Clinical Trials Updated in 2025

NCT06640283 | RECRUITING | PHASE2

150 Participants

Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-14

Completion: 2026-12-31

Conditions

HPV-Related Carcinoma Uterine Cervical Cancer Anal Canal Cancer HPV-Related Anal Squamous Cell Carcinoma HPV-Related Cervical Carcinoma

Interventions

DIAGNOSTIC_TEST DRUG

No Results Yet

NCT06636032 | RECRUITING | PHASE1/PHASE2

9 Participants

Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-12

Completion: 2027-09-30

Conditions

Crohn Disease

Interventions

DRUG

No Results Yet

NCT06626256 | WITHDRAWN | PHASE1

0 Participants

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-05

Completion: 2027-10-30

Conditions

Locally Advanced Cervical Carcinoma Locally Advanced Colorectal Carcinoma Locally Advanced Malignant Solid Neoplasm Locally Advanced Melanoma Locally Advanced Pancreatic Ductal Adenocarcinoma Locally Advanced Renal Cell Carcinoma Metastatic Cervical Carcinoma Metastatic Colorectal Carcinoma Metastatic Malignant Solid Neoplasm Metastatic Melanoma Metastatic Pancreatic Ductal Adenocarcinoma Metastatic Renal Cell Carcinoma Stage II Pancreatic Cancer AJCC v8 Stage III Cervical Cancer AJCC v8 Stage III Colorectal Cancer AJCC v8 Stage III Pancreatic Cancer AJCC v8 Stage III Renal Cell Cancer AJCC v8 Stage IV Cervical Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Pancreatic Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8 Unresectable Cervical Carcinoma Unresectable Colorectal Carcinoma Unresectable Malignant Solid Neoplasm Unresectable Melanoma Unresectable Pancreatic Ductal Adenocarcinoma Unresectable Renal Cell Carcinoma

Interventions

BIOLOGICAL PROCEDURE DRUG

No Results Yet

NCT06623422 | RECRUITING | PHASE3

680 Participants

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-21

Completion: 2033-05-16

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

BIOLOGICAL DRUG OTHER

No Results Yet

NCT06618287 | RECRUITING | PHASE1/PHASE2

416 Participants

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-04

Completion: 2031-02-26

Conditions

Lung Cancer Breast Cancer

Interventions

DRUG

No Results Yet

NCT06616623 | SUSPENDED | PHASE1

24 Participants

Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-31

Completion: 2026-12-31

Conditions

Metastatic Lung Non-Small Cell Carcinoma Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8

Interventions

BIOLOGICAL PROCEDURE DRUG

No Results Yet

NCT06613516 | WITHDRAWN | PHASE2

0 Participants

Effect of Capivasertib on ctDNA in ER Positive Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-01

Completion: 2025-09-16

Conditions

Breast Cancer Oestrogen Receptor Positive Breast Cancer

Interventions

DRUG

No Results Yet

NCT06612827 | RECRUITING

20 Participants

Development of Tumor Organoids From Undifferentiated Primary Carcinomas to Guide Therapeutic Decisions

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-03-05

Completion: 2028-12-15

Conditions

Undifferentiated Carcinoma

Interventions

OTHER

No Results Yet

NCT06610838 | RECRUITING

600 Participants

Effects of E-cigarette Use on Health

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-01-06

Completion: 2029-06-30

Conditions

Electronic Cigarette Use

Interventions

OTHER

No Results Yet

NCT06600321 | RECRUITING | PHASE1

158 Participants

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-30

Completion: 2027-09-30

Conditions

Advanced Hepatocellular Carcinoma Metastatic Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT06599736 | ACTIVE_NOT_RECRUITING | NA

25 Participants

A Study of RhinAer Stylus for Treating Chronic Rhinitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-03

Completion: 2025-12-31

Conditions

Chronic Rhinitis

Interventions

DEVICE

No Results Yet

NCT06598943 | RECRUITING | PHASE2

140 Participants

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-10

Completion: 2027-12-31

Conditions

Ulcerative Colitis Ulcerative Colitis Chronic

Interventions

DRUG

No Results Yet

NCT06592040 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated: 2025-12-24

No Results Yet

NCT06589596 | RECRUITING | PHASE1

244 Participants

An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-11

Completion: 2029-01-31

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT06585449 | RECRUITING | PHASE1

54 Participants

A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-14

Completion: 2028-07-05

Conditions

Huntington's Disease

Interventions

DRUG

No Results Yet

NCT06582160 | COMPLETED | NA

286 Participants

Enhancing Uptake of Preconception Care Services in Family Practice Clinics Using a Patient Centered Screening Tool

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-09-23

Completion: 2025-08-26

Conditions

Women Reproductive Age

Interventions

OTHER

No Results Yet

NCT06579469 | RECRUITING

100 Participants

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-31

Completion: 2027-03-31

Conditions

B-ALL Hematologic Malignancy Solid Tumor

No Results Yet

NCT06567314 | RECRUITING | PHASE2

24 Participants

Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-02

Completion: 2028-09-01

Conditions

Cutaneous Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06560918 | RECRUITING | NA

27 Participants

Self-efficacy-based Auditory Rehabilitation With Over-the-Counter Hearing Aids

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-30

Completion: 2026-01-31

Conditions

Hearing Loss, Sensorineural

Interventions

DEVICE

No Results Yet

NCT06554405 | COMPLETED | NA

28 Participants

Bilateral vs. Unilateral Neuromobilization in Carpal Tunnel Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-08-31

