Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

NCT ID: NCT04423211

Last Updated: 2025-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

804 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-08

Study Completion Date

2032-12-31

Brief Summary

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This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in patients with prostate cancer who experience biochemical recurrence (a rise in the blood level of prostate specific antigen \[PSA\] after surgical removal of the prostate cancer).

A second question tests treatment in patients with biochemical recurrence who show prostate cancer spreading outside the pelvis (metastasis) by positron emission tomography (PET) imaging. In these patients, the benefit of adding metastasis-directed radiation to enhanced therapy (apalutamide in combination with abiraterone + prednisone) is tested.

Diagnostic procedures, such as PET, may help doctors look for cancer that has spread to the pelvis. Androgens are hormones that may cause the growth of prostate cancer cells. Apalutamide may help fight prostate cancer by blocking the use of androgens by the tumor cells. Metastasis-directed targeted radiation therapy uses high energy rays to kill tumor cells and shrink tumors that have spread. This trial may help doctors determine if using PET results to deliver more tailored treatment (i.e., adding apalutamide, with or without targeted radiation therapy, to standard of care treatment) works better than standard of care treatment alone in patients with biochemical recurrence of prostate cancer.

Detailed Description

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PRIMARY OBJECTIVES:

I. For patients without PET-evidence of extrapelvic metastases, to evaluate whether the addition of enhanced systemic therapy to standard of care (SOC) salvage radiation therapy (RT) could prolong progression-free survival (PFS).

II. For patients with PET-evidence of extrapelvic metastases, to evaluate whether the addition of metastasis-directed RT to enhanced systemic therapy and SOC salvage RT could prolong PFS.

III. To compare overall quality of life, measured by Functional Assessment of Cancer Therapy - Prostate (FACT-P) total score, at 6 months between the two sets of treatment arms (A with B and C with D). (QUALITY OF LIFE \[QOL\] OBJECTIVE)

SECONDARY OBJECTIVES:

I. To evaluate overall survival in each arm. II. To evaluate event-free survival in each arm. III. To evaluate time to prostate-specific antigen (PSA) progression in each arm.

IV. To assess the incidence of adverse events with the addition of enhanced systemic therapy in patients without PET-evidence of extrapelvic metastases.

V. To assess the incidence of adverse events with local ablative metastasis-directed RT for PET-positive metastatic disease in patients with PET-evidence of extrapelvic metastases.

VI. To estimate the detection rate of PET at the patient and regional level, and to evaluate its concordance with the follow-up Food and Drug Administration (FDA)-approved conventional imaging modalities (CIM) (as available) considered standard-of-care per institution, including computed tomography (CT), bone scintigraphy, magnetic resonance imaging (MRI) and PET imaging.

VII. To determine the distribution of PET-positive lesions among anatomic sites (prostate fossa, intrapelvic soft tissue/lymph node, extrapelvic soft tissue/lymph node, and bone metastases) in patients with post-radical prostatectomy (RP) biochemical recurrence (BCR), correlated with PSA (level, doubling time, velocity) and other relevant clinical parameters.

VIII. To compare the change in overall QOL, measured by FACT-P total score, from baseline to 6 months between the two sets of treatment arms (A with B and C with D). (QOL OBJECTIVE) IX. To compare patient-reported fatigue (Functional Assessment of Chronic Illness Therapy \[FACIT\]-Fatigue scores) at 6 months between the two sets of treatment arms (A with B and C with D). (QOL OBJECTIVE) X. To compare patient-reported overall QOL (FACT-P scores), fatigue (FACIT-Fatigue scores) and pain interference (patient reported outcomes measurement information system \[PROMIS\] Pain Interference Short Form 4a) between the two sets of treatment arms (A with B and C with D) at the time of disease progression. (QOL OBJECTIVE)

EXPLORATORY OBJECTIVES:

I.To determine the value of repeat PET (PET2) at time of second PSA progression, clinical concern for progression, or 12 months after completion of enhanced systemic therapy, whichever comes first to assess response to therapy (enhanced systemic therapy +/- focal RT and/or androgen deprivation therapy \[ADT\]) compared to available standard response assessments (PSA and conventional imaging modalities \[CIM\]).

II. To compare cognitive function, measured by FACT - cognitive function (Cog) peritoneal cancer index (PCI) and total scores, between the three treatment arms receiving enhanced systemic treatment with ADT and apalutamide (Arms B, C, and D) and antiandrogen therapy (ADT) alone (Arm A) at 6 and 12 month. (QOL OBJECTIVE) III. To compare the change in cognitive function, measured by change in FACT-Cog PCI and total scores, from baseline to 6 and baseline to 12 months, between the three treatment arms receiving enhanced systemic treatment with ADT and apalutamide (Arms B, C, and D) and ADT alone (Arm A) at 6 and 12 months. (QOL OBJECTIVE) IV. To characterize longitudinal change in cognitive function between baseline and 24 months in patients with prostate cancer receiving treatment for biochemical recurrence (BCR) and define clinical and disease related characteristics associated with greater cognitive change by the FACT-Cog PCI and total scores. (QOL OBJECTIVE)

OUTLINE:

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 intravenously (IV) undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.

