Clinical Trials Updated in 2025

NCT07165951 | RECRUITING | PHASE3

566 Participants

Clinical Trial Comparing TQB2868 Injection Combined With Anlotinib Hydrochloride Capsules With Placebo Combined With Chemotherapy as First-line Treatment for Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-02

Completion: 2028-05-31

Conditions

Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT07165028 | RECRUITING | PHASE3

4500 Participants

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-15

Completion: 2030-08-31

Conditions

Metabolic Dysfunction-Associated Steatotic Liver Disease

Interventions

DRUG

No Results Yet

NCT07161414 | RECRUITING | PHASE1

40 Participants

A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-11-25

Completion: 2027-07-19

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT07157930 | COMPLETED

180 Participants

Prenatal Hormonal Markers and Sleep Characteristics in Young Adults With Joint Hypermobility

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-20

Completion: 2025-12-17

Conditions

Joint Hypermobility Healty Controls Sleep Androgen Effect Hormonal

Interventions

BEHAVIORAL

No Results Yet

NCT07156149 | RECRUITING

50 Participants

Fabhalta Capsules Specified Drug-use Survey

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-17

Completion: 2028-06-30

Conditions

C3 Glomerulopathy

No Results Yet

NCT07154264 | RECRUITING | PHASE2

66 Participants

A Study of DZD8586 Combination in CLL/SLL (TAI-SHAN10)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-22

Completion: 2029-12-31

Conditions

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Interventions

DRUG

No Results Yet

NCT07153471 | RECRUITING | PHASE3

800 Participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-15

Completion: 2028-04-30

Conditions

Osteoarthritis

Interventions

DRUG

No Results Yet

NCT07146230 | NOT_YET_RECRUITING | PHASE2

52 Participants

The Selective Personalized Radio-Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer Trial 2

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-03-01

Completion: 2027-10-31

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG RADIATION

No Results Yet

NCT07144787 | COMPLETED | NA

10 Participants

Four Implant Retained Mandibular Overdenture VERSUS Fixed-detachable Prosthesis.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-01

Completion: 2024-08-01

Conditions

Oral Health Impact Profile Short Version 14 (OHIP 14)

Interventions

OTHER

No Results Yet

NCT07143890 | RECRUITING | NA

45 Participants

Iron Absorption From Plant Heme Iron

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-22

Completion: 2025-12-18

Conditions

Iron Deficiency (ID) Iron Absorption

Interventions

OTHER

No Results Yet

NCT07141004 | RECRUITING | PHASE4

100 Participants

A Study of Guselkumab Administered Subcutaneously in Treatment of Indian Participants With Psoriatic Arthritis (PsA)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-12

Completion: 2027-06-05

Conditions

Arthritis, Psoriatic

Interventions

DRUG

No Results Yet

NCT07136467 | RECRUITING

2795 Participants

A Real World Study to Globally Assess Disease Burden in Adolescent and Adult Participants With Alopecia Areata, Vitiligo, or Hidradenitis Suppurativa

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-02

Completion: 2027-08-31

Conditions

Non-Segmental Vitiligo (NSV) Alopecia Areata Hidradenitis Suppurativa

No Results Yet

NCT07133919 | RECRUITING | NA

60 Participants

Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-15

Completion: 2026-01-31

Conditions

Caries, Dental Local Anesthesia Inferior Alveolar Nerve Block Dental Anxiety

Interventions

BEHAVIORAL

No Results Yet

NCT07133139 | RECRUITING | NA

80 Participants

Treatment Validation for Myofascial Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-06

Completion: 2027-08-31

Conditions

Chronic Low-back Pain (cLBP) Myofacial Pain

Interventions

DEVICE OTHER

No Results Yet

NCT07129993 | RECRUITING | PHASE2/PHASE3

630 Participants

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-26

Completion: 2029-06-01

Conditions

Urothelial Cancer Bladder Cancer

Interventions

DRUG

No Results Yet

NCT07126600 | COMPLETED

100 Participants

Data Collection for Echocardiography-Based Software Assessment

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-11

Completion: 2025-11-19

Conditions

Atrial Fibrillation Left Atrial Appendage Closure Cardiovascular Diseases

Interventions

OTHER

No Results Yet

NCT07117890 | RECRUITING | PHASE2

34 Participants

Sunvozertinib Treatment in Untreated Advanced NSCLC With EGFR Uncommon Mutations

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-07

Completion: 2027-02-20

Conditions

Non Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT07111234 | RECRUITING | NA

30 Participants

Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-15

Completion: 2026-12-31

Conditions

Cigarette Smoking-Related Carcinoma

Interventions

PROCEDURE DRUG OTHER

No Results Yet

NCT07109869 | RECRUITING | PHASE3

201 Participants

Safety and Efficacy of Boric Acid Inserts for Treatment of Vulvovaginal Candidiasis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-08

Completion: 2026-06-30

Conditions

Vulvovaginal Candidiases Vulvovaginal Candidiasis, Genital Vulvovaginal Candidiasis (VVC)

Interventions

DRUG OTHER

No Results Yet

NCT07107230 | RECRUITING | PHASE1

380 Participants

A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-15

Completion: 2027-11-18

Conditions

Colorectal Neoplasms

Interventions

DRUG

No Results Yet

NCT07105722 | ACTIVE_NOT_RECRUITING | PHASE1

127 Participants

A Trial to Evaluate the Safety and Immune Response of an Investigational Pneumococcal Vaccine in Adults 50 To 64 Years of Age

