Clinical Trials Updated in 2025

NCT03549559 | RECRUITING | NA

96 Participants

Imaging Histone Deacetylase in the Heart

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-09-07

Completion: 2026-03-01

Conditions

Heart Failure With Normal Ejection Fraction Left Ventricular Hypertrophy Aortic Valve Stenosis Diabetes

Interventions

DRUG DEVICE

No Results Yet

NCT03533582 | ACTIVE_NOT_RECRUITING | PHASE3

537 Participants

Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-05-24

Completion: 2026-12-31

Conditions

Childhood Hepatocellular Carcinoma Childhood Malignant Liver Neoplasm Fibrolamellar Carcinoma Hepatoblastoma Hepatocellular Malignant Neoplasm, Not Otherwise Specified

Interventions

PROCEDURE DRUG OTHER

No Results Yet

NCT03517878 | COMPLETED

1490 Participants

Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2014-08-11

Completion: 2018-06-01

Conditions

Alcohol; Harmful Use Child Development Child Malnutrition Child Nutrition Disorders Birth Weight Less Than 10Th Percentile Depression Depressive Symptoms Alcohol Use Disorder Alcohol Drinking Stunting HIV Infections HIV/AIDS

Interventions

BEHAVIORAL

No Results Yet

NCT03495986 | COMPLETED | NA

26 Participants

Spinal Cord Injury Exercise and Nutrition Conceptual Engagement

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2021-06-10

Completion: 2024-07-24

Conditions

Spinal Cord Injuries Metabolic Syndrome Dietary Modification Paraplegia Tetraplegia

Interventions

DEVICE BEHAVIORAL

Results Available

NCT03490240 | ACTIVE_NOT_RECRUITING | NA

280 Participants

Project BIPAMS: Behavioral Intervention for Physical Activity in Multiple Sclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-03-01

Completion: 2023-03-01

Conditions

Multiple Sclerosis

Interventions

BEHAVIORAL

No Results Yet

NCT03466411 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

1409 Participants

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-04-13

Completion: 2023-10-20

Conditions

Crohn's Disease

Interventions

DRUG

Results Available

NCT03464721 | COMPLETED | NA

30 Participants

Usability of SMART ANGEL Medical Device to Record and Transmit Health Data From Patient's Home Following Outpatient Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-05-14

Completion: 2018-09-30

Conditions

Surgery

Interventions

DEVICE

No Results Yet

NCT03462719 | ACTIVE_NOT_RECRUITING | PHASE3

211 Participants

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-04-17

Completion: 2021-02-26

Conditions

Leukemia, Lymphocytic, Chronic, B-Cell

Interventions

DRUG

Results Available

NCT03435510 | COMPLETED | NA

111 Participants

Implementation of the Live Donor Champion Program

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-05-30

Completion: 2025-03-30

Conditions

End-stage Renal Disease

Interventions

BEHAVIORAL

No Results Yet

NCT03423628 | RECRUITING | PHASE1

180 Participants

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-04-02

Completion: 2026-09-16

Conditions

Recurrent Glioblastoma Multiforme Primary Glioblastoma Multiforme Brain Neoplasms, Malignant Leptomeningeal Disease (LMD)

Interventions

RADIATION DRUG

No Results Yet

NCT03390504 | ACTIVE_NOT_RECRUITING | PHASE3

629 Participants

A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-03-23

Completion: 2024-04-15

Conditions

Urothelial Cancer

Interventions

DRUG DEVICE

Results Available

NCT03379220 | COMPLETED

147 Participants

Spreading Depolarizations in Traumatic Brain Injury

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2017-03-28

Completion: 2021-06-15

Conditions

Traumatic Brain Injury

No Results Yet

NCT03333343 | ACTIVE_NOT_RECRUITING | PHASE1

105 Participants

Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-01-29

Completion: 2026-03-09

Conditions

EGFR-mutant Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT03315819 | COMPLETED | NA

40 Participants

Anterior Capsulo-labral Reinsertion by Arthroscopic Approach Versus Immobilization

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2014-03-27

Completion: 2019-03-26

Conditions

Bankart Lesion

Interventions

PROCEDURE

No Results Yet

NCT03303209 | COMPLETED

51 Participants

Patient-Centered Opioid Tapering Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2015-09-15

