A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
NCT ID: NCT05253651
Last Updated: 2025-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
400 participants
INTERVENTIONAL
2022-10-24
2029-07-27
Brief Summary
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Participants in this study have colorectal cancer that has spread through the body (metastatic) and/or cannot be removed with surgery (unresectable).
Participants will be assigned randomly to the tucatinib group or standard of care group. The tucatinib group will get tucatinib, trastuzumab, and mFOLFOX6. The standard of care group will get either:
* mFOLFOX6 alone,
* mFOLFOX6 with bevacizumab, or
* mFOLFOX6 with cetuximab mFOLFOX6 is a combination of multiple drugs. All of the drugs given in this study are used to treat this type of cancer.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Tucatinib Arm
Tucatinib + trastuzumab + mFOLFOX6
tucatinib
300mg given by mouth (orally) twice daily
trastuzumab
8mg/kg loading dose will be given into the vein (IV; intravenously) on Cycle 1 day 1, followed by 6mg/kg given by IV every 3 weeks thereafter.
oxaliplatin
85mg/m2 given by IV every 2 weeks. Component of mFOLFOX6.
leucovorin
400mg/ m2 given by IV every 2 weeks. Component of mFOLFOX6.
levoleucovorin
200mg/ m2 given by IV every 2 weeks. May be given in place of leucovorin. Component of mFOLFOX6.
fluorouracil
400mg/m2 given by IV bolus then 2400mg/m2 given by continuous IV infusion (over 46-48 hours) every 2 weeks. Component of mFOLFOX6.
Standard of Care Arm
Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab
bevacizumab
5mg/kg given by IV every 2 weeks
cetuximab
400mg/m2 loading dose will be given by IV on Cycle 1 day 1, followed by 250mg/m2 given by IV weekly
oxaliplatin
85mg/m2 given by IV every 2 weeks. Component of mFOLFOX6.
leucovorin
400mg/ m2 given by IV every 2 weeks. Component of mFOLFOX6.
levoleucovorin
200mg/ m2 given by IV every 2 weeks. May be given in place of leucovorin. Component of mFOLFOX6.
fluorouracil
400mg/m2 given by IV bolus then 2400mg/m2 given by continuous IV infusion (over 46-48 hours) every 2 weeks. Component of mFOLFOX6.
Interventions
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tucatinib
300mg given by mouth (orally) twice daily
trastuzumab
8mg/kg loading dose will be given into the vein (IV; intravenously) on Cycle 1 day 1, followed by 6mg/kg given by IV every 3 weeks thereafter.
bevacizumab
5mg/kg given by IV every 2 weeks
cetuximab
400mg/m2 loading dose will be given by IV on Cycle 1 day 1, followed by 250mg/m2 given by IV weekly
oxaliplatin
85mg/m2 given by IV every 2 weeks. Component of mFOLFOX6.
leucovorin
400mg/ m2 given by IV every 2 weeks. Component of mFOLFOX6.
levoleucovorin
200mg/ m2 given by IV every 2 weeks. May be given in place of leucovorin. Component of mFOLFOX6.
fluorouracil
400mg/m2 given by IV bolus then 2400mg/m2 given by continuous IV infusion (over 46-48 hours) every 2 weeks. Component of mFOLFOX6.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Able to provide the most recently available formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks (or freshly sectioned slides) obtained prior to treatment initiation to a central laboratory
* If archival tissue is not available, a newly-obtained baseline biopsy of an accessible tumor lesion is required within 35 days prior to start of study treatment
* HER2+ disease as determined by a tissue based assay performed at a central laboratory.
* Participant has rat sarcoma viral oncogene homolog wild-type (RAS WT) disease as determined by local or central testing. For central RAS analysis, tissue sample must be analyzed within 1 year of biopsy date.
* Radiographically measurable disease per RECIST v1.1 with:
* At least one site of disease that is measurable and that has not been previously irradiated, or
* If the participant has had previous radiation to the target lesion(s), there must be evidence of progression since the radiation
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
* CNS Inclusion - based on contrast brain magnetic resonance imaging, participants may have any of the following:
* No evidence of brain metastases
* Previously treated brain metastases which are asymptomatic
Exclusion Criteria
* Note: May have received chemotherapy for CRC in the adjuvant setting if it was completed \>6 months prior to enrollment
* Radiation therapy within 14 days prior to enrollment (or within 7 days in the setting of stereotactic radiosurgery)
* Previous treatment with anti-HER2 therapy
* Ongoing Grade 3 or higher neuropathy
* Active or untreated gastrointestinal (GI) perforation at the time of screening.
