Clinical Trials Updated in 2025

NCT06890884 | RECRUITING | PHASE2

594 Participants

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-04-11

Completion: 2027-12-13

Conditions

Lymphoma, Large B-Cell, Diffuse

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06881784 | RECRUITING | PHASE3

420 Participants

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-06

Completion: 2027-12-01

Conditions

NSCLC (Non-small Cell Lung Cancer) Non-Small Cell Lung Cancer NSCLC NSCLC (Non-small Cell Lung Carcinoma) NSCLC (Advanced Non-small Cell Lung Cancer)

Interventions

DRUG

No Results Yet

NCT06880055 | RECRUITING

3375 Participants

Shield Post-Approval Study Protocol

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-14

Completion: 2030-09-01

Conditions

Colo-rectal Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06875115 | COMPLETED | NA

60 Participants

Evaluation of the Efficacy of Laser Acupuncture on Uremic Pruritus

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-09

Completion: 2024-05-11

Conditions

Uremia

Interventions

DEVICE

Results Available

NCT06871410 | RECRUITING | PHASE1

26 Participants

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-15

Completion: 2028-04-01

Conditions

Recurrent Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia

Interventions

DRUG PROCEDURE OTHER

No Results Yet

NCT06865651 | RECRUITING | PHASE2

44 Participants

Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-22

Completion: 2027-09-01

Conditions

Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)

Interventions

DRUG

No Results Yet

NCT06864104 | ACTIVE_NOT_RECRUITING | PHASE2

206 Participants

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-04-10

Completion: 2026-01-09

Conditions

Hypertension

Interventions

DRUG

No Results Yet

NCT06864026 | RECRUITING | PHASE4

200 Participants

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-06

Completion: 2027-11-30

Conditions

Psoriatic Arthritis Overweight or Obesity

Interventions

DRUG

No Results Yet

NCT06863272 | RECRUITING | PHASE1/PHASE2

360 Participants

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-03

Completion: 2030-02-18

Conditions

Castration-Resistant Prostatic Cancer Metastasis

Interventions

DRUG

No Results Yet

NCT06853860 | COMPLETED | NA

70 Participants

Effects of Hand Massage Applied With Two Different Methods

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-15

Completion: 2025-05-15

Conditions

Angiopathy, Peripheral Pain, Acute Reflexology

Interventions

OTHER

No Results Yet

NCT06853158 | RECRUITING | NA

90 Participants

MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-04-02

Completion: 2027-01-31

Conditions

Sickle Cell Disease

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT06851559 | RECRUITING | PHASE2

80 Participants

A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-30

Completion: 2026-12-31

Conditions

Eosinophilic Esophagitis

Interventions

DRUG

No Results Yet

NCT06849947 | NOT_YET_RECRUITING | PHASE2

272 Participants

Fulvestrant With Ribociclib Versus Physician's Choice Treatments Recurred After Completion of Adjuvant Cyclin-Dependent Kinase 4/6 Inhibitors in HR+, HER2- Metastatic Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-02-01

Completion: 2031-06-30

Conditions

Breast Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT06848348 | RECRUITING | PHASE2

200 Participants

Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-21

Completion: 2026-07-31

Conditions

Chemotherapy Induced Neuropathic Pain

Interventions

DRUG

No Results Yet

NCT06847854 | RECRUITING | PHASE1

176 Participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-12-08

Completion: 2027-02-28

Conditions

Diabetic Macular Edema

Interventions

DRUG

No Results Yet

NCT06844318 | RECRUITING

153 Participants

Impact of IBD Activity on Frailty in Patients Over 60 Years

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-04-14

Completion: 2026-04-30

Conditions

IBD

No Results Yet

NCT06843252 | RECRUITING | NA

16 Participants

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-02

Completion: 2026-12-31

Conditions

Huntington Disease

Interventions

DEVICE

No Results Yet

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-28

Completion: 2031-09-30

Conditions

Diffuse Large B-cell Lymphoma Follicular Lymphoma

No Results Yet

NCT06830720 | RECRUITING

3250 Participants

A Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer at High Risk of Recurrence

