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Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

NCT ID: NCT06644664

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-24

Study Completion Date

2026-12-31

Brief Summary

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This clinical trial evaluates the effect of message framing on smoking behaviors among lesbian, gay, bisexual, transgender, queer (LGBTQ+) young adults who use nicotine and/or tobacco. Tobacco regulation has contributed to a steady decline in tobacco products designed to be smoked (combustible), but there has been an increase in the use of new tobacco products, such as electronic nicotine delivery systems (ENDS). The use of more than one tobacco product (polytobacco) is high in LGBTQ+ populations. Both LGBTQ+ people and people who engage in polytobacco use are less likely to view tobacco as harmful, which may reinforce tobacco use. Message framing includes culturally targeted messages to communicate the absolute risks (AR) and relative risks (RR) of polytobacco use. Using message framing may increase quit rates or change smoking behaviors in LGBTQ+ young adults who use nicotine and/or tobacco products.

Detailed Description

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PRIMARY OBJECTIVES:

I. Assess the feasibility of delivering mobile multimedia messaging (MMS) anti-tobacco messages developed in the K99 to LGBT young adults via texting.

II. Estimate effect sizes of exposure to anti-tobacco messages on risk perceptions and tobacco use over time.

OUTLINE: Participants are randomized to 1 of 3 arms.

ARM I: Participants receive AR anti-polytobacco MMS messages 3 times a week (TIW) and a check-in text message once a week (QW) for a total of 6 weeks.

ARM II: Participants receive RR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks.

ARM III: Participants receive control MMS messages on health risks of ultraviolet (UV)/sun exposure TIW and a check-in text message QW for a total of 6 weeks.

All participants also receive smoking cessation resources via email during follow up.

After completion of study intervention, participants are followed up at 6 and 12 weeks.

Conditions

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Tobacco-Related Carcinoma

Keywords

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Sexual and Gender Minorities Health Communication Tobacco Products Cigarettes Electronic Nicotine Delivery Systems E-cigarettes young adult text messaging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants
Participants are blinded to their randomization category (absolute risks, relative risks, or control)

Study Groups

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Arm I (Absolute Risk messages)

Participants receive AR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Group Type EXPERIMENTAL

Interview

Intervention Type OTHER

Ancillary studies

Smoking Cessation Intervention

Intervention Type BEHAVIORAL

Receive AR MMS messages

Smoking Cessation Intervention

Intervention Type BEHAVIORAL

Receive smoking cessation resources

Survey Administration

Intervention Type OTHER

Ancillary studies

Text Message-Based Navigation Intervention

Intervention Type OTHER

Receive check-in text message

Arm II (Relative Risk messages)

Participants receive RR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Group Type EXPERIMENTAL

Interview

Intervention Type OTHER

Ancillary studies

Smoking Cessation Intervention

Intervention Type BEHAVIORAL

Receive RR MMS messages

Smoking Cessation Intervention

Intervention Type BEHAVIORAL

Receive smoking cessation resources

Survey Administration

Intervention Type OTHER

Ancillary studies

Text Message-Based Navigation Intervention

Intervention Type OTHER

Receive check-in text message

Arm III (control messages)

Participants receive control MMS messages on health risks of UV/sun exposure TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.

Group Type ACTIVE_COMPARATOR

Health Education

Intervention Type BEHAVIORAL

Receive control MMS messages

Smoking Cessation Intervention

Intervention Type BEHAVIORAL

Receive smoking cessation resources

Survey Administration

Intervention Type OTHER

Ancillary studies

Text Message-Based Navigation Intervention

Intervention Type OTHER

Receive check-in text message

Interventions

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Health Education

Receive control MMS messages

Intervention Type BEHAVIORAL

Interview

Ancillary studies

Intervention Type OTHER

Smoking Cessation Intervention

Receive AR MMS messages

Intervention Type BEHAVIORAL

Smoking Cessation Intervention

Receive RR MMS messages

Intervention Type BEHAVIORAL

Smoking Cessation Intervention

Receive smoking cessation resources

Intervention Type BEHAVIORAL

Survey Administration

Ancillary studies

Intervention Type OTHER

Text Message-Based Navigation Intervention

Receive check-in text message

Intervention Type OTHER

Other Intervention Names

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Smoking and Tobacco Use Cessation Interventions Smoking and Tobacco Use Cessation Interventions Smoking and Tobacco Use Cessation Interventions Automated Text Message-Based Navigation Text Message-Based Navigation

Eligibility Criteria

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Inclusion Criteria

* 18-35 years old
* Self-identify as LGBTQ+
* Able to speak English fluently
* An ever user of ENDS and combustible tobacco who currently use ENDS, combustible cigarettes, or both ENDS and combustible cigarettes
* Currently reside in the United States (US)
* Have a mobile phone through a U.S. carrier with MMS messaging and can send and receive text messages for study participation
* Access to the internet with Zoom capabilities

Exclusion Criteria

* Have a landline or Voice Over Internet Protocol (VOIP) phone number
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Ohio State University Comprehensive Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Joanne Patterson

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joanne G Patterson

Role: PRINCIPAL_INVESTIGATOR

Ohio State University Comprehensive Cancer Center

Locations

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Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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The Ohio State University Comprehensive Cancer Center

Role: CONTACT

Phone: 800-293-5066

Email: [email protected]

Facility Contacts

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Joanne G. Patterson

Role: primary

Related Links

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https://u.osu.edu/lgbtqhealthequity/research/my-health-matters/

Our Health Matters

Other Identifiers

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NCI-2024-04955

Identifier Type: REGISTRY

Identifier Source: secondary_id

R00CA260718

Identifier Type: NIH

Identifier Source: secondary_id

View Link

OSU-23436

Identifier Type: -

Identifier Source: org_study_id