18 Years
ALL
No
Sponsors
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Seagen, a wholly owned subsidiary of Pfizer
INDUSTRY
Responsible Party
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Principal Investigators
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Pfizer CT.gov Call Center
Role: STUDY_DIRECTOR
Pfizer
Locations
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Palo Verde Hematology Oncology
Glendale, Arizona, United States
Mayo Clinic Building - Phoenix
Phoenix, Arizona, United States
Mayo Clinic Hospital
Phoenix, Arizona, United States
Mayo Clinic
Scottsdale, Arizona, United States
Los Angeles Cancer Network - Anaheim
Anaheim, California, United States
Kaiser Permanente Anaheim Kraemer Medical Offices
Anaheim, California, United States
Kaiser Permanente Baldwin Park Medical Center
Baldwin Park, California, United States
Kaiser Permanente Bellflower Medical Offices
Bellflower, California, United States
Kaiser Permanente Fontana Medical Center
Fontana, California, United States
Los Angeles Cancer Network - Fountain Vally
Fountain Valley, California, United States
Los Angeles Hematology Oncology Medical Group
Glendale, California, United States
Los Angeles Hematology Oncology Medical Group
Glendale, California, United States
Kaiser Permanente South Bay Medical center
Harbor City, California, United States
Kaiser Permanente Alton/Sand Canyon Medical Offices
Irvine, California, United States
Los Angeles Hematology Oncology Medical Group
Los Angeles, California, United States
USC Norris Koreatown - Medical Oncology
Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Offices
Los Angeles, California, United States
Keck Hospital of USC
Los Angeles, California, United States
Los Angeles General Medical Center
Los Angeles, California, United States
University of Southern California
Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States
Kaiser Permanente West Los Angeles Medical Center
Los Angeles, California, United States
USC Norris Oncology/Hematology - Newport Beach
Newport Beach, California, United States
Kaiser Permanente Ontario Medical Center
Ontario, California, United States
Kaiser Permanente Panorama City Medical Center
Panorama City, California, United States
Keck Medical Center of USC Pasadena
Pasadena, California, United States
Los Angeles Hematology Oncology Medical Group
Pasadena, California, United States
Kaiser Permanente Riverside Medical Center
Riverside, California, United States
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies)
San Diego, California, United States
Kaiser Permanente Zion Medical Center
San Diego, California, United States
Kaiser Permanente San Marcos Medical Offices
San Marcos, California, United States
Los Angeles Hematology Oncology Medical Group
Van Nuys, California, United States
Kaiser Permanente Woodland Hills Medical Center
Woodland Hills, California, United States
Rocky Mountain Cancer Centers, LLP
Aurora, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Boulder, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Lakewood, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Littleton, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Lone Tree, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Longmont, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Pueblo, Colorado, United States
Rocky Mountain Cancer Centers, LLP
Thornton, Colorado, United States
Mount Sinai Medical Center Aventura ER
Aventura, Florida, United States
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, United States
Mount Sinai Medical Center
Miami Beach, Florida, United States
Grady Health System
Atlanta, Georgia, United States
Emory University Hospital Midtown
Atlanta, Georgia, United States
Emory University Hospital
Atlanta, Georgia, United States
Winship Cancer Institute
Atlanta, Georgia, United States
Alliance for Multispecialty Research LLC.
