Clinical Trials

Showing trials with last updates posted in 2025.

NCT07191561 | NOT_YET_RECRUITING
25 Participants

Hepatic Lipid Metabolism-Alcohol Use Disorder

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-11-30
Conditions
Alcohol Use Disorder
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT07190794 | RECRUITING
150 Participants

RESCUE: Discontinuation of GLP-1

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-17
Completion: 2026-06-30
Conditions
Obesity
Interventions
DEVICE BEHAVIORAL
No Results Yet
NCT07190170 | RECRUITING | NA
110 Participants

Time Restricted Eating for WeIght LoSs MainTenance-2

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-10-01
Completion: 2028-01-01
Conditions
Weight Loss Maintenance Weight Gain Weight Loss
Interventions
BEHAVIORAL
No Results Yet
NCT07188844 | ENROLLING_BY_INVITATION | PHASE2
108 Participants

An Open-Label Extension Study of Batoclimab in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-28
Completion: 2028-11-30
Conditions
Chronic Inflammatory Demyelinating Polyneuropathy
Interventions
DRUG
No Results Yet
NCT07179393 | COMPLETED | NA
197 Participants

Evaluating the Efficacy of a Ladies Gaelic Football-Specific Injury Prevention Programme

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-23
Completion: 2025-10-03
Conditions
Injury Physical Performances
Interventions
BEHAVIORAL
No Results Yet
NCT07176390 | RECRUITING | PHASE2
182 Participants

A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-10-08
Completion: 2027-03-08
Conditions
Arthritis, Rheumatoid
Interventions
DRUG
No Results Yet
NCT07174336 | RECRUITING | PHASE3
920 Participants

A Study of LY4064809 With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-22
Completion: 2029-05-31
Conditions
Breast Neoplasms Neoplasm Metastasis
Interventions
DRUG
No Results Yet
NCT07169630 | RECRUITING | PHASE1
90 Participants

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2029-04-11
Conditions
Alzheimer s Disease Mild Cognitive Impairment Healthy
Interventions
DRUG
No Results Yet
NCT07167628 | COMPLETED
274 Participants

Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-01-01
Completion: 2025-04-30
Conditions
Aortic Dissection Stroke Paraplegia AKI - Acute Kidney Injury Coma Delirium
No Results Yet
NCT07167433 | RECRUITING
250 Participants
NCT07163221 | RECRUITING | NA
60 Participants

At-home Ultrasound Localized Therapy for Rheumatoid Arthritis Study [At-home ULTRA Study]

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-03
Completion: 2026-08-31
Conditions
Rheumatoid Arthritis (RA)
Interventions
DEVICE DRUG
No Results Yet
NCT07156227 | NOT_YET_RECRUITING | PHASE1
39 Participants

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-26
Completion: 2029-05-31
Conditions
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Recurrent Head and Neck Squamous Cell Carcinoma Recurrent Hypopharyngeal Squamous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Oral Cavity Squamous Cell Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma Recurrent Paranasal Sinus Squamous Cell Carcinoma Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage III Hypopharyngeal Carcinoma AJCC v8 Stage III Laryngeal Cancer AJCC v8 Stage III Lip and Oral Cavity Cancer AJCC v8 Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage III Sinonasal Cancer AJCC v8 Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage IVA Hypopharyngeal Carcinoma AJCC v8 Stage IVA Laryngeal Cancer AJCC v8 Stage IVA Lip and Oral Cavity Cancer AJCC v8 Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVA Sinonasal Cancer AJCC v8 Stage IVB Hypopharyngeal Carcinoma AJCC v8 Stage IVB Laryngeal Cancer AJCC v8 Stage IVB Lip and Oral Cavity Cancer AJCC v8 Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVB Sinonasal Cancer AJCC v8 Unresectable Head and Neck Squamous Cell Carcinoma Unresectable Hypopharyngeal Squamous Cell Carcinoma Unresectable Laryngeal Squamous Cell Carcinoma Unresectable Oral Cavity Squamous Cell Carcinoma Unresectable Oropharyngeal Squamous Cell Carcinoma Unresectable Paranasal Sinus Squamous Cell Carcinoma
Interventions
PROCEDURE DRUG RADIATION
No Results Yet
NCT07155187 | RECRUITING | PHASE2/PHASE3
430 Participants

