Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
25 participants
INTERVENTIONAL
2025-12-19
2027-04-30
Brief Summary
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Participants will attend 2 study visits, each of which may last up to 4-5 hours. During these visits, participants will wear a high density electroencephalography (hdEEG) cap and take a nap.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Stimulation followed by no stimulation
Participants will receive stimulation during their nap at the first visit, and no stimulation during their nap at the second visit.
Transcranial electrical stimulation with Temporal Interference (TES-TI)
TES-TI uses specific electrode arrangement patterns to selectively stimulate the brain. Participants will wear an hdEEG (high density electroencephalography) cap which will allow intermittent periods of stimulation from TES-TI.
No stimulation followed by stimulation
Participants will not receive stimulation during their nap at the first visit, and receive stimulation during their nap at the second visit.
Transcranial electrical stimulation with Temporal Interference (TES-TI)
TES-TI uses specific electrode arrangement patterns to selectively stimulate the brain. Participants will wear an hdEEG (high density electroencephalography) cap which will allow intermittent periods of stimulation from TES-TI.
Interventions
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Transcranial electrical stimulation with Temporal Interference (TES-TI)
TES-TI uses specific electrode arrangement patterns to selectively stimulate the brain. Participants will wear an hdEEG (high density electroencephalography) cap which will allow intermittent periods of stimulation from TES-TI.
Eligibility Criteria
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Inclusion Criteria
* Self-reported non-restorative sleep, as measured by a REST-Q score
* English-speaking (able to provide consent and complete questionnaires)
* Capable of taking daytime naps
* US Citizen
Exclusion Criteria
* History of inpatient psychiatric hospitalization
* History of head trauma resulting in prolonged loss of consciousness; or a history of \>3 grade I concussions
* Current history of poorly controlled headaches including intractable or poorly controlled migraines
• Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
* History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
* Possible pregnancy or plan to become pregnant in the next 6 months
* Any metal in the head
* Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)
* Dental implants
* Permanent retainers
* Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions
* Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions
* Any medication that may alter seizure threshold taken during the study i.e., ADHD stimulants (Adderall, amphetamine); Tricyclic/atypical antidepressants (amitriptyline, doxepine, imipramine, maprotiline, nortriptyline, bupropion); Antipsychotics (chlorpromazine, clozapine), Bronchodilators (theophylline, aminophylline); Antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antivirals (valacyclovir, ritonavir); OTC antihistamines (diphenhydramine, Benadryl)
* Claustrophobia (a fear of small or closed places)
* Back problems that would prevent lying flat for up to two hours
* Regular night-shift work (second or third shift)
18 Years
75 Years
ALL
Yes
Sponsors
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Corundum Convergence Institute
UNKNOWN
University of Wisconsin, Madison
OTHER
Responsible Party
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Principal Investigators
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Guilio Tononi, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Wisconsin, Madison
Locations
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University of Wisconsin - Madison
Madison, Wisconsin, United States
Countries
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Central Contacts
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Facility Contacts
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Sean Prahl
Role: primary
Other Identifiers
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A538900
Identifier Type: OTHER
Identifier Source: secondary_id
SMPH/PSYCHIATRY/PSYCHIATRY
Identifier Type: OTHER
Identifier Source: secondary_id
Protocol Version 12/4/25
Identifier Type: OTHER
Identifier Source: secondary_id
2025-0481
Identifier Type: -
Identifier Source: org_study_id