Clinical Trials
Showing trials with last updates posted in 2025.
16
Participants
Investigating the Acute Effects of Increasing Glucagon Exposure in Healthy Participants
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-31
Completion:
2025-09-19
Conditions
Glucose Metabolism
Glucagon
Interventions
OTHER
No Results Yet
42
Participants
A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-09
Completion:
2027-11-30
Conditions
Metabolic Dysfunction-Associated Steatohepatitis
Interventions
DRUG
No Results Yet
92
Participants
FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-12-05
Completion:
2028-03-31
Conditions
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Interventions
DRUG
No Results Yet
72
Participants
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-01
Completion:
2027-06-22
Conditions
Systemic Lupus Erythematosus
Idiopathic Inflammatory Myopathies
Rheumatoid Arthritis
Interventions
DRUG
No Results Yet
905
Participants
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-25
Completion:
2027-05-31
Conditions
Type 1 Diabetes
Obesity
Overweight
Interventions
DRUG
No Results Yet
60
Participants
Safety of a Single, Intravitreal Injection of 8.8M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-06-20
Completion:
2026-09-30
Conditions
Retinitis Pigmentosa
Interventions
BIOLOGICAL
OTHER
No Results Yet
6000
Participants
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-07-23
Completion:
2029-10-31
Conditions
Percutaneous Coronary Intervention
Peripheral Endovascular Intervention
Interventions
DRUG
No Results Yet
100
Participants
Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-04
Completion:
2025-08-01
Conditions
Intra-Abdominal Infections
Intestinal Obstruction
Appendicitis Acute
Perforated Viscus
240
Participants
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-28
Completion:
2026-12-31
Conditions
Type 2 Diabetes
Interventions
DRUG
No Results Yet
420
Participants
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-06
Completion:
2027-12-01
Conditions
NSCLC (Non-small Cell Lung Cancer)
Non-Small Cell Lung Cancer
NSCLC
NSCLC (Non-small Cell Lung Carcinoma)
NSCLC (Advanced Non-small Cell Lung Cancer)
Interventions
DRUG
No Results Yet
3375
Participants
Shield Post-Approval Study Protocol
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2025-07-14
Completion:
2030-09-01
Conditions
Colo-rectal Cancer
Interventions
DIAGNOSTIC_TEST
No Results Yet
60
Participants
Evaluation of the Efficacy of Laser Acupuncture on Uremic Pruritus
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-04-09
Completion:
2024-05-11
Conditions
Uremia
Interventions
DEVICE
26
Participants
Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2026-01-15
Completion:
2028-04-01
Conditions
Recurrent Acute Myeloid Leukemia
Refractory Acute Myeloid Leukemia
Interventions
DRUG
PROCEDURE
OTHER
No Results Yet
44
Participants
Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-22
Completion:
2027-09-01
Conditions
Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)
Interventions
DRUG
No Results Yet
206
Participants
A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-10
Completion:
2026-01-09
Conditions
Hypertension
Interventions
DRUG
No Results Yet
200
Participants
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-06
Completion:
2027-11-30
Conditions
Psoriatic Arthritis
Overweight or Obesity
Interventions
DRUG
No Results Yet
70
Participants
Effects of Hand Massage Applied With Two Different Methods
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-15
Completion:
2025-05-15
Conditions
Angiopathy, Peripheral
Pain, Acute
Reflexology
Interventions
OTHER
No Results Yet
90
Participants
MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-02
Completion:
2027-01-31
Conditions
Sickle Cell Disease
Interventions
BEHAVIORAL
OTHER
No Results Yet
80
Participants
A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-10-30
Completion:
2026-12-31
Conditions
Eosinophilic Esophagitis
Interventions
DRUG
No Results Yet
272
Participants
Fulvestrant With Ribociclib Versus Physician's Choice Treatments Recurred After Completion of Adjuvant Cyclin-Dependent Kinase 4/6 Inhibitors in HR+, HER2- Metastatic Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2026-02-01
Completion:
2031-06-30
Conditions
Breast Cancer Metastatic
Interventions
DRUG
No Results Yet
153
Participants
Impact of IBD Activity on Frailty in Patients Over 60 Years
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-14
