Clinical Trials Updated in 2025

NCT06028022 | RECRUITING | PHASE2

80 Participants

Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-18

Completion: 2026-10-16

Conditions

Estrogen Receptor-Positive Breast Carcinoma

Interventions

DIETARY_SUPPLEMENT DRUG OTHER

No Results Yet

NCT06027307 | ACTIVE_NOT_RECRUITING | PHASE3

541 Participants

Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-25

Completion: 2027-06-30

Conditions

Tricuspid Regurgitation Heart Failure With Preserved Ejection Fraction

Interventions

DRUG

No Results Yet

NCT06016088 | RECRUITING | PHASE1/PHASE2

72 Participants

A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-04-01

Completion: 2026-04-30

Conditions

Cystic Fibrosis Lung Respiratory Infections, Recurrent, Chronic Pseudomonas Aeruginosa

Interventions

DRUG

No Results Yet

NCT06013176 | COMPLETED | NA

476 Participants

Behavioral Economic Strategies to Improve PRO Adherence

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-12-04

Completion: 2024-06-04

Conditions

Cancer

Interventions

OTHER

Results Available

NCT06011759 | COMPLETED | NA

4 Participants

Maintaining Implementation Through Dynamic Adaptations (MIDAS) Suicide Prevention 2.0 Clinical Telehealth

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2022-11-01

Completion: 2024-08-29

Conditions

Suicidal Self-directed Violence Suicidal Preparatory Behavior

Interventions

BEHAVIORAL

Results Available

NCT06008691 | RECRUITING

1500 Participants

A Prospective, Observational Cohort Study on the Clinical Impact of Novel Monoclonal Antibodies in B-cell Non-Hodgkin Lymphoma in Italian Clinical Practice

Study Type: OBSERVATIONAL

Last Updated: 2025-12-29

Start Date: 2023-12-27

Completion: 2038-10-31

Conditions

Non-Hodgkin Lymphoma, B-cell

Interventions

DRUG

No Results Yet

NCT05999877 | ACTIVE_NOT_RECRUITING

192 Participants

PICAROS - Acalabrutinib RWE on 1L CLL in Spain

Study Type: OBSERVATIONAL

Last Updated: 2025-12-29

Start Date: 2023-07-11

Completion: 2026-12-31

Conditions

Chronic Lymphocytic Leukemia

No Results Yet

NCT05993481 | ENROLLING_BY_INVITATION | NA

640 Participants

The Noninvasive Blood Pressure Measurement Effect on the Hypotension

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-10-25

Completion: 2026-11-25

Conditions

Hypotension During Surgery

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05983887 | COMPLETED | NA

12 Participants

The Effect of Therapeutic Climbing on Muscle Strength, Tone and Balance in Hemiplegic Children

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-04-10

Completion: 2023-08-31

Conditions

Hemiplegia and Hemiparesis

Interventions

OTHER

No Results Yet

NCT05945823 | ACTIVE_NOT_RECRUITING | PHASE2

53 Participants

Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-07-13

Completion: 2026-03-31

Conditions

Siewert Type 1 GEJ Cancer Pancreatic Cancer Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer Esophageal Adenocarcinoma Esophageal Squamous Cell Cancer

Interventions

DRUG

No Results Yet

NCT05945485 | ACTIVE_NOT_RECRUITING | PHASE1

50 Participants

A Study to Evaluate the Safety and Immunogenicity of Two Doses of DCVC H1 HA mRNA-LNP in Healthy Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-16

Completion: 2026-05-26

Conditions

Influenza

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT05944861 | COMPLETED | NA

38 Participants

Combination of Fluoroscopy and Ultrasonography Guidance in Sacroiliac Joint Injections

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-02-15

Completion: 2024-01-15

Conditions

Sacroiliac Joint Somatic Dysfunction Sacroiliac Joint Pain

Interventions

OTHER

No Results Yet

NCT05935514 | COMPLETED | NA

152 Participants

Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-08-22

Completion: 2025-10-23

Conditions

Diabetes Mellitus Type 2 Diabetes Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT05906238 | RECRUITING | NA

210 Participants

Interventions to Remedy the Negative Effects of Obesity Stigma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-10