STEP 1: Patients are randomized to 1 of 4 arms based on results of fluciclovine F18 PET/CT or PET/MR in Step 0.

ARM A (PET NEGATIVE FOR EXTRA PELVIC-METASTASES): Patients undergo SOC external beam radiation therapy (EBRT) for 6 months. Patients also receive goserelin acetate subcutaneously (SC), leuprolide acetate intramuscularly (IM), triptorelin IM, relugolix orally (PO), or degarelix SC for 6 months starting up to 3 months prior to EBRT but no later than 7 days after start of EBRT. All treatment continues for 6 months in the absence of disease progression or unacceptable toxicity.

ARM B (PET NEGATIVE FOR EXTRA PELVIC-METASTASES): Patients undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO once daily (QD) for 6 months in the absence of disease progression or unacceptable toxicity.

ARM C: (PET POSITIVE FOR EXTRA PELVIC-METASTASES): Patients undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD as in Arm B.

ARM D (PET POSITIVE FOR EXTRA PELVIC-METASTASES): Patients undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A and apalutamide PO QD as in Arm B. Patients also undergo stereotactic body radiation therapy (SBRT) or 3-dimensional (3D) conformal radiation therapy (CRT), intensity-modulated radiation therapy (IMRT) (including volume modulated arc therapy \[VMAT\]), and intensity-modulated proton therapy (IMPT) over 3-10 fractions in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for the first 2 years, every 6 months for years 3-5, and then annually for years 6-10.

Conditions

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Biochemically Recurrent Prostate Carcinoma Metastatic Prostate Carcinoma Prostate Adenocarcinoma Stage IVB Prostate Cancer AJCC v8

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm A (EBRT, short-term androgen deprivation therapy [STAD])

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.

STEP 1: Patients who are PET negative for extera pelvic metastases undergo SOC EBRT for 6 months. Patients also receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC for 6 months starting up to 3 months prior to EBRT but no later than 7 days after start of EBRT. All treatment continues for 6 months in the absence of disease progression or unacceptable toxicity.

Group Type ACTIVE_COMPARATOR

Computed Tomography

Intervention Type PROCEDURE

Undergo PET/CT

Degarelix

Intervention Type DRUG

Given SC

External Beam Radiation Therapy

Intervention Type RADIATION

Undergo EBRT

Fluciclovine F18

Intervention Type OTHER

Given IV

Goserelin Acetate

Intervention Type DRUG

Given SC

Leuprolide Acetate

Intervention Type DRUG

Given IM

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Undergo PET/MR

Positron Emission Tomography

Intervention Type PROCEDURE

Undergo PET/CT or PET/MR

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Relugolix

Intervention Type DRUG

Given PO

Triptorelin

Intervention Type DRUG

Given IM

Arm B (EBRT, STAD, apalutamide)

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.

STEP 1: Patients who are PET negative for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD for 6 months in the absence of disease progression or unacceptable toxicity.

Group Type EXPERIMENTAL

Apalutamide

Intervention Type DRUG

Given PO

Computed Tomography

Intervention Type PROCEDURE

Undergo PET/CT

Degarelix

Intervention Type DRUG

Given SC

External Beam Radiation Therapy

Intervention Type RADIATION

Undergo EBRT

Fluciclovine F18

Intervention Type OTHER

Given IV

Goserelin Acetate

Intervention Type DRUG

Given SC

Leuprolide Acetate

Intervention Type DRUG

Given IM

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Undergo PET/MR

Positron Emission Tomography

Intervention Type PROCEDURE

Undergo PET/CT or PET/MR

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Relugolix

Intervention Type DRUG

Given PO

Triptorelin

Intervention Type DRUG

Given IM

Arm C (EBRT, STAD, apalutamide)

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.

STEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD as in Arm B.

Group Type EXPERIMENTAL

Apalutamide

Intervention Type DRUG

Given PO

Computed Tomography

Intervention Type PROCEDURE

Undergo PET/CT

Degarelix

Intervention Type DRUG

Given SC

External Beam Radiation Therapy

Intervention Type RADIATION

Undergo EBRT

Fluciclovine F18

Intervention Type OTHER

Given IV

Goserelin Acetate

Intervention Type DRUG

Given SC

Leuprolide Acetate

Intervention Type DRUG

Given IM

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Undergo PET/MR

Positron Emission Tomography

Intervention Type PROCEDURE

Undergo PET/CT or PET/MR

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Relugolix

Intervention Type DRUG

Given PO

Triptorelin

Intervention Type DRUG

Given IM

Arm D (EBRT, STAD, apalutamide, RT)

STEP 0: Patients undergo SOC PET/CT or PET/MR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.

STEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A and apalutamide PO QD as in Arm B. Patients also undergo SBRT or 3D CRT, IMRT (including VMAT), and IMPT over 3-10 fractions in the absence of disease progression or unacceptable toxicity.

