Clinical Trials

NCT05199571 | COMPLETED | PHASE4

99 Participants

Study of Efficacy and Safety of Ofatumumab in Relapsing Multiple Sclerosis (RMS) Patients in China

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-07-22

Completion: 2025-02-13

Conditions

Relapsing Multiple Sclerosis

Interventions

BIOLOGICAL

Results Available

NCT05172596 | TERMINATED | PHASE2

146 Participants

PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-03-03

Completion: 2025-05-21

Conditions

Multiple Myeloma

Interventions

BIOLOGICAL

No Results Yet

NCT05171647 | ACTIVE_NOT_RECRUITING | PHASE3

242 Participants

A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-04-25

Completion: 2025-02-17

Conditions

Non-Hodgkin Lymphoma

Interventions

DRUG

No Results Yet

NCT05170412 | RECRUITING

80 Participants

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2022-05-26

Completion: 2026-12-31

Conditions

Sickle Cell Disease

No Results Yet

NCT05161169 | COMPLETED | NA

500 Participants

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-12-21

Completion: 2025-06-30

Conditions

Genetic Predisposition to Disease Hereditary Diseases

Interventions

GENETIC

No Results Yet

NCT05156398 | RECRUITING | PHASE3

640 Participants

Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-02-28

Completion: 2031-11-29

Conditions

Migraine

Interventions

DRUG

No Results Yet

NCT05146739 | ACTIVE_NOT_RECRUITING | PHASE1

8 Participants

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-10

Completion: 2025-03-31

Conditions

Acute Myeloid Leukemia Post Cytotoxic Therapy Myelodysplastic Syndrome Post Cytotoxic Therapy Myeloid Leukemia Associated With Down Syndrome Recurrent Acute Myeloid Leukemia Recurrent Mixed Phenotype Acute Leukemia Recurrent Myelodysplastic Syndrome Refractory Acute Myeloid Leukemia Refractory Mixed Phenotype Acute Leukemia Refractory Myelodysplastic Syndrome

Interventions

DRUG

No Results Yet

NCT05145062 | ACTIVE_NOT_RECRUITING

8 Participants

Long - Term Follow Up of Sickle Cell Disease and Beta-thalassemia Subjects Previously Exposed to BIVV003 or ST-400.

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2021-12-21

Completion: 2038-07-14

Conditions

Blood and Lymphatic Diseases

Interventions

DRUG

No Results Yet

NCT05142189 | RECRUITING | PHASE1

280 Participants

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-06-17

Completion: 2030-02-28

Conditions

Non-Small Cell Lung Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT05141019 | ACTIVE_NOT_RECRUITING | NA

492 Participants

Trial of Preemptive Pharmacogenetics in Underserved Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-08-01

Completion: 2025-09-08

Conditions

Use of Prescription Medications Pharmacogenetic Testing

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05133531 | RECRUITING | PHASE3

190 Participants

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-08-01

Completion: 2027-01-28

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Interventions

DRUG

No Results Yet

NCT05119335 | TERMINATED | PHASE1/PHASE2

120 Participants

A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-26

Completion: 2025-08-22

Conditions

ccRCC Clear Cell Renal Cell Carcinoma Kidney Cancer Kidney Neoplasms Renal Cancer Renal Neoplasms Recurrent Renal Cell Carcinoma Metastatic Renal Cell Carcinoma Refractory Renal Cell Carcinoma Advanced Renal Cell Carcinoma Hypoxia Renal Cell Carcinoma Hypoxia Inducible Factor (HIF) HIF2α Inhibitor Hypoxia Inducible Factor 2 Alpha (HIF-2 Alpha) Hypoxia Inducible Factor 2α (HIF-2α) Clear Cell

Interventions

DRUG

No Results Yet

NCT05116163 | COMPLETED | NA

201 Participants

Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-06-17

Completion: 2024-09-27

Conditions

Systemic Lupus Erythematosus Rheumatoid Arthritis Inflammatory Arthritis Osteoarthritis

Interventions

BEHAVIORAL OTHER

Results Available

NCT05112679 | COMPLETED | NA

6 Participants

Limb Health and Socket Pressure in Response to Powered Ankle Protheses

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-11-15

Completion: 2023-07-19

Conditions

Pressure Ulcer, Ankle Prosthesis User Prosthesis Durability Mobility Limitation Skin Wound Amputation; Traumatic, Foot Amputation Limb Deficiencies

Interventions

DEVICE

Results Available

NCT05109728 | RECRUITING | PHASE1

60 Participants

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-05-10

Completion: 2026-06-05

Conditions

Glioblastoma

Interventions

DRUG OTHER

No Results Yet

NCT05099965 | COMPLETED | PHASE2

90 Participants

Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-11-02

Completion: 2024-11-08

Conditions

Cytomegalovirus Infections HIV Infections Vaccine

Interventions

BIOLOGICAL

No Results Yet

NCT05099172 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

370 Participants

First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-25

Completion: 2026-11-30

Conditions

Advanced Non-small Cell Lung Cancer EGFR Mutation HER2 Mutation

Interventions

DRUG

No Results Yet

NCT05099003 | RECRUITING | PHASE1/PHASE2

132 Participants

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-05-31

Completion: 2027-06-30

Conditions

Malignant Glioma

Interventions

PROCEDURE RADIATION DRUG

No Results Yet

NCT05094115 | RECRUITING | NA

600 Participants

Enhancing Resiliency and Optimizing Readiness in Military Personnel

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-04

Completion: 2026-09-30

Conditions

Resilience, Psychological Stress, Physiological

Interventions

BEHAVIORAL

No Results Yet

NCT05085548 | ACTIVE_NOT_RECRUITING | PHASE1

58 Participants

ProAgio in Previously Treated Advanced Pancreatic Cancer and Other Solid Tumor Malignancies