Merriam, Kansas, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Norton Cancer Institute - Downtown
Louisville, Kentucky, United States
Norton Cancer Institute, Downtown
Louisville, Kentucky, United States
Norton Hospital
Louisville, Kentucky, United States
Norton Audubon Hospital
Louisville, Kentucky, United States
Norton Cancer Institute, Audubon Hospital Campus
Louisville, Kentucky, United States
Norton Brownsboro Hospital
Louisville, Kentucky, United States
Norton Cancer Institute, Brownsboro Hospital Campus
Louisville, Kentucky, United States
Minnesota Oncology Hematology, PA
Burnsville, Minnesota, United States
Allina Health Cancer institute
Coon Rapids, Minnesota, United States
Minnesota Oncology Hematology, PA
Coon Rapids, Minnesota, United States
M Health Fairview Cancer Clinic-Edina
Edina, Minnesota, United States
Minnesota Oncology Hematology, PA
Edina, Minnesota, United States
Minnesota Oncology Hematology, PA
Fridley, Minnesota, United States
Minnesota Oncology Hematology, PA
Maple Grove, Minnesota, United States
M Health Fairview St. John's Hospital
Maplewood, Minnesota, United States
Minnesota Oncology Hematology, PA
Maplewood, Minnesota, United States
Allina Health Cancer Institute (Virginia Piper Cancer Institute)
Minneapolis, Minnesota, United States
Minnesota Oncology Hematology, PA
Minneapolis, Minnesota, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
North Memorial Health Cancer Center
Robbinsdale, Minnesota, United States
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota, United States
Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota, United States
Regulatory Location: MMCORC
Saint Louis Park, Minnesota, United States
Regions Hospital
Saint Paul, Minnesota, United States
Allina Health Cancer Institute-United(VPCI)
Saint Paul, Minnesota, United States
Minnesota Oncology Hematology, PA Cornerstone Medical Specialty Center
Woodbury, Minnesota, United States
MSK Basking Ridge
Basking Ridge, New Jersey, United States
MSK Monmouth
Middletown, New Jersey, United States
MSK Bergen
Montvale, New Jersey, United States
MSK Commack
Commack, New York, United States
MSK Westchester
Harrison, New York, United States
Rockefeller Outpatient Pavilion (53rd Street)
New York, New York, United States
Memorial Solan Kettering Cancer Center- Main Campus
New York, New York, United States
MSK Nassau
Uniondale, New York, United States
Duke University Hospital
Durham, North Carolina, United States
Duke University Medical Center, Duke Cancer Center
Durham, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
FirstHealth Cancer Center
Pinehurst, North Carolina, United States
FirstHealth Moore Regional Hospital
Pinehurst, North Carolina, United States
Gabrail Cancer Center Research
Canton, Ohio, United States
Northwest Cancer Specialists, P.C.
Portland, Oregon, United States
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States
Providence Portland Medical Center
Portland, Oregon, United States
Providence Oncology and Hematology Care Clinic - Westside
Portland, Oregon, United States
Providence St. Vincent Medical Center
Portland, Oregon, United States
Northwest Cancer Specialists, P.C.
Portland, Oregon, United States
Northwest Cancer Specialists, P.C.
Tigard, Oregon, United States
UPMC Hillman Cancer Center - Beaver
Beaver, Pennsylvania, United States
UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania, United States
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania, United States
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Greensburg, Pennsylvania, United States
UPMC Hillman Cancer Center - Pinnacle (Community Osteopathic / Medical Sciences Pavillion)
Harrisburg, Pennsylvania, United States
UPMC Hillman Cancer Center at Arnold Palmer Pavilion, In Partnership with Excela Health
Irwin, Pennsylvania, United States
UPMC Hillman Cancer Center - Pinnacle (Ortenzio Cancer Center)
Mechanicsburg, Pennsylvania, United States
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania, United States
UPMC Hillman Cancer Center - St Margarets
Pittsburgh, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC)/Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant (HOA)
Pittsburgh, Pennsylvania, United States
St. Clair Cancer Center Medical Oncology
Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Washington
Washington, Pennsylvania, United States
Avera Cancer Institute
Sioux Falls, South Dakota, United States
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States
US Oncology Investigational Products Center(IPC)
Irving, Texas, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia
Low Moor, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
Roanoke, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
Salem, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia
Wytheville, Virginia, United States
Providence Regional Cancer Partnership
Everett, Washington, United States
Providence Regional Medical Center Everett
Everett, Washington, United States
Northwest Cancer Specialists, P.C.
