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Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

NCT ID: NCT04625478

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2021-12-20

Brief Summary

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Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI.

The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Detailed Description

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Conditions

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Staphylococcus Bone and Joint Infection

Keywords

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Bone and Joint Infection Staphylococcus intracellulare

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients having had an osteo-articular infection with Stahylococcus

Patients having had an osteo-articular infection with Stahylococcus managed at the Croix Rousse hospital

Patients having had an osteo-articular infection with Stahylococcus

Intervention Type OTHER

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Interventions

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Patients having had an osteo-articular infection with Stahylococcus

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients having had an osteo-articular infection with Staphylococci

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

Related Links

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https://www.crioac-lyon.fr/

Related Info

Other Identifiers

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229

Identifier Type: -

Identifier Source: org_study_id