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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05800405 | RECRUITING | EARLY_PHASE1
9 Participants

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-20
Completion: 2026-01-13
Conditions
Recurrent Diffuse Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma
Interventions
PROCEDURE BIOLOGICAL RADIATION
No Results Yet
NCT05799105 | RECRUITING | PHASE4
122 Participants

OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-14
Completion: 2025-12-23
Conditions
Marginal Ulcer
Interventions
DRUG
No Results Yet
NCT05798117 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
21 Participants

An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractory Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-02-28
Completion: 2026-09-09
Conditions
Systemic Lupus Erythematosus Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05797168 | RECRUITING | PHASE1/PHASE2
506 Participants

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-05
Completion: 2028-01-06
Conditions
Ovarian Cancer Lung Adenocarcinoma Endometrial Cancer
Interventions
DRUG
No Results Yet
NCT05796375 | RECRUITING | NA
240 Participants

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-11-