Vancouver, Washington, United States
Centro de Investigacion Pergamino SA
Pergamino, Buenos Aires, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
Rosario, Santa Fe Province, Argentina
Instituto Medico Especializado Alexander Fleming
Buenos Aires, , Argentina
Hospital Britanico de Buenos Aires
CABA, , Argentina
IONC Instituto Oncologico de Cordoba Fundacion Richardet Longo
Córdoba, , Argentina
CEMAIC - Centro Medico Privado
Córdoba, , Argentina
Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
St Vincent's Hospital
Fitzroy, Victoria, Australia
Klinikum Wels-Grieskirchen GmbH Austria
Wels, Upper Austria, Austria
Landesapotheke Salzburg
Salzburg, , Austria
Uniklinikum Salzburg, Landeskrankenhaus
Salzburg, , Austria
Klinikum Wels-Grieskirchen GmbH Austria
Wels, , Austria
Landesklinikum Wiener Neustadt
Wiener Neustadt, , Austria
Institut Jules Bordet
Anderlecht, , Belgium
Cliniques Universitaires Saint-Luc
Brussels, , Belgium
UZA
Edegem, , Belgium
CHU HELORA - Hopital de Jolimont
Haine-Saint-Paul, , Belgium
Universitair Ziekenhuis Leuven
Leuven, , Belgium
Centre Hospitalier Chretien - Clinique MontLegia
Liège, , Belgium
Maag-,Darm- en Leverziekten AZ Turnhout
Turnhout, , Belgium
Oncologisch Dagziekenhuis AZ Turnhout Campus Sint-Elisabeth
Turnhout, , Belgium
CIONC-Centro Integrado de Oncologia de Curitiba
Curitiba, Paraná, Brazil
Instituto De Educação, Pesquisa e Gestão em Saúde - Instituto Américas
Barra da Tijuca, Rio de Janeiro, Brazil
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro, Rio de Janeiro, Brazil
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
Rio de Janeiro, Rio de Janeiro, Brazil
Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul, Brazil
Hospital de Cancer de Barretos/Fundacao Pio XII
Barretos, São Paulo, Brazil
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho
Jaú, São Paulo, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia.
Santo André, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira.
São Paulo, , Brazil
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
Sunnybrook Research Institute
Toronto, Ontario, Canada
Mount Sinai Hospital
Toronto, Ontario, Canada
Jewish General Hospital
Montreal, Quebec, Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Oncocentro Apys
Viña del Mar, Región de Valparaíso, Chile
Biocenter
Concepción, , Chile
Centro de estudios clinicos SAGA
Santiago, , Chile
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
Fuzhou, Fujian, China
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
The Sixth Affiliated hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Meizhou People's hospital
Meizhou, Guangdong, China
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Affiliated Hospital of Chengde Medical University
Chengde, Hebei, China
Affiliated Hospital of Chengde Medical University
Chengde, Hebei, China
Tangshan People's Hospital
Tangshan, Hebei, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Nanyang Second General Hospital
Nanyang, Henan, China
Henan Provincial People's Hospital
Zhengzhou, Henan, China
Hubei Cancer Hospital
Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China
The First People's Hospital of Changzhou
Changzhou, Jiangsu, China
The First Affiliated Hospital of Suzhou University
Suzhou, Jiangsu, China
Xuzhou Central Hospital
Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, China
Liaoning Cancer Hospital & Institute
Shenyang, Liaoning, China
Jinan Central Hospital
Jinan, Shandong, China
Shandong Cancer Hospital
Jinan, Shandong, China
LinYi Cancer Hospital
Linyi, Shandong, China
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Shanxi Province Cancer Hospital
Taiyuan, Shanxi, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Beijing Cancer Hospital
Beijing, , China
Hunan Cancer Hospital
Changsha, , China
Army Specialty Medical Center of The Chinese People's Liberation Army
Chongqing, , China
Shanghai General Hospital
Shanghai, , China
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
Besançon, Other, France
Institut Sainte Catherine
Avignon, , France
CHU Brest Hopital Cavale Blanche
Brest, , France
CHU Estaing
Clermont-Ferrand, , France
Hopital Henri Mondor
Créteil, , France
