Clinical Trials

Showing trials with last updates posted in 2025.

NCT04188457 | COMPLETED
859 Participants

Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-15
Completion: 2025-10-09
Conditions
Cerebrovascular Accidents Myocardial Infarction
Interventions
OTHER
No Results Yet
NCT04165824 | COMPLETED | PHASE3
185 Participants

Safety Study of Oral Edaravone Administered in Subjects With ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-11-18
Completion: 2021-10-07
Conditions
ALS
Interventions
DRUG
NCT04160455 | RECRUITING
180 Participants

Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-11-07
Completion: 2029-11-07
Conditions
Autophagy Galectins HIV Infections Highly Active Antiretroviral Therapy
Interventions
BIOLOGICAL
No Results Yet
NCT04130997 | ACTIVE_NOT_RECRUITING | PHASE3
1100 Participants

An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-11-18
Completion: 2030-02-01
Conditions
Relapsing Multiple Sclerosis (RMS)
Interventions
BIOLOGICAL
No Results Yet
NCT04106349 | ACTIVE_NOT_RECRUITING
150 Participants

Observational Real-life Study of Cabozantinib in Monotherapy or in Combination With Nivolumab in Advanced Renal Cell Carcinoma (RCC)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2020-03-03
Completion: 2027-03-31
Conditions
Advanced or Metastatic Renal Cell Carcinoma
No Results Yet
NCT04091945 | COMPLETED | PHASE2
25 Participants

A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-01-27
Completion: 2021-02-22
Conditions
Acute Ischemic Stroke
Interventions
DRUG
NCT04078568 | ACTIVE_NOT_RECRUITING | PHASE3
3208 Participants

Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-01-15
Completion: 2024-12-30
Conditions
Kawasaki Disease
Interventions
DRUG
No Results Yet
NCT04041583 | RECRUITING
45 Participants

Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-09-01
Completion: 2026-08-31
Conditions
Cervical Fusion
Interventions
DEVICE
No Results Yet
NCT04022980 | COMPLETED | PHASE1
14 Participants

Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-03-31
Completion: 2025-01-21
Conditions
Brain and Nervous System Eye and Orbit
Interventions
DRUG
No Results Yet
NCT03993678 | COMPLETED | PHASE1/PHASE2
28 Participants

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-12
Completion: 2025-07-15
Conditions
Advanced Solid Tumors
Interventions
DRUG DEVICE
No Results Yet
NCT03988608 | COMPLETED | PHASE2
20 Participants

Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-12-09
Completion: 2021-07-16
Conditions
Aplastic Anemia
Interventions
DRUG
NCT03984708 | COMPLETED | NA
9 Participants

New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-01-27
Completion: 2023-01-10
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
NCT03969329 | RECRUITING | PHASE3
24 Participants

A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-12-20
Completion: 2027-06-30
Conditions
Secondary Hyperparathyroidism
Interventions
DRUG
No Results Yet
NCT03956095 | COMPLETED
23 Participants

Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-05-16
Completion: 2025-12-19
Conditions
Debulking Surgery for Ovarian Cancer
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT03937635 | RECRUITING | PHASE3
288 Participants

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-09-16
Completion: 2029-12-31
Conditions
Smoldering Plasma Cell Myeloma
Interventions
BIOLOGICAL DRUG OTHER
No Results Yet
NCT03932201 | ACTIVE_NOT_RECRUITING
371 Participants

Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-10-21
Completion: 2026-12-31
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
NCT03921554 | COMPLETED | PHASE2
54 Participants

JAK Inhibitor Treatment in AGS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-06-03
Completion: 2024-01-04
Conditions
Aicardi Goutieres Syndrome
Interventions
DRUG
NCT03921008 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
20 Participants

Induction Paclitaxel Followed by Concurrent Paclitaxel and Radiation Therapy for Cutaneous Angiosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-05-21
Completion: 2028-02-29
Conditions
Cutaneous Angiosarcoma
Interventions
DRUG RADIATION PROCEDURE
No Results Yet
NCT03884998 | ACTIVE_NOT_RECRUITING | PHASE1
27 Participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-02-26
Completion: 2026-11-04
Conditions
Chronic Lymphocytic Leukemia Diffuse Large B-Cell Lymphoma Follicular Lymphoma Indolent Non-Hodgkin Lymphoma Lymphoplasmacytic Lymphoma Marginal Zone Lymphoma Richter Syndrome
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT03879252 | COMPLETED | PHASE3
76 Participants

Tolerance of Teeth Brushing During Prolonged Aplasia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-07-22
Completion: 2023-02-01
Conditions
Aplasia
Interventions
DEVICE DRUG
No Results Yet
NCT03837626 | COMPLETED | PHASE2/PHASE3
137 Participants

ENAC Blockade and Arterial Stiffness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-07-15
Completion: 2024-10-05
Conditions
Overweight and Obesity Insulin Resistance
Interventions
DRUG
NCT03820947 | TERMINATED | NA
506 Participants

