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Clinical Trials

Showing trials with last updates posted in 2025.

NCT07061951 | RECRUITING | PHASE2
20 Participants

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-09-08
Completion: 2030-02-01
Conditions
Recurrent Chronic Lymphocytic Leukemia Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Small Lymphocytic Lymphoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT07053384 | RECRUITING | PHASE1
100 Participants

A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-07-10
Completion: 2027-01-18
Conditions
HIV Infections
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT07052266 | RECRUITING | NA
550 Participants

Trial of Combined Obstetric Carrier Screening and Hereditary Cancer Screening

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-09-02
Completion: 2027-06-30
Conditions
Hereditary Cancer Syndromes
Interventions
GENETIC
No Results Yet
NCT07051707 | NOT_YET_RECRUITING | PHASE3
400 Participants

Evaluating the Safety and Efficacy of TLD in Patients With COPD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-02-15
Completion: 2027-05-31
Conditions
COPD Chronic Obstructive Pulmonary Disease
Interventions
DEVICE DRUG
No Results Yet
NCT07046819 | NOT_YET_RECRUITING | PHASE2
120 Participants

Tirzepatide in MetALD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-07-30
Conditions
Metabolic Alcohol-associated Liver Disease Alcohol Use Disorder
Interventions
DRUG OTHER
No Results Yet
NCT07044687 | RECRUITING | PHASE4
100 Participants

Study to Assess Adverse Events and Change in Disease Activity of Oral Venetoclax in Combination With Subcutaneous (SC) or Intravenous (IV) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Standard Induction Therapy in India

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-07-24
Completion: 2027-11-30
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT07042295 | NOT_YET_RECRUITING | PHASE2
86 Participants

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-22
Completion: 2029-02-28
Conditions
Locally Recurrent Skin Squamous Cell Carcinoma Metastatic Skin Squamous Cell Carcinoma
Interventions
DRUG PROCEDURE BIOLOGICAL
No Results Yet
NCT07040475 | RECRUITING
2500 Participants

Effects of the Clinical Application of Traditional, Complementary and Integrative Medicine (TCIM) Procedures During Inpatient Stays in Germany

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-07-01
Completion: 2026-12-31
Conditions
Chronic Disease
Interventions
OTHER
No Results Yet
NCT07039916 | RECRUITING | PHASE3
231 Participants

Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-05-27
Completion: 2027-12-31
Conditions
Generalized Myasthenia Gravis
Interventions
DRUG
No Results Yet
NCT07039864 | COMPLETED | NA
100 Participants

A Novel Strategy for Evaluating Gallbladder Contraction Function by Ultrasound

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-26
Completion: 2025-12-20
Conditions
Gallbladder; Functional Disturbance
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT07035769 | RECRUITING | PHASE1
88 Participants

A First-in-Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of Debio 1453P in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-18
Completion: 2026-04-30
Conditions
Healthy Participants
Interventions
DRUG
No Results Yet
NCT07032662 | RECRUITING | PHASE2
162 Participants

IMVT-1402 in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-03-18
Completion: 2028-08-31
Conditions
Chronic Inflammatory Demyelinating Polyneuropathy
Interventions
DRUG
No Results Yet
NCT07031076 | WITHDRAWN | NA
0 Participants

Investigating the Cognitive and Brain Health Benefits of Lean Pork Consumption

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-31
Completion: 2026-12-31
Conditions
Dietary Intervention Dietary Proteins Dietary Assessment Older Adults (65 Years and Older) Cognitive Ability, General
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT07029581 | RECRUITING | PHASE2
180 Participants

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-06
Completion: 2028-02-29
Conditions
Lewy Body Dementia Psychosis
Interventions
DRUG
No Results Yet
NCT07027826 | RECRUITING | NA
70 Participants

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-08-31
Conditions
Dysphagia Eosinophilic Esophagitis
Interventions
DEVICE
No Results Yet
NCT07023289 | RECRUITING | PHASE2
140 Participants

