A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT ID: NCT07153471
Last Updated: 2025-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
800 participants
INTERVENTIONAL
2025-09-15
2028-05-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Orforglipron (GZT1)
Participants will receive orforglipron orally
Orforglipron
Administered orally
Placebo (GZT1)
Participants will receive placebo orally
Placebo
Administered orally
Orforglipron (GZT2)
Participants will receive orforglipron orally
Orforglipron
Administered orally
Placebo (GZT2)
Participants will receive placebo orally
Placebo
Administered orally
Interventions
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Orforglipron
Administered orally
Placebo
Administered orally
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Have tried at least once to lose weight through diet but were unsuccessful
* Have osteoarthritis of the knee and at least one of the following conditions:
* Be over 50 years old
* Have morning knee stiffness that lasts about 30 minutes
* Have a crackling or grinding sound or feeling in the knee
Exclusion Criteria
* Have had a surgery for obesity or plan to have one in the next 18 months
* Have an active knee infection
* Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
* Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure
* Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening
18 Years
ALL
No
Sponsors
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Eli Lilly and Company
INDUSTRY
Responsible Party
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Principal Investigators
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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Role: STUDY_DIRECTOR
Eli Lilly and Company
Locations
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Arizona Research Center
Phoenix, Arizona, United States
AMR Clinical
Tempe, Arizona, United States
Care Access - Huntington Beach
Huntington Beach, California, United States
Care Access - Thousand Oaks
Thousand Oaks, California, United States
Legacy Clinical Trials
Colorado Springs, Colorado, United States
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Care Access - Decatur
Decatur, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Northwestern University
Chicago, Illinois, United States
AMR Clinical
Newton, Kansas, United States
MedVadis Research Corporation
Waltham, Massachusetts, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
AMR Clinical
Kansas City, Missouri, United States
Cardio Metabolic Institute
Somerset, New Jersey, United States
Carolina Research Center
Shelby, North Carolina, United States
University Orthopedics Center
Altoona, Pennsylvania, United States
Care Access - Rapid City
Rapid City, South Dakota, United States
AMR Clinical
Knoxville, Tennessee, United States
Mercy Family Clinic
Dallas, Texas, United States
Juno Research
Houston, Texas, United States
Biopharma Informatic, LLC
Houston, Texas, United States
Activian Clinical Research
Kingwood, Texas, United States
Advanced Rheumatology of Houston - Woodlands
The Woodlands, Texas, United States
Charlottesville Medical Research
Charlottesville, Virginia, United States
Gershon Pain Specialists
Virginia Beach, Virginia, United States
Northwest Clinical Research Center
Bellevue, Washington, United States
Aggarwal and Associates Limited
Brampton, , Canada
Winterberry Research Inc.
Hamilton, , Canada
Diex Recherche Inc. Division Joliette
Joliette, , Canada
Your Research Network
Niagara Falls, , Canada
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
Québec, , Canada
Alpha Recherche Clinique
Québec, , Canada
ALPHA Recherche Clinique
Québec, , Canada
Bluewater Clinical Research Group Inc.
Sarnia, , Canada
Dr. M.B. Jones Inc.
Victoria, , Canada
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T
Baotou, , China
Xuanwu Hospital Capital Medical University
Beijing, , China
The Second Affiliated Hospital Chongqing Medical University
Chongqing, , China
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, , China
The Second People's Hospital of Hefei
Hefei, , China
Jinan Central Hospital
Jinan, , China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, , China
Jiangsu Province Hospital
Nanjing, , China
Pingxiang People's Hospital
Pingxiang, , China
Huashan Hospital, Fudan University
Shanghai, , China
The First Affiliated Hospital of Shantou University Medical College
Shantou, , China
The University of Hong Kong-Shenzhen Hospital
Shenzhen, , China
Klinische Forschung Berlin-Mitte
Berlin, , Germany
Siteworks GmbH - Bochum
Bochum, , Germany
Klinische Forschung Dresden
Dresden, , Germany
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
Hamburg, , Germany
Klinische Forschung Hamburg
Hamburg, , Germany
Klinische Forschung Hannover-Mitte
Hanover, , Germany
Siteworks GmbH - Hannover
Hanover, , Germany
Siteworks GmbH - Heidelberg
Heidelberg, , Germany
Klinische Forschung Karlsruhe
Karlsruhe, , Germany
AmBeNet GmbH
Leipzig, , Germany
CDG Studienambulanz Hartard
München, , Germany
Dedicated Research Site FutureMeds
Offenbach, , Germany
Private Practice - Dr. Jochen Walter
Rendsburg, , Germany
Universitaetsklinikum Wuerzburg
Würzburg, , Germany
All India Institute of Medical Sciences
Bhubaneswar, , India
Rajiv Gandhi Government General Hospital
Chennai, , India
Atmaram Child Care
Kanpur, , India
Kims Kingsway Hospital
Nagpur, , India
Maulana Azad Medical College and Associated with Lok Nayak Hospital
New Delhi, , India
Vencer Hospital
Pimpri-Chinchwad, , India
Hamanomachi Hospital
Fukuoka, , Japan
Fukuoka Wajiro Hospital
Fukuoka, , Japan
Shimane University Hospital
Izumo, , Japan
Kariya Toyota General Hospital
Kariya, , Japan
Ando Orthopedic
Kawasaki, , Japan
Tokyo Saiseikai Central Hospital
Minatoku, , Japan
Goto Orthopedic Surgery Clinic
Miyazaki, , Japan
Kato Orthopedic Clinic
Morioka, , Japan
Japan Community Health Care Organization - Saitama Medical Center
Saitama, , Japan
Sapporo Maruyama Orthopedic Hospital
Sapporo, , Japan
Masumoto Orthopedics Clinic
Suginami City, , Japan
Investigacion y Biomedicina de Chihuahua
Chihuahua City, , Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
Ciudad Madero, , Mexico
Centro Medico del Angel
Mexicali, , Mexico
Kohler & Milstein Research S.A. De C.V.
Mérida, , Mexico
IMED Internal Medicine Clin Trials
Monterrey, , Mexico
Clínica García Flores SC
Monterrey, , Mexico
Hospital San Rafael - La Coruña
A Coruña, , Spain
Hospital Universitari Vall d'Hebron
Barcelona, , Spain
Hospital Quirón Málaga
Málaga, , Spain
Hospital Universitario Marqués de Valdecilla
Santander, , Spain
Clínica Gaias - Santiago
Santiago de Compostela, , Spain
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, , Spain
Hospital Quiron Infanta Luisa
Seville, , Spain
Hospital Clínico Universitario de Valladolid
Valladolid, , Spain
Countries
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Central Contacts
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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Role: CONTACT
Phone: 1-317-615-4559
Email: [email protected]
Physicians interested in becoming principal investigators please contact
Role: CONTACT
Email: [email protected]
Facility Contacts
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Related Links
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A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee ( ATTAIN-OA PAIN )
Other Identifiers
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2025-522631-34-00
Identifier Type: CTIS
Identifier Source: secondary_id
J2A-MC-GZPT
Identifier Type: OTHER
Identifier Source: secondary_id
J2A-MC-GZT1
Identifier Type: OTHER
Identifier Source: secondary_id
J2A-MC-GZT2
Identifier Type: OTHER
Identifier Source: secondary_id
27633
Identifier Type: -
Identifier Source: org_study_id