Group Type EXPERIMENTAL

3-Dimensional Conformal Radiation Therapy

Intervention Type RADIATION

Undergo 3D CRT

Apalutamide

Intervention Type DRUG

Given PO

Computed Tomography

Intervention Type PROCEDURE

Undergo PET/CT

Degarelix

Intervention Type DRUG

Given SC

External Beam Radiation Therapy

Intervention Type RADIATION

Undergo EBRT

Fluciclovine F18

Intervention Type OTHER

Given IV

Goserelin Acetate

Intervention Type DRUG

Given SC

Intensity-Modulated Proton Therapy

Intervention Type PROCEDURE

Undergo IMPT

Intensity-Modulated Radiation Therapy

Intervention Type RADIATION

Undergo IMRT

Leuprolide Acetate

Intervention Type DRUG

Given IM

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Undergo PET/MR

Positron Emission Tomography

Intervention Type PROCEDURE

Undergo PET/CT or PET/MR

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Relugolix

Intervention Type DRUG

Given PO

Stereotactic Body Radiation Therapy

Intervention Type RADIATION

Undergo SBRT

Triptorelin

Intervention Type DRUG

Given IM

Volume Modulated Arc Therapy

Intervention Type RADIATION

Undergo VMAT

Interventions

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3-Dimensional Conformal Radiation Therapy

Undergo 3D CRT

Intervention Type RADIATION

Apalutamide

Given PO

Intervention Type DRUG

Computed Tomography

Undergo PET/CT

Intervention Type PROCEDURE

Degarelix

Given SC

Intervention Type DRUG

External Beam Radiation Therapy

Undergo EBRT

Intervention Type RADIATION

Fluciclovine F18

Given IV

Intervention Type OTHER

Goserelin Acetate

Given SC

Intervention Type DRUG

Intensity-Modulated Proton Therapy

Undergo IMPT

Intervention Type PROCEDURE

Intensity-Modulated Radiation Therapy

Undergo IMRT

Intervention Type RADIATION

Leuprolide Acetate

Given IM

Intervention Type DRUG

Magnetic Resonance Imaging

Undergo PET/MR

Intervention Type PROCEDURE

Positron Emission Tomography

Undergo PET/CT or PET/MR

Intervention Type PROCEDURE

Quality-of-Life Assessment

Ancillary studies

Intervention Type OTHER

Questionnaire Administration

Ancillary studies

Intervention Type OTHER

Relugolix

Given PO

Intervention Type DRUG

Stereotactic Body Radiation Therapy

Undergo SBRT

Intervention Type RADIATION

Triptorelin

Given IM

Intervention Type DRUG

Volume Modulated Arc Therapy

Undergo VMAT

Intervention Type RADIATION

Other Intervention Names

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3-dimensional radiation therapy 3D Conformal 3D CONFORMAL RADIATION THERAPY 3D CRT 3D radiotherapy 3D-CRT Conformal Therapy Radiation Conformal Therapy Radiation, 3D Conformal Three dimensional external beam radiation therapy (procedure) ARN 509 ARN-509 ARN509 Erleada JNJ 56021927 JNJ-56021927 CAT CAT Scan Computed Axial Tomography Computerized Axial Tomography Computerized axial tomography (procedure) Computerized Tomography CT CT Scan tomography FE200486 Firmagon Definitive Radiation Therapy EBRT External Beam Radiation External Beam Radiotherapy External Beam Radiotherapy (conventional) External Beam RT external radiation External Radiation Therapy external-beam radiation Radiation, External Beam Teleradiotherapy Teletherapy Teletherapy Radiation (18F)Fluciclovine (18F)GE-148 18F-Fluciclovine [18F]FACBC Anti-(18f)FABC Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid Anti-[18F] FACBC Axumin Fluciclovine (18F) FLUCICLOVINE F-18 GE-148 (18F) GE-148 F-18 ZDX Zoladex IMPT IMRT Intensity modulated radiation therapy (procedure) Intensity Modulated RT Intensity-Modulated Radiotherapy Radiation, Intensity-Modulated Radiotherapy A-43818 Abbott 43818 Abbott-43818 Carcinil Depo-Eligard Eligard Enanton Enantone Enantone-Gyn Ginecrin LEUP Leuplin Leuprorelin Acetate Lucrin Lucrin Depot Lupron Lupron Depot Lupron Depot-3 Month Lupron Depot-4 Month Lupron Depot-Ped Lutrate Procren Procrin Prostap TAP-144 Trenantone Uno-Enantone Viadur Magnetic Resonance Magnetic resonance imaging (procedure) Magnetic Resonance Imaging Scan Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance MR MR Imaging MRI MRI Scan NMR Imaging NMRI Nuclear Magnetic Resonance Imaging Medical Imaging, Positron Emission Tomography PET PET Scan Positron emission tomography (procedure) Positron Emission Tomography Scan Positron-Emission Tomography proton magnetic resonance spectroscopic imaging PT Quality of Life Assessment N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea Orgovyx TAK 385 TAK-385 SABR SBRT Stereotactic Ablative Body Radiation Therapy 6-D-Tryptophan-LH-RH 6-D-Tryptophanluteinizing Hormone-releasing Factor AY-25650 CL-118,532 Detryptoreline VMAT Volumetric Modulated Arc Therapy (procedure)

