Clinical Trials

NCT06586112 | ACTIVE_NOT_RECRUITING | PHASE3
840 Participants

A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-25
Completion: 2025-09-19
Conditions
Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT06585774 | RECRUITING | PHASE3
240 Participants

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-21
Completion: 2027-09-28
Conditions
Chronic Graft-versus-host-disease
Interventions
DRUG
No Results Yet
NCT06581406 | RECRUITING | PHASE2/PHASE3
280 Participants

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-17
Completion: 2030-01-31
Conditions
Metastatic Uveal Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT06577025 | ACTIVE_NOT_RECRUITING | PHASE2
43 Participants
NCT06576427 | RECRUITING | NA
145 Participants

Selective Pulmonary-artery Intervention to Reduce Acute Right-heart tEnsion-II

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-15
Completion: 2026-02-28
Conditions
Pulmonary Embolism
Interventions
DEVICE
No Results Yet
NCT06576076 | RECRUITING | NA
200 Participants

Cannabis, Linked Emotions, and Adolescent Risk Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-18
Completion: 2028-12-31
Conditions
Cannabis Use Depression Suicidal Ideation Adolescent Behavior
Interventions
BEHAVIORAL
No Results Yet
NCT06575192 | RECRUITING | PHASE3
783 Participants

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-11-05
Completion: 2029-12-31
Conditions
Breast Reconstruction
Interventions
DEVICE OTHER
No Results Yet
NCT06571383 | ACTIVE_NOT_RECRUITING | PHASE4
500 Participants

STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-09-17
Completion: 2028-11-15
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT06567717 | RECRUITING | PHASE2
60 Participants

Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-11-03
Completion: 2027-01-31
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG OTHER
No Results Yet
NCT06552741 | RECRUITING
10000 Participants

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2024-09-04
Completion: 2045-01-01
Conditions
Substance Use Disorder Alcohol Use Disorder
No Results Yet
NCT06550895 | ACTIVE_NOT_RECRUITING | PHASE2
11 Participants

A Study of Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants With High-Risk Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-09-16
Completion: 2026-08-31
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT06549595 | RECRUITING | PHASE3
1015 Participants

A Study of AZD0486 Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-07
Completion: 2031-11-26
Conditions
Untreated Follicular Lymphoma
Interventions
DRUG
No Results Yet
NCT06549036 | NOT_YET_RECRUITING | NA
228 Participants

Veteran Peer Navigators to Promote Shared Decision Making for PSA Screening

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-01-05
Completion: 2028-03-01
Conditions
Prostate Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT06548360 | RECRUITING | PHASE3
180 Participants

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-01-24
Completion: 2026-08-10
Conditions
NonSegmental Vitiligo
Interventions
DRUG
No Results Yet
NCT06547489 | RECRUITING | PHASE2
164 Participants

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-03
Completion: 2026-08-31
Conditions
Major Depressive Disorder
Interventions
DRUG
No Results Yet
NCT06545682 | RECRUITING | PHASE1
50 Participants

Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-15
Completion: 2027-08-03
Conditions
Melanoma (Skin Cancer) Breast Cancer Brain Metastasases
Interventions
DRUG
No Results Yet
NCT06544616 | RECRUITING | PHASE2
498 Participants

A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-22
Completion: 2031-07-17
Conditions
Preclinical Alzheimer's Disease
Interventions
DRUG
No Results Yet
NCT06540144 | ENROLLING_BY_INVITATION | PHASE3
12 Participants

An Extension Study Evaluating 6-week Treatment Cycles of Rozanolixizumab in Pediatric Study Participants With Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-08
Completion: 2027-08-17
Conditions
Generalized Myasthenia Gravis
Interventions
DRUG
No Results Yet
NCT06535178 | RECRUITING | NA
30 Participants

The Influence of Sleep on Cardiovascular Outcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-01
Completion: 2026-09-30
Conditions
Circadian Rhythm Cardiometabolic Health Vascular Health Pain
Interventions
BEHAVIORAL
No Results Yet
NCT06533098 | RECRUITING | PHASE3
50 Participants

A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-02-10
Completion: 2027-12-15
Conditions
Thrombocytopenia, Neonatal Alloimmune
Interventions
DRUG
No Results Yet
NCT06529835 | RECRUITING | NA
80 Participants

