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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05381454 | COMPLETED | PHASE1/PHASE2
80 Participants

An Open Label Study in Adults to Test the Efficacy of Mitoquinone/Mitoquinol Mesylate to Prevent Severe Viral Illness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-04-28
Completion: 2023-05-09
Conditions
Respiratory Viral Infection Antiviral Treatment COVID-19
Interventions
DRUG
Results Available
NCT05374590 | ENROLLING_BY_INVITATION | PHASE2/PHASE3
12 Participants

Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-08-18
Completion: 2029-09-30
Conditions
Generalized Myasthenia Gravis gMG
Interventions
BIOLOGICAL
No Results Yet
NCT05367063 | COMPLETED | PHASE4
45 Participants

Canagliflozin and Myocardial Fibrosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-01-05
Completion: 2024-12-31
Conditions
Type 2 Diabetes Cardiovascular Risk
Interventions
DRUG
No Results Yet
NCT05362292 | RECRUITING | PHASE4
270 Participants

TReating Incontinence for Underlying Mental and Physical Health

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-10-04
Completion: 2027-05-02
Conditions
Urinary Incontinence, Urge Urinary Incontinence Overactive Bladder Incontinence, Urge Incontinence, Urinary Incontinence
Interventions
DRUG
No Results Yet
NCT05313009 | TERMINATED | PHASE1/PHASE2
5 Participants

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-03-07
Completion: 2023-07-07
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
Results Available
NCT05296512 | ACTIVE_NOT_RECRUITING | PHASE2
30 Participants

Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-09-23
Completion: 2026-09-23
Conditions
Ovarian Clear Cell Carcinoma Gynecologic Cancer
Interventions
DRUG
No Results Yet
NCT05271578 | COMPLETED | NA
55 Participants

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-06-07
Completion: 2025-06-06
Conditions
Vascular Reactivity Serum Biomarkers
Interventions
DEVICE
No Results Yet
NCT05267912 | ACTIVE_NOT_RECRUITING | NA
152 Participants

Prospective Multicenter Study Evaluating Feasibility and Efficacy of Tumor Organoid-based Precision Medicine in Patients With Advanced Refractory Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-01-19
Completion: 2028-01-18
Conditions
Advanced, Pretreated Solid Tumors
Interventions
PROCEDURE
No Results Yet
NCT05263830 | RECRUITING
240 Participants

Glypican-3 as a Prognostic Factor in Patients With Hepatocellular Carcinoma Treated by Immunotherapy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2023-09-08
Completion: 2029-09-08
Conditions
Hepatocellular Carcinoma
Interventions
OTHER
No Results Yet
NCT05256875 | TERMINATED
90 Participants

An Analysis to Assess Non-adherence in People With Type 2 Diabetes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-08-30
Completion: 2025-06-17
Conditions
Diabetes Mellitus, Type 2 Hypertension Medication Adherence
Interventions
OTHER
No Results Yet
NCT05253287 | COMPLETED | PHASE2/PHASE3
96 Participants

Growth Hormone in Decompensated Liver Cirrhosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-02-01
Completion: 2024-12-31
Conditions
Liver Cirrhosis Fibrosis End Stage Liver Disease Digestive System Disease Physiological Effect of Drugs Growth Hormone Treatment Sarcopenia
Interventions
DRUG
No Results Yet
NCT05234372 | COMPLETED | NA
468 Participants

MiVacunaLA: an Intervention to Improve COVID-19 Vaccination Behaviors Among Latinos

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-06-01
Completion: 2022-11-30
Conditions
COVID-19 Pandemic
Interventions
BEHAVIORAL
No Results Yet
NCT05232643 | RECRUITING
720 Participants

A Study Evaluating the Associations Between Clinical Characteristics and Use of Oral Anticoagulants in Italian Elderly Participants With Non-Valvular Atrial Fibrillation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2020-07-09
Completion: 2026-01-30
Conditions
Non-Valvular Atrial Fibrillation (NVAF)
No Results Yet
NCT05220631 | ACTIVE_NOT_RECRUITING | NA
369 Participants

Digital Nutrition Intervention for Older Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-06-01
Completion: 2024-09-30
Conditions
Nutrition Poor Physical Inactivity Social Isolation
Interventions
BEHAVIORAL
No Results Yet
NCT05217927 | COMPLETED | PHASE4
1415 Participants

Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-03-04
Completion: 2024-10-22
Conditions
Migraine
Interventions
DRUG
Results Available
NCT05211830 | COMPLETED | PHASE1/PHASE2
9 Participants

A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-12-07
Completion: 2025-06-10
Conditions
Netherton Syndrome
Interventions
DRUG
No Results Yet
NCT05195138 | RECRUITING | NA
96 Participants

Mindfulness-Based Diabetes Education for Adults With Elevated Diabetes Distress

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2023-05-31
Completion: 2025-12-31
Conditions
Type 2 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05195060 | COMPLETED
1178 Participants

TURN-COVID Biobank: The Dutch Cohort Study for the Evaluation of the Use of Neutralizing Monoclonal Antibodies and Other Antiviral Agents Against SARS-CoV-2

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2021-12-14
Completion: 2025-09-01
Conditions
COVID-19
Interventions
DRUG
No Results Yet
NCT05165433 | COMPLETED | PHASE1
14 Participants

Study of NG-350A Plus Pembrolizumab in Metastatic or Advanced Epithelial Tumours (FORTIFY)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-04-13
Completion: 2025-08-29
Conditions
Epithelial Tumor Metastatic Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT05161598 | NO_LONGER_AVAILABLE

Pre-approval Access Single Patient Request for Teclistamab (JNJ-64007957)

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-16
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05156398 | RECRUITING | PHASE3
640 Participants