Eligibility Criteria

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Inclusion Criteria

* STEP 0: REGISTRATION ELIGIBILITY CRITERIA
* Patient must be male and \>= 18 years of age.
* Patient must have had a radical prostatectomy (RP) as definitive therapy for histopathologically-proven prostatic adenocarcinoma
* Patient must have biochemical recurrence (BCR) after RP, defined as follows:

* If time to BCR, defined as time to first detectable PSA ( \> lower limit of normal for assay used) after RP, is \< 12 months, a minimum PSA level of \>= 0.2 ng/mL and a confirmatory reading of \>= 0.2 ng/mL is required, per the American Urological Association (AUA) definition (Note: patients with a persistent PSA reading of at least 0.2 ng/mL are eligible)
* If time to BCR, defined as time to first detectable PSA (\> lower limit of normal for assay used) after RP, is \>= 12 months, a minimum absolute PSA of 0.5 ng/mL is required
* If the patient has a detectable PSA (\> lower limit of normal for assay used) at any time after RP AND has an eligible baseline SOC PET (PET1) with at least one positive lesion in any location, then there is no minimum PSA requirement
* Patients must have no definite evidence for extrapelvic metastatic disease by conventional imaging modalities (CIM) (CT abdomen/pelvis or MRI abdomen/pelvis AND bone scintigraphy, or equivalent), within 26 weeks prior to Step 0 registration. If a patient only has a study-eligible PET/CT or PET/MR (i.e., PET done without prior CIM): if the PET is negative for extrapelvic lesions, then baseline CIM is NOT required. If the PET positive for extrapelvic lesions, then patient should have a baseline CT/MRI for soft tissue lesions and/or a bone scan for osseous lesions

* Study eligible = PET using FDA-approved radiotracer and performed within 16 weeks prior to study registration
* Extra-pelvic metastases is defined as any osseous metastases and/or any extrapelvic soft tissue, lymph nodes and organ metastases; extra-pelvic is defined as superior to common iliac bifurcation, outside of standard prostate bed + whole pelvis nodal RT fields. Baseline PET/CT or PET/MR scan (PET1) is eligible for this study if the SOC PET scan is completed with an FDA approved radiotracer for prostate cancer after Step 0 registration and prior to Step 1 randomization OR up to 16 weeks prior to Step 0 registration
* Patient must be a candidate for SOC post-prostatectomy radiation therapy (RT) to the prostate bed and pelvic nodes with androgen deprivation therapy (ADT)
* Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
* Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Patient must not have started ADT for biochemical recurrence prior to baseline PET (PET1) imaging. A short course of low-dose anti-androgen such as bicalutamide, given after baseline study PET/CT but prior to study registration, is permitted as a brief temporizing measure in advance of starting protocol-approved SOC ADT.
* Patient must not be enrolled in another therapeutic clinical trial
* Patient must be able to lie flat and still for approximately 20-30 minutes or otherwise tolerate a PET scan and radiation treatment planning and delivery
* Patients undergoing a PET/MR must meet local institutional safety guidelines for MRI
* Patient must not have history of seizures or known condition that may cause predisposal to seizures (e.g., stroke or head trauma resulting in loss of consciousness) within 1 year prior to registration
* Patient must not have history of inflammatory bowel disease or any gastrointestinal disorder affecting absorption that is expected to increase risk of complication from radiotherapy
* Hemoglobin (Hgb) \>= 9.0 g/dL (independent of transfusion and/or growth factors within 3 months prior to Step 0 registration) (obtained within 8 weeks prior to Step 0 registration)
* Leukocytes \>= 3,000/mcL (obtained within 8 weeks prior to Step 0 registration)
* Absolute neutrophil count \>= 1,500/mcL (obtained within 8 weeks prior to Step 0 registration)
* Platelets \>= 100,000/mcL (obtained within 8 weeks prior to Step 0 registration)
* Total bilirubin \< 1.5 x institutional upper limit of normal (ULN) (patients with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, must have a direct bilirubin of \< 1.5 x ULN to be eligible) (obtained within 8 weeks prior to Step 0 registration)
* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional ULN (obtained within 8 weeks prior to Step 0 registration)
* Creatine \< 1.5 x instituional ULN (or measured creatinine clearance \> 30 mL/min)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class I or II (by patient symptoms) or A or B (by objective assessment)
* Patient must not have completed a course of prior pelvic radiation therapy for any reason
* Patient must agree not to father children while on study
* Patient must be English or Spanish speaking to be eligible for the QOL component of the study

* NOTE: Sites cannot translate the associated QOL forms
* STEP 1: RANDOMIZATION ELIGIBILITY CRITERIA
* Patient must have completed a baseline SOC PET/CT or PET/MR (PET1 scan) using FDA approved radiotracer with results of extra-pelvic metastases involvement known (positive or negative). The PET1 must have been completed after Step 0 registration and prior to Step 1 randomization OR up to 12 weeks prior to Step 0 registration
* For patients with negative extra-pelvic metastases, PET-imaging status of intra-pelvic nodes must be known (positive or negative)
* For patients with positive extra-pelvic metastases (defined as any PET positive lesions outside of standard salvage RT fields \[prostate bed +/- typical whole pelvis\]), the number of extra-pelvic lesions must be known (1 - 5 or \> 5 extra-pelvic lesions)
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