Completion:
2026-04-30
Conditions
IBD
No Results Yet
16
Participants
Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-09-02
Completion:
2026-12-31
Conditions
Huntington Disease
Interventions
DEVICE
No Results Yet
Expanded Access Program of Taletrectinib in Patients With Advanced or Metastatic ROS1-Positive NSCLC
Study Type:
EXPANDED_ACCESS
Last Updated:
2025-12-24
Conditions
Bronchogenic Carcinoma
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma
Non Small Cell Carcinoma of the Lung
ROS1-positive Non-Small Cell Lung Cancer (NSCLC)
Interventions
DRUG
No Results Yet
23
Participants
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-06-16
Completion:
2029-03-31
Conditions
Primary Hyperoxaluria Type 1 (PH1)
Interventions
DRUG
No Results Yet
210
Participants
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-12
Completion:
2027-01-08
Conditions
Chronic Rhinosinusitis With Nasal Polyps
Interventions
DRUG
No Results Yet
84
Participants
Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-04-30
Completion:
2029-06-01
Conditions
Neuroblastoma
High-risk Neuroblastoma
Interventions
BEHAVIORAL
No Results Yet
700
Participants
Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-28
Completion:
2031-09-30
Conditions
Diffuse Large B-cell Lymphoma
Follicular Lymphoma
No Results Yet
3250
Participants
A Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer at High Risk of Recurrence
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-20
Completion:
2030-06-30
Conditions
Breast Neoplasms
Interventions
DRUG
No Results Yet
58
Participants
A Study of Safety, Tolerability, PK, and PD of Subcutaneous GenSci120 in Healthy Adults.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-20
Completion:
2025-11-27
Conditions
Autoimmune Disease
Interventions
DRUG
No Results Yet
28
Participants
Safety, Tolerability and Efficacy of Intravitreal KIO-104 in Patients With Macular Edema
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-01
Completion:
2026-11-30
Conditions
Macular Edema
Interventions
DRUG
No Results Yet
200
Participants
Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-14
Completion:
2027-01-31
Conditions
Central Line Associated Blood Stream Infections (CLABSI)
Interventions
DRUG
No Results Yet
437
Participants
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-11-10
Completion:
2032-07-15
Conditions
CIC-Rearranged Sarcoma
Metastatic Ewing Sarcoma
Metastatic High Grade Sarcoma
Metastatic Undifferentiated Round Cell Sarcoma
Metastatic Undifferentiated Sarcoma, Not Otherwise Specified
Round Cell Sarcoma With EWSR1-non-ETS Fusion
Sarcoma With BCOR Genetic Alterations
Interventions
PROCEDURE
DRUG
OTHER
RADIATION
No Results Yet
190
Participants
Ischemic Stroke Nutrition Intervention Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-03-23
Completion:
2027-01-15
Conditions
Ischemic Stroke
Interventions
DIETARY_SUPPLEMENT
No Results Yet
300
Participants
A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-06
Completion:
2026-08-31
Conditions
Alcohol Use Disorder
Interventions
DRUG
No Results Yet
107
Participants
A Mobile Application for Female Athletes With Pelvic Floor Dysfunctions (ACTITUD2.0)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-10
Completion:
2025-06-30
Conditions
Pelvic Floor Disorders
Interventions
BEHAVIORAL
No Results Yet
420
Participants
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-02-13
Completion:
2031-03-31
Conditions
Chronic Migraine
Interventions
DRUG
No Results Yet
40
Participants
Progesterone in Gender Affirming Hormone Therapy Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-12
Completion:
2027-02-28
Conditions
Transgender Women
Interventions
DRUG
No Results Yet
2100
Participants
HIFEM Technology for Post-Radical Prostatectomy and Post-Holmium Laser Prostate Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-07-01
Completion:
2027-03-31
Conditions
Holmium Laser Prostate Surgery
Radical Prostatectomy
Interventions
DEVICE
No Results Yet
36
Participants
A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-05-14
Completion:
2027-12-02
Conditions
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Interventions
BIOLOGICAL
No Results Yet
166
Participants
mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-01-18
Completion:
2030-12-31
Conditions
Colorectal Cancer (CRC)
pMMR/MSS Adenocarcinoma of the Colon or Rectum
Interventions
DRUG
No Results Yet
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