Clinical Trials Updated in 2025

NCT04431024 | RECRUITING

800 Participants

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-03-30

Completion: 2038-06-30

Conditions

Familial Cancer BRCA1-Associated Protein-1 (BAP1) Mutations Tumor Predisposition Syndrome (TPDS) Mesothelioma

No Results Yet

NCT04362826 | NOT_YET_RECRUITING | NA

100 Participants

Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-02-28

Completion: 2026-12-31

Conditions

Breast Cancer

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT04339764 | RECRUITING | PHASE1/PHASE2

20 Participants

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-09-23

Completion: 2029-05-31

Conditions

Dry Age-Related Macular Degeneration Geographic Atrophy

Interventions

DRUG

No Results Yet

NCT04305431 | RECRUITING | NA

55 Participants

Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-02-25

Completion: 2026-12-19

Conditions

Diet Cooking

Interventions

BEHAVIORAL

No Results Yet

NCT04294693 | ACTIVE_NOT_RECRUITING

1000 Participants

Total Joint Arthroplasty in a Pediatric Population

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-03

Completion: 2050-03-31

Conditions

Total Joint Arthroplasty

No Results Yet

NCT04294160 | TERMINATED | PHASE1

122 Participants

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-07-22

Completion: 2024-09-25

Conditions

BRAF V600 Colorectal Cancer

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04271774 | ACTIVE_NOT_RECRUITING

600 Participants

Genome Environment Microbiome and Metabolome in Autism Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-01

Completion: 2025-12-31

Conditions

Autism Spectrum Disorder

No Results Yet

NCT04255615 | RECRUITING | NA

4000 Participants

Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-12

Completion: 2029-01-31

Conditions

Infertility in Vitro Fertilization (IVF) ART

Interventions

OTHER

No Results Yet

NCT04244877 | WITHDRAWN | PHASE3

0 Participants

Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-09-15

Completion: 2023-05-01

Conditions

Cirrhosis, Liver Minimal Hepatic Encephalopathy Small Intestinal Bacterial Overgrowth Gastrointestinal Motility Disorder

Interventions

DRUG

No Results Yet

NCT04160052 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

51 Participants

Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-01

Completion: 2027-12-31

Conditions

Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Recurrent Myelodysplastic Syndrome Refractory Myelodysplastic Syndrome Therapy-Related Myelodysplastic Syndrome

Interventions

DRUG

No Results Yet

NCT04155710 | COMPLETED | PHASE1

7 Participants

Study of Autologous Peripheral Blood Lymphocytes in the Treatment of Patients With CLL or SLL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-19

Completion: 2024-11-11

Conditions

Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04146298 | RECRUITING | PHASE1/PHASE2

30 Participants

Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-10-21

Completion: 2027-06-30

Conditions

Pancreatic Cancer Pancreatic Neoplasms Pancreatic Ductal Adenocarcinoma Advanced Cancer

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04137939 | RECRUITING | NA

400 Participants

The Effect of IoT-based Smart Exercises System in the Senior Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-15

Completion: 2027-08-31

Conditions

Elderly Exercise

Interventions

DEVICE

No Results Yet

NCT04123418 | TERMINATED | PHASE1

56 Participants

A Study of WVT078 in Patients With Multiple Myeloma (MM)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-12-05

Completion: 2024-12-02

Conditions

Multiple Myeloma (MM)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04088396 | RECRUITING | PHASE3

58 Participants

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2020-02-12

Completion: 2026-04-30

Conditions

Systemic Juvenile Idiopathic Arthritis

Interventions

DRUG

No Results Yet

NCT04081714 | TEMPORARILY_NOT_AVAILABLE

Intermediate Expanded Access Protocol CNMAu8.EAP03

Study Type: EXPANDED_ACCESS

Last Updated: 2025-12-24

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT04077463 | ACTIVE_NOT_RECRUITING | PHASE1

701 Participants

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-04

Completion: 2026-06-03

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

No Results Yet

NCT04069754 | TERMINATED | NA

10 Participants

Passport to Freedom (P2F): Adaptation and Implementation of a Wellness Program

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-28

Completion: 2021-10-23

Conditions

Trauma

Interventions

BEHAVIORAL

No Results Yet

NCT04020276 | SUSPENDED | NA

32 Participants

OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-11-04

Completion: 2026-12-31

Conditions

Liver Metastases Stereotactic Body Radiation Therapy MRI-guided Treatment

Interventions

RADIATION

No Results Yet

NCT03991962 | ACTIVE_NOT_RECRUITING | PHASE2

28 Participants

Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-24

Completion: 2026-08-31

Conditions

Pancreatic Cancer

Interventions

DRUG RADIATION

No Results Yet

NCT03981640 | RECRUITING | NA

32 Participants

Neural Control of Kidney Blood Flow During Exercise in African American Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-30