Completion: 2017-08-10

Conditions

Opioid Use Chronic Pain

Interventions

OTHER

No Results Yet

NCT03290079 | COMPLETED | PHASE2

20 Participants

Phase II Study of Pembrolizumab and Lenvatinib in Advanced Well-differentiated Neuroendocrine Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-12-15

Completion: 2023-01-10

Conditions

Neuroendocrine Tumors Neuroendocrine Carcinoma Neuroendocrine Cancer

Interventions

DRUG

Results Available

NCT03285412 | ACTIVE_NOT_RECRUITING | PHASE2

120 Participants

CDK 4/6 Inhibitor, Ribociclib, With Adjuvant Endocrine Therapy for ER-positive Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-12-12

Completion: 2026-04-30

Conditions

Breast Cancer

Interventions

DRUG OTHER

No Results Yet

NCT03238430 | COMPLETED | PHASE2/PHASE3

186 Participants

Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2015-05-20

Completion: 2019-05-25

Conditions

Pain, Postoperative

Interventions

DRUG

No Results Yet

NCT03234556 | ACTIVE_NOT_RECRUITING | NA

288 Participants

Diagnosing Clinically Significant Prostate Cancer In African American and White Men With Elevated PSA

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-09-25

Completion: 2026-06-30

Conditions

Health Status Unknown Elevated PSA

Interventions

PROCEDURE OTHER DIAGNOSTIC_TEST

No Results Yet

NCT03217422 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

68 Participants

ADCC Mediated B-Cell dEpletion and BAFF-R Blockade

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-02-15

Completion: 2023-12-28

Conditions

Autoimmune Hepatitis

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT03172598 | COMPLETED | PHASE2

61 Participants

Study to Assess the Efficacy, Safety and Tolerability of MT- 8554 in Subjects With Painful Diabetic Peripheral Neuropathy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-07-25

Completion: 2018-08-08

Conditions

Painful Diabetic Peripheral Neuropathy

Interventions

DRUG

No Results Yet

NCT03149640 | COMPLETED | PHASE3

850 Participants

Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-07-19

Completion: 2021-03-09

Conditions

Pneumonia, Ventilator-Associated

Interventions

DRUG

No Results Yet

NCT03126916 | RECRUITING | PHASE3

750 Participants

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-05-14

Completion: 2030-09-30

Conditions

Ganglioneuroblastoma Ganglioneuroblastoma, Nodular Neuroblastoma

Interventions

PROCEDURE DRUG BIOLOGICAL RADIATION

No Results Yet

NCT03113981 | ACTIVE_NOT_RECRUITING | NA

340 Participants

Osseointegration of THA Grafted by PolyNASS (ACTISURF-CERAFIT® ) Versus Non-grafted THA (CERAFIT®)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-05-08

Completion: 2024-12-31

Conditions

Osteoarthritis, Hip Coxarthrosis; Primary Coxarthrosis; Secondary Osteonecrosis; Aseptic, Idiopathic Hip Arthroplasty Replacement Hip Arthroplasty, Total Hip Arthroplasty

