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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04714840 | ACTIVE_NOT_RECRUITING | NA
181 Participants

Telehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-02-08
Completion: 2025-09-15
Conditions
Childhood Cancer Mobility Limitation
Interventions
OTHER
No Results Yet
NCT04691960 | ACTIVE_NOT_RECRUITING | PHASE2
18 Participants

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2016-08-31
Completion: 2026-06-30
Conditions
Glioblastoma
Interventions
OTHER DRUG
No Results Yet
NCT04691297 | ACTIVE_NOT_RECRUITING | NA
153 Participants

Digitally Enhanced Smoking Cessation for High Risk Smokers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-02-01
Completion: 2023-02-01
Conditions
Smoking Smoking Cessation Lung Cancer Screening Smoking, Tobacco Smoking Behaviors
Interventions
OTHER
No Results Yet
NCT04659616 | RECRUITING | PHASE1
32 Participants

Pemigatinib After Chemotherapy for the Treatment of Newly Diagnosed Acute Myeloid Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-01-14
Completion: 2026-12-31
Conditions
Acute Myeloid Leukemia
Interventions
PROCEDURE DRUG
No Results Yet
NCT04626024 | RECRUITING | PHASE2
100 Participants

Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-12-22
Completion: 2028-11-15
Conditions
Chronic Myeloid Leukemia Chronic Myeloid Leukemia, BCR/ABL-Positive, in Remission Chronic Myeloid Leukemia in Remission
Interventions
OTHER DRUG
No Results Yet
NCT04625478 | COMPLETED
50 Participants

Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-12-01
Completion: 2021-09-20
Conditions
Staphylococcus Bone and Joint Infection
Interventions
OTHER
No Results Yet
NCT04590885 | ACTIVE_NOT_RECRUITING | NA
440 Participants

Coping Together: Couple-based Interventions for Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-10-20
Completion: 2025-12-30
Conditions
Advanced Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04585503 | COMPLETED | NA
20 Participants

Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-01-01
Completion: 2023-04-07
Conditions
Brain Lesion Head Trauma Subarachnoid Hemorrhage
Interventions
DEVICE
No Results Yet
NCT04579848 | ACTIVE_NOT_RECRUITING | PHASE4
163 Participants

Methotrexate in Erosive Inflammatory Hand Osteoarthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-08-12
Completion: 2026-12-31
Conditions
Hand Osteoarthritis Erosive Osteoarthritis
Interventions
DRUG
No Results Yet
NCT04579380 | ACTIVE_NOT_RECRUITING | PHASE2
217 Participants

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-01-11
Completion: 2023-11-01
Conditions
Uterine Neoplasms Uterine Cervical Neoplasms Biliary Tract Neoplasms Urologic Neoplasms Carcinoma, Non-Small-Cell Lung HER2 Mutations Breast Neoplasms
Interventions
DRUG
Results Available
NCT04552834 | ACTIVE_NOT_RECRUITING
500 Participants

Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-15
Completion: 2026-06-01
Conditions
Critical Illness Microbiome
No Results Yet
NCT04550104 | RECRUITING | PHASE1
200 Participants

A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-03-17
Completion: 2026-03-31
Conditions
Non Small Cell Lung Cancer
Interventions
RADIATION DRUG
No Results Yet
NCT04539964 | ACTIVE_NOT_RECRUITING | PHASE3
243 Participants

Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-01-11
Completion: 2024-05-16
Conditions
Rheumatoid Arthritis
Interventions
PROCEDURE DRUG DEVICE
Results Available
NCT04517279 | COMPLETED | NA
113 Participants

Peer Approaches to Substances in Early Psychosis Programs: A Pilot Study of a Peer-Led Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-08-22
Completion: 2025-07-25
Conditions
Substance Use Psychotic Disorders
Interventions
BEHAVIORAL
No Results Yet
NCT04495296 | RECRUITING | PHASE1/PHASE2
320 Participants

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-08-13
Completion: 2026-06-25
Conditions
Advanced Cancer
Interventions
DRUG
No Results Yet
NCT04481919 | ACTIVE_NOT_RECRUITING | PHASE2
474 Participants

Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-05-01
Completion: 2026-09-30
Conditions
Heart Failure Acute Heart Failure
Interventions
DRUG
No Results Yet
NCT04464707 | COMPLETED | PHASE3
292 Participants

A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-24
Completion: 2024-11-29
Conditions
Migraine
Interventions
DRUG
Results Available
NCT04447118 | COMPLETED | PHASE3
151 Participants

Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-11
Completion: 2023-06-02
Conditions
Non-squamous NSCLC HER2 Exon 20 Mutation
Interventions
DRUG
No Results Yet
NCT04439552 | RECRUITING
60 Participants

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-10-04
Completion: 2027-08-31
Conditions
Pain, Postoperative Pain, Chronic Pain, Acute Surgical Injury Surgical Wound Cornea Injury Cornea Keratoconus
No Results Yet
NCT04437225 | ACTIVE_NOT_RECRUITING | NA
15 Participants

Renal Metabolism of Glycolate to Oxalate

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-03-12
Completion: 2026-09-01
Conditions
Healthy
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT04435054 | COMPLETED | NA
1000 Participants