Completion: 2027-04-30

Conditions

Obesity Stigma, Weight

Interventions

BEHAVIORAL

No Results Yet

NCT05865028 | SUSPENDED | PHASE2

32 Participants

A Proof of Concept Trial Investigating Safety and Efficacy of APG-157 in Oral Dysplasia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-05-24

Completion: 2027-05-24

Conditions

Oropharyngeal Dysplasia Oral Cavity Dysplasia Oral Carcinoma in Situ

Interventions

DRUG

No Results Yet

NCT05863195 | RECRUITING | PHASE3

408 Participants

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-19

Completion: 2029-06-30

Conditions

Metastatic Colorectal Carcinoma Metastatic Malignant Neoplasm in the Liver Stage IV Colorectal Cancer AJCC v8 Unresectable Colorectal Carcinoma

Interventions

BIOLOGICAL PROCEDURE DRUG

No Results Yet

NCT05858008 | RECRUITING | NA

15 Participants

Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-04-01

Completion: 2026-06-30

Conditions

Mild Cognitive Impairment

Interventions

BEHAVIORAL

No Results Yet

NCT05829889 | RECRUITING | NA

960 Participants

Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-04-25

Completion: 2027-06-30

Conditions

Coronary Artery Disease Left Main Coronary Artery Disease

Interventions

PROCEDURE

No Results Yet

NCT05820386 | RECRUITING | NA

118 Participants

Skin-to-skin Contact During the Transfer From the Delivery Room to the Neonatal Intensive Care Unit: Impact on Very Preterm Infants and Their Parents

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-05-03

Completion: 2027-07-31

Conditions

Skin to Skin Premature Newborns

Interventions

PROCEDURE

No Results Yet

NCT05816850 | RECRUITING

654 Participants

Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

Study Type: OBSERVATIONAL

Last Updated: 2025-12-29

Start Date: 2023-09-19

Completion: 2026-12-01

Conditions

Follicular Lymphoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05814627 | ACTIVE_NOT_RECRUITING | PHASE3

487 Participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-06-15

Completion: 2026-07-31

Conditions

Rheumatoid Arthritis

Interventions

DRUG

No Results Yet

NCT05799339 | COMPLETED

144 Participants

Optimizing CAB-LA as PrEP for Women Who Inject Drugs

Study Type: OBSERVATIONAL

Last Updated: 2025-12-29

Start Date: 2022-01-13

Completion: 2025-07-31

Conditions

HIV Infections Opioid Use Trauma, Psychological

No Results Yet

NCT05776082 | RECRUITING

5000 Participants

Association of Gestational Cardiovascular Health With Pregnancy Outcomes

Study Type: OBSERVATIONAL

Last Updated: 2025-12-29

Start Date: 2023-03-01

Completion: 2026-12-31

Conditions

Pregnant Women

Interventions

OTHER

No Results Yet

NCT05770596 | COMPLETED | NA

204 Participants

Vitamin C on Acute and Chronic Post Mastectomy Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-04-01

Completion: 2024-12-03

Conditions

Vitamin C Post-mastectomy Pain Syndrome

Interventions

DRUG OTHER

No Results Yet

NCT05760534 | COMPLETED | PHASE4

110 Participants

Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-03-06

Completion: 2025-11-25

Conditions

Arthritis Knee Arthritis Hip

Interventions

DRUG

No Results Yet

NCT05747196 | RECRUITING | NA

60 Participants

The Safety and Feasibility of the eLym™ System

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-02-28

Completion: 2026-06-30

Conditions

Heart; Decompensation, Congestive

Interventions

DEVICE

No Results Yet

NCT05744427 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

725 Participants

Safety and Tolerability of JSKN003 in Chinese Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-03-15

Completion: 2025-12-31

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT05736562 | ACTIVE_NOT_RECRUITING | NA

70 Participants

Use of Ritual Epost Postnatal Multivitamins During the Postpartum Period

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-10-15

Completion: 2025-09-30

Conditions

Lactation Disorder - Postpartum Condition or Complication Nutrition, Healthy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT05727176 | RECRUITING | PHASE2