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-10
Completion: 2030-09-30
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT07154472 | COMPLETED
32 Participants

Upper Limb Function in Paraplegic Individuals: Exploring Endurance, Performance, and Symptoms

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-01-15
Completion: 2025-10-08
Conditions
Paraplegia Endurance Symptoms
No Results Yet
NCT07153497 | NOT_YET_RECRUITING | PHASE2
132 Participants

Testing the Use of an IDH1 Inhibitor, Olutasidenib, in Acute Myeloid Leukemia Added to ASTX727 and Venetoclax; in High-Risk MDS Added to ASTX727; and Alone in Low Risk MDS (A MyeloMATCH Treatment Substudy)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-05-27
Completion: 2030-04-26
Conditions
Acute Myeloid Leukemia Myelodysplastic Syndrome
Interventions
PROCEDURE DRUG
No Results Yet
NCT07149428 | NOT_YET_RECRUITING
80 Participants

Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2029-09-30
Conditions
Respiratory Tract Infection Smell Disorder Influenza Rhinosinusitis COVID-19 Depression Parosmia Hyposomia Normosomia Anosmia
No Results Yet
NCT07147231 | NOT_YET_RECRUITING | PHASE1/PHASE2
86 Participants

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461) in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-31
Completion: 2027-09-01
Conditions
Metastatic Colorectal Adenocarcinoma Refractory Colorectal Adenocarcinoma Stage III Colorectal Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Unresectable Colorectal Adenocarcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT07144319 | NOT_YET_RECRUITING
500 Participants

Exploration of Novel AI-enabled Blue Light Enhanced Cystoscopy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2026-01-31
Completion: 2027-12-31
Conditions
Bladder Cancer Non-muscle Invasive Bladder Cancer
No Results Yet
NCT07143942 | COMPLETED | NA
42 Participants

Effects of Kinesio Taping on Gait Biomechanics in Patellar Tendinopathy Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-31
Completion: 2025-12-01
Conditions
Patellar Tendinopathy / Jumpers Knee Kinesio Taping
Interventions
BEHAVIORAL
No Results Yet
NCT07140315 | NOT_YET_RECRUITING | PHASE1
6 Participants

DK222 Study at Hopkins

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-02-01
Completion: 2027-02-01
Conditions
Non-Small Cell Lung Cancer Urothelial Cancer
Interventions
DRUG
No Results Yet
NCT07137455 | NOT_YET_RECRUITING | NA
50 Participants

EDEN Intracardiac Electrogram Recording and Classifying System

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-11-01
Conditions
Ventricular Arrhythmia
Interventions
DEVICE
No Results Yet
NCT07137442 | RECRUITING
75 Participants

Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2034-08-01
Conditions
Tics Functional Tics
No Results Yet
NCT07137429 | NOT_YET_RECRUITING
400 Participants

Platelet Volunteers, Longitudinal and Multi-omic Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2041-09-15
Conditions
Thrombosis
No Results Yet
NCT07137416 | NOT_YET_RECRUITING | PHASE1
36 Participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-09
Completion: 2027-03-09
Conditions
Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IV Breast Cancer AJCC v8 Invasive Breast Carcinoma Locally Advanced Breast Carcinoma Metastatic Breast Carcinoma Metastatic HER2-Low Breast Carcinoma Metastatic HER2-Positive Breast Carcinoma Metastatic Hormone Receptor-Positive Breast Carcinoma Metastatic Malignant Solid Neoplasm Metastatic Triple-Negative Breast Carcinoma Unresectable Breast Carcinoma Unresectable HER2-Low Breast Carcinoma Unresectable HER2-Positive Breast Carcinoma Unresectable Hormone Receptor-Positive Breast Carcinoma Unresectable Malignant Solid Neoplasm Unresectable Triple-Negative Breast Carcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT07133841 | RECRUITING
30 Participants

Validity of Thermal Imaging in Injury Risk Assessment in Volleyball Players

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-10-21
Completion: 2026-01-21
Conditions
Athletes
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT07133633 | RECRUITING | PHASE2
315 Participants

