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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05351229 | RECRUITING | PHASE4
90 Participants

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-09-29
Completion: 2026-06-01
Conditions
Pain, Postoperative
Interventions
DRUG OTHER
No Results Yet
NCT05348915 | TERMINATED | PHASE3
242 Participants

A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-03-29
Completion: 2025-11-07
Conditions
Sickle Cell Disease Vaso-occlusive Crisis Vaso-occlusive Pain Episode in Sickle Cell Disease
Interventions
DRUG
No Results Yet
NCT05344859 | COMPLETED | NA
88 Participants

GODART Pilot and Feasibility

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-05-15
Completion: 2025-10-31
Conditions
Diabetes Mellitus, Type 2
Interventions
BEHAVIORAL
No Results Yet
NCT05342636 | COMPLETED | PHASE1/PHASE2
90 Participants

A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-07-27
Completion: 2025-12-05
Conditions
Esophageal Squamous Cell Carcinoma (ESCC)
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT05333471 | RECRUITING | PHASE1/PHASE2
20 Participants

Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-08-08
Completion: 2026-03-01
Conditions
Chronic Granulomatous Disease-associated Colitis
Interventions
DRUG
No Results Yet
NCT05327985 | TERMINATED
21 Participants

Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2024-09-10
Completion: 2025-07-08
Conditions
Cervical Dystonia
No Results Yet
NCT05323292 | ENROLLING_BY_INVITATION
90 Participants

Vitamin A Status in Patients With Vocal Fold Leukoplakia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2022-06-29
Completion: 2026-06-30
Conditions
Vitamin A Vitamin A Deficiency Leukoplakia Vocal Cord Neoplasm
No Results Yet
NCT05319444 | SUSPENDED | NA
40 Participants

Cleansing Device for the Treatment of Scalp and Hair Conditions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2026-05-01
Completion: 2026-11-30
Conditions
Dandruff Seborrheic Dermatitis Hair Loss
Interventions
DEVICE
No Results Yet
NCT05309928 | COMPLETED | PHASE1
13 Participants

Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-08-29
Completion: 2025-01-16
Conditions
Pregnancy Related
Interventions
DRUG
No Results Yet
NCT05289661 | ACTIVE_NOT_RECRUITING | PHASE3
160 Participants

Descemet Endothelial Thickness Comparison Trial I

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-07-15
Completion: 2026-11-30
Conditions
Fuchs
Interventions
DRUG
No Results Yet
NCT05285891 | RECRUITING | PHASE4
123 Participants

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-01-12
Completion: 2030-05-01
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05273970 | ENROLLING_BY_INVITATION | NA
10 Participants

Electrochemical and Electrophysiological Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-09-07
Completion: 2027-02-28
Conditions
Cognition Medically Intractable Epilepsy
Interventions
OTHER
No Results Yet
NCT05263206 | RECRUITING | PHASE3
284 Participants

Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-02-15
Completion: 2027-06-02
Conditions
Pruritus
Interventions
DRUG
No Results Yet
NCT05259605 | RECRUITING
1650 Participants

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2023-03-21
Completion: 2027-12-30
Conditions
Glioma Glioneuronal Tumor Choroid Plexus Tumor Pineal Tumors Germ Cell Tumor Tumor of the Sellar Region Diffuse Midline Glioma, H3 K27M-Mutant Ependymoma Embryonal Tumor Pineal Tumor Hemangiopericytoma Hemangioblastoma Melanocytic Tumor of CNS
Interventions
OTHER
No Results Yet
NCT05257590 | RECRUITING | PHASE2
95 Participants

CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-23
Completion: 2026-03-31
Conditions
Hepatocellular Carcinoma Advanced Cancer
Interventions
DRUG
No Results Yet
NCT05255003 | RECRUITING | PHASE4
50 Participants

STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-08-29
Completion: 2026-12-31
Conditions
Cancer-associated Thrombosis Thrombocytopenia
Interventions
BIOLOGICAL
No Results Yet
NCT05253651 | RECRUITING | PHASE3
400 Participants

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-10-24
Completion: 2026-04-03
Conditions
Colorectal Neoplasms
Interventions
DRUG
No Results Yet
NCT05248204 | COMPLETED | NA
51 Participants

Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-06-14
Completion: 2025-03-06
Conditions
Cavities of Teeth Dental Decay
Interventions
DEVICE
Results Available
NCT05248191 | COMPLETED | PHASE1
23 Participants

FMT for Postop Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-04-20
Completion: 2023-12-25
Conditions
Crohn Disease
Interventions
BIOLOGICAL
No Results Yet
NCT05237505 | RECRUITING | PHASE2
240 Participants