Completion: 2026-04-30

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT03976674 | COMPLETED | NA

94 Participants

A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-02-05

Completion: 2020-09-05

Conditions

Bariatric Surgery Candidate Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT03971422 | COMPLETED | PHASE3

200 Participants

A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-03

Completion: 2021-08-31

Conditions

Generalized Myasthenia Gravis

Interventions

DRUG OTHER

Results Available

NCT03952624 | RECRUITING

692 Participants

Patient-Centered Assessment of Symptoms and Outcomes

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-13

Completion: 2026-06-01

Conditions

Sjogrens Fatigue Cancer CFS ME/CFS Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lupus Systemic Lupus Erthematosus

No Results Yet

NCT03949647 | RECRUITING

2000 Participants

Collection of Bone Marrow Aspirate From Normal Volunteers

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-08

Completion: 2050-12-31

Conditions

Normal Aging

No Results Yet

NCT03930056 | ACTIVE_NOT_RECRUITING | NA

30 Participants

C-Brace II Spinal Cord Injury

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-16

Completion: 2026-11-30

Conditions

Spinal Cord Injury

Interventions

DEVICE

No Results Yet

NCT03928743 | COMPLETED | PHASE3

332 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-25

Completion: 2021-09-03

Conditions

Ankylosing Spondylitis

Interventions

DRUG OTHER

Results Available

NCT03928704 | COMPLETED | PHASE3

274 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Nonradiographic Axial Spondyloarthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-25

Completion: 2022-06-29

Conditions

Nonradiographic Axial Spondyloarthritis

Interventions

DRUG OTHER

Results Available

NCT03896620 | RECRUITING

50 Participants

Recognition of Circulating Tumor DNA in Soft Tissue Sarcoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-18

Completion: 2026-06-01

Conditions

Sarcoma

Interventions

DEVICE DRUG OTHER

No Results Yet

NCT03892655 | ACTIVE_NOT_RECRUITING

170 Participants

Real World Study of Biosimilar Trastuzumab in Her2 Positive Breast Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-07

Completion: 2022-12-30

Conditions

Breast Cancer

No Results Yet

NCT03833167 | ACTIVE_NOT_RECRUITING | PHASE3

450 Participants

Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-01

Completion: 2024-06-28

Conditions

Carcinoma, Squamous Cell

Interventions

BIOLOGICAL DRUG

Results Available

NCT03783377 | COMPLETED | PHASE1

112 Participants

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-08

Completion: 2021-02-11

Conditions

Hypertriglyceridemia Familial Chylomicronemia

Interventions

DRUG

No Results Yet

NCT03750227 | RECRUITING | PHASE3

140 Participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-11-19

Completion: 2030-11-08

Conditions

Malignant Solid Neoplasm Metastatic Malignant Neoplasm in the Brain

Interventions

PROCEDURE OTHER RADIATION

No Results Yet

NCT03747224 | COMPLETED | PHASE1

93 Participants

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-01-07

Completion: 2021-05-17

Conditions

Dyslipidemias Familial Hypercholesterolemia Hypertriglyceridemia

Interventions

DRUG

No Results Yet

NCT03734809 | ACTIVE_NOT_RECRUITING | PHASE2

43 Participants

NEO-SPACE Trial: Pembrolizumab and Chemoradiation in Nasopharyngeal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-03

Completion: 2025-01-25

Conditions

NPC

Interventions

DRUG

Results Available

NCT03731234 | ACTIVE_NOT_RECRUITING | PHASE2

75 Participants

Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-02

Completion: 2024-07-30

Conditions

DLBCL

Interventions

DRUG

No Results Yet

NCT03713853 | RECRUITING

104 Participants

Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-31

Completion: 2029-12-31

Conditions

Acetabular Fracture

No Results Yet

NCT03692273 | COMPLETED | NA

17 Participants

Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-20

Completion: 2025-10-06

Conditions

Burns Hypertrophic Scar

Interventions

PROCEDURE

No Results Yet

NCT03686488 | COMPLETED | PHASE2

23 Participants

TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-12-20

Completion: 2022-01-19

Conditions

Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Gastric Cancer

Interventions

DRUG

Results Available

NCT03646045 | ACTIVE_NOT_RECRUITING

46 Participants

Transpyloric Feeding for Prevention of Micro-aspiration

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2016-11-04

Completion: 2018-05-30

Conditions

Microaspiration Gastro Esophageal Reflux

Interventions

OTHER

No Results Yet