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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06648434 | RECRUITING | PHASE1
51 Participants

MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-05-15
Completion: 2027-06-30
Conditions
Metastatic Pancreatic Ductal Adenocarcinoma Pancreatic Cancer Cancer of the Pancreas
Interventions
DRUG
No Results Yet
NCT06647979 | RECRUITING | PHASE1
10 Participants

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-12-01
Completion: 2028-12-31
Conditions
Sickle Cell Disease Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) Beta-Thalassemia Transfusion Dependent Beta-Thalassaemia
Interventions
BIOLOGICAL DEVICE
No Results Yet
NCT06647953 | RECRUITING | PHASE3
110 Participants

Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-03-21
Completion: 2029-03-31
Conditions
Pleuropulmonary Blastoma
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT06644664 | ACTIVE_NOT_RECRUITING | NA
300 Participants

Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-24
Completion: 2026-08-31
Conditions
Tobacco-Related Carcinoma
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT06627764 | RECRUITING | NA
400 Participants

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-06-30
Completion: 2028-07-31
Conditions
Substance Abuse Intimate Partner Violence (IPV) HIV Infections Depression Anxiety
Interventions
BEHAVIORAL
No Results Yet
NCT06627647 | RECRUITING | PHASE3
878 Participants

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-11-27
Completion: 2029-05-10
Conditions
Non-squamous Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT06627439 | COMPLETED | NA
160 Participants

A Web-Based Healthy Living Training for Promotores

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-13
Completion: 2025-07-31
Conditions
Obesity Prevention
Interventions
BEHAVIORAL
No Results Yet
NCT06625775 | RECRUITING | PHASE1
392 Participants

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-10-29
Completion: 2028-11-30
Conditions
Advanced Breast Cancer Solid Tumor, Adult Metastatic Breast Cancer HER2 Mutation-Related Tumors HER2-positive Metastatic Breast Cancer KRAS Mutant Metastatic Colorectal Cancer Metastatic Lung Cancer Metastatic Colorectal Cancer Advanced Lung Cancer HR-positive, HER2-negative Advanced Breast Cancer HER2-positive Advanced Breast Cancer
Interventions
DRUG
No Results Yet
NCT06620276 | RECRUITING | NA
30 Participants

ACT_for Alcohol Use Disorder and Depression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-05-01
Completion: 2026-12-01
Conditions
Depression - Major Depressive Disorder Alcohol Use Disorder
Interventions
BEHAVIORAL DRUG
No Results Yet
NCT06613620 | COMPLETED | NA
46 Participants

Additional Effects of Surface Electromyographic Biofeedback on Post Facilitation Stretching and Strengthening in Lower Crossed Syndrome;A Randomized Control Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-07-18
Completion: 2025-06-02
Conditions
Lower Cross Syndrome
Interventions
OTHER
No Results Yet
NCT06609343 | RECRUITING | PHASE1/PHASE2
16 Participants

Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-02-02
Completion: 2026-11-30
Conditions
End Stage Renal Disease Fatigue
Interventions
DRUG
No Results Yet
NCT06588855 | RECRUITING | PHASE3
350 Participants

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-12-11
Completion: 2027-06-30
Conditions
Moderately to Severely Active Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT06588491 | ACTIVE_NOT_RECRUITING | PHASE2
25 Participants

KYSA-8: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-25
Completion: 2026-04-30
Conditions
Stiff-Person Syndrome SPS
Interventions
BIOLOGICAL
No Results Yet
NCT06586515 | RECRUITING | PHASE1
630 Participants

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-12
Completion: 2029-03-31
Conditions
Pancreatic Ductal Adenocarcinoma Non-small Cell Lung Cancer Colorectal Cancer
Interventions
DRUG
No Results Yet
NCT06584916 | COMPLETED | PHASE3
376 Participants

A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-13
Completion: 2025-11-21
Conditions
Obesity Overweight
Interventions
DRUG
No Results Yet
NCT06581198 | RECRUITING | PHASE2
179 Participants

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-04
Completion: 2028-02-14
Conditions
Lupus Erythematosus, Systemic Lupus Nephritis
Interventions
BIOLOGICAL
No Results Yet
NCT06576440 | COMPLETED | NA
24 Participants

Effects of Ghrelin Administration on Motivation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-02
Completion: 2024-12-20
Conditions
Major Depressive Disorder
Interventions
DRUG
No Results Yet
NCT06572228 | RECRUITING | PHASE4
250 Participants

Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-26
Completion: 2026-12-31
Conditions
Asthma
Interventions
DRUG
No Results Yet
NCT06571994 | COMPLETED | NA
60 Participants

The Plastic Exposure Reduction Transforms Health Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-05
Completion: 2025-07-03
Conditions
Endocrine Disruptors Inflammation Cardiometabolic Risk Factors
Interventions
BEHAVIORAL
No Results Yet
NCT06568939 | RECRUITING | PHASE2
150 Participants

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-01-20
Completion: 2028-02-29
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT06568237 | RECRUITING | PHASE2
200 Participants

