Clinical Trials
Showing trials with last updates posted in 2025.
23
Participants
Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2022-12-19
Completion:
2027-06-15
Conditions
Anatomic Stage IV Breast Cancer AJCC v8
Metastatic Malignant Neoplasm in the Brain
Metastatic Triple-Negative Breast Carcinoma
Prognostic Stage IV Breast Cancer AJCC v8
Interventions
BIOLOGICAL
No Results Yet
254
Participants
Efficacy and Safety of Odevixibat in Children With Biliary Atresia Who Have Undergone a Kasai HPE (BOLD)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-07-08
Completion:
2026-06-26
Conditions
Biliary Atresia
Interventions
DRUG
No Results Yet
60
Participants
Continuous Versus Intermittent cARdiac Electrical moNitorinG
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2023-11-21
Completion:
2026-12-31
Conditions
Torsades de Pointe Caused by Drug
Long QT Syndrome
Interventions
DEVICE
No Results Yet
17
Participants
Duvelisib Maintenance After Autologous Stem Cell Transplant in T-Cell Lymphomas
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-07-23
Completion:
2026-04-22
Conditions
T-Cell Lymphoma
Interventions
DRUG
PROCEDURE
No Results Yet
42
Participants
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2021-08-24
Completion:
2026-04-30
Conditions
Pancreas Cancer
Cancer of the Pancreas
Pancreas Adenocarcinoma
Interventions
DEVICE
DRUG
PROCEDURE
No Results Yet
508
Participants
Efficacy and Safety of Tildrakizumab Compared to Placebo in Subjects With Active Psoriatic Arthritis I (INSPIRE 1)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-07-01
Completion:
2025-03-26
Conditions
Active Psoriatic Arthritis
Interventions
DRUG
No Results Yet
296
Participants
Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-07-01
Completion:
2025-09-04
Conditions
Active Psoriatic Arthritis
Interventions
DRUG
No Results Yet
0
Participants
Gamification to Increase Mobility in the Hospital
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2026-01-01
Completion:
2026-04-30
Conditions
Coronary Artery Disease
Coronary Heart Disease
Hypertension
Diabete Mellitus
Dyslipidemias
Obesity
Heart Failure
Interventions
BEHAVIORAL
No Results Yet
115
Participants
Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-10-15
Completion:
2023-10-12
Conditions
Obesity
Interventions
BEHAVIORAL
20
Participants
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2026-10-31
Completion:
2028-12-31
Conditions
Opioid Use Disorder
Interventions
DRUG
DEVICE
No Results Yet
8
Participants
Daratumumab and Ibrutinib for the Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia, DIRECT Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-11-11
Completion:
2023-05-01
Conditions
Recurrent Chronic Lymphocytic Leukemia
Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Recurrent Small Lymphocytic Lymphoma
Refractory Chronic Lymphocytic Leukemia
Refractory Small Lymphocytic Lymphoma
Interventions
BIOLOGICAL
DRUG
22
Participants
Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-12-29
Completion:
2024-10-09
Conditions
Multiple Sclerosis
Interventions
DRUG
261
Participants
LIFE-BTK Randomized Controlled Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-08-18
Completion:
2023-08-17
Conditions
Critical Limb Ischemia (CLI)
Interventions
DEVICE
859
Participants
Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2020-10-15
Completion:
2025-10-09
Conditions
Cerebrovascular Accidents
Myocardial Infarction
Interventions
OTHER
No Results Yet
185
Participants
Safety Study of Oral Edaravone Administered in Subjects With ALS
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-11-18
Completion:
2021-10-07
Conditions
ALS
Interventions
DRUG
180
Participants
Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-11-07
Completion:
2029-11-07
Conditions
Autophagy
Galectins
HIV Infections
Highly Active Antiretroviral Therapy
Interventions
BIOLOGICAL
No Results Yet
1100
Participants
An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-11-18
Completion:
2030-02-01
Conditions
Relapsing Multiple Sclerosis (RMS)
Interventions
BIOLOGICAL
No Results Yet
150
Participants
Observational Real-life Study of Cabozantinib in Monotherapy or in Combination With Nivolumab in Advanced Renal Cell Carcinoma (RCC)
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2020-03-03
Completion:
2027-03-31
Conditions
Advanced or Metastatic Renal Cell Carcinoma
No Results Yet
25
Participants
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-01-27