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2024-02-13
Completion: 2028-08-31
Conditions
Obstructive Sleep Apnea Chronic Obstructive Pulmonary Disease Overlap Syndrome
Interventions
DEVICE DRUG
No Results Yet
NCT05236725 | COMPLETED | NA
1602 Participants

Monitoring and Testing of Blood Pressure in Postpartum Women

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-03-01
Completion: 2025-01-07
Conditions
Hypertension
Interventions
DEVICE BEHAVIORAL
No Results Yet
NCT05220241 | COMPLETED | NA
51 Participants

Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-07-01
Completion: 2025-06-20
Conditions
SARS-CoV-2 Infection Cognitive Disorder
Interventions
BIOLOGICAL
No Results Yet
NCT05220046 | ACTIVE_NOT_RECRUITING | PHASE1
24 Participants

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-04-10
Completion: 2026-05-31
Conditions
Pancreas Cancer Biliary Tract Cancer Psychological Distress Gastrointestinal Cancer
Interventions
DRUG
No Results Yet
NCT05219929 | ENROLLING_BY_INVITATION | PHASE2
60 Participants

Tetracycline Treatment Tolerability Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-11-02
Completion: 2026-07-31
Conditions
Post-Treatment Lyme Disease
Interventions
DRUG OTHER
No Results Yet
NCT05212428 | ACTIVE_NOT_RECRUITING | NA
110000 Participants

DNA Sequencing in Clinical Practice, Mayo Clinic Health Tapestry Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-01-22
Completion: 2024-11-14
Conditions
Genetic Disorder
Interventions
PROCEDURE OTHER
No Results Yet
NCT05212272 | RECRUITING | NA
16 Participants

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-09-02
Completion: 2026-01-31
Conditions
High Grade Glioma
Interventions
PROCEDURE DIAGNOSTIC_TEST BEHAVIORAL
No Results Yet
NCT05188508 | RECRUITING | PHASE2
57 Participants

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-01-14
Completion: 2026-01-31
Conditions
Glioma
Interventions
DRUG COMBINATION_PRODUCT
No Results Yet
NCT05183165 | RECRUITING | NA
20 Participants

Description of the Copper Concentration in Breast Milk in Women Treated for Wilson's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-11
Completion: 2026-08-31
Conditions
Wilson's Disease
Interventions
OTHER
No Results Yet
NCT05172726 | ACTIVE_NOT_RECRUITING | PHASE3
58 Participants

Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-02
Completion: 2026-10-31
Conditions
Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT05171478 | RECRUITING
20 Participants

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-09
Completion: 2026-12-08
Conditions
Lung Cancer Sarcoidosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05166850 | RECRUITING | NA
2900 Participants

Preventative Intervention for Cholera for 7 Days

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-22
Completion: 2026-12-22
Conditions
Cholera Water-Related Diseases Diarrhea Infectious
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05166785 | ACTIVE_NOT_RECRUITING | NA
238 Participants

BRInging the Diabetes Prevention Program to GEriatric Populations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-10-05
Completion: 2026-05-31
Conditions
Pre Diabetes
Interventions
OTHER
No Results Yet
NCT05161663 | COMPLETED | NA
98 Participants

Peer-driven Intervention on PrEP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-01-06
Completion: 2024-12-23
Conditions
HIV Infections
Interventions
BEHAVIORAL
No Results Yet
NCT05156281 | RECRUITING | PHASE3
800 Participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-13
Completion: 2026-04-30
Conditions
Relapsing Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05152147 | ACTIVE_NOT_RECRUITING | PHASE3
920 Participants

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-02
Completion: 2026-07-31
Conditions
Gastric Neoplasms Gastroesophageal Adenocarcinoma Esophageal Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05149755 | ACTIVE_NOT_RECRUITING | NA
650 Participants

Evolut™ EXPAND TAVR II Pivotal Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-04-27
Completion: 2026-02-28
Conditions
Moderate Aortic Valve Stenosis
Interventions
DEVICE
No Results Yet
NCT05147220 | RECRUITING | PHASE3
800 Participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-16
Completion: 2026-04-30
Conditions
Relapsing Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05145309 | NOT_YET_RECRUITING | PHASE2
45 Participants

Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2026-11-15
Completion: 2031-12-01
Conditions
Hypertension
Interventions
DRUG
No Results Yet
NCT05144997 | ACTIVE_NOT_RECRUITING | PHASE4
76 Participants

Lorlatinib Continuation Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-28
Completion: 2026-12-28
Conditions
Non-Small-Cell Lung Cancer NSCLC
Interventions
DRUG
No Results Yet
NCT05134012 | RECRUITING | PHASE3
215 Participants

RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-08
Completion: 2026-04-30
Conditions
Coronary Artery Disease
Interventions
DRUG
No Results Yet
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