Center Georges-Francois Leclerc
Dijon, , France
Hopital Edouard Herriot
Lyon, , France
Höpital Saint-Joseph
Marseille, , France
Centre Hospitalier Universitaire Nantes-Hotel Dieu
Nantes, , France
Centre Antoine Lacassagne
Nice, , France
Hopital Saint-Louis
Paris, , France
Pharmacy Address:Hopital Saint-Louis
Paris, , France
Hopital Saint-Antoine
Paris, , France
Hopital Europeen Georges Pompidou
Paris, , France
CHU Bordeaux Hopital Haut Leveque
Pessac, , France
CHU Poitiers
Poitiers, , France
CHU de Rouen
Rouen, , France
Institut de Cancérologie de l'Ouest - Saint-Herblain
Saint-Herblain, , France
Centre Hospitalier Universitaire Sainte-Etienne - Hopital Nord
Saint-Priest-en-Jarez, , France
Institut de Cancerologie Strasbourg Europe
Strasbourg, , France
CHU Toulouse-Rangueil
Toulouse, , France
CCC Muenchen TUM
Munich, Bavaria, Germany
LMU Klinikum - Campus Großhadern
München, Bavaria, Germany
Medizinische Hochschule Hannover (MHH)
Hanover, Lower Saxony, Germany
Universitätsklinikum Leipzig
Leipzig, Saxony, Germany
Landesdirektion Sachsen Dienststelle Leipzig
Leipzig, Saxony, Germany
Klinikum St. Marien Amberg
Amberg, , Germany
Charité - Universitätsmedizin Berlin
Berlin, , Germany
Klinikum Chemnitz gGmbH
Chemnitz, , Germany
Apotheke Johannstadt
Dresden, , Germany
Gemeinschaftspraxis Hämatologie - Onkologie
Dresden, , Germany
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
Dresden, , Germany
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, , Germany
Hämatologisch Onkologische Praxis Eppendorf (HOPE)
Hamburg, , Germany
ZytoService Deutschland GmbH
Hamburg, , Germany
Asklepios Kliniken Hamburg GmbH
Hamburg, , Germany
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona
Hamburg, , Germany
Medizinische Hochschule Hannover (MHH)
Hanover, , Germany
Universitätsklinikum Leipzig
Leipzig, , Germany
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
München, , Germany
Klinikum rechts der Isar der TU München, Krankenhausapotheke
München, , Germany
Universitaetsklinikum Ulm
Ulm, , Germany
Athens Medical Center - Psychikon branch
Athens, Attikí, Greece
University General Hospital "Attikon"
Athens, Chaidari, Greece
"University General Hospital of Heraklion Oncology Unit "
Heraklion, Crete, Greece
"Papageorgiou" General Hospital of Thessaloniki 2nd Internal Medicine/Oncology Clinic of Aristotle
Nea Efkarpia, Thessaloniki, Greece
Evgenidion Clinic Agia Trias Oncology Department
Athens, , Greece
Cork University Hospital,Department of Medical Onncology
Cork, , Ireland
Bon Secours Hospital
Cork, , Ireland
St Vincents University Hospital
Dublin, , Ireland
Mater Misericordiae University Hospital
Dublin, , Ireland
Mater Private Hospital
Dublin, , Ireland
Beaumont Hospital
Dublin, , Ireland
University Hospital Waterford
Waterford, , Ireland
Azienda Ospedaliera Universitaria Cagliari
Monserrato, Cagliari, Italy
Farmacia AOU Cagliari - Presidio Ospedaliero ' Duilio Casula' di Monserrate
Monserrato, Cagliari, Italy
UOC Oncologia Medica - Dipartimento Onco Ematologico AORN San Giuseppe Moscati di Avellino
Avellino, Campania, Italy
IRCCS Ospedale Policlinico San Martino Farmacia
Genova, GE, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio, Italy
UOC Oncologia, Azienda Ospedaliera Cardinale Giovanni Panico
Tricase, Lecce, Italy
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Lombardy, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, Italy
lstituto Europeo di Oncologia
Milan, Lombardy, Italy
Niguarda Cancer Center Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Lombardy, Italy
UMaCA U.O.S.D. Farmacia Ospedaliera
Napoli, Naples, Italy
IRCCS Ospedale Policlinico San Martino
Genova, Other, Italy
Ospedale S Chiara Farmacia
Pisa, Other, Italy
Servizio Farmacia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona, Other, Italy
Farmacia Sperimentazioni
Reggio Emilia, RE, Italy
UOC Oncologia Medica, ARNAS GARIBALDI - PRESIDIO OSPEDALIERO NESIMA
Catania, Sicily, Italy
SODc Oncologia Medica e Clinica, AOU Careggi
Florence, Tuscany, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Tuscany, Italy
Istituto Oncologico Veneto - IRCCS
Padua, Veneto, Italy
Struttura Semplice Dipartimentale di Oncologia Medica e Terapia Biomolecolare Azienda Ospedaliero