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-12

Completion: 2026-06-09

Conditions

Pneumonia, Bacterial

Interventions

BIOLOGICAL COMBINATION_PRODUCT

No Results Yet

NCT07103018 | RECRUITING | PHASE1

144 Participants

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-11-21

Completion: 2027-09-30

Conditions

Metastatic Castration-resistant Prostate Cancer Metastatic Castration-Resistant Prostate Cancer Patients Metastatic Castration-resistant Prostate Cancer, mCRPC mCRPC mCRPC (Metastatic Castration-resistant Prostate Cancer)

Interventions

DRUG

No Results Yet

NCT07102576 | RECRUITING | PHASE1

30 Participants

MDMA-Assisted Therapy for Mental Healthcare Providers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-31

Completion: 2029-09-21

Conditions

Mental Wellbeing

Interventions

DRUG

No Results Yet

NCT07102212 | NOT_YET_RECRUITING | NA

120 Participants

Telemedicine-mHealth Symptom Cluster Intervention for Advanced Cancer Patients: Finding Our Center Under Stress (FOCUS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-02-01

Completion: 2028-08-31

Conditions

Lung Cancer Breast Cancer Prostate Cancer Multiple Myeloma Melanoma

Interventions

BEHAVIORAL

No Results Yet

NCT07100119 | RECRUITING | PHASE1

32 Participants

A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-05

Completion: 2027-08-31

Conditions

ALS (Amyotrophic Lateral Sclerosis)

Interventions

DRUG

No Results Yet

NCT07097012 | RECRUITING | PHASE4

60 Participants

Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-16

Completion: 2026-01-31

Conditions

RSV Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination Pregnancy Healthy

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT07091071 | RECRUITING | NA

73 Participants

Evaluation of the CochSyn Device in Clinical Practice

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-29

Completion: 2025-12-31

Conditions

Hearing Loss, Sensorineural Cochlear Hearing Loss Cochlear Synaptopathy DFNA9

Interventions

DEVICE

No Results Yet

NCT07086976 | RECRUITING | PHASE3

90 Participants

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-18

Completion: 2028-05-31

Conditions

Autoimmune Haemolytic Anaemia

Interventions

DRUG

No Results Yet

NCT07085754 | RECRUITING | NA

60 Participants

Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-08

Completion: 2025-12-31

Conditions

Sleep Sleep Deprivation

Interventions

BEHAVIORAL

No Results Yet

NCT07082829 | RECRUITING | PHASE1

208 Participants

A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-06-30

Completion: 2026-06-15

Conditions

Excessive Daytime Sleepiness

Interventions

DRUG OTHER

No Results Yet

NCT07081880 | RECRUITING

100 Participants

Study of the Pathophysiological Mechanisms Involved in the SAPHO Syndrome: Genetic Component and Immune Response

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-15

Completion: 2028-07-15

Conditions

SAPHO Syndrome

Interventions

OTHER

No Results Yet

NCT07080853 | COMPLETED | NA

23 Participants

Acute Exercise With Overdressing

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-06-22

Completion: 2025-04-28

Conditions

Heat Stress, Exertional Heat Acclimation and Thermotolerance

Interventions

OTHER

No Results Yet

NCT07079475 | RECRUITING | PHASE1/PHASE2

200 Participants

Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-31

Completion: 2028-12-31

Conditions

Non-Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT07079462 | RECRUITING | PHASE2

40 Participants

Comparing 68Ga-FAPI PET-Guided Abdominal Radiotherapy Combined With Second-Line Standard Therapy and Cadonilimab Versus Second-Line Standard Therapy in Colorectal Cancer With Peritoneal Metastasis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-01

Completion: 2026-03-01

Conditions

Colorectal Cancer Peritoneal (Metastatic) Cancer FAPI PET

Interventions

COMBINATION_PRODUCT DRUG

No Results Yet

NCT07075861 | RECRUITING

75 Participants

The ARTEMIS Data Collection Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-08-10

Completion: 2028-08-10

Conditions

Aortic Regurgitation Disease

No Results Yet

NCT07074756 | RECRUITING | NA

120 Participants

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-12

Completion: 2028-08-31

Conditions

Glioma Recurrent Glioma

Interventions

DRUG PROCEDURE OTHER BEHAVIORAL

No Results Yet

NCT07069725 | RECRUITING | PHASE1

12 Participants

The Phase 1, Open-label, PET Trial Designed to Investigate the Effect of AZD2389 on FAP Occupancy in the Liver in Participants With Advanced Liver Fibrosis.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-26

Completion: 2026-03-31

Conditions

Liver Fibrosis Hepatic Cirrhosis

Interventions

DRUG DIAGNOSTIC_TEST

No Results Yet

NCT07063589 | RECRUITING

350 Participants

Cannabis Use Patterns Among Young Adults and Associations With Social and Health Outcomes.

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-16

Completion: 2027-08-31

Conditions

Cannabis Use

Interventions

OTHER

No Results Yet

NCT07061925 | COMPLETED | PHASE2

169 Participants

To Evaluate the Efficacy and Safety of ALC-2203 in Patients With Acute Bronchitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-04-23

Completion: 2025-11-21

Conditions

Acute Bronchitis

Interventions

DRUG

No Results Yet

NCT07046546 | RECRUITING | NA

10 Participants

Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-29

Completion: 2026-11-30

Conditions

Thyroid Nodule (Benign) Graves Disease Goitre

Interventions

PROCEDURE

No Results Yet