A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
NCT ID: NCT06864026
Last Updated: 2025-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
200 participants
INTERVENTIONAL
2025-03-06
2027-11-30
Brief Summary
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The study will last up to 12 months.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Tirzepatide
Participants will continue on ixekizumab and take tirzepatide administered subcutaneously (SC) as per label.
Tirzepatide
Administered SC
Interventions
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Tirzepatide
Administered SC
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Body Mass Index (BMI) of 30 kilograms per meter squared (kg/m²) or greater (obesity) or 27 kg/m2 to \<30 kg/m² (overweight) in the presence of at least 1 weight-related comorbid condition (hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease).
* Who have been treated with ixekizumab for approximately 3 months (±1 month) prior to decision to add tirzepatide.
* Must be able to initiate tirzepatide (Day 0) within 30 days of treatment decision (baseline or screening).
Exclusion Criteria
* Had any exposure to tirzepatide or other glucagon-like peptide-1 (GLP-1) receptor agonist (for example, dulaglutide, liraglutide, or semaglutide).
* Are currently enrolled in any other clinical study.
* Have a known hypersensitivity to any component of tirzepatide.
* Have a personal or family history of medullary thyroid cancer.
* Have multiple endocrine neoplasia type 2.
* Have type 1 diabetes mellitus.
* Have a history of chronic or acute pancreatitis at any time before screening.
* Have a history of proliferative diabetic retinopathy, diabetic maculopathy, or nonproliferative diabetic retinopathy that requires acute treatment.
* Have a history of ketoacidosis or hyperosmolar state/coma.
* Have a history of severe hypoglycemia unawareness within the 6 months before screening.
* Have a history of severe gastrointestinal complications, including gastroparesis, gastroesophageal reflux disease, dyspepsia, chronic nausea/vomiting.
18 Years
ALL
No
Sponsors
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Eli Lilly and Company
INDUSTRY
Responsible Party
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Principal Investigators
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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Role: STUDY_DIRECTOR
Eli Lilly and Company
Locations
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AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale
Avondale, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler
Chandler, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff
Flagstaff, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert
Gilbert, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale
Glendale, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa
Mesa, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV
Phoenix, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City
Sun City, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson
Tucson, Arizona, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast
Tucson, Arizona, United States
Medvin Clinical Research - Apple Valley
Apple Valley, California, United States
Medvin Clinical Research - Covina
Covina, California, United States
Newport Huntington Medical Group
Huntington Beach, California, United States
Purushotham & Akther Kotha MD, Inc
La Mesa, California, United States
Medvin Clinical Research - Riverside
Riverside, California, United States
Rheumatology Center of San Diego
San Diego, California, United States
Providence Saint John's Medical Foundation
Santa Monica, California, United States
Medvin Clinical Research - Temecula
Temecula, California, United States
Medvin Clinical Research - Tujunga
Tujunga, California, United States
Medvin Clinical Research - Whittier
Whittier, California, United States
Vida Clinical Research
Kissimmee, Florida, United States
Life Clinical Trials
Margate, Florida, United States
CZ Rheumatology
Miami Beach, Florida, United States
Vitalia Medical Research
Palm Beach Gardens, Florida, United States
International Center for Research
Tampa, Florida, United States
Atlanta Research Center for Rheumatology
Marietta, Georgia, United States
Satilla Rheumatology & Internal Medicine
Waycross, Georgia, United States
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Greater Chicago Specialty Physicians
Schaumburg, Illinois, United States
Arnold Arthritis & Rheumatology
Skokie, Illinois, United States
Willow Rheumatology and Wellness PLLC
Willowbrook, Illinois, United States
Lake Cumberland Rheumatology
New Albany, Indiana, United States
Accurate Clinical Research, Inc
Lake Charles, Louisiana, United States
Klein & Associates, M.D., P.A.
Cumberland, Maryland, United States
Klein & Associates, M.D., P.A.
Hagerstown, Maryland, United States
Clinical Research Institute of Michigan, LLC
Saint Clair Shores, Michigan, United States
Logan Health Rheumatology
Kalispell, Montana, United States
University of Rochester Medical Center
Rochester, New York, United States
Onsite Clinical Solutions, LLC - Brenner Ave
Salisbury, North Carolina, United States
Paramount Medical Research & Consulting, LLC
Middleburg Heights, Ohio, United States
Essential Medical Research
Tulsa, Oklahoma, United States
West Tennessee Research Institute
Jackson, Tennessee, United States
AARA Clinical Research - Murfreesboro Medical Clinic
Murfreesboro, Tennessee, United States
Precision Comprehensive Clinical Research Solutions - Colleyville
Colleyville, Texas, United States
AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Fort Worth
Fort Worth, Texas, United States
Accurate Clinical Research, Inc
Houston, Texas, United States
Research Physicians Network, LLC
Houston, Texas, United States
AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving
Irving, Texas, United States
Biopharma Informatic, LLC
Katy, Texas, United States
Advanced Rheumatology of Houston - Woodlands
The Woodlands, Texas, United States
DM Clinical Research - TRA
Tomball, Texas, United States
Seattle Rheumatology Associates PLLC
Seattle, Washington, United States
Arthritis Northwest, PLLC
Spokane Valley, Washington, United States
Reuviva Research Center
Guaynabo, , Puerto Rico
Caribbean Medical Research Center
San Juan, , Puerto Rico
Countries
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Central Contacts
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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Role: CONTACT
Phone: 1-317-615-4559
Email: [email protected]
Physicians interested in becoming principal investigators please contact
Role: CONTACT
Email: [email protected]
Facility Contacts
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Related Links
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Related Info
Other Identifiers
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I1F-MC-RHDE
Identifier Type: OTHER
Identifier Source: secondary_id
27350
Identifier Type: -
Identifier Source: org_study_id