Clinical Trials Updated in 2025

NCT04362826 | NOT_YET_RECRUITING | NA

100 Participants

Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-02-28

Completion: 2026-12-31

Conditions

Breast Cancer

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT04339764 | RECRUITING | PHASE1/PHASE2

20 Participants

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-09-23

Completion: 2029-05-31

Conditions

Dry Age-Related Macular Degeneration Geographic Atrophy

Interventions

DRUG

No Results Yet

NCT04305431 | RECRUITING | NA

55 Participants

Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-02-25

Completion: 2026-12-19

Conditions

Diet Cooking

Interventions

BEHAVIORAL

No Results Yet

NCT04294693 | ACTIVE_NOT_RECRUITING

1000 Participants

Total Joint Arthroplasty in a Pediatric Population

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-03

Completion: 2050-03-31

Conditions

Total Joint Arthroplasty

No Results Yet

NCT04294160 | TERMINATED | PHASE1

122 Participants

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-07-22

Completion: 2024-09-25

Conditions

BRAF V600 Colorectal Cancer

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04271774 | ACTIVE_NOT_RECRUITING

600 Participants

Genome Environment Microbiome and Metabolome in Autism Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-01

Completion: 2025-12-31

Conditions

Autism Spectrum Disorder

No Results Yet

NCT04255615 | RECRUITING | NA

4000 Participants

Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-12

Completion: 2029-01-31

Conditions

Infertility in Vitro Fertilization (IVF) ART

Interventions

OTHER

No Results Yet

NCT04244877 | WITHDRAWN | PHASE3

0 Participants

Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-09-15

Completion: 2023-05-01

Conditions

Cirrhosis, Liver Minimal Hepatic Encephalopathy Small Intestinal Bacterial Overgrowth Gastrointestinal Motility Disorder

Interventions

DRUG

No Results Yet

NCT04160052 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

51 Participants

Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-01

Completion: 2027-12-31

Conditions

Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Recurrent Myelodysplastic Syndrome Refractory Myelodysplastic Syndrome Therapy-Related Myelodysplastic Syndrome

Interventions

DRUG

No Results Yet

NCT04155710 | COMPLETED | PHASE1

7 Participants

Study of Autologous Peripheral Blood Lymphocytes in the Treatment of Patients With CLL or SLL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-19

Completion: 2024-11-11

Conditions

Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04146298 | RECRUITING | PHASE1/PHASE2

30 Participants

Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-10-21

Completion: 2027-06-30

Conditions

Pancreatic Cancer Pancreatic Neoplasms Pancreatic Ductal Adenocarcinoma Advanced Cancer

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04137939 | RECRUITING | NA

400 Participants

The Effect of IoT-based Smart Exercises System in the Senior Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-15

Completion: 2027-08-31

Conditions

Elderly Exercise

Interventions

DEVICE

No Results Yet

NCT04123418 | TERMINATED | PHASE1

56 Participants

A Study of WVT078 in Patients With Multiple Myeloma (MM)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-12-05

Completion: 2024-12-02

Conditions

Multiple Myeloma (MM)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04088396 | RECRUITING | PHASE3

58 Participants

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-12

Completion: 2026-04-30

Conditions

Systemic Juvenile Idiopathic Arthritis

Interventions

DRUG

No Results Yet

NCT04081714 | TEMPORARILY_NOT_AVAILABLE

Intermediate Expanded Access Protocol CNMAu8.EAP03

Study Type: EXPANDED_ACCESS

Last Updated: 2025-12-24

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT04077463 | ACTIVE_NOT_RECRUITING | PHASE1

701 Participants

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-04

Completion: 2026-06-03

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

No Results Yet

NCT04069754 | TERMINATED | NA

10 Participants

Passport to Freedom (P2F): Adaptation and Implementation of a Wellness Program

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-28

Completion: 2021-10-23

Conditions

Trauma

Interventions

BEHAVIORAL

No Results Yet

NCT04020276 | SUSPENDED | NA

32 Participants

OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-11-04

Completion: 2026-12-31

Conditions

Liver Metastases Stereotactic Body Radiation Therapy MRI-guided Treatment

Interventions

RADIATION

No Results Yet

NCT03991962 | ACTIVE_NOT_RECRUITING | PHASE2

28 Participants

Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-24

Completion: 2026-08-31

Conditions

Pancreatic Cancer

Interventions

DRUG RADIATION

No Results Yet

NCT03981640 | RECRUITING | NA

32 Participants

Neural Control of Kidney Blood Flow During Exercise in African American Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-30

Completion: 2026-04-30

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT03976674 | COMPLETED | NA

94 Participants

A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-02-05

Completion: 2020-09-05

Conditions

Bariatric Surgery Candidate Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT03971422 | COMPLETED | PHASE3