ECOG-ACRIN Cancer Research Group

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Neha Vapiwala

Role: PRINCIPAL_INVESTIGATOR

ECOG-ACRIN Cancer Research Group

Locations

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Anchorage Associates in Radiation Medicine

Anchorage, Alaska, United States

Site Status RECRUITING

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, United States

Site Status RECRUITING

Alaska Oncology and Hematology LLC

Anchorage, Alaska, United States

Site Status RECRUITING

Alaska Women's Cancer Care

Anchorage, Alaska, United States

Site Status RECRUITING

Anchorage Oncology Centre

Anchorage, Alaska, United States

Site Status SUSPENDED

Katmai Oncology Group

Anchorage, Alaska, United States

Site Status RECRUITING

Providence Alaska Medical Center

Anchorage, Alaska, United States

Site Status RECRUITING

Cancer Center at Saint Joseph's

Phoenix, Arizona, United States

Site Status RECRUITING

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States

Site Status RECRUITING

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, United States

Site Status RECRUITING

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States

Site Status RECRUITING

Mercy Cancer Center - Carmichael

Carmichael, California, United States

Site Status RECRUITING

Mercy San Juan Medical Center

Carmichael, California, United States

Site Status RECRUITING

City of Hope Corona

Corona, California, United States

Site Status RECRUITING

City of Hope Comprehensive Cancer Center

Duarte, California, United States

Site Status RECRUITING

Mercy Cancer Center - Elk Grove

Elk Grove, California, United States

Site Status RECRUITING

UC San Diego Moores Cancer Center

La Jolla, California, United States

Site Status RECRUITING

City of Hope Antelope Valley

Lancaster, California, United States

Site Status RECRUITING

Los Angeles General Medical Center

Los Angeles, California, United States

Site Status RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

Site Status RECRUITING

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, United States

Site Status RECRUITING

Mercy Cancer Center

Merced, California, United States

Site Status SUSPENDED

Mercy Cancer Center - Rocklin

Rocklin, California, United States

Site Status RECRUITING

Mercy Cancer Center - Sacramento

Sacramento, California, United States

Site Status RECRUITING

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, United States

Site Status RECRUITING

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, United States

Site Status RECRUITING

City of Hope South Pasadena

South Pasadena, California, United States

Site Status RECRUITING

City of Hope Upland

Upland, California, United States

Site Status RECRUITING

Woodland Memorial Hospital

Woodland, California, United States

Site Status RECRUITING

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, United States

Site Status RECRUITING

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, United States

Site Status RECRUITING

Saint Francis Cancer Center

Colorado Springs, Colorado, United States

Site Status RECRUITING

Porter Adventist Hospital

Denver, Colorado, United States

Site Status SUSPENDED

Saint Anthony Hospital

Lakewood, Colorado, United States

Site Status RECRUITING

Littleton Adventist Hospital

Littleton, Colorado, United States

Site Status SUSPENDED

Longmont United Hospital

Longmont, Colorado, United States

Site Status RECRUITING

Parker Adventist Hospital

Parker, Colorado, United States

Site Status SUSPENDED

Saint Mary Corwin Medical Center

Pueblo, Colorado, United States

Site Status RECRUITING

Sibley Memorial Hospital

Washington D.C., District of Columbia, United States

Site Status RECRUITING

Moffitt Cancer Center-International Plaza

Tampa, Florida, United States

Site Status RECRUITING

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, United States

Site Status RECRUITING

Moffitt Cancer Center

Tampa, Florida, United States

Site Status RECRUITING

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

Site Status RECRUITING

Saint Luke's Cancer Institute - Boise

Boise, Idaho, United States

Site Status RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, United States