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-07
Completion: 2029-11-30
Conditions
Colorectal Cancer
Interventions
DRUG
No Results Yet
NCT07022938 | COMPLETED | PHASE4
71 Participants

Nutritional Supplement for Treating Chemotherapy Induced Neuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-11-01
Completion: 2025-01-31
Conditions
Cancer Neuropathy Chemotherapy Induced Pain Neuropathy Chemotherapy-Induced Peripheral Neuropathy
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT07010159 | RECRUITING | PHASE2/PHASE3
165 Participants

Phase 2/3 Study of KPL-387 in Recurrent Pericarditis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-07-25
Completion: 2027-12-31
Conditions
Pericarditis Pericarditis Acute Recurrent Pericarditis
Interventions
DRUG
No Results Yet
NCT07007117 | RECRUITING | PHASE1
38 Participants

PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-20
Completion: 2032-06-30
Conditions
Refractory Neuroblastoma Relapsed Neuroblastoma High-Risk Neuroblastoma
Interventions
BIOLOGICAL
No Results Yet
NCT07007065 | RECRUITING | PHASE3
561 Participants

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-05
Completion: 2033-03-31
Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG
No Results Yet
NCT07005297 | NOT_YET_RECRUITING
1000 Participants

Clinical Genetics Branch Eligibility Screening Survey

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2035-01-01
Conditions
Melanoma Li-Fraumeni Syndrome Pulmonary Blastoma Chordoma Congenital Bone Marrow Failure Syndromes Costello Syndrome Fanconi Anemia CFC Syndrome (CFCS) Legius Syndrome RASopathies
No Results Yet
NCT07005102 | RECRUITING | PHASE2/PHASE3
694 Participants

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-03
Completion: 2031-12-31
Conditions
Non-Squamous Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT07003906 | RECRUITING | NA
720 Participants

Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-16
Completion: 2028-12-31
Conditions
Surgical Incision Wound Dehiscence Surgical Site Infection Incisional Hernia Quality of Life
Interventions
DEVICE
No Results Yet
NCT07003295 | RECRUITING | PHASE2
20 Participants

Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-08-14
Completion: 2027-08-31
Conditions
Recurrent Mantle Cell Lymphoma Refractory Mantle Cell Lymphoma
Interventions
PROCEDURE BIOLOGICAL
No Results Yet
NCT07000526 | RECRUITING | PHASE4
620 Participants

Inhaled Sedation in Critically Ill Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-15
Completion: 2027-03-31
Conditions
Sedation Airway Extubation
Interventions
DRUG
No Results Yet
NCT06998134 | RECRUITING
23 Participants

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2028-08-18
Conditions
Muscle Weakness Problems Moving Their Arms and Legs
Interventions
DEVICE
No Results Yet
NCT06995898 | RECRUITING | NA
24000 Participants

The Vanguard Study: Testing a New Way to Screen for Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-16
Completion: 2027-12-31
Conditions
Bladder Carcinoma Breast Carcinoma Colorectal Carcinoma Esophageal Carcinoma Gastric Carcinoma Liver Carcinoma Lung Carcinoma Malignant Solid Neoplasm Ovarian Carcinoma Pancreatic Carcinoma Prostate Carcinoma
Interventions
PROCEDURE DEVICE OTHER
No Results Yet
NCT06995885 | ENROLLING_BY_INVITATION
30 Participants

Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-05-31
Conditions
Substance Use Disorders (SUDs)
No Results Yet
NCT06992037 | COMPLETED
1110 Participants

An Ambispective Registry Study Comparing Clinical Outcomes of Surgical Interventions for the Treatment of Nasal Airway Obstruction.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-03-14
Completion: 2025-07-21
Conditions
Nasal Airway Obstruction
No Results Yet
NCT06991751 | NOT_YET_RECRUITING
50 Participants

A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Cross-Sectional Bhutanese Community of Central Ohio Health Study to Understand Acculturation as Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating ...