Interventions

DEVICE

No Results Yet

NCT03095352 | COMPLETED | PHASE2

76 Participants

Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-09-02

Completion: 2024-11-30

Conditions

Breast Cancer Chest Wall Disease

Interventions

BIOLOGICAL DRUG

Results Available

NCT03089827 | ENROLLING_BY_INVITATION

800 Participants

Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2014-05-21

Completion: 2030-04-30

Conditions

Alzheimer Disease Mild Cognitive Impairment

No Results Yet

NCT03071406 | ACTIVE_NOT_RECRUITING | PHASE2

50 Participants

Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-03-14

Completion: 2022-04-06

Conditions

Merkel Cell Carcinoma Skin Cancer

Interventions

DRUG RADIATION

Results Available

NCT03067181 | RECRUITING | PHASE3

1780 Participants

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-05-25

Completion: 2027-06-30

Conditions

Childhood Extracranial Germ Cell Tumor Extragonadal Embryonal Carcinoma Germ Cell Tumor Malignant Germ Cell Tumor Malignant Ovarian Teratoma Stage I Ovarian Choriocarcinoma Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage I Testicular Choriocarcinoma AJCC v6 and v7 Stage I Testicular Embryonal Carcinoma AJCC v6 and v7 Stage I Testicular Seminoma AJCC v6 and v7 Stage I Testicular Yolk Sac Tumor AJCC v6 and v7 Stage II Ovarian Choriocarcinoma Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage II Testicular Choriocarcinoma AJCC v6 and v7 Stage II Testicular Embryonal Carcinoma AJCC v6 and v7 Stage II Testicular Yolk Sac Tumor AJCC v6 and v7 Stage III Ovarian Choriocarcinoma Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage III Testicular Choriocarcinoma AJCC v6 and v7 Stage III Testicular Embryonal Carcinoma AJCC v6 and v7 Stage III Testicular Yolk Sac Tumor AJCC v6 and v7 Stage IV Ovarian Choriocarcinoma Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7 Testicular Mixed Choriocarcinoma and Embryonal Carcinoma Testicular Mixed Choriocarcinoma and Teratoma Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

Interventions

OTHER PROCEDURE BIOLOGICAL DRUG

No Results Yet

NCT03027479 | COMPLETED | NA

70 Participants

Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-03-01

Completion: 2019-07-16

Conditions

Weight Loss Ovarian Carcinoma Endometrial Carcinoma

Interventions

OTHER

No Results Yet

NCT02985957 | COMPLETED | PHASE2

351 Participants

A Study of Nivolumab Plus Ipilimumab, Ipilimumab Alone, or Cabazitaxel in Men With Metastatic Castration-Resistant Prostate Cancer (CheckMate 650)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-03-26

Completion: 2022-04-05

Conditions

Prostate Cancer

Interventions

BIOLOGICAL DRUG

Results Available

NCT02981628 | RECRUITING | PHASE2

80 Participants

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-06-19

Completion: 2026-12-31

Conditions

Recurrent B Acute Lymphoblastic Leukemia Recurrent B Lymphoblastic Lymphoma Refractory B Acute Lymphoblastic Leukemia Refractory B Lymphoblastic Lymphoma

Interventions

DRUG PROCEDURE BIOLOGICAL

No Results Yet

NCT02909673 | COMPLETED | NA

3028 Participants

School Based Program to Prevent Teen Dating Violence

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2018-01-18

Completion: 2021-10-03

Conditions

Violence

Interventions

BEHAVIORAL

Results Available

NCT02907060 | COMPLETED | PHASE3

1224 Participants

Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-01-27

Completion: 2018-12-12

Conditions

Prolonged Pregnancy

Interventions

DEVICE DRUG

No Results Yet

NCT02905071 | COMPLETED | NA

226 Participants

Validation of a Scale of Well-being at Work

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2013-11-30

Completion: 2017-11-26

Conditions

Adjustment Disorder

Interventions

OTHER

No Results Yet

NCT02893267 | COMPLETED | NA

96 Participants

Multimodal Treatment for Hemiplegic Shoulder Pain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-01-31

Completion: 2024-09-30

Conditions

Shoulder Pain Stroke

Interventions

DEVICE OTHER

Results Available

NCT02891395 | COMPLETED | PHASE2

65 Participants

Efficacy and Safety of Nilotinib in Patients With a Chronic Disease of the Graft Against the Host

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2012-12-24

Completion: 2017-07-26

Conditions

Graft Versus Host Disease

Interventions

DRUG

No Results Yet

NCT02870517 | ACTIVE_NOT_RECRUITING | NA

212 Participants

Pre-operative Stress Reduction With Music

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-01-31

Completion: 2026-12-31

Conditions

Pediatric Pre-operative Stress

Interventions

OTHER

No Results Yet

NCT02854436 | COMPLETED | PHASE2

289 Participants

An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2016-08-31

Completion: 2021-01-26

Conditions

Prostatic Neoplasms

Interventions

DRUG

Results Available

NCT02844101 | COMPLETED | NA

80 Participants

Assess Whether Knowledge by the Younger of the Function of the Accelerometer Determines Its Amount of Physical Activity

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2013-07-31

Completion: 2015-06-30

Conditions

Physical Activity

Interventions

DEVICE

No Results Yet

NCT02829918 | COMPLETED | PHASE2

54 Participants

Study of Nivolumab in Patients With Advanced Refractory Biliary Tract Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2016-10-05

Completion: 2019-03-27

Conditions

Biliary Tract Cancer Biliary Tract Neoplasms

Interventions

DRUG

Results Available