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-02-05
Completion: 2024-06-12
Conditions
Venous Reflux
Interventions
DEVICE PROCEDURE
NCT03809000 | ACTIVE_NOT_RECRUITING | PHASE2
188 Participants

A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-04-15
Completion: 2023-04-07
Conditions
Prostate Cancer
Interventions
RADIATION DRUG
NCT03804255 | WITHDRAWN
0 Participants

Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-01-08
Completion: 2020-05-29
Conditions
Breast Carcinoma Colorectal Carcinoma Community Practice Lung Carcinoma Melanoma Solid Neoplasm
Interventions
OTHER
No Results Yet
NCT03708003 | TERMINATED | PHASE2
30 Participants

Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-03-11
Completion: 2025-11-30
Conditions
Relapsed/Refractory Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia Leukemia
Interventions
DRUG
No Results Yet
NCT03699995 | RECRUITING | NA
100 Participants

MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-05-18
Completion: 2026-12-31
Conditions
Cutaneous Melanoma Melanocytic Nevus Skin Carcinoma
Interventions
OTHER PROCEDURE DRUG
No Results Yet
NCT03696017 | RECRUITING
120 Participants

Opioid/Benzodiazepine Polydrug Abuse

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-02-08
Completion: 2026-12-31
Conditions
Polysubstance Abuse
Interventions
OTHER
No Results Yet
NCT03694457 | COMPLETED | NA
90 Participants

Comparison Between Anterior Approach (Deltopectoral) and Lateral Approach (Deltoid Splitting) in Shoulder Reverse Arthroplasty for Proximal Humerus Fracture

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-11-26
Completion: 2023-12-31
Conditions
Humeral Fracture Aged Patient Reversed Total Shoulder Arthroplasty Surgical Approach
Interventions
PROCEDURE
No Results Yet
NCT03663348 | RECRUITING
500 Participants

Registry of Patients With Takotsubo Syndrome

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2009-09-11
Completion: 2028-09-01
Conditions
Takotsubo Cardiomyopathy Broken Heart Syndrome Tako-tsubo Cardiomyopathy
No Results Yet
NCT03650764 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
43 Participants

Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-05-29
Completion: 2026-06-30
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG OTHER PROCEDURE
No Results Yet
NCT03647878 | ACTIVE_NOT_RECRUITING
224 Participants

Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2018-09-24
Completion: 2027-09-30
Conditions
Advanced Renal Cell Carcinoma Metastatic Renal Cell Carcinoma
No Results Yet
NCT03630536 | ACTIVE_NOT_RECRUITING
28 Participants

TFE Renal Cell Carcinoma: A Prospective Registry and Translational Research Initiative

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2018-08-12
Completion: 2026-06-30
Conditions
Renal Cell Carcinoma
No Results Yet
NCT03615794 | COMPLETED
300 Participants

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2017-10-01
Completion: 2024-01-31
Conditions
Bipolar Disorder Major Depressive Disorder Postpartum Depression Postpartum Psychosis
No Results Yet
NCT03609944 | COMPLETED | NA
181 Participants

SpHincterotomy for Acute Recurrent Pancreatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-09-27
Completion: 2025-02-28
Conditions
Pancreatitis Pancreas Divisum Pancreatitis, Acute Pancreatitis Idiopathic Pancreas Inflamed
Interventions
PROCEDURE
NCT03605524 | COMPLETED | NA
150 Participants

Olfactory Training and Emotional State

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-08-28
Completion: 2023-06-27
Conditions
Depressive Symptoms Depressive Disorder, Major
Interventions
OTHER
No Results Yet
NCT03574363 | COMPLETED | PHASE2
162 Participants

Phase 2b Study of KBP-5074 in Subjects With Uncontrolled Hypertension and Advanced Chronic Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-04-25
Completion: 2020-08-05
Conditions
Chronic Kidney Diseases Hypertension
Interventions
DRUG
NCT03554083 | ACTIVE_NOT_RECRUITING | PHASE2
59 Participants

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-10-05
Completion: 2027-11-30
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Pathologic Stage III Cutaneous Melanoma AJCC v8 Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT03516279 | ACTIVE_NOT_RECRUITING | PHASE2
40 Participants

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-06-26
Completion: 2028-08-31
Conditions
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Minimal Residual Disease
Interventions
DRUG OTHER BIOLOGICAL
No Results Yet
NCT03481010 | RECRUITING | NA
204 Participants

Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-04-04
Completion: 2030-07-31
Conditions
Hip Dysplasia
Interventions
PROCEDURE
No Results Yet
NCT03443492 | COMPLETED | PHASE2
130 Participants

SLOG vs mFOLFIRINOX as the First-line Treatment in Locally Advanced Uncresectable or Metastatic Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2018-03-26
Completion: 2019-11-30
Conditions
Locally Advanced or Metastatic Pancreatic Cancer
Interventions
DRUG
No Results Yet
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