2032-12-31
Conditions
Biochemically Recurrent Prostate Carcinoma Metastatic Prostate Carcinoma Prostate Adenocarcinoma Stage IVB Prostate Cancer AJCC v8
Interventions
RADIATION DRUG PROCEDURE OTHER
No Results Yet
NCT04421625 | COMPLETED | NA
1102 Participants

Patients and Health Staff of Cancer Centres During the Covid-19 Pandemic

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-06-15
Completion: 2022-06-28
Conditions
COVID-19
Interventions
DIAGNOSTIC_TEST
Results Available
NCT04417023 | ENROLLING_BY_INVITATION
500 Participants

B3 for NMD: Bench to Bedside and Back

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-05-06
Completion: 2031-12-31
Conditions
Neuromuscular Disease
Interventions
OTHER
No Results Yet
NCT04416581 | RECRUITING | PHASE4
3320 Participants

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-05-12
Completion: 2026-09-30
Conditions
Coronary Artery Disease Percutaneous Coronary Intervention Acute Coronary Syndrome Myocardial Infarction
Interventions
DRUG
No Results Yet
NCT04402489 | COMPLETED | PHASE3
184 Participants

Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria or X-Linked Protoporphyria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-06-01
Completion: 2021-12-14
Conditions
EPP XLP
Interventions
DRUG
Results Available
NCT04359875 | COMPLETED | NA
22000 Participants

A Phone-call With a Student/General Practitioner Team to Impact Morbidity of Chronic Patients During COVID-19 Containment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-04-30
Completion: 2020-06-30
Conditions
Cardiovascular Diseases Mental Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT04348747 | RECRUITING | PHASE2
23 Participants

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-12-19
Completion: 2027-06-15
Conditions
Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Malignant Neoplasm in the Brain Metastatic Triple-Negative Breast Carcinoma Prognostic Stage IV Breast Cancer AJCC v8
Interventions
BIOLOGICAL
No Results Yet
NCT04336722 | ACTIVE_NOT_RECRUITING | PHASE3
254 Participants

Efficacy and Safety of Odevixibat in Children With Biliary Atresia Who Have Undergone a Kasai HPE (BOLD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-07-08
Completion: 2026-06-26
Conditions
Biliary Atresia
Interventions
DRUG
No Results Yet
NCT04336644 | RECRUITING | NA
60 Participants

Continuous Versus Intermittent cARdiac Electrical moNitorinG

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-11-21
Completion: 2026-12-31
Conditions
Torsades de Pointe Caused by Drug Long QT Syndrome
Interventions
DEVICE
No Results Yet
NCT04331119 | ACTIVE_NOT_RECRUITING | PHASE2
17 Participants

Duvelisib Maintenance After Autologous Stem Cell Transplant in T-Cell Lymphomas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-07-23
Completion: 2026-04-22
Conditions
T-Cell Lymphoma
Interventions
DRUG PROCEDURE
No Results Yet
NCT04331041 | ACTIVE_NOT_RECRUITING | PHASE2
42 Participants

Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-08-24
Completion: 2026-04-30
Conditions
Pancreas Cancer Cancer of the Pancreas Pancreas Adenocarcinoma
Interventions
DEVICE DRUG PROCEDURE
No Results Yet
NCT04314544 | ACTIVE_NOT_RECRUITING | PHASE3
508 Participants

Efficacy and Safety of Tildrakizumab Compared to Placebo in Subjects With Active Psoriatic Arthritis I (INSPIRE 1)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-07-01
Completion: 2025-03-26
Conditions
Active Psoriatic Arthritis
Interventions
DRUG
No Results Yet
NCT04314531 | ACTIVE_NOT_RECRUITING | PHASE3
296 Participants

Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-07-01
Completion: 2025-09-04
Conditions
Active Psoriatic Arthritis
Interventions
DRUG
No Results Yet
NCT04300764 | WITHDRAWN | NA
0 Participants

Gamification to Increase Mobility in the Hospital

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2026-01-01
Completion: 2026-04-30
Conditions
Coronary Artery Disease Coronary Heart Disease Hypertension Diabete Mellitus Dyslipidemias Obesity Heart Failure
Interventions
BEHAVIORAL
No Results Yet
NCT04259632 | ACTIVE_NOT_RECRUITING | NA
115 Participants

Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-15
Completion: 2023-10-12
Conditions
Obesity
Interventions
BEHAVIORAL
Results Available
NCT04231708 | NOT_YET_RECRUITING | PHASE2
20 Participants

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2026-10-31
Completion: 2028-12-31
Conditions
Opioid Use Disorder
Interventions
DRUG DEVICE
No Results Yet
NCT04230304 | TERMINATED | PHASE2
8 Participants

Daratumumab and Ibrutinib for the Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia, DIRECT Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-11
Completion: 2023-05-01
Conditions
Recurrent Chronic Lymphocytic Leukemia Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Small Lymphocytic Lymphoma
Interventions
BIOLOGICAL DRUG
Results Available
NCT04230174 | COMPLETED | PHASE4
22 Participants

Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-12-29
Completion: 2024-10-09
Conditions
Multiple Sclerosis
Interventions
DRUG
Results Available
NCT04227899 | ACTIVE_NOT_RECRUITING | NA
261 Participants

LIFE-BTK Randomized Controlled Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-08-18
Completion: 2023-08-17
Conditions
Critical Limb Ischemia (CLI)
Interventions
DEVICE
Results Available
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