Multimodal Outcome CHAracterization in Comatose Cardiac Arrest Patients Registry and Tissue Repository
NCT ID: NCT03261089
Last Updated: 2024-12-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
600 participants
OBSERVATIONAL
2017-08-02
2027-08-31
Brief Summary
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The primary study objective of MOCHA is to develop an accurate and reliable assessment algorithm for determining neurologic prognosis in patients initially unconscious (no eye opening, GCS-M\<6 and not following commands) post-cardiac arrest, using multiple prognostic modalities at standardized time points.
Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Unresponsive patients post-cardiac arrest
As early as possible post-resuscitation, patients should undergo a detailed neurologic examination, comprised of a thorough assessment for consciousness and detailed cranial nerve function and motor response assessments. Neurologic assessment scores such as the Full Outline of Unresponsiveness, Glasgow Coma Scale (GCS), and Pittsburgh Cardiac Arrest Category Score will be also be used. On the first assessment (day of cardiac arrest), the PCAC score should be assigned only on the basis of the best neurologic exam in the first 6 hours after ROSC. Patients that are sedated or intubated will have the verbal score of GCS be estimated by a derivation of motor and eye scores. The presence of potential confounders, including core body temperature, medications, and/or intoxicants, as well as metabolic derangements should be noted.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Initially unconscious following cardiac arrest from any non-perfusing rhythm (i.e., ventricular tachycardia, ventricular fibrillation, pulseless electrical activity, asystole)
* Sustained return of spontaneous circulation (ROSC) as defined by maintained spontaneous circulation for at least 20 minutes after cardiopulmonary resuscitation.
Exclusion Criteria
* Isolated respiratory arrest without concomitant or ensuing cardiac arrest
18 Years
ALL
No
Sponsors
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University of Florida
OTHER
Hospital Israelita Albert Einstein
OTHER
Faculty of Medicine of Ribeirão Preto (FMRP-USP)
OTHER
University of Sao Paulo General Hospital
OTHER
Yale University
OTHER
University of Pennsylvania
OTHER
University of California, San Francisco
OTHER
D'Or Institute for Research and Education
OTHER
Americas Medical City: Hospital Samaritano and Hospital Vitória
UNKNOWN
Boston Medical Center
OTHER
Responsible Party
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Principal Investigators
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David Greer, MD MA
Role: STUDY_CHAIR
Boston Medical Center
Locations
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Boston Medical Center
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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David Greer, MD MA
Role: primary
Other Identifiers
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H-36257
Identifier Type: -
Identifier Source: org_study_id