Foggia, , Italy
lstituto Europeo di Oncologia Servizio Farmacia
Milan, , Italy
Fondazione IRCCS Istituto Nazionale dei Tumori Farmacia
Milan, , Italy
Istituto Oncologico Veneto-IRCCS Farmacia
Padua, , Italy
Fondazione IRCCS Policlinico San Matteo Farmacia
Pavia, , Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, , Italy
Farmacia UFA
Reggio Emilia, , Italy
S.C Oncologia Arcispedale Santa Maria Nuova
Reggio Emilia, , Italy
Farmacia degli Sperimentali Policlinico Gemelli IRCCS
Roma, , Italy
ASST della Valtellina e dell'alto Lario - Presidio Ospedaliero di Sondrio
Sondrio, , Italy
ASST della Valtellina e dell'alto Lario- Presidio Ospedaliero di Sondrio Farmacia
Sondrio, , Italy
U.O.C. Oncologia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
Verona, , Italy
Chiba Cancer Center
Chiba, Chiba, Japan
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan
NHO Shikoku Cancer Center
Matsuyama, Ehime, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Fukuoka, Japan
Hokkaido University Hospital
Sapporo, Hokkaido, Japan
Kobe City Hospital Organization Kobe City Medical Center General Hospital
Kobe, Hyōgo, Japan
Kagawa University Hospital
Kita-gun, Kagawa-ken, Japan
St. Marianna University Hospital
Kawasaki-shi, Kanagawa, Japan
Kanagawa Cancer Center
Yokohama, Kanagawa, Japan
Osaka General Medical Center
Osaka, Osaka, Japan
Kindai University Hospital
Osakasayama-shi, Osaka, Japan
Osaka University Hospital
Suita-shi, Osaka, Japan
Osaka Medical and Pharmaceutical University Hospital
Takatsuki-shi, Osaka, Japan
Saitama Cancer Center
Kitaadachi-gun, Saitama, Japan
National Cancer Center Hospital
Chuo-Ku, Tokyo, Japan
Cancer Institute Hospital of JFCR
Koto-ku, Tokyo, Japan
National Hospital Organization Osaka National Hospital
Osaka, , Japan
St. Antonius Hospital
Nieuwegein, Other, Netherlands
Netherlands Cancer Institute
Amsterdam, , Netherlands
Klinische Farmacie
Nieuwegein, , Netherlands
St. Antonius Ziekenhuis - Ziekenhuis Utrecht
Utrecht, , Netherlands
Viecuri Medisch Centrum
Venlo, , Netherlands
Sjukehusapoteket i Bergen [Bergen Hospital Pharmacy]
Bergen, , Norway
Helse Bergen HF, Haukeland University Hospital
Bergen, , Norway
Oslo University Hospital (OUH) - The Norwegian Radium Hospital
Oslo, , Norway
Przychodnia Lekarska KOMED Roman Karaszewski
Konin, Greater Poland Voivodeship, Poland
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy lnstytut Badawczy
Warsaw, Masovian Voivodeship, Poland
Marii Sklodowskiej-Curie Panstwowy lnstytut Badawczy
Warsaw, Masovian Voivodeship, Poland
Wojskowy Instytut Medyczny Klinika Onkologii
Warsaw, Masovian Voivodeship, Poland
Wojskowy Instytut Medyczny
Warsaw, Masovian Voivodeship, Poland
MRUK-MED | Sp. z.o.o Apteka szpitalna
Rzeszów, Podkarpackie Voivodeship, Poland
MRUK-MED | Sp. z.o.o
Rzeszów, Podkarpackie Voivodeship, Poland
Apteka Szpitalna Uniwersytie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, Poland
Salve Medica Apteka Szpitalna
Lodz, , Poland
Hospital Garcia de Orta
Almada, , Portugal
Unidade Local de Saude da Guarda-Hospital Sousa Martins
Guarda, , Portugal
Fundacao Champalimaud
Lisbon, , Portugal
Centro Hospitalar Universitário de Santo Antonio,E.P.E.
Porto, , Portugal
Narodny Onkologicky ustav II.Onkologicka Klinika LFUK a NOU
Bratislava, , Slovakia
Gachon University Gil Medical Center
Incheon, , South Korea
Korea University Anam Hospital
Seoul, , South Korea
Seoul National University Hospital
Seoul, , South Korea
Severance Hospital, Yonsei University Health System
Seoul, , South Korea
Asan Medical Center
Seoul, , South Korea
Samsung Medical Center
Seoul, , South Korea
Korea University Guro Hospital
Seoul, , South Korea
Hospital Duran i Reynals - Institut Catala d'Oncologia L'Hospitalet (ICO L'Hospitalet)
L'Hospitalet de Llobregat, Barcelona, Spain
Clinica Universidad de Navarra
Pamplona, Navarre, Spain
CETIR Viladomat
Barcelona, Other, Spain
Complejo Hospitalario Universitario de Canarias
San Cristóbal de La Laguna, Santa CRUZ DE Tenerife, Spain
Hospital General Universitario de Alicante
Alicante, , Spain
Radiology: CETIR Ascires
Barcelona, , Spain
Data review: Vall d'Hebron institute of Oncology (VHIO).