Completion:
2021-02-22
Conditions
Acute Ischemic Stroke
Interventions
DRUG
3208
Participants
Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-01-15
Completion:
2024-12-30
Conditions
Kawasaki Disease
Interventions
DRUG
No Results Yet
45
Participants
Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-09-01
Completion:
2026-08-31
Conditions
Cervical Fusion
Interventions
DEVICE
No Results Yet
14
Participants
Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-03-31
Completion:
2025-01-21
Conditions
Brain and Nervous System
Eye and Orbit
Interventions
DRUG
No Results Yet
28
Participants
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-10-12
Completion:
2025-07-15
Conditions
Advanced Solid Tumors
Interventions
DRUG
DEVICE
No Results Yet
20
Participants
Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-12-09
Completion:
2021-07-16
Conditions
Aplastic Anemia
Interventions
DRUG
9
Participants
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-01-27
Completion:
2023-01-10
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
363
Participants
Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-10-22
Completion:
2028-04-01
Conditions
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Double-Expressor Lymphoma
EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
High Grade B-Cell Lymphoma, Not Otherwise Specified
Neoplastic Cells With Double Expression of MYC and BCL2 Proteins Present
Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions
PROCEDURE
DRUG
BIOLOGICAL
No Results Yet
24
Participants
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-12-20
Completion:
2027-06-30
Conditions
Secondary Hyperparathyroidism
Interventions
DRUG
No Results Yet
23
Participants
Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-05-16
Completion:
2025-12-19
Conditions
Debulking Surgery for Ovarian Cancer
Interventions
DIETARY_SUPPLEMENT
OTHER
No Results Yet
288
Participants
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-09-16
Completion:
2029-12-31
Conditions
Smoldering Plasma Cell Myeloma
Interventions
BIOLOGICAL
DRUG
OTHER
No Results Yet
371
Participants
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-10-21
Completion:
2026-12-31
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
54
Participants
JAK Inhibitor Treatment in AGS
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-06-03
Completion:
2024-01-04
Conditions
Aicardi Goutieres Syndrome
Interventions
DRUG
20
Participants
Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-05-21
Completion:
2028-02-29
Conditions
Cutaneous Angiosarcoma
Interventions
DRUG
RADIATION
PROCEDURE
No Results Yet
27
Participants
Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-02-26
Completion:
2026-11-04
Conditions
Chronic Lymphocytic Leukemia
Diffuse Large B-Cell Lymphoma
Follicular Lymphoma
Indolent Non-Hodgkin Lymphoma
Lymphoplasmacytic Lymphoma
Marginal Zone Lymphoma
Richter Syndrome
Interventions
DRUG
BIOLOGICAL
No Results Yet
76
Participants
Tolerance of Teeth Brushing During Prolonged Aplasia
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-07-22
Completion:
2023-02-01
Conditions
Aplasia
Interventions
DEVICE
DRUG
No Results Yet
137
Participants
ENAC Blockade and Arterial Stiffness
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-07-15
Completion:
2024-10-05
Conditions
Overweight and Obesity
Insulin Resistance
Interventions
DRUG
506
Participants
VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-02-05
Completion:
2024-06-12
Conditions
Venous Reflux
Interventions
DEVICE
PROCEDURE
188
Participants
A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-04-15
Completion:
2023-04-07
Conditions
Prostate Cancer
Interventions
RADIATION
DRUG
0
Participants
Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-01-08
Completion:
2020-05-29
Conditions
Breast Carcinoma
Colorectal Carcinoma
Community Practice
Lung Carcinoma
Melanoma
Solid Neoplasm
Interventions
OTHER
No Results Yet
30
Participants
Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-03-11
Completion:
2025-11-30
Conditions
Relapsed/Refractory Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
Leukemia
Interventions
DRUG
No Results Yet
100
Participants
MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-05-18
Completion:
2026-12-31
Conditions
Cutaneous Melanoma
Melanocytic Nevus
Skin Carcinoma
Interventions
OTHER
PROCEDURE
DRUG
No Results Yet
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