Clinical Trials Updated in 2025

NCT03928704 | COMPLETED | PHASE3

274 Participants

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Nonradiographic Axial Spondyloarthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-25

Completion: 2022-06-29

Conditions

Nonradiographic Axial Spondyloarthritis

Interventions

DRUG OTHER

Results Available

NCT03896620 | RECRUITING

50 Participants

Recognition of Circulating Tumor DNA in Soft Tissue Sarcoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-06-18

Completion: 2026-06-01

Conditions

Sarcoma

Interventions

DEVICE DRUG OTHER

No Results Yet

NCT03892655 | ACTIVE_NOT_RECRUITING

170 Participants

Real World Study of Biosimilar Trastuzumab in Her2 Positive Breast Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-10-07

Completion: 2022-12-30

Conditions

Breast Cancer

No Results Yet

NCT03833167 | ACTIVE_NOT_RECRUITING | PHASE3

450 Participants

Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-04-01

Completion: 2024-06-28

Conditions

Carcinoma, Squamous Cell

Interventions

BIOLOGICAL DRUG

Results Available

NCT03783377 | COMPLETED | PHASE1

112 Participants

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-08

Completion: 2021-02-11

Conditions

Hypertriglyceridemia Familial Chylomicronemia

Interventions

DRUG

No Results Yet

NCT03750227 | RECRUITING | PHASE3

140 Participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-11-19

Completion: 2030-11-08

Conditions

Malignant Solid Neoplasm Metastatic Malignant Neoplasm in the Brain

Interventions

PROCEDURE OTHER RADIATION

No Results Yet

NCT03747224 | COMPLETED | PHASE1

93 Participants

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-01-07

Completion: 2021-05-17

Conditions

Dyslipidemias Familial Hypercholesterolemia Hypertriglyceridemia

Interventions

DRUG

No Results Yet

NCT03734809 | ACTIVE_NOT_RECRUITING | PHASE2

43 Participants

NEO-SPACE Trial: Pembrolizumab and Chemoradiation in Nasopharyngeal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-03

Completion: 2025-01-25

Conditions

NPC

Interventions

DRUG

Results Available

NCT03731234 | ACTIVE_NOT_RECRUITING | PHASE2

75 Participants

Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-07-02

Completion: 2024-07-30

Conditions

DLBCL

Interventions

DRUG

No Results Yet

NCT03713853 | RECRUITING

104 Participants

Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-31

Completion: 2029-12-31

Conditions

Acetabular Fracture

No Results Yet

NCT03692273 | COMPLETED | NA

17 Participants

Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-03-20

Completion: 2025-10-06

Conditions

Burns Hypertrophic Scar

Interventions

PROCEDURE

No Results Yet

NCT03686488 | COMPLETED | PHASE2

23 Participants

TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-12-20

Completion: 2022-01-19

Conditions

Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Gastric Cancer

Interventions

DRUG

Results Available

NCT03646045 | ACTIVE_NOT_RECRUITING

46 Participants

Transpyloric Feeding for Prevention of Micro-aspiration

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2016-11-04

Completion: 2018-05-30

Conditions

Microaspiration Gastro Esophageal Reflux

Interventions

OTHER

No Results Yet

NCT03613532 | ACTIVE_NOT_RECRUITING | PHASE1

102 Participants

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-10-24

Completion: 2026-05-01

Conditions

Acute Myeloid Leukemia (AML) Myelodysplastic Syndrome (MDS) Chronic Myelomonocytic Leukemia (CMML) MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable) Hematopoietic Stem Cell Transplant

Interventions

DRUG

No Results Yet

NCT03576846 | COMPLETED | NA

131 Participants

Spinal Pain and Autonomic Responses to Chiropractic Care

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-01-04

Completion: 2020-05-02

Conditions

Neck Pain

Interventions

OTHER

Results Available

NCT03514017 | TERMINATED | PHASE2

5 Participants

Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-05-31

Completion: 2023-05-16

Conditions

Chronic Lymphocytic Leukemia

Interventions

DRUG

Results Available

NCT03506867 | ENROLLING_BY_INVITATION | NA

250 Participants

Healthy People Initiative (HPI)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-01-03

Completion: 2027-03-31

Conditions

Nicotine Dependence Substance Use Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT03488628 | COMPLETED | NA

51 Participants

High-Flow Nasal Oxygen Therapy for Exacerbation of Chronic Pulmonary Obstructive Disease.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-06-27

Completion: 2025-10-03

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

OTHER

No Results Yet

NCT03473249 | ACTIVE_NOT_RECRUITING | PHASE4

120 Participants

Effectiveness of Contrast-Enhanced Ultrasound

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-05-09

Completion: 2026-12-31

Conditions

Abdominal Injuries Physical Abuse Accidental Fall Motor Vehicle Injury

Interventions

DRUG

No Results Yet

NCT03467867 | ACTIVE_NOT_RECRUITING | PHASE2

25 Participants

A Study of Venetoclax and Rituximab/Hyaluronidase Human in Relapsed/Refractory CLL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-04-26