Screening for NAFLD-related Advanced Fibrosis in High Risk Population in Diabetology.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-10-28
Completion: 2023-10-28
Conditions
Non-Alcoholic Fatty Liver Disease
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04414540 | ACTIVE_NOT_RECRUITING | PHASE2
20 Participants

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-08-31
Completion: 2025-12-31
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT04411602 | WITHDRAWN | PHASE1
0 Participants

Intermediate IND Severe Illness COVID-19 CP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-04-07
Completion: 2021-04-07
Conditions
Severe Acute Respiratory Syndrome COVID
Interventions
DRUG
No Results Yet
NCT04379921 | COMPLETED | NA
255 Participants

Improving Spine Surgical Care With Real-Time Objective Patient Tracking Using the Apple Watch

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-09-01
Completion: 2024-11-30
Conditions
Spine Disease Spine Degeneration Spinal Stenosis Surgery Spine Fusion
Interventions
DEVICE
Results Available
NCT04378439 | RECRUITING | NA
141 Participants

Appalachian Partnership to Reduce Disparities (Aim 2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-04-01
Completion: 2026-05-31
Conditions
HIV/AIDS STI HCV
Interventions
BEHAVIORAL
No Results Yet
NCT04361656 | WITHDRAWN
0 Participants

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-05-01
Completion: 2021-02-04
Conditions
Colonoscopy Preparation
Interventions
DRUG
No Results Yet
NCT04360538 | ACTIVE_NOT_RECRUITING
500 Participants

Long Term Outcomes of Patients With COVID-19

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-04-08
Completion: 2026-06-01
Conditions
Critical Illness Corona Virus Infection Respiratory Failure Covid-19
Interventions
OTHER
No Results Yet
NCT04349852 | RECRUITING | NA
150 Participants

Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-08-01
Completion: 2027-09-01
Conditions
Traumatic Brain Injury
Interventions
BEHAVIORAL
No Results Yet
NCT04325828 | ACTIVE_NOT_RECRUITING | PHASE2
31 Participants

A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-04-07
Completion: 2021-06-09
Conditions
Salivary Gland Neoplasms
Interventions
DRUG
Results Available
NCT04281056 | RECRUITING | NA
40 Participants

Impact of Tooth Loss and Denture on Oral Senses and Food Preferences

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-16
Completion: 2027-04-30
Conditions
Tooth-loss
Interventions
PROCEDURE
No Results Yet
NCT04275973 | COMPLETED | NA
20 Participants

Evaluating Mobility Interventions in the Real World

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-09-03
Completion: 2024-08-01
Conditions
Lower Limb Amputation Drop Foot
Interventions
DEVICE
Results Available
NCT04244604 | COMPLETED | NA
71 Participants

Vascular Effects of Acute Sodium (VEAS) Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-05-03
Completion: 2025-12-15
Conditions
Sodium Excess Racial Disparities Blood Pressure Cardiovascular Risk Factor
Interventions
OTHER
No Results Yet
NCT04242394 | COMPLETED
1019 Participants

If Chronic Gallbladder Diseases Increase the Incidence of PEC

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-02-14
Completion: 2024-11-16
Conditions
Cholecystitis
Interventions
PROCEDURE
No Results Yet
NCT04204408 | COMPLETED | PHASE2
275 Participants

A Research Study Investigating Mim8 in People With Haemophilia A

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-01-10
Completion: 2023-10-06
Conditions
Healthy Volunteers Haemophilia A With or Without Inhibitors
Interventions
DRUG
No Results Yet
NCT04190394 | COMPLETED | NA
100 Participants

Comparison of Two Exercise Training Modes on Left Myocardial Regional Function After Myocardial Infarction Evaluated by 2D Strain Ultrasound

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-03-12
Completion: 2023-07-20
Conditions
Ischemic Cardiomyopathy
Interventions
OTHER
No Results Yet
NCT04189172 | ACTIVE_NOT_RECRUITING
328 Participants

MiDura-Study (Neuro-Patch in Duraplasty)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2020-02-06
Completion: 2026-02-28
Conditions
Meningioma Tumor, Brain Chiari Malformation Vascular Malformation Hydrocephalus Tethered Cord Dural Fistula Craniotomy Spinal Surgery Duraplasty
No Results Yet
NCT04184700 | COMPLETED | NA
90 Participants

Epigenetic Effects in Children With Cow's Milk Allergy Treated With Different Formulas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2019-12-10
Completion: 2023-12-31
Conditions
Cow Milk Allergy
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04184089 | COMPLETED | NA
60 Participants

High Flow Nasal Cannula in Patients Undergoing ERCP Retrograde Cholangiopancreatography With Intravenous Sedation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2020-08-25
Completion: 2025-03-17
Conditions
High-flow Nasal Cannula Intravenous Sedation
Interventions
DEVICE
No Results Yet
NCT04182776 | RECRUITING
420 Participants

Fragility Fractures of the Pelvis (FFP)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-01
Completion: 2026-06-30
Conditions
Pelvic Fracture
No Results Yet
NCT04157517 | TERMINATED | PHASE1/PHASE2
45 Participants

A Study of Modakafusp Alfa (TAK-573) Given by Itself and Together With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2019-12-12
Completion: 2023-12-20
Conditions
Neoplasms Melanoma
Interventions
DRUG
Results Available
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