Barcelona, , Spain
Hospital Vall d'Hebron Unidad de Farmacia de Ensayos Clinicos Oncohematologia
Barcelona, , Spain
Hospital Vall d'Hebron
Barcelona, , Spain
Hospital Clinic de Barcelona
Barcelona, , Spain
Hospital Universitario Reina Sofia
Córdoba, , Spain
Hospital Universitari Arnau de Vilanova
Lleida, , Spain
Hospital General Universitario Gregorio Maranon
Madrid, , Spain
Clínica Universidad de Navarra (Madrid)
Madrid, , Spain
Hospital Universitario Ramon y Cajal
Madrid, , Spain
Hospital Universitario 12 de Octubre
Madrid, , Spain
Hospital Universitario La Paz
Madrid, , Spain
Hospital Regional Universitario de Malaga (Hospital Civil)
Málaga, , Spain
Complejo Hospitalario Universitario de Ourense
Ourense, , Spain
Hospital Universitario Central de Asturias
Oviedo, , Spain
Complejo Hospitalario de Navarra
Pamplona, , Spain
Hospital Universitario Marques de Valdecilla
Santander, , Spain
Hospital Universitario Virgen del Rocio
Seville, , Spain
Hospital General Universitario de Valencia
Valencia, , Spain
Hospital Quiron Salud Zaragoza
Zaragoza, , Spain
Hospital Universitario Miguel Servet
Zaragoza, , Spain
Pharmacy:Kantonsspital Winterthur
Winterthur, Other, Switzerland
Zuripharm AG
Schlieren, , Switzerland
Kantonsspital Winterthur
Winterthur, , Switzerland
Universitatsspital Zurich - Klinik fur Medizinische Onkologie und Hamatologie USZ
Zurich, , Switzerland
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, , Taiwan
National Cheng Kung University Hospital
Tainan, , Taiwan
National Taiwan University Hospital
Taipei, , Taiwan
National Taiwan University Hospital Clinical Trial Pharmacy
Taipei, , Taiwan
Taipei Veterans General Hospital
Taipei, , Taiwan
Chang Gung Memorial Hospital LinKou
Taoyuan District, , Taiwan
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, Chelsea, United Kingdom
The Royal Marsden Hospital
Sutton, Surrey, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, , United Kingdom
Cambridge University Hospitals NHS Foundation Trust, Oncology Centre
Cambridge, , United Kingdom
Leeds Teaching Hospitals NHS Trust, st James's Institute of Oncology
Leeds, , United Kingdom
Guy's and Saint Thomas' NHS Foundation Trust
London, , United Kingdom
The Royal Marsden Hospital - Chelsea Site
London, , United Kingdom
The Royal Marsden NHS Foundation Trust
London, , United Kingdom
Imperial College Healthcare NHS Trust
London, , United Kingdom
The Christie NHS Foundation Trust
Manchester, , United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, , United Kingdom
Countries
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Central Contacts
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References
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Strickler JH, Bekaii-Saab T, Cercek A, Heinemann V, Nakamura Y, Raghav K, Siena S, Tabernero J, Van Cutsem E, Yoshino T, Ramos J, Guan X, Andre T. MOUNTAINEER-03 phase III study design: first-line mFOLFOX6 + tucatinib + trastuzumab for HER2+ metastatic colorectal cancer. Future Oncol. 2025 Feb;21(3):303-311. doi: 10.1080/14796694.2024.2441101. Epub 2024 Dec 26.
Related Links
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To obtain contact information for a study center near you, click here.
Other Identifiers
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C4251008
Identifier Type: OTHER
Identifier Source: secondary_id
2024-514180-25-00
Identifier Type: REGISTRY
Identifier Source: secondary_id
SGNTUC-029
Identifier Type: -
Identifier Source: org_study_id