200 Participants

A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-03

Completion: 2021-08-31

Conditions

Generalized Myasthenia Gravis

Interventions

DRUG OTHER

Results Available

NCT03952624 | RECRUITING

692 Participants

Patient-Centered Assessment of Symptoms and Outcomes

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-13

Completion: 2026-06-01

Conditions

Sjogrens Fatigue Cancer CFS ME/CFS Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lupus Systemic Lupus Erthematosus

No Results Yet

NCT03949647 | RECRUITING

2000 Participants

Collection of Bone Marrow Aspirate From Normal Volunteers

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-08

Completion: 2050-12-31

Conditions

Normal Aging

No Results Yet

NCT03930056 | ACTIVE_NOT_RECRUITING | NA

30 Participants

C-Brace II Spinal Cord Injury

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-16

Completion: 2026-11-30

Conditions

Spinal Cord Injury

Interventions

DEVICE

No Results Yet

NCT03928743 | COMPLETED | PHASE3

332 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-25

Completion: 2021-09-03

Conditions

Ankylosing Spondylitis

Interventions

DRUG OTHER

Results Available

NCT03928704 | COMPLETED | PHASE3

274 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Nonradiographic Axial Spondyloarthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-25

Completion: 2022-06-29

Conditions

Nonradiographic Axial Spondyloarthritis

Interventions

DRUG OTHER

Results Available

NCT03896620 | RECRUITING

50 Participants

Recognition of Circulating Tumor DNA in Soft Tissue Sarcoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-18

Completion: 2026-06-01

Conditions

Sarcoma

Interventions

DEVICE DRUG OTHER

No Results Yet

NCT03892655 | ACTIVE_NOT_RECRUITING

170 Participants

Real World Study of Biosimilar Trastuzumab in Her2 Positive Breast Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-07

Completion: 2022-12-30

Conditions

Breast Cancer

No Results Yet

NCT03833167 | ACTIVE_NOT_RECRUITING | PHASE3

450 Participants

Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-01

Completion: 2024-06-28

Conditions

Carcinoma, Squamous Cell

Interventions

BIOLOGICAL DRUG

Results Available

NCT03783377 | COMPLETED | PHASE1

112 Participants

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-08

Completion: 2021-02-11

Conditions

Hypertriglyceridemia Familial Chylomicronemia

Interventions

DRUG

No Results Yet

NCT03750227 | RECRUITING | PHASE3

140 Participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-11-19

Completion: 2030-11-08

Conditions

Malignant Solid Neoplasm Metastatic Malignant Neoplasm in the Brain

Interventions

PROCEDURE OTHER RADIATION

No Results Yet

NCT03747224 | COMPLETED | PHASE1

93 Participants

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-01-07

Completion: 2021-05-17

Conditions

Dyslipidemias Familial Hypercholesterolemia Hypertriglyceridemia

Interventions

DRUG

No Results Yet

NCT03734809 | ACTIVE_NOT_RECRUITING | PHASE2

43 Participants

NEO-SPACE Trial: Pembrolizumab and Chemoradiation in Nasopharyngeal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-03

Completion: 2025-01-25

Conditions

NPC

Interventions

DRUG

Results Available

NCT03731234 | ACTIVE_NOT_RECRUITING | PHASE2

75 Participants

Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-02

Completion: 2024-07-30

Conditions

DLBCL

Interventions

DRUG

No Results Yet

NCT03713853 | RECRUITING

104 Participants

Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-31

Completion: 2029-12-31

Conditions

Acetabular Fracture

No Results Yet

NCT03692273 | COMPLETED | NA

17 Participants

Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-20

Completion: 2025-10-06

Conditions

Burns Hypertrophic Scar

Interventions

PROCEDURE

No Results Yet

NCT03686488 | COMPLETED | PHASE2

23 Participants

TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-12-20

Completion: 2022-01-19

Conditions

Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Gastric Cancer

Interventions

DRUG

Results Available

NCT03646045 | ACTIVE_NOT_RECRUITING

46 Participants

Transpyloric Feeding for Prevention of Micro-aspiration

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2016-11-04

Completion: 2018-05-30

Conditions

Microaspiration Gastro Esophageal Reflux

Interventions

OTHER

No Results Yet

NCT03613532 | ACTIVE_NOT_RECRUITING | PHASE1

102 Participants

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-10-24

Completion: 2026-05-01

Conditions

Acute Myeloid Leukemia (AML) Myelodysplastic Syndrome (MDS) Chronic Myelomonocytic Leukemia (CMML) MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable) Hematopoietic Stem Cell Transplant

Interventions

DRUG

No Results Yet