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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04708431 | RECRUITING
650 Participants

Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-04-29
Completion: 2040-02-01
Conditions
Androgen Insensitivity Syndrome Metabolic Parameters in AIS, CAIS, PAIS and MAIS Tumor Formation in AIS, CAIS, PAIS and MAIS Sexual Function AIS, CAIS, PAIS and MAIS
No Results Yet
NCT04685200 | RECRUITING
143 Participants

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-31
Completion: 2026-10-31
Conditions
Primary Sclerosing Cholangitis
No Results Yet
NCT04655404 | RECRUITING | EARLY_PHASE1
15 Participants

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-04-08
Completion: 2026-12-01
Conditions
High Grade Glioma Diffuse Intrinsic Pontine Glioma
Interventions
DRUG PROCEDURE
No Results Yet
NCT04653896 | ACTIVE_NOT_RECRUITING | NA
16 Participants

A Powered Exoskeleton for Veterans With Knee OA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-06-01
Completion: 2026-03-31
Conditions
Knee Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT04639830 | RECRUITING
244 Participants

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-11-09
Completion: 2027-04-15
Conditions
Healthy Children Children With Neurodevelopmental Disorders Children With Neuropsychiatric Disorders Children With Behavioral Syndromes
No Results Yet
NCT04638205 | COMPLETED
39 Participants

The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2019-11-01
Completion: 2022-12-31
Conditions
Suicide, Attempted
No Results Yet
NCT04636138 | ACTIVE_NOT_RECRUITING | NA
5 Participants

Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-06-03
Completion: 2023-07-30
Conditions
HMG-CoA Reductase Inhibitor Toxicity
Interventions
OTHER
No Results Yet
NCT04609072 | RECRUITING
200000 Participants

Connect for Cancer Prevention Study (Connect)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-07-26
Completion: 2070-12-31
Conditions
Cancer General Research Use
No Results Yet
NCT04595760 | ACTIVE_NOT_RECRUITING
231 Participants

Factors Influencing Fertility or Pregnancy Health

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-10-19
Completion: 2030-12-31
Conditions
Menstrual Cycles Conception Early Pregnancy Loss Pregnancy Outcomes
No Results Yet
NCT04577339 | COMPLETED
2500 Participants

The Best Care for Abdominal Emergencies Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-01-08
Completion: 2022-05-01
Conditions
Acute Abdomen Bowel Obstruction Bowel; Ischemic, Acute Bowel Perforated Peritonitis
Interventions
PROCEDURE
No Results Yet
NCT04569591 | NOT_YET_RECRUITING | NA
22 Participants

Corticotrophin-releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing s Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2025-12-31
Conditions
Cushing's Disease Pituitary Adenoma
Interventions
DRUG
No Results Yet
NCT04557969 | RECRUITING
400 Participants

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-12-18
Completion: 2040-12-30
Conditions
Gastric Cancer Gastric Neoplasm Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Neoplasm Gastrointestinal Stromal Tumor (GIST)
No Results Yet
NCT04557618 | RECRUITING | NA
50 Participants

Auricular VNS Following Subarachnoid Hemorrhage

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-01-05
Completion: 2026-06-30
Conditions
Subarachnoid Hemorrhage
Interventions
DEVICE
No Results Yet
NCT04557150 | ACTIVE_NOT_RECRUITING | PHASE1
225 Participants

A Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Forimtamig in Participants With Relapsed or Refractory Multiple Myeloma (r/r MM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-11-11
Completion: 2026-02-20
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT04505254 | RECRUITING | PHASE2
60 Participants

Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-08-25
Completion: 2027-06-30
Conditions
Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT04500119 | ENROLLING_BY_INVITATION | NA
200 Participants

Neuronal Mechanisms of Human Episodic Memory

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-08-12
Completion: 2026-07-31
Conditions
Epilepsy Intractable
Interventions
BEHAVIORAL
No Results Yet
NCT04496947 | RECRUITING | NA
30 Participants

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2018-09-01
Completion: 2026-01-31
Conditions
Atherosclerosis Stress Inflammation
Interventions
BEHAVIORAL
No Results Yet
NCT04493645 | ACTIVE_NOT_RECRUITING | NA
150 Participants

Ankle Instability Using Foot Intensive Rehabilitation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-28
Completion: 2026-12-01
Conditions
Ankle Injuries Ankle Sprains
Interventions
BEHAVIORAL
No Results Yet
NCT04485013 | RECRUITING | PHASE1
240 Participants

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-07-14
Completion: 2027-06-01
Conditions
Cancer
Interventions
DRUG
No Results Yet
NCT04475783 | ACTIVE_NOT_RECRUITING | NA
478 Participants

Sirolimus- vs. Paclitaxel-Drug Coated Ballons in Patients With Peripheral Artery Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-04-13
Completion: 2023-12-31
Conditions
Peripheral Artery Disease
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04474353 | COMPLETED | PHASE1
12 Participants

Study of Tumor Treating Fields With Hypofractionated Chemoradiotherapy in Newly Diagnosed Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-05-21
Completion: 2024-11-14
Conditions
Glioblastoma Newly Diagnosed Glioblastoma
Interventions
DEVICE DRUG RADIATION
No Results Yet
NCT04466865 | COMPLETED | NA
407 Participants

