Trial Outcomes & Findings for Behavioral Economic Strategies to Improve PRO Adherence (NCT NCT06013176)

NCT ID: NCT06013176

Last Updated: 2025-12-29

Results Overview

The primary outcome will be PRO adherence, measured at the patient level as the proportion of expected PRO questionnaires completed per patient.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 476 participants
• Primary outcome timeframe: 3 months
• Results posted on: 2025-12-29

Participant Flow

Participant milestones

Measure	Usual Practice This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO Monitoring Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO Monitoring Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Overall Study STARTED	171	144	161
Overall Study Completed at least one questionnaire	115	106	118
Overall Study COMPLETED	171	144	161
Overall Study NOT COMPLETED	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Behavioral Economic Strategies to Improve PRO Adherence

Baseline characteristics by cohort

Measure	Usual Practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO Monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO Monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Total n=476 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=174 Participants	0 Participants n=166 Participants	0 Participants n=167 Participants	0 Participants n=164 Participants
Age, Categorical Between 18 and 65 years	69 Participants n=174 Participants	51 Participants n=166 Participants	64 Participants n=167 Participants	184 Participants n=164 Participants
Age, Categorical >=65 years	102 Participants n=174 Participants	93 Participants n=166 Participants	97 Participants n=167 Participants	292 Participants n=164 Participants
Sex: Female, Male Female	66 Participants n=174 Participants	58 Participants n=166 Participants	55 Participants n=167 Participants	179 Participants n=164 Participants
Sex: Female, Male Male	105 Participants n=174 Participants	86 Participants n=166 Participants	106 Participants n=167 Participants	297 Participants n=164 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	161 Participants n=174 Participants	135 Participants n=166 Participants	154 Participants n=167 Participants	450 Participants n=164 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	4 Participants n=174 Participants	6 Participants n=166 Participants	2 Participants n=167 Participants	12 Participants n=164 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	6 Participants n=174 Participants	3 Participants n=166 Participants	5 Participants n=167 Participants	14 Participants n=164 Participants
Race (NIH/OMB) American Indian or Alaska Native	1 Participants n=174 Participants	0 Participants n=166 Participants	0 Participants n=167 Participants	1 Participants n=164 Participants
Race (NIH/OMB) Asian	5 Participants n=174 Participants	7 Participants n=166 Participants	10 Participants n=167 Participants	22 Participants n=164 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	1 Participants n=174 Participants	0 Participants n=166 Participants	1 Participants n=167 Participants	2 Participants n=164 Participants
Race (NIH/OMB) Black or African American	44 Participants n=174 Participants	27 Participants n=166 Participants	36 Participants n=167 Participants	107 Participants n=164 Participants
Race (NIH/OMB) White	110 Participants n=174 Participants	102 Participants n=166 Participants	104 Participants n=167 Participants	316 Participants n=164 Participants
Race (NIH/OMB) More than one race	1 Participants n=174 Participants	3 Participants n=166 Participants	0 Participants n=167 Participants	4 Participants n=164 Participants
Race (NIH/OMB) Unknown or Not Reported	9 Participants n=174 Participants	5 Participants n=166 Participants	10 Participants n=167 Participants	24 Participants n=164 Participants
Region of Enrollment United States	171 participants n=174 Participants	144 participants n=166 Participants	161 participants n=167 Participants	476 participants n=164 Participants

PRIMARY outcome

Timeframe: 3 months

The primary outcome will be PRO adherence, measured at the patient level as the proportion of expected PRO questionnaires completed per patient.

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
PRO Adherence	50.0 pct. assigned questionnaires completed Interval 43.9 to 56.1	56.9 pct. assigned questionnaires completed Interval 50.4 to 63.4	34.9 pct. assigned questionnaires completed Interval 29.8 to 40.0

SECONDARY outcome

Timeframe: 3 months

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Percent of Patients With at Least One Note Documenting PROs During Study Period	67 Participants	82 Participants	96 Participants

SECONDARY outcome

Timeframe: 3 months

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Percent of Patients With at Least One Note Documenting PROs Per Month During Study Period	20 Participants	16 Participants	32 Participants

SECONDARY outcome

Timeframe: 3 months

Population: Clinical teams documented responses to patients' questionnaire submissions within the electronic health record.

Outcome measures

Measure	Usual practice n=113 Responses to questionnaire submissions This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=176 Responses to questionnaire submissions Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Time to Alert Response (for Arms 2 and 3 Only)	1.24 days Standard Deviation 1.06	1.20 days Standard Deviation 1.01	—

SECONDARY outcome

Timeframe: 3 months

Outcome measures

Measure	Usual practice n=144 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=161 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Percent of Patients Who Trigger an Alert for Triage Nurses (for Arms 2 and 3 Only)	71 Participants	84 Participants	—

SECONDARY outcome

Timeframe: 3 months

Percent of patients with an emergency department visit or hospitalization

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Acute Care Utilization	48 Participants	45 Participants	51 Participants

SECONDARY outcome

Timeframe: 3 months

Percent of patients with a treatment modification

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Treatment Modifications	43 Participants	35 Participants	29 Participants

SECONDARY outcome

Timeframe: 3 months

Average duration of therapy during the study period

Outcome measures

Measure	Usual practice n=171 Participants This arm will consist of encounter-based PRO monitoring, in which patients have an opportunity to complete PRO questionnaires via patient portal in advance of clinical encounters or via tablet during clinical encounters. While clinicians will be encouraged to view and discuss PROs with patients during clinical encounters, they will not be prompted to do so in real-time, nor will there be alerts for escalating symptoms.	Encounter-based PRO monitoring n=144 Participants Encounter-based PRO monitoring (usual practice) plus patient reminders and triage nurse alerts Encounter-based PRO monitoring: This arm consists of usual practice plus the addition of patient reminders to complete PRO questionnaires and triage nurse alerts for severe symptoms. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.	Remote PRO monitoring n=161 Participants Remote PRO monitoring plus patient reminders and triage nurse alerts Remote PRO monitoring: This arm will consist of weekly PRO questionnaires administered via the patient portal, de-linked from clinical encounters. Patient reminders will be operationalized through the Epic patient portal. Triage nurse alerts will be routed to Epic symptom management pools in response to a patient reporting moderate or severe symptoms. Patients will have the opportunity to decline or opt-out of triage nurse support. Clinical interventions stemming from triage nurse alerts will be up to the discretion of clinical teams - i.e., clinical responses will be neither prescriptive nor mandatory. Notably, the entry point for triage nurse alerts (i.e., Epic symptom management pools), as well as resultant clinical responses, are existing standard operating procedures/practices for patients reporting symptoms by phone.
Duration of Therapy	56.82 days Standard Deviation 31.67	55.94 days Standard Deviation 33.91	53.66 days Standard Deviation 32.62

Adverse Events

Usual Practice

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Encounter-based PRO Monitoring

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Remote PRO Monitoring

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Samuel Takvorian

Abramson Cancer Center

Phone: 267-438-8269

Email: Samuel.takvorian@pennmedicine.upenn.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place