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-20

Completion: 2030-06-30

Conditions

Breast Neoplasms

Interventions

DRUG

No Results Yet

NCT06827457 | COMPLETED | PHASE1

58 Participants

A Study of Safety, Tolerability, PK, and PD of Subcutaneous GenSci120 in Healthy Adults.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-20

Completion: 2025-11-27

Conditions

Autoimmune Disease

Interventions

DRUG

No Results Yet

NCT06825702 | RECRUITING | PHASE2

28 Participants

Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-01

Completion: 2026-11-30

Conditions

Macular Edema

Interventions

DRUG

No Results Yet

NCT06822426 | RECRUITING | PHASE3

200 Participants

Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-14

Completion: 2027-01-31

Conditions

Central Line Associated Blood Stream Infections (CLABSI)

Interventions

DRUG

No Results Yet

NCT06820957 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

437 Participants

Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-11-10

Completion: 2032-07-15

Conditions

CIC-Rearranged Sarcoma Metastatic Ewing Sarcoma Metastatic High Grade Sarcoma Metastatic Undifferentiated Round Cell Sarcoma Metastatic Undifferentiated Sarcoma, Not Otherwise Specified Round Cell Sarcoma With EWSR1-non-ETS Fusion Sarcoma With BCOR Genetic Alterations

Interventions

PROCEDURE DRUG OTHER RADIATION

No Results Yet

NCT06817512 | ACTIVE_NOT_RECRUITING | NA

190 Participants

Ischemic Stroke Nutrition Intervention Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-23

Completion: 2027-01-15

Conditions

Ischemic Stroke

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT06817356 | RECRUITING | PHASE2

300 Participants

A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-06

Completion: 2026-08-31

Conditions

Alcohol Use Disorder

Interventions

DRUG

No Results Yet

NCT06814743 | COMPLETED | NA

107 Participants

A Mobile Application for Female Athletes With Pelvic Floor Dysfunctions (ACTITUD2.0)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-10

Completion: 2025-06-30

Conditions

Pelvic Floor Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT06810505 | RECRUITING | PHASE3

420 Participants

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-13

Completion: 2031-03-31

Conditions

Chronic Migraine

Interventions

DRUG

No Results Yet

NCT06807580 | RECRUITING | PHASE2

40 Participants

Progesterone in Gender Affirming Hormone Therapy Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-12

Completion: 2027-02-28

Conditions

Transgender Women

Interventions

DRUG

No Results Yet

NCT06803602 | ENROLLING_BY_INVITATION | NA

2100 Participants

HIFEM Technology for Post-Radical Prostatectomy and Post-Holmium Laser Prostate Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-01

Completion: 2027-03-31

Conditions

Holmium Laser Prostate Surgery Radical Prostatectomy

Interventions

DEVICE

No Results Yet

NCT06798012 | RECRUITING | PHASE2

36 Participants

A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-05-14

Completion: 2027-12-02

Conditions

Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Interventions

BIOLOGICAL

No Results Yet

NCT06795893 | RECRUITING

240 Participants

The Anifrolumab PRIM Program

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-11-07

Completion: 2031-04-15

Conditions

Systemic Lupus Erythematosus

Interventions

DRUG

No Results Yet

NCT06791512 | RECRUITING | PHASE3

166 Participants

mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-01-18

Completion: 2030-12-31

Conditions

Colorectal Cancer (CRC) pMMR/MSS Adenocarcinoma of the Colon or Rectum

Interventions

DRUG

No Results Yet

NCT06791291 | RECRUITING | PHASE2

10 Participants

Efficacy and Safety of Teplizumab in Japanese Participants With Stage 2 Type 1 Diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-07-25

Completion: 2028-03-06

Conditions

Type 1 Diabetes Mellitus

Interventions

DRUG

No Results Yet

NCT06784466 | RECRUITING | NA

360 Participants

Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-09-10

Completion: 2027-06-30

Conditions

Atrial Fibrillation (AF) Persistant Atrial Fibrillation Paroxysmal AF

Interventions

DEVICE

No Results Yet

NCT06782516 | ENROLLING_BY_INVITATION | NA

1687 Participants

Native-RISE (Risk Identification for Suicide and Enhanced Care)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-02-01

Completion: 2029-09-30

Conditions

Suicide Prevention

Interventions

DEVICE BEHAVIORAL

No Results Yet