A Communication Tool to Assist Older Adults Facing Dialysis Choices

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-11-02
Completion: 2025-11-10
Conditions
Palliative Care Kidney Failure, Chronic Decision Making Decision Support Techniques Renal Dialysis Dialysis Kidney Diseases Nephrologists Decision Aid End of Life End-Stage Renal Disease Late-Stage Renal Disease Communication Life-Supporting Treatments
Interventions
OTHER
No Results Yet
NCT04458532 | RECRUITING | NA
152 Participants

Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-10-08
Completion: 2027-03-31
Conditions
Early Stage Breast Cancer
Interventions
OTHER
No Results Yet
NCT04450927 | ENROLLING_BY_INVITATION
10000 Participants

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-06-16
Completion: 2040-12-31
Conditions
Wide Spectrum of Diseases Hematologic Diseases
No Results Yet
NCT04442425 | COMPLETED
83 Participants

Machine Learning to Analyze Facial Imaging, Voice and Spoken Language for the Capture and Classification of Cancer/Tumor Pain

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-10-27
Completion: 2024-03-27
Conditions
Cancer Neoplasms Solid Tumors
No Results Yet
NCT04411147 | ACTIVE_NOT_RECRUITING
583 Participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-06-17
Completion: 2027-12-31
Conditions
COVID-19
No Results Yet
NCT04402125 | COMPLETED | NA
160 Participants

Reducing Stroke Risk in African-American Men

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-05-05
Completion: 2025-09-08
Conditions
Stroke Transient Ischemic Attack
Interventions
BEHAVIORAL
No Results Yet
NCT04371432 | COMPLETED
721 Participants

Genetics of COVID-19 Susceptibility and Manifestations

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-05-05
Completion: 2021-11-23
Conditions
COVID-19 Coronavirus 2019
No Results Yet
NCT04369053 | COMPLETED
48995 Participants

Prevention of Colorectal Cancer Through Multiomics Blood Testing

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-05-20
Completion: 2024-02-29
Conditions
Colon Cancer Rectal Cancer Colon Neoplasm Colon Diseases Colon Lesion Colon Polyp Colorectal Cancer Polyp Adenoma Rectal Diseases Gastrointestinal Tract Cancers
Interventions
DIAGNOSTIC_TEST
Results Available
NCT04361994 | RECRUITING
500 Participants

The GErman Italian Spanish Takotsubo (GEIST) Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2015-04-30
Completion: 2035-12-31
Conditions
Takotsubo Syndrome
No Results Yet
NCT04324944 | COMPLETED | NA
39 Participants

Adapting and Examining Collaborative Decision Skills Training Among Veterans With Serious Mental Illness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-05
Completion: 2025-09-13
Conditions
Schizophrenia Schizoaffective Disorder Delusional Disorder Major Depressive Disorder With Psychotic Features
Interventions
BEHAVIORAL
No Results Yet
NCT04319939 | COMPLETED
66 Participants

Diaphragm Ultrasound Measurements With Variations in Modes of Ventilation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-02-05
Completion: 2022-04-11
Conditions
Mechanical Ventilation
Interventions
OTHER
No Results Yet
NCT04316546 | RECRUITING | PHASE2
45 Participants

MK-7075 (Miransertib) in Proteus Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-05-20
Completion: 2026-07-01
Conditions
Proteus Syndrome
Interventions
DRUG
No Results Yet
NCT04296305 | ACTIVE_NOT_RECRUITING | PHASE4
84 Participants

Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-09-10
Completion: 2027-12-31
Conditions
Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm
Interventions
DRUG OTHER
No Results Yet
NCT04278313 | RECRUITING | NA
90 Participants

Ovarian Function Following Intraovarian Injection of PRP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-02-24
Completion: 2026-07-31
Conditions
Diminished Ovarian Reserve Diminished Ovarian Reserve Due to Advanced Maternal Age
Interventions
PROCEDURE
No Results Yet
NCT04267848 | RECRUITING | PHASE3
1210 Participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-06-16
Completion: 2025-12-15
Conditions
Lung Non-Small Cell Carcinoma Lung Non-Small Cell Squamous Carcinoma Lung Non-Squamous Non-Small Cell Carcinoma Stage II Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8
Interventions
PROCEDURE DRUG OTHER BIOLOGICAL
No Results Yet
NCT04242563 | COMPLETED | NA
156 Participants

Virtual Reality for Preoperative Anxiety in Interventional Cardiology

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-02-02
Completion: 2021-07-12
Conditions
Anxiety
Interventions
OTHER
No Results Yet
NCT04200937 | ENROLLING_BY_INVITATION
450 Participants

IT Matters: The Erectile Restoration Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-08-05
Completion: 2031-01-31
Conditions
Erectile Dysfunction
Interventions
DEVICE
No Results Yet
NCT04179448 | ACTIVE_NOT_RECRUITING | NA
22 Participants

A Comparison of Side Access Mucosal Releasing Incision (SAMRI) and Sulcular Tunnel Access to Treat Gingival Recession.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-02-11
Completion: 2023-12-11
Conditions
Gingival Recession Lack of Keratinized Gingiva
Interventions
PROCEDURE
No Results Yet
NCT04165941 | ACTIVE_NOT_RECRUITING | PHASE1
22 Participants

Novel Gamma-Delta (γδ)T Cell Therapy for Treatment of Patients With Newly Diagnosed Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2020-02-11
Completion: 2026-12-31
Conditions
Brain Tumor Adult
Interventions
BIOLOGICAL
No Results Yet
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