120 Participants

Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-07-05

Completion: 2026-12-31

Conditions

Advanced Cholangiocarcinoma FGFR2 Fusions Gene Rearrangement

Interventions

DRUG

No Results Yet

NCT05724108 | ACTIVE_NOT_RECRUITING | PHASE2

94 Participants

Testing the Effectiveness of an Anti-cancer Drug, Triapine, When Used With Targeted Radiation-based Treatment (Lutetium Lu 177 Dotatate), Compared to Lutetium Lu 177 Dotatate Alone for Metastatic Neuroendocrine Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-08-30

Completion: 2026-12-09

Conditions

Metastatic Neuroendocrine Tumor

Interventions

PROCEDURE DRUG

No Results Yet

NCT05721755 | RECRUITING | PHASE3

290 Participants

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-06-08

Completion: 2029-03-31

Conditions

Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Hypopharyngeal Squamous Cell Carcinoma Metastatic Laryngeal Squamous Cell Carcinoma Metastatic Oral Cavity Squamous Cell Carcinoma Metastatic Oropharyngeal Squamous Cell Carcinoma Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage IV Hypopharyngeal Carcinoma AJCC v8 Stage IV Laryngeal Cancer AJCC v8 Stage IV Lip and Oral Cavity Cancer AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8

Interventions

DRUG PROCEDURE BIOLOGICAL OTHER RADIATION

No Results Yet

NCT05711615 | RECRUITING | PHASE1

30 Participants

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-02-06

Completion: 2026-05-03

Conditions

Metastatic Dedifferentiated Liposarcoma Metastatic Leiomyosarcoma Metastatic Myxofibrosarcoma Metastatic Sarcoma Metastatic Synovial Sarcoma Metastatic Undifferentiated Pleomorphic Sarcoma Unresectable Dedifferentiated Liposarcoma Unresectable Leiomyosarcoma Unresectable Myxofibrosarcoma Unresectable Sarcoma Unresectable Synovial Sarcoma Unresectable Undifferentiated Pleomorphic Sarcoma

Interventions

PROCEDURE DRUG

No Results Yet

NCT05710328 | RECRUITING | PHASE2

235 Participants

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-05-10

Completion: 2027-05-31

Conditions

Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 HER2-Positive Breast Carcinoma Invasive Breast Carcinoma

Interventions

DRUG PROCEDURE OTHER

No Results Yet

NCT05704049 | ACTIVE_NOT_RECRUITING | PHASE2

118 Participants

A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-04-05

Completion: 2025-12-22

Conditions

Relapsed/Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05703672 | RECRUITING | PHASE3

500 Participants

Switching to E-cigarettes in Smokers Not Interested in Quitting

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-07-17

Completion: 2026-12-07

Conditions

Smoking Reduction

Interventions

DRUG OTHER

No Results Yet

NCT05702931 | RECRUITING | PHASE4

104 Participants

Semaglutide Treatment for Hyperglycaemia After Renal Transplantation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2024-09-19

Completion: 2027-12-31

Conditions

Hyperglycemia Renal Transplant Complication Primary Non-Function Diabetes

Interventions

DRUG

No Results Yet

NCT05657652 | RECRUITING | NA

36 Participants

CAV Regimen for R/R Ph- B-ALL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2022-10-01

Completion: 2026-10-31

Conditions

Acute Lymphoblastic Leukemia

Interventions

DRUG

No Results Yet

NCT05657639 | RECRUITING | PHASE2

68 Participants

CAV Regimen for R/R AML

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2022-10-01

Completion: 2026-10-01

Conditions

Acute Myeloid Leukemia

Interventions

DRUG

No Results Yet

NCT05650749 | RECRUITING | PHASE1

45 Participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2023-05-23

Completion: 2028-01-30

Conditions

Refractory Neuroblastoma Relapsed Neuroblastoma High-risk Neuroblastoma Retinoblastoma Metastatic Retinoblastoma

Interventions

BIOLOGICAL

No Results Yet

NCT05641987 | ENROLLING_BY_INVITATION | NA

4000 Participants

Effectiveness of the Educator Well-being Program

Study Type: INTERVENTIONAL

Last Updated: 2025-12-29

Start Date: 2022-11-09

Completion: 2026-08-31

Conditions

Employee Health Occupational Health Educator Well-being Participatory Action Research

Interventions

BEHAVIORAL

No Results Yet