A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-03-21
Completion: 2027-12-31
Conditions
Peripheral Nerve Injuries
Interventions
DEVICE
No Results Yet
NCT06528496 | RECRUITING | PHASE2
45 Participants

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-22
Completion: 2029-07-22
Conditions
High-risk Neuroblastoma Neuroblastoma Childhood Neuroblastoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06527872 | RECRUITING
300 Participants

Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-04
Completion: 2029-03-29
Conditions
Lupus Nephritis
Interventions
OTHER
No Results Yet
NCT06524973 | RECRUITING | NA
136 Participants

Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-07
Completion: 2027-05-03
Conditions
Metastatic Pancreatic Adenocarcinoma
Interventions
OTHER
No Results Yet
NCT06517758 | RECRUITING | PHASE3
146 Participants

A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 75 Years With gMG.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-31
Completion: 2026-12-28
Conditions
Generalized Myasthenia Gravis
Interventions
DRUG OTHER
No Results Yet
NCT06516965 | RECRUITING | PHASE3
330 Participants

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-10
Completion: 2026-10-19
Conditions
Prurigo Nodularis
Interventions
DRUG
No Results Yet
NCT06516952 | RECRUITING | PHASE3
330 Participants

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-10
Completion: 2026-10-19
Conditions
Prurigo Nodularis
Interventions
DRUG
No Results Yet
NCT06504914 | RECRUITING | NA
24 Participants

Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-02-05
Completion: 2026-06-30
Conditions
Hypertension Obesity Nutrition, Healthy
Interventions
BEHAVIORAL
No Results Yet
NCT06501625 | RECRUITING | PHASE1/PHASE2
52 Participants

Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-16
Completion: 2026-07-23
Conditions
Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation
Interventions
DRUG
No Results Yet
NCT06500884 | RECRUITING | PHASE2
130 Participants

A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicity

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-26
Completion: 2026-04-15
Conditions
Relapse Multiple Myeloma Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT06500455 | RECRUITING | PHASE3
269 Participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-12
Completion: 2028-06-30
Conditions
Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Breast Carcinoma Metastatic Digestive System Carcinoma Metastatic Lung Non-Small Cell Carcinoma Metastatic Malignant Neoplasm in the Brain Metastatic Malignant Solid Neoplasm Metastatic Melanoma Metastatic Renal Cell Carcinoma Stage IV Lung Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8
Interventions
PROCEDURE RADIATION
No Results Yet
NCT06479447 | RECRUITING | NA
17000 Participants

Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-15
Completion: 2026-07-14
Conditions
PTSD
Interventions
OTHER
No Results Yet
NCT06478160 | RECRUITING | NA
216 Participants

Closed-blood Sampling Devices in the Adult Critically Ill Patient

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-11-11
Completion: 2026-06-07
Conditions
Acceptability of Health Care
Interventions
DEVICE OTHER
No Results Yet
NCT06477289 | RECRUITING
65 Participants

Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2024-09-16
Completion: 2027-06-30
Conditions
Sickle Cell Disease
No Results Yet
NCT06472245 | RECRUITING | PHASE3
363 Participants

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-03
Completion: 2027-12-15
Conditions
Patients With Non-Small Cell Lung Cancer
Interventions
DRUG DEVICE
No Results Yet
NCT06472128 | RECRUITING | NA
200 Participants

Novel Digital Application for Patients With Acute Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-10-21
Completion: 2029-04-30
Conditions
Relapsed Adult Acute Myeloid Leukemia Primary Refractory Acute Myeloid Leukemia High Risk Acute Myeloid Leukemia
Interventions
BEHAVIORAL
No Results Yet
NCT06469944 | RECRUITING | PHASE1/PHASE2
130 Participants

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-09-20
Completion: 2027-01-17
Conditions
Gastroesophageal Junction Gastroesophageal Adenocarcinoma Esophageal Neoplasms Esophageal Cancer
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06469151 | COMPLETED | PHASE1
84 Participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-06-24
Completion: 2025-10-22
Conditions
Healthy Participants
Interventions
DRUG
No Results Yet
NCT06464926 | RECRUITING | NA
148 Participants

Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-06-23
Completion: 2030-06-30
Conditions
Nausea Vomiting
Interventions
DEVICE
No Results Yet
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