Site Status RECRUITING

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, United States

Site Status RECRUITING

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, United States

Site Status RECRUITING

Idaho Urologic Institute-Meridian

Meridian, Idaho, United States

Site Status RECRUITING

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, United States

Site Status RECRUITING

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, United States

Site Status RECRUITING

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, United States

Site Status RECRUITING

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, United States

Site Status RECRUITING

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, United States

Site Status RECRUITING

Alton Memorial Hospital

Alton, Illinois, United States

Site Status SUSPENDED

Rush - Copley Medical Center

Aurora, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Bloomington

Bloomington, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Canton

Canton, Illinois, United States

Site Status RECRUITING

Memorial Hospital of Carbondale

Carbondale, Illinois, United States

Site Status RECRUITING

SIH Cancer Institute

Carterville, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Carthage

Carthage, Illinois, United States

Site Status RECRUITING

Centralia Oncology Clinic

Centralia, Illinois, United States

Site Status RECRUITING

Saint Mary's Hospital

Centralia, Illinois, United States

Site Status RECRUITING

Northwestern University

Chicago, Illinois, United States

Site Status RECRUITING

Rush University Medical Center

Chicago, Illinois, United States

Site Status RECRUITING

University of Illinois

Chicago, Illinois, United States

Site Status RECRUITING

Carle at The Riverfront

Danville, Illinois, United States

Site Status RECRUITING

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, United States

Site Status RECRUITING

Decatur Memorial Hospital

Decatur, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Dixon

Dixon, Illinois, United States

Site Status RECRUITING

Carle Physician Group-Effingham

Effingham, Illinois, United States

Site Status RECRUITING

Crossroads Cancer Center

Effingham, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Eureka

Eureka, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Galesburg

Galesburg, Illinois, United States

Site Status RECRUITING

Western Illinois Cancer Treatment Center

Galesburg, Illinois, United States

Site Status SUSPENDED

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Macomb

Macomb, Illinois, United States

Site Status RECRUITING

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, United States

Site Status RECRUITING

Loyola University Medical Center

Maywood, Illinois, United States

Site Status ACTIVE_NOT_RECRUITING

Good Samaritan Regional Health Center

Mount Vernon, Illinois, United States

Site Status RECRUITING

Cancer Care Center of O'Fallon

O'Fallon, Illinois, United States

Site Status RECRUITING

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Pekin

Pekin, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Peoria

Peoria, Illinois, United States

Site Status RECRUITING

Methodist Medical Center of Illinois

Peoria, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Peru

Peru, Illinois, United States

Site Status RECRUITING

Valley Radiation Oncology

Peru, Illinois, United States

Site Status RECRUITING

Illinois CancerCare-Princeton

Princeton, Illinois, United States

Site Status RECRUITING

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, United States

Site Status RECRUITING

Southern Illinois University School of Medicine

Springfield, Illinois, United States

Site Status RECRUITING

Springfield Clinic

Springfield, Illinois, United States

Site Status RECRUITING

Memorial Medical Center

Springfield, Illinois, United States

Site Status RECRUITING

Carle Cancer Center

Urbana, Illinois, United States

Site Status RECRUITING

The Carle Foundation Hospital

Urbana, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

Site Status RECRUITING

Illinois CancerCare - Washington

Washington, Illinois, United States

Site Status RECRUITING

Central Care Cancer Center - Garden City

Garden City, Kansas, United States

Site Status RECRUITING

Central Care Cancer Center - Great Bend

Great Bend, Kansas, United States

Site Status RECRUITING

Saint Joseph Hospital

Lexington, Kentucky, United States

Site Status RECRUITING

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, United States

Site Status RECRUITING

Saint Joseph Hospital East

Lexington, Kentucky, United States

Site Status RECRUITING

Jewish Hospital

Louisville, Kentucky, United States

Site Status SUSPENDED

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

Biddeford, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

Maine Medical Center-Bramhall Campus

Portland, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

MaineHealth Cancer Care Center of York County

Sanford, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

Maine Medical Center- Scarborough Campus

Scarborough, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

Maine Medical Partners - South Portland

South Portland, Maine, United States

Site Status ACTIVE_NOT_RECRUITING

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, United States

Site Status ACTIVE_NOT_RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States

Site Status RECRUITING

Suburban Hospital

Bethesda, Maryland, United States

Site Status RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, United States

Site Status ACTIVE_NOT_RECRUITING

Minnesota Oncology - Burnsville

Burnsville, Minnesota, United States

Site Status RECRUITING

Mercy Hospital

Coon Rapids, Minnesota, United States

Site Status RECRUITING

Fairview Southdale Hospital

Edina, Minnesota, United States

Site Status RECRUITING

Unity Hospital

Fridley, Minnesota, United States

Site Status ACTIVE_NOT_RECRUITING

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, United States

Site Status RECRUITING

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, United States

Site Status RECRUITING

Saint John's Hospital - Healtheast

Maplewood, Minnesota, United States

Site Status RECRUITING

Abbott-Northwestern Hospital

Minneapolis, Minnesota, United States

Site Status RECRUITING

Hennepin County Medical Center

Minneapolis, Minnesota, United States

Site Status RECRUITING

Health Partners Inc

Minneapolis, Minnesota, United States

Site Status RECRUITING

Monticello Cancer Center

Monticello, Minnesota, United States

Site Status RECRUITING

North Memorial Medical Health Center

Robbinsdale, Minnesota, United States

Site Status RECRUITING

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, United States

Site Status RECRUITING

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States

Site Status RECRUITING

Regions Hospital

Saint Paul, Minnesota, United States

Site Status RECRUITING

United Hospital

Saint Paul, Minnesota, United States

Site Status RECRUITING

Saint Francis Regional Medical Center

Shakopee, Minnesota, United States

Site Status RECRUITING

Lakeview Hospital

Stillwater, Minnesota, United States

Site Status RECRUITING

Ridgeview Medical Center

Waconia, Minnesota, United States

Site Status RECRUITING

Rice Memorial Hospital

Willmar, Minnesota, United States

Site Status RECRUITING

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, United States

Site Status RECRUITING

Baptist Cancer Center-Grenada

Grenada, Mississippi, United States

Site Status RECRUITING

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status ACTIVE_NOT_RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, United States

Site Status RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, United States

