Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
NCT ID: NCT05120635
Last Updated: 2025-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2021-10-01
2026-06-30
Brief Summary
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The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
DOUBLE
Study Groups
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EMU Participants
Subjects participating in the study at the Epilepsy Monitoring Unity (EMU).
Deep Brain Stimulation
Deep brain stimulation will be used
Virtual and augmented reality tasks
Virtual and augmented reality tasks will be used.
RNS Participants
Subjects with RNS implants.
Deep Brain Stimulation
Deep brain stimulation will be used
Virtual and augmented reality tasks
Virtual and augmented reality tasks will be used.
Interventions
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Deep Brain Stimulation
Deep brain stimulation will be used
Virtual and augmented reality tasks
Virtual and augmented reality tasks will be used.
Eligibility Criteria
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Inclusion Criteria
* Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
* Willing to provide informed consent and participate in the study
* Ability to read and write English fluently
Exclusion Criteria
* Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
* Pregnant women
* Participants with active psychosis
* Participants with suicidal ideation
* Participants with substance abuse issues
18 Years
70 Years
ALL
Yes
Sponsors
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National Institutes of Health (NIH)
NIH
VA Greater Los Angeles Healthcare System
FED
NeuroPace
INDUSTRY
National Institute of Mental Health (NIMH)
NIH
Duke University
OTHER
Responsible Party
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Principal Investigators
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Nanthia Suthana, PhD
Role: PRINCIPAL_INVESTIGATOR
Duke Health
Locations
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University of California Los Angeles
Los Angeles, California, United States
Duke University Health System
Durham, North Carolina, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Pro00117931
Identifier Type: OTHER
Identifier Source: secondary_id
PRO00118015
Identifier Type: -
Identifier Source: org_study_id