A Study to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy (MSA): A Safety and Efficacy Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-10-02
Completion: 2027-05-20
Conditions
Multiple System Atrophy
Interventions
DRUG
No Results Yet
NCT06540326 | RECRUITING | PHASE2
100 Participants

Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-11-12
Completion: 2026-04-15
Conditions
Colorectal Cancer Metastatic
Interventions
DRUG
No Results Yet
NCT06538038 | RECRUITING
538 Participants

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-17
Completion: 2028-08-31
Conditions
Non Small Cell Lung Cancer Epidermal Growth Factor Receptor Gene Mutation Stage III Lung Cancer Stage IV Lung Cancer
Interventions
DRUG
No Results Yet
NCT06534892 | ACTIVE_NOT_RECRUITING | PHASE3
10212 Participants

An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-01
Completion: 2026-09-30
Conditions
Respiratory Syncytial Virus Infections
Interventions
BIOLOGICAL
No Results Yet
NCT06531824 | RECRUITING | PHASE3
11000 Participants

EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-13
Completion: 2028-08-30
Conditions
Kidney Disease, Chronic
Interventions
DRUG
No Results Yet
NCT06525623 | RECRUITING | NA
50 Participants

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-12
Completion: 2026-09-30
Conditions
Cirrhosis, Liver Acute Kidney Injury Hepatorenal Syndrome
Interventions
OTHER
No Results Yet
NCT06523608 | RECRUITING
600 Participants

Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2024-09-01
Completion: 2027-09-30
Conditions
Liver Diseases Hepatocellular Carcinoma Hepatocarcinoma Advanced Chronic Liver Disease
Interventions
OTHER
No Results Yet
NCT06522204 | COMPLETED | NA
60 Participants

Comparing the Gastric Emptying Times of Underweight and Healthy-weight School-aged Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-07-30
Completion: 2025-12-15
Conditions
Preoperative Fasting
Interventions
DRUG
No Results Yet
NCT06520865 | COMPLETED
560 Participants

TIDE Project: Biomarker Discovery for Chronic Tinnitus Diagnosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-01
Completion: 2025-11-30
Conditions
Tinnitus
Interventions
OTHER
No Results Yet
NCT06513962 | RECRUITING | PHASE3
60 Participants

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-02-27
Completion: 2029-10-30
Conditions
Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm
Interventions
OTHER PROCEDURE DRUG
No Results Yet
NCT06513208 | RECRUITING | PHASE4
140 Participants

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-01-31
Completion: 2027-06-30
Conditions
Lumbar Spinal Fusion
Interventions
DRUG
No Results Yet
NCT06500273 | RECRUITING | PHASE2
250 Participants

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-06-18
Completion: 2027-08-24
Conditions
Large B-cell Lymphoma
Interventions
GENETIC DRUG DEVICE
No Results Yet
NCT06493604 | COMPLETED | PHASE3
116 Participants

A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-06-24
Completion: 2025-02-27
Conditions
Dry Eye Disease
Interventions
DRUG
No Results Yet
NCT06487585 | RECRUITING | PHASE4
100 Participants

ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-05-06
Completion: 2026-01-31
Conditions
Vasodilatory Hypotension During or After Cardiac Surgery
Interventions
DRUG
No Results Yet
NCT06470048 | RECRUITING | PHASE2
200 Participants

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-10-09
Completion: 2027-07-06
Conditions
Diffuse Cutaneous Systemic Sclerosis
Interventions
DRUG
No Results Yet
NCT06468124 | RECRUITING
20 Participants

Sensitivity of Organoids to Predict Treatment Outcome in Breast Cancer Metastases

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2025-05-27
Completion: 2026-06-30
Conditions
Breast Neoplasms
No Results Yet
NCT06465069 | RECRUITING | PHASE1
420 Participants

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-07-01
Completion: 2027-05-31
Conditions
Metastatic Solid Tumor Recurrent Solid Tumor Advanced Solid Tumor Urinary Bladder Neoplasm Triple Negative Breast Cancer Non-small Cell Lung Cancer Esophageal Cancer Pancreatic Cancer Ovarian Cancer Cervical Cancer Head and Neck Squamous Cell Carcinoma Prostate Cancer Renal Pelvis Cancer Bladder Cancer
Interventions
DRUG
No Results Yet
NCT06462391 | ACTIVE_NOT_RECRUITING | NA
50 Participants

Adapting and Piloting Acceptance and Commitment Therapy (ACT) for Severe Premenstrual Mood Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-12-01
Completion: 2026-06-30
Conditions
Premenstrual Dysphoric Disorder Premenstrual Exacerbation of Mood Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT06459024 | RECRUITING
4000 Participants

Master Framework For Relapse or Refractory Acute Myeloid Leukemia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2024-06-28
Completion: 2032-07-31
Conditions
Acute Myeloid Leukemia, in Relapse Acute Myeloid Leukemia Refractory
Interventions
OTHER
No Results Yet
NCT06452277 | RECRUITING | PHASE3
278 Participants

A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-28
Completion: 2027-10-28
Conditions
Advanced Non-small Cell Lung Cancer HER2 Mutation
Interventions
DRUG
No Results Yet
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