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-29

Completion: 2025-12-31

Conditions

Advanced Pancreatic Cancer Solid Tumor Malignancies

Interventions

DRUG

No Results Yet

NCT05076266 | TERMINATED

14 Participants

COVID-19 Related Financial Hardship and Distress in Women Who Decline TMIST (EA1151) Participation

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2022-03-14

Completion: 2023-02-02

Conditions

Breast Cancer, NOS

Interventions

OTHER

Results Available

NCT05065047 | TERMINATED | PHASE1

6 Participants

Belantamab Mafadotin Maintenance Therapy After Salvage Autologous Hematopoietic Cell Transplantation in Patients With Relapse Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-01-05

Completion: 2025-11-06

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05047263 | ACTIVE_NOT_RECRUITING | PHASE3

1584 Participants

A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-09-21

Completion: 2026-01-05

Conditions

Non-diabetic Chronic Kidney Disease

Interventions

DRUG

No Results Yet

NCT05037500 | TERMINATED | PHASE1

8 Participants

Decitabine/Cedazuridine and Enzalutamide for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-01-26

Completion: 2024-12-17

Conditions

Castration-Resistant Prostate Carcinoma Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8

Interventions

DRUG

No Results Yet

NCT05036278 | COMPLETED | PHASE4

21 Participants

Prophylaxis Regimen for Hemophilia A Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-07-28

Completion: 2024-09-12

Conditions

Hemophilia A Prophylaxis of Bleeding

Interventions

BIOLOGICAL

Results Available

NCT05019664 | RECRUITING

100 Participants

Affixus Natural Nail System Humeral Nail PMCF

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2022-08-29

Completion: 2027-08-31

Conditions

Humeral Fractures, Proximal Humeral Fractures

Interventions

DEVICE

No Results Yet

NCT04982393 | RECRUITING

200 Participants

BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2021-12-13

Completion: 2028-09-01

Conditions

Primary Hyperoxaluria Type 1

No Results Yet

NCT04973605 | RECRUITING | PHASE1/PHASE2

246 Participants

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-09-16

Completion: 2026-11-30

Conditions

Relapsed/Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04958239 | RECRUITING | PHASE1

160 Participants

A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-18

Completion: 2026-07-28

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT04949542 | COMPLETED | NA

60 Participants

Bolster: Caregiver App to Reduce Duration of Untreated Psychosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-08-11

Completion: 2024-10-04

Conditions

Caregiver to a Young Adult With Early Psychosis

Interventions

BEHAVIORAL

Results Available

NCT04938817 | RECRUITING | PHASE1/PHASE2

110 Participants

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-08-19

Completion: 2026-05-20

Conditions

Small Cell Lung Carcinoma

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04925453 | COMPLETED | NA

56 Participants

tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-01-19

Completion: 2025-06-30

Conditions

Brain Concussion Brain Trauma Attention Concentration Difficulty Brain Injuries Brain Injuries, Traumatic Neurocognitive Dysfunction Attention Impaired Memory Impairment Mild Traumatic Brain Injury Mild Cognitive Impairment

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04924088 | ACTIVE_NOT_RECRUITING | NA

85 Participants

Medical-legal Partnerships to Prevent Evictions and Homelessness Among Veterans

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2022-02-01

Completion: 2026-03-01

Conditions

Homelessness Mental Health

Interventions

BEHAVIORAL

No Results Yet

NCT04923178 | RECRUITING

1100 Participants

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2022-10-24

Completion: 2041-12-01

Conditions

Urothelial Cancer Bladder Cancer Genitourinary Cancer Urogenital Neoplasms Urogenital Cancer

No Results Yet

NCT04922307 | ACTIVE_NOT_RECRUITING | NA

240 Participants

Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-07-23

Completion: 2025-02-12

Conditions

Kidney Cancer

Interventions

PROCEDURE

No Results Yet

NCT04910269 | RECRUITING | PHASE3

820 Participants

Outpatient Treatment With Anti-Coronavirus Immunoglobulin

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-08-06

Completion: 2026-08-01

Conditions

COVID SARS-CoV2 Infection Covid19

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT04906434 | RECRUITING | PHASE1

200 Participants

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-02-26

Completion: 2027-12-31

Conditions

Advanced Liver Cancer

Interventions

DRUG

No Results Yet

NCT04874519 | COMPLETED

12 Participants

Registry to Collect Health Information Related to Fibrolamellar Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2021-11-24

Completion: 2025-11-10

Conditions

Fibrolamellar Cancer FLC Liver Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04867837 | RECRUITING | PHASE3

260 Participants

Study of OCTAPLEX in Patients With Acute Major Bleeding on DOAC Therapy With Factor Xa Inhibitor

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-09-01

Completion: 2026-12-31

Conditions

Acute Major Bleeding

Interventions

DRUG

No Results Yet

NCT04851288 | ACTIVE_NOT_RECRUITING | PHASE2

112 Participants

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-04-02

Completion: 2025-12-31

Conditions

Aging

Interventions

DIETARY_SUPPLEMENT

No Results Yet