Completion: 2025-05-30

Conditions

Carpal Tunnel Syndrome

Interventions

OTHER

No Results Yet

NCT06543914 | RECRUITING

1000 Participants

Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-11-26

Completion: 2029-02-28

Conditions

Migraine

No Results Yet

NCT06537934 | RECRUITING

123 Participants

Advanced Mutidimensional and Ultra High Resolution Computed Tomography to Inspect Cardiopulmonary Involvement in Progressive Fibrosing Interstitial Lung Diseases

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-01

Completion: 2025-09-01

Conditions

Interstitial Lung Diseases

No Results Yet

NCT06535451 | RECRUITING

1000 Participants

Lung Cancer Screening Program in Mexico

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2022-03-24

Completion: 2026-03-24

Conditions

Lung Cancer

Interventions

OTHER

No Results Yet

NCT06529809 | RECRUITING | PHASE1/PHASE2

50 Participants

Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-02-11

Completion: 2031-12-31

Conditions

Locally Advanced Cervical Carcinoma

Interventions

RADIATION DRUG

No Results Yet

NCT06526494 | WITHDRAWN | PHASE2

0 Participants

Metformin and Vascular Function in Prediabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-11-13

Completion: 2025-12-01

Conditions

PreDiabetes

Interventions

DRUG OTHER

No Results Yet

NCT06523660 | ACTIVE_NOT_RECRUITING | NA

40 Participants

Improving Executive Function in Korean Children With Autism

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-11

Completion: 2026-03-15

Conditions

Autism Spectrum Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06518655 | RECRUITING

3000 Participants

Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-30

Completion: 2026-12-30

Conditions

Pulmonary Nodules, Multiple Pulmonary Nodules, Solitary Lung Cancer

Interventions

OTHER

No Results Yet

NCT06515691 | RECRUITING | NA

60 Participants

Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-01-03

Completion: 2026-02-15

Conditions

Obesity Bariatric Surgery Laparoscopic Sleeve Gastrectomy Acute Post Operative Pain

Interventions

PROCEDURE

No Results Yet

NCT06511895 | COMPLETED | PHASE2

57 Participants

AZD4205 in Relapsed or Refractory Peripheral T Cell Lymphoma (JACKPOT27)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-05-31

Completion: 2025-10-17

Conditions

Peripheral T Cell Lymphoma

Interventions

DRUG

No Results Yet

NCT06501118 | RECRUITING | NA

3600 Participants

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-01

Completion: 2026-06-30

Conditions

Respiratory Failure Acute Hypoxemic Respiratory Failure Acute Hypoxic Respiratory Failure Hypoxemia Hypoxia Hypoxic Respiratory Failure

Interventions

OTHER BEHAVIORAL

No Results Yet

NCT06500702 | RECRUITING | PHASE2

84 Participants

A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-19

Completion: 2026-12-23

Conditions

Focal Segmental Glomerulosclerosis Glomerulonephritis Minimal Lesion

Interventions

DRUG

No Results Yet

NCT06492616 | RECRUITING | PHASE3

4220 Participants

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-27

Completion: 2029-08-31

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06490991 | COMPLETED | PHASE1

16 Participants

Comparison of HRS-5965 Capsules and Tablets in Healthy Subjects

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-17

Completion: 2024-08-06

Conditions

Paroxysmal Nocturnal Hemoglobinuria，IgA Nephropathy

Interventions

DRUG

No Results Yet

NCT06488716 | TERMINATED | PHASE1

12 Participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7759065 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-16

Completion: 2025-11-05

Conditions

Solid Tumour

Interventions

DRUG

No Results Yet

NCT06486779 | RECRUITING

160 Participants

Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-10

Completion: 2028-12-30

Conditions

Relapsing Multiple Sclerosis (RMS)

Interventions

OTHER

No Results Yet

NCT06479070 | RECRUITING | NA

188 Participants

Prognostic Value of Measuring CtDNA in a Cohort of Patients With Stage III and IV Upper Aero-digestive Tract (UADT) Cancer , Treated With Curative RADiOtherapy With or Without Concomitant Treatment.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-30

Completion: 2026-09-30

Conditions

SCC - Squamous Cell Carcinoma Upper Aero-digestive Tract (UADT) Neoplasm

Interventions

OTHER

No Results Yet

NCT06475963 | COMPLETED

41 Participants

Evaluation of Clinical Outcomes of Scaffold Treatment of Partial Meniscal Injuries of the Knee

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-03-17

Completion: 2025-07-31

Conditions

Knee Osteoarthritis Knee Injuries Meniscus Lesion

Interventions

OTHER

No Results Yet

NCT06470438 | RECRUITING | PHASE1

170 Participants

A Study of JNJ-88998377 for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-28

Completion: 2027-10-29

Conditions

Lymphoma, Non-Hodgkin Refractory B-Cell NHL Relapsed B-cell NHL

Interventions

DRUG

No Results Yet

NCT06468202 | RECRUITING | PHASE4

10742 Participants

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-18

Completion: 2029-01-01

Conditions

Hypertensive Disorders of Pregnancy Preeclampsia Gestational Hypertension

Interventions

DRUG

No Results Yet

NCT06465810 | RECRUITING

1850 Participants

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-25

Completion: 2031-12-29

Conditions

Transthyretin Amyloidosis ATTR-CM ATTRv-PN ATTR ATTR-Mixed hATTR

Interventions

DRUG

No Results Yet