Clinical Trials
Showing trials with last updates posted in 2025.
9
Participants
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-01-27
Completion:
2023-01-10
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
24
Participants
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-12-20
Completion:
2027-06-30
Conditions
Secondary Hyperparathyroidism
Interventions
DRUG
No Results Yet
23
Participants
Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-05-16
Completion:
2025-12-19
Conditions
Debulking Surgery for Ovarian Cancer
Interventions
DIETARY_SUPPLEMENT
OTHER
No Results Yet
288
Participants
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-09-16
Completion:
2029-12-31
Conditions
Smoldering Plasma Cell Myeloma
Interventions
BIOLOGICAL
DRUG
OTHER
No Results Yet
371
Participants
Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-10-21
Completion:
2026-12-31
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
54
Participants
JAK Inhibitor Treatment in AGS
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-06-03
Completion:
2024-01-04
Conditions
Aicardi Goutieres Syndrome
Interventions
DRUG
20
Participants
Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-05-21
Completion:
2028-02-29
Conditions
Cutaneous Angiosarcoma
Interventions
DRUG
RADIATION
PROCEDURE
No Results Yet
27
Participants
Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-02-26
Completion:
2026-11-04
Conditions
Chronic Lymphocytic Leukemia
Diffuse Large B-Cell Lymphoma
Follicular Lymphoma
Indolent Non-Hodgkin Lymphoma
Lymphoplasmacytic Lymphoma
Marginal Zone Lymphoma
Richter Syndrome
Interventions
DRUG
BIOLOGICAL
No Results Yet
76
Participants
Tolerance of Teeth Brushing During Prolonged Aplasia
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-07-22
Completion:
2023-02-01
Conditions
Aplasia
Interventions
DEVICE
DRUG
No Results Yet
137
Participants
ENAC Blockade and Arterial Stiffness
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-07-15
Completion:
2024-10-05
Conditions
Overweight and Obesity
Insulin Resistance
Interventions
DRUG
506
Participants
VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2020-02-05
Completion:
2024-06-12
Conditions
Venous Reflux
Interventions
DEVICE
PROCEDURE
188
Participants
A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-04-15
Completion:
2023-04-07
Conditions
Prostate Cancer
Interventions
RADIATION
DRUG
0
Participants
Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-01-08
Completion:
2020-05-29
Conditions
Breast Carcinoma
Colorectal Carcinoma
Community Practice
Lung Carcinoma
Melanoma
Solid Neoplasm
Interventions
OTHER
No Results Yet
30
Participants
Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-03-11
Completion:
2025-11-30
Conditions
Relapsed/Refractory Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
Leukemia
Interventions
DRUG
No Results Yet
100
Participants
MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-05-18
Completion:
2026-12-31
Conditions
Cutaneous Melanoma
Melanocytic Nevus
Skin Carcinoma
Interventions
OTHER
PROCEDURE
DRUG
No Results Yet
120
Participants
Opioid/Benzodiazepine Polydrug Abuse
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2019-02-08
Completion:
2026-12-31
Conditions
Polysubstance Abuse
Interventions
OTHER
No Results Yet
90
Participants
Comparison Between Anterior Approach (Deltopectoral) and Lateral Approach (Deltoid Splitting) in Shoulder Reverse Arthroplasty for Proximal Humerus Fracture
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-11-26
Completion:
2023-12-31
Conditions
Humeral Fracture
Aged Patient
Reversed Total Shoulder Arthroplasty
Surgical Approach
Interventions
PROCEDURE
No Results Yet
500
Participants
Registry of Patients With Takotsubo Syndrome
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2009-09-11
Completion:
2028-09-01
Conditions
Takotsubo Cardiomyopathy
Broken Heart Syndrome
Tako-tsubo Cardiomyopathy
No Results Yet
43
Participants
Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-05-29
Completion:
2026-06-30
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG
OTHER
PROCEDURE
No Results Yet
224
Participants
Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2018-09-24
Completion:
2027-09-30
Conditions
Advanced Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
No Results Yet
28
Participants
TFE Renal Cell Carcinoma: A Prospective Registry and Translational Research Initiative
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2018-08-12
Completion:
2026-06-30
Conditions
Renal Cell Carcinoma
No Results Yet
300
Participants
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2017-10-01
Completion:
2024-01-31
Conditions
Bipolar Disorder
Major Depressive Disorder