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-02-28
Completion: 2031-11-29
Conditions
Migraine
Interventions
DRUG
No Results Yet
NCT05155332 | RECRUITING | PHASE1
190 Participants

A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-03-28
Completion: 2027-12-13
Conditions
Solid Tumors
Interventions
DRUG
No Results Yet
NCT05143931 | ACTIVE_NOT_RECRUITING | NA
503 Participants

Avoid and Resist Strategies for Weight Management

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-06-06
Completion: 2026-12-01
Conditions
Obesity Overweight
Interventions
BEHAVIORAL
No Results Yet
NCT05133492 | ACTIVE_NOT_RECRUITING | NA
46 Participants

First In Human Study for Small to Medium-sized Abdominal Aortic Aneurysm (AAA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2019-06-24
Completion: 2026-12-31
Conditions
Abdominal Aortic Aneurysm AAA Dilation Aorta
Interventions
DEVICE
No Results Yet
NCT05120635 | RECRUITING | NA
80 Participants

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-10-01
Completion: 2026-06-30
Conditions
Fear GAD Emotional Memory PTSD
Interventions
DEVICE BEHAVIORAL
No Results Yet
NCT05117515 | COMPLETED
200 Participants

Retrospective Study of the Uni-Graft® K DV Patch in the Clinical Routine

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2022-04-27
Completion: 2024-11-27
Conditions
Femoral Artery Stenosis Iliac Artery Stenosis Carotid Artery Stenosis
Interventions
DEVICE
No Results Yet
NCT05116943 | RECRUITING
100 Participants

Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2013-08-19
Completion: 2030-01-31
Conditions
Amyotrophic Lateral Sclerosis
No Results Yet
NCT05107219 | ACTIVE_NOT_RECRUITING | PHASE1
43 Participants

GCC Agonist Signal in the Small Intestine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-11-30
Completion: 2026-02-28
Conditions
Barrett Esophagus Gastroesophageal Reflux Disease Malignant Digestive System Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT05097274 | RECRUITING
50 Participants

The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2015-10-15
Completion: 2027-12-31
Conditions
Prostate Cancer BRCA Mutation Mismatch Repair Gene Mutation ATM Gene Mutation HOXB13 Germline Mutation CHEK2 Gene Mutation PALB2 Gene Mutation
Interventions
OTHER
No Results Yet
NCT05083364 | COMPLETED | PHASE1/PHASE2
62 Participants

Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-02-01
Completion: 2025-05-05
Conditions
C3 Glomerulopathy IgA Nephropathy
Interventions
DRUG
No Results Yet
NCT05077332 | COMPLETED | PHASE2
4 Participants

LEAP-CT for Treatment of COVID-19 Patients (Master Protocol)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-12-29
Completion: 2025-11-10
Conditions
2019 Novel Coronavirus Disease 2019 Novel Coronavirus Infection 2019-nCoV Disease 2019-nCoV Infection COVID-19 Pandemic COVID-19 Virus Disease COVID-19 Virus Infection Covid19 Coronavirus Disease 2019 SARS-CoV-2 Infection SARS-CoV-2 Acute Respiratory Disease COVID-19
Interventions
DRUG OTHER
No Results Yet
NCT05065580 | COMPLETED | NA
25 Participants

OMT as an Adjunctive Treatment in MDD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-03-12
Completion: 2023-03-23
Conditions
Major Depressive Disorder
Interventions
PROCEDURE
No Results Yet
NCT05032261 | COMPLETED
100 Participants

ICU Norepinephrine Load

Study Type: OBSERVATIONAL
Last Updated: 2025-12-16
Start Date: 2021-09-01
Completion: 2024-12-31
Conditions
Circulatory Collapse and Shock
Interventions
DRUG
No Results Yet
NCT05024773 | RECRUITING | PHASE3
112 Participants

Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-12-29
Completion: 2026-03-31
Conditions
Bladder Carcinoma in Situ (CIS)
Interventions
DRUG
No Results Yet
NCT05001347 | COMPLETED | PHASE2
25 Participants

A Clinical Study of TJ004309 With Atezolizumab (TECENTRIQ®) in Patients With Ovarian Cancer and Selected Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-11-02
Completion: 2023-02-08
Conditions
Ovarian Cancer Head and Neck Cancer Non Small Cell Lung Cancer Gastrointestinal Cancer Triple Negative Breast Cancer Ovarian Carcinoma
Interventions
DRUG
Results Available
NCT05000866 | ACTIVE_NOT_RECRUITING | NA
484 Participants

Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-10-13
Completion: 2026-05-31
Conditions
Substance Use HIV Infections
Interventions
BEHAVIORAL
No Results Yet
NCT04987489 | COMPLETED | PHASE2
53 Participants

A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2022-03-28
Completion: 2025-09-03
Conditions
Sickle Cell Disease Thalassemia
Interventions
DRUG
No Results Yet
NCT04985695 | RECRUITING | NA
110 Participants

Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-10-11
Completion: 2028-10-10
Conditions
Laparotomy
Interventions
DRUG PROCEDURE
No Results Yet
NCT04973137 | TERMINATED | PHASE3
208 Participants

A Study to Evaluate the Efficacy and Safety of Birtamimab in Mayo Stage IV Patients With AL Amyloidosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2021-08-30
Completion: 2025-04-02
Conditions
Light Chain (AL) Amyloidosis
Interventions
DRUG OTHER
Results Available
NCT04958694 | COMPLETED | NA
36 Participants

CEDARS Intervention: A Coping, Emotional Development, & Stress Reduction Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-16
Start Date: 2024-02-29
Completion: 2024-12-24
Conditions
Adolescent Behavior Stress Reduction Adverse Childhood Experiences Positive Attitude
Interventions
BEHAVIORAL
No Results Yet
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