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-08-31
Conditions
Cardiometabolic Risk Factors Mental Health
No Results Yet
NCT06991738 | NOT_YET_RECRUITING | PHASE1/PHASE2
18 Participants

177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2032-07-01
Conditions
Thyroid Cancer
Interventions
DIAGNOSTIC_TEST OTHER DRUG
No Results Yet
NCT06991101 | RECRUITING | PHASE2
190 Participants

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-03
Completion: 2030-12-31
Conditions
Glioblastoma Brain Cancer Glioblastoma Multiforme Glioblastoma Multiforme of Brain Glioblastoma Multiforme, Adult MGMT-Unmethylated Glioblastoma MGMT-Methylated Glioblastoma
Interventions
DRUG RADIATION
No Results Yet
NCT06983899 | RECRUITING | NA
100 Participants

Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-small Cell Lung Cancer, BOOST Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-01-23
Completion: 2028-05-31
Conditions
Lung Non-Small Cell Carcinoma
Interventions
OTHER PROCEDURE
No Results Yet
NCT06982222 | NOT_YET_RECRUITING | PHASE1
24 Participants

Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-31
Completion: 2027-02-12
Conditions
Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Breast Carcinoma Metastatic Lung Non-Small Cell Carcinoma Metastatic Malignant Neoplasm in the Bone Metastatic Prostate Adenocarcinoma Stage IV Lung Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8
Interventions
PROCEDURE RADIATION
No Results Yet
NCT06980805 | RECRUITING | PHASE2
56 Participants

A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-02-19
Completion: 2027-04-30
Conditions
Subacute Cutaneous Lupus Erythematosus Chronic Cutaneous Lupus Erythematosus
Interventions
DRUG
No Results Yet
NCT06980038 | RECRUITING | PHASE2
44 Participants

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-08-21
Completion: 2027-11-24
Conditions
Head and Neck Cutaneous Squamous Cell Carcinoma Head and Neck Squamous Cell Carcinoma Hypopharyngeal Squamous Cell Carcinoma Laryngeal Squamous Cell Carcinoma Nasal Cavity Squamous Cell Carcinoma Oral Cavity Squamous Cell Carcinoma Oropharyngeal Squamous Cell Carcinoma Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma Recurrent Head and Neck Squamous Cell Carcinoma Recurrent Hypopharyngeal Squamous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Nasal Cavity Squamous Cell Carcinoma Recurrent Oral Cavity Squamous Cell Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage III Laryngeal Cancer AJCC v8 Stage III Lip and Oral Cavity Cancer AJCC v8 Stage III Nasopharyngeal Carcinoma AJCC v8 Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVA Laryngeal Cancer AJCC v8 Stage IVA Lip and Oral Cavity Cancer AJCC v8 Stage IVA Nasopharyngeal Carcinoma AJCC v8 Stage IVB Laryngeal Cancer AJCC v8 Stage IVB Lip and Oral Cavity Cancer AJCC v8
Interventions
BIOLOGICAL PROCEDURE
No Results Yet
NCT06975020 | RECRUITING | NA
120 Participants

Pilot-Study for the Comparison of Biomarkers Between Regular Cannabis Users and Non-Users

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-19
Completion: 2026-12-31
Conditions
Driving Under the Influence of Cannabis
Interventions
DRUG
No Results Yet
NCT06972446 | RECRUITING | PHASE2
180 Participants

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-20
Completion: 2027-02-28
Conditions
Rheumatoid Arthritis
Interventions
DRUG
No Results Yet
NCT06969430 | RECRUITING | PHASE1/PHASE2
134 Participants

A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-05-30
Completion: 2031-11-30
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT06958744 | COMPLETED | NA
40 Participants

Effects of Functional Inspiratory Muscle Training in Patients With Chronic Non-Specific Low Back Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-04-30
Completion: 2025-09-17
Conditions
Low Back Pain
Interventions
OTHER
No Results Yet
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