Completion: 2026-12-31

Conditions

Chronic Lymphocytic Leukemia

Interventions

DRUG

No Results Yet

NCT03406208 | COMPLETED | NA

228 Participants

Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-10-01

Completion: 2022-02-28

Conditions

Neurofibromatoses Neurofibromatosis 1 Neurofibromatosis 2 Schwannomatosis

Interventions

BEHAVIORAL

No Results Yet

NCT03394066 | RECRUITING | NA

70 Participants

Mechanism of Non-invasive Magnetic Stimulation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-09-19

Completion: 2026-12-31

Conditions

Healthy Volunteers

Interventions

DEVICE

No Results Yet

NCT03362242 | COMPLETED | PHASE1

45 Participants

Study of ARO-AAT in Normal Adult Volunteers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-03-12

Completion: 2018-10-23

Conditions

Alpha 1-Antitrypsin Deficiency

Interventions

DRUG OTHER

No Results Yet

NCT03351764 | COMPLETED | NA

83 Participants

Development of Non-Invasive Brain Stimulation Techniques

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-01-11

Completion: 2025-12-15

Conditions

Normal Physiology

Interventions

DEVICE

No Results Yet

NCT03348280 | ACTIVE_NOT_RECRUITING

40 Participants

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-09-01

Completion: 2026-12-31

Conditions

Diabetes Mellitus, Type 2 Hypertension Vitamin D Deficiency

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03294863 | ACTIVE_NOT_RECRUITING | NA

12 Participants

Effectiveness of Embrace Scar Therapy Device After Cutaneous Wound Closure

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-03-15

Completion: 2021-12-01

Conditions

Linear Cutaneous Wound

Interventions

DEVICE OTHER

No Results Yet

NCT03269721 | COMPLETED

170 Participants

COPD-Related Physiology and the Brain

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-05-01

Completion: 2025-04-30

Conditions

Pulmonary Disease, Chronic Obstructive (COPD) Cognitive Impairment

Interventions

BEHAVIORAL PROCEDURE DIAGNOSTIC_TEST BIOLOGICAL

No Results Yet

NCT03261089 | RECRUITING

600 Participants

Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-08-02

Completion: 2027-08-31

Conditions

Cardiac Arrest

No Results Yet

NCT03111745 | COMPLETED

730 Participants

Retrospective Study of Viral Reactivation Across All Bone Marrow Transplant Protocols Since 2010

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-04-13

Completion: 2018-12-29

Conditions

Viral Infections

No Results Yet

NCT03091452 | RECRUITING

2000 Participants

CArdioSurgEry Atrial Fibrillation Register

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-01-31

Completion: 2028-12-31

Conditions

Atrial Fibrillation

No Results Yet

NCT03049475 | COMPLETED

99 Participants

Pathophysiology of Acute Pain in Patients With Sickle Cell Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2017-03-13

Completion: 2019-12-09

Conditions

Sickle Cell Disease

No Results Yet

NCT03017573 | RECRUITING | NA

1050 Participants

Prospective Biobanking Study in Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself, Its Microenvironment and Immune Response (SCANDARE)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-01-06

Completion: 2029-08-06

Conditions

Ovarian Cancer Triple-Negative Breast Cancer Head and Neck Cancer Cervical Cancer Sarcoma

Interventions

PROCEDURE

No Results Yet

NCT03008291 | RECRUITING

80 Participants

His Bundle Pacing in Bradycardia and Heart Failure

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2016-10-31

Completion: 2026-12-31

Conditions

Bradycardia Heart Failure

Interventions

PROCEDURE

No Results Yet

NCT03003962 | ACTIVE_NOT_RECRUITING | PHASE3

669 Participants

Study of Durvalumab Alone or Chemotherapy for Patients With Advanced Non Small-Cell Lung Cancer (PEARL)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-01-02

Completion: 2022-10-27

Conditions

Non Small Cell Lung Carcinoma NSCLC

Interventions

DRUG

Results Available

NCT02991469 | RECRUITING | PHASE2

51 Participants

A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-08-09

Completion: 2026-04-01

Conditions

Juvenile Idiopathic Arthritis

Interventions

DRUG

No Results Yet

NCT02988128 | RECRUITING

4000 Participants

Neurovascular Product Surveillance Registry

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2016-12-31

Completion: 2032-08-31

Conditions

Intracranial Aneurysm Stroke, Ischemic

Interventions

DEVICE

No Results Yet

NCT02975180 | COMPLETED | NA

11 Participants

FES in Young Children With Perinatal Stroke

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-01-01

Completion: 2020-12-10

Conditions

Cerebral Palsy

Interventions

DEVICE BEHAVIORAL

No Results Yet

NCT02973633 | RECRUITING | EARLY_PHASE1

160 Participants

Diffusion MRI in Heart Failure

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-06-30

Completion: 2027-12-31

Conditions

Myocardial Infarction Heart Failure Left Ventricular Hypertrophy

Interventions

DEVICE DRUG

No Results Yet

NCT02966756 | RECRUITING | PHASE2

110 Participants

A Study of Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2017-10-12

Completion: 2029-05-31

Conditions

Chronic Lymphocytic Leukemia (CLL) Small Lymphocytic Lymphoma (SLL)

Interventions

DRUG

No Results Yet

NCT02911714 | TERMINATED | PHASE1

20 Participants

Contrast-Enhanced Ultrasound for Kidney Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2018-02-21

Completion: 2022-06-30

Conditions

Kidney Transplantation

Interventions

DRUG

No Results Yet