Site Status RECRUITING

Central Care Cancer Center - Bolivar

Bolivar, Missouri, United States

Site Status RECRUITING

Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Site Status RECRUITING

Southeast Cancer Center

Cape Girardeau, Missouri, United States

Site Status RECRUITING

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

Site Status RECRUITING

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

Site Status RECRUITING

Parkland Health Center - Farmington

Farmington, Missouri, United States

Site Status RECRUITING

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, United States

Site Status SUSPENDED

Freeman Health System

Joplin, Missouri, United States

Site Status RECRUITING

Mercy Hospital Joplin

Joplin, Missouri, United States

Site Status RECRUITING

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, United States

Site Status RECRUITING

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, United States

Site Status RECRUITING

Heartland Regional Medical Center

Saint Joseph, Missouri, United States

Site Status RECRUITING

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, United States

Site Status RECRUITING

Mercy Hospital Springfield

Springfield, Missouri, United States

Site Status RECRUITING

CoxHealth South Hospital

Springfield, Missouri, United States

Site Status RECRUITING

Washington University School of Medicine

St Louis, Missouri, United States

Site Status RECRUITING

Mercy Hospital South

St Louis, Missouri, United States

Site Status RECRUITING

Siteman Cancer Center-South County

St Louis, Missouri, United States

Site Status RECRUITING

Missouri Baptist Medical Center

St Louis, Missouri, United States

Site Status RECRUITING

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, United States

Site Status RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, United States

Site Status RECRUITING

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, United States

Site Status RECRUITING

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, United States

Site Status RECRUITING

Billings Clinic Cancer Center

Billings, Montana, United States

Site Status RECRUITING

Bozeman Health Deaconess Hospital

Bozeman, Montana, United States

Site Status RECRUITING

Benefis Sletten Cancer Institute

Great Falls, Montana, United States

Site Status RECRUITING

Great Falls Clinic

Great Falls, Montana, United States

Site Status RECRUITING

Kalispell Regional Medical Center

Kalispell, Montana, United States

Site Status RECRUITING

Saint Patrick Hospital - Community Hospital

Missoula, Montana, United States

Site Status RECRUITING

Community Medical Center

Missoula, Montana, United States

Site Status RECRUITING

CHI Health Good Samaritan

Kearney, Nebraska, United States

Site Status RECRUITING

Alegent Health Immanuel Medical Center

Omaha, Nebraska, United States

Site Status RECRUITING

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States

Site Status RECRUITING

Alegent Health Lakeside Hospital

Omaha, Nebraska, United States

Site Status RECRUITING

Creighton University Medical Center

Omaha, Nebraska, United States

Site Status RECRUITING

Cooper Hospital University Medical Center

Camden, New Jersey, United States

Site Status RECRUITING

Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status RECRUITING

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Site Status RECRUITING

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, United States

Site Status RECRUITING

Community Medical Center

Toms River, New Jersey, United States

Site Status RECRUITING

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees Township, New Jersey, United States

Site Status RECRUITING

Northwell Health Imbert Cancer Center

Bay Shore, New York, United States

Site Status RECRUITING

Northwell Health/Center for Advanced Medicine

Lake Success, New York, United States

Site Status RECRUITING

Mount Sinai Union Square

New York, New York, United States

Site Status RECRUITING

Mount Sinai Chelsea

New York, New York, United States

Site Status RECRUITING

Mount Sinai West

New York, New York, United States

Site Status RECRUITING

Lenox Hill Hospital

New York, New York, United States

Site Status RECRUITING

Mount Sinai Hospital

New York, New York, United States

Site Status RECRUITING

Manhattan Eye Ear and Throat Hospital

New York, New York, United States

Site Status RECRUITING

Phelps Memorial Hospital Center

Sleepy Hollow, New York, United States

Site Status RECRUITING

Stony Brook University Medical Center

Stony Brook, New York, United States

Site Status RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, United States

Site Status RECRUITING

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, United States

Site Status RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, United States

Site Status RECRUITING

Westchester Medical Center

Valhalla, New York, United States

Site Status RECRUITING

ECU Health Oncology Kenansville

Kenansville, North Carolina, United States

Site Status RECRUITING

ECU Health Oncology Kinston

Kinston, North Carolina, United States

Site Status RECRUITING

ECU Health Oncology Richlands

Richlands, North Carolina, United States

Site Status RECRUITING

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, United States

Site Status ACTIVE_NOT_RECRUITING

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, United States

Site Status RECRUITING

Bethesda North Hospital

Cincinnati, Ohio, United States

Site Status RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status RECRUITING

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, United States

Site Status ACTIVE_NOT_RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Saint Charles Health System

Bend, Oregon, United States

Site Status RECRUITING

Clackamas Radiation Oncology Center

Clackamas, Oregon, United States

Site Status RECRUITING

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, United States

Site Status RECRUITING

Bay Area Hospital

Coos Bay, Oregon, United States

Site Status RECRUITING

Legacy Mount Hood Medical Center

Gresham, Oregon, United States

Site Status ACTIVE_NOT_RECRUITING

Providence Newberg Medical Center

Newberg, Oregon, United States

Site Status RECRUITING

Providence Willamette Falls Medical Center

Oregon City, Oregon, United States

Site Status RECRUITING

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, United States

Site Status ACTIVE_NOT_RECRUITING

Providence Portland Medical Center

Portland, Oregon, United States

Site Status RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, United States