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-09-26
Completion: 2027-06-15
Conditions
Radiographic Axial Spondyloarthritis
Interventions
DRUG
No Results Yet
NCT07127965 | RECRUITING | NA
226 Participants

Exercise Adherence and Cognitive Decline: Phase 2

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-05
Completion: 2028-08-31
Conditions
Cognitive Decline
Interventions
BEHAVIORAL
No Results Yet
NCT07113743 | ENROLLING_BY_INVITATION | PHASE1/PHASE2
10 Participants

Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-09-10
Completion: 2028-09-01
Conditions
Chronic Granulomatous Disease (CGD)
Interventions
DRUG OTHER
No Results Yet
NCT07111065 | NOT_YET_RECRUITING | PHASE2
300 Participants

FAST for DM Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2030-11-03
Conditions
Dermatomyositis (DM) Juvenile Dermatomyositis (JDM)
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT07099092 | NOT_YET_RECRUITING | EARLY_PHASE1
80 Participants

Causal Mechanisms of Odor-Guided Behavior in Humans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2035-07-14
Conditions
Normal Physiology
Interventions
DEVICE
No Results Yet
NCT07099053 | NOT_YET_RECRUITING
400 Participants

Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2029-12-12
Conditions
Aging
No Results Yet
NCT07095465 | ENROLLING_BY_INVITATION | PHASE3
126 Participants

Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-31
Completion: 2029-02-28
Conditions
Lewy Body Dementia Psychosis
Interventions
DRUG
No Results Yet
NCT07090135 | RECRUITING | NA
25 Participants

Power Nap With TES-TI

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-19
Completion: 2027-04-30
Conditions
Non-restorative Sleep Healthy Volunteer
Interventions
DEVICE
No Results Yet
NCT07077005 | RECRUITING | NA
24 Participants

Mavacamten Enables Exercise in Hypertrophic Obstructive Cardiomyopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-01
Completion: 2026-10-31
Conditions
Cardiomyopathy, Hypertrophic
Interventions
OTHER
No Results Yet
NCT07071623 | RECRUITING | PHASE3
4580 Participants

A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-10
Completion: 2027-10-18
Conditions
Human Immunodeficiency Virus (HIV) HIV Pre-Exposure Prophylaxis
Interventions
DRUG
No Results Yet
NCT07069699 | NOT_YET_RECRUITING | PHASE1/PHASE2
50 Participants

Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-31
Completion: 2027-09-19
Conditions
Burkitt Lymphoma Double-Expressor Lymphoma High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
Interventions
PROCEDURE DRUG
No Results Yet
NCT07067151 | ENROLLING_BY_INVITATION
30 Participants

Using Smartwatches to Monitor Smoking in Real-life Situations

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-04-30
Conditions
Smoking
No Results Yet
NCT07067138 | NOT_YET_RECRUITING | NA
175 Participants

A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-08-04
Conditions
Breast Cancer Breast Carcinoma Cancer of the Breast Malignant Neoplasm of Breast
Interventions
DEVICE
No Results Yet
NCT07061977 | RECRUITING | PHASE3
336 Participants

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-05
Completion: 2030-12-31
Conditions
Locally Advanced Cervical Adenocarcinoma Locally Advanced Cervical Adenosquamous Carcinoma Locally Advanced Cervical Squamous Cell Carcinoma Stage IIIA Cervical Cancer FIGO 2018 Stage IIIB Cervical Cancer FIGO 2018 Stage IIIC1 Cervical Cancer FIGO 2018 Stage IIIC2 Cervical Cancer FIGO 2018 Stage IVA Cervical Cancer FIGO 2018
Interventions
PROCEDURE RADIATION DRUG BIOLOGICAL
No Results Yet
NCT07061964 | RECRUITING | PHASE2
111 Participants

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-11-25
Completion: 2027-07-31
Conditions
Muscle Invasive Bladder Urothelial Carcinoma Stage II Bladder Cancer AJCC v8 Stage IIIA Bladder Cancer AJCC v8
Interventions
PROCEDURE BIOLOGICAL RADIATION OTHER
No Results Yet
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