Postpartum Depression
Postpartum Psychosis
No Results Yet
181
Participants
SpHincterotomy for Acute Recurrent Pancreatitis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-09-27
Completion:
2025-02-28
Conditions
Pancreatitis
Pancreas Divisum
Pancreatitis, Acute
Pancreatitis Idiopathic
Pancreas Inflamed
Interventions
PROCEDURE
150
Participants
Olfactory Training and Emotional State
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-08-28
Completion:
2023-06-27
Conditions
Depressive Symptoms
Depressive Disorder, Major
Interventions
OTHER
No Results Yet
162
Participants
Phase 2b Study of KBP-5074 in Subjects With Uncontrolled Hypertension and Advanced Chronic Kidney Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-04-25
Completion:
2020-08-05
Conditions
Chronic Kidney Diseases
Hypertension
Interventions
DRUG
59
Participants
Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-10-05
Completion:
2027-11-30
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8
Pathologic Stage III Cutaneous Melanoma AJCC v8
Pathologic Stage IIIA Cutaneous Melanoma AJCC v8
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Interventions
DRUG
BIOLOGICAL
No Results Yet
40
Participants
Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-06-26
Completion:
2028-08-31
Conditions
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Minimal Residual Disease
Interventions
DRUG
OTHER
BIOLOGICAL
No Results Yet
204
Participants
Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-04-04
Completion:
2030-07-31
Conditions
Hip Dysplasia
Interventions
PROCEDURE
No Results Yet
130
Participants
SLOG vs mFOLFIRINOX as the First-line Treatment in Locally Advanced Uncresectable or Metastatic Pancreatic Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-03-26
Completion:
2019-11-30
Conditions
Locally Advanced or Metastatic Pancreatic Cancer
Interventions
DRUG
No Results Yet
1054
Participants
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2017-12-18
Completion:
2022-10-03
Conditions
mCRPC
Interventions
DRUG
2053
Participants
Diet, Physical Activity and Related Candidate Biomarkers in Relation to Prostate Cancer Risk (BIOCaPPE)
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2013-06-20
Completion:
2022-09-23
Conditions
Epidemiology
Prostate Cancer
Interventions
OTHER
DIAGNOSTIC_TEST
No Results Yet
102
Participants
Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2017-12-12
Completion:
2022-08-30
Conditions
Stage II Breast Cancer
Stage IIA Breast Cancer
Stage IIB Breast Cancer
Ductal Breast Carcinoma In Situ
Invasive Breast Carcinoma
Stage 0 Breast Cancer
Stage I Breast Cancer
Stage IA Breast Cancer
Stage IB Breast Cancer
Interventions
RADIATION
117
Participants
Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-01-22
Completion:
2021-12-29
Conditions
Spasmodic Dysphonia
Voice Tremor
Interventions
DRUG
531
Participants
Study to Determine the Efficacy and Safety of TG-C in Subjects With Kellgren/Lawrence Grade 2 or 3 OA of the Knee
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2021-12-09
Completion:
2024-03-06
Conditions
Degenerative Osteoarthritis
Interventions
BIOLOGICAL
No Results Yet
375
Participants
MT-8554 for Reduction of Vasomotor Symptoms in Postmenopausal Women
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2017-10-09
Completion:
2018-10-19
Conditions
Menopause Hot Flashes
Interventions
DRUG
535
Participants
A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2018-10-30
Completion:
2024-07-10
Conditions
Degenerative Osteoarthritis
Interventions
BIOLOGICAL
No Results Yet
190
Participants
Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2019-04-05
Completion:
2024-04-30
Conditions
Metastatic Breast Adenocarcinoma
Metastatic HER2-Positive Breast Carcinoma
Recurrent Breast Adenocarcinoma
Recurrent HER2-Positive Breast Carcinoma
Stage III Breast Cancer AJCC v7
Stage IV Breast Cancer AJCC v6 and v7
Unresectable Breast Carcinoma
Unresectable HER2-Positive Breast Carcinoma
Interventions
DRUG
PROCEDURE
BIOLOGICAL
OTHER
2349
Participants
Stress CMR Perfusion Imaging in the United States (SPINS) Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2016-12-01
Completion:
2019-11-30
Conditions
Myocardial Ischemia
Interventions
DIAGNOSTIC_TEST
146
Participants
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-30
Start Date:
2017-07-25
Completion:
2025-12-31
Conditions
Gliosarcoma
Recurrent Glioblastoma
Interventions
DIAGNOSTIC_TEST
No Results Yet
8000
Participants
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-30
Start Date:
2017-03-10
Completion:
2026-12-31
Conditions
Lumbar Spinal Stenosis
Interventions
DEVICE
No Results Yet
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