Site Status RECRUITING

Oregon Health and Science University

Portland, Oregon, United States

Site Status RECRUITING

Legacy Meridian Park Hospital

Tualatin, Oregon, United States

Site Status ACTIVE_NOT_RECRUITING

UPMC Altoona

Altoona, Pennsylvania, United States

Site Status RECRUITING

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, United States

Site Status RECRUITING

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, United States

Site Status RECRUITING

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, United States

Site Status RECRUITING

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, United States

Site Status RECRUITING

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

East Norriton, Pennsylvania, United States

Site Status RECRUITING

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, United States

Site Status RECRUITING

Fox Chase Cancer Center Buckingham

Furlong, Pennsylvania, United States

Site Status RECRUITING

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, United States

Site Status RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, United States

Site Status RECRUITING

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status RECRUITING

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, United States

Site Status RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, United States

Site Status RECRUITING

UPMC Hillman Cancer Center in Coraopolis

Moon Township, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Center-Natrona Heights

Natrona Heights, Pennsylvania, United States

Site Status RECRUITING

UPMC Hillman Cancer Center - New Castle

New Castle, Pennsylvania, United States

Site Status RECRUITING

Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Temple University Hospital

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, United States

Site Status RECRUITING

UPMC Cancer Center-Uniontown

Uniontown, Pennsylvania, United States

Site Status RECRUITING

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, United States

Site Status RECRUITING

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, United States

Site Status RECRUITING

UPMC Susquehanna

Williamsport, Pennsylvania, United States

Site Status RECRUITING

UPMC Memorial

York, Pennsylvania, United States

Site Status RECRUITING

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status RECRUITING

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States

Site Status SUSPENDED

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States

Site Status SUSPENDED

UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, United States

Site Status RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

Site Status RECRUITING

Tarrant County Hospital District/JPS Health Network

Fort Worth, Texas, United States

Site Status RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, United States

Site Status RECRUITING

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, United States

Site Status RECRUITING

Audie L Murphy VA Hospital

San Antonio, Texas, United States

Site Status ACTIVE_NOT_RECRUITING

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status SUSPENDED

University of Virginia Cancer Center

Charlottesville, Virginia, United States

Site Status RECRUITING

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, United States

Site Status RECRUITING

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, United States

Site Status RECRUITING

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, United States

Site Status RECRUITING

Providence Regional Cancer System-Centralia

Centralia, Washington, United States

Site Status RECRUITING

Swedish Cancer Institute-Edmonds

Edmonds, Washington, United States

Site Status RECRUITING

Providence Regional Cancer Partnership

Everett, Washington, United States

Site Status RECRUITING

Swedish Cancer Institute-Issaquah

Issaquah, Washington, United States

Site Status RECRUITING

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, United States

Site Status RECRUITING

Providence Regional Cancer System-Lacey

Lacey, Washington, United States

Site Status RECRUITING

PeaceHealth Saint John Medical Center

Longview, Washington, United States

Site Status RECRUITING

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, United States

Site Status RECRUITING

Swedish Medical Center-Ballard Campus

Seattle, Washington, United States

Site Status RECRUITING

FHCC South Lake Union

Seattle, Washington, United States

Site Status RECRUITING

Fred Hutchinson Cancer Center

Seattle, Washington, United States

Site Status RECRUITING

Swedish Medical Center-First Hill

Seattle, Washington, United States

Site Status RECRUITING

FHCC at Northwest Hospital

Seattle, Washington, United States

Site Status RECRUITING

University of Washington Medical Center - Montlake

Seattle, Washington, United States

Site Status RECRUITING

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, United States

Site Status RECRUITING

Saint Michael Cancer Center

Silverdale, Washington, United States

Site Status RECRUITING

PeaceHealth Southwest Medical Center

Vancouver, Washington, United States

Site Status RECRUITING

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, United States

Site Status ACTIVE_NOT_RECRUITING

Legacy Salmon Creek Hospital

Vancouver, Washington, United States

Site Status ACTIVE_NOT_RECRUITING

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, United States

Site Status RECRUITING

Langlade Hospital and Cancer Center

Antigo, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, United States

Site Status RECRUITING

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, United States

Site Status RECRUITING

William S Middleton VA Medical Center

Madison, Wisconsin, United States

Site Status RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States

Site Status RECRUITING

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, United States

Site Status RECRUITING

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, United States

Site Status RECRUITING

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, United States

Site Status RECRUITING

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, United States

Site Status RECRUITING

Aspirus Regional Cancer Center

Wausau, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center - Weston

Weston, Wisconsin, United States

Site Status RECRUITING

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, United States

Site Status RECRUITING

Welch Cancer Center

Sheridan, Wyoming, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

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Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

NCI-2020-02686

Identifier Type: REGISTRY

Identifier Source: secondary_id

EA8191

Identifier Type: OTHER

Identifier Source: secondary_id

EA8191

Identifier Type: OTHER

Identifier Source: secondary_id

U10CA180820

Identifier Type: NIH

Identifier Source: secondary_id

View Link

EA8191

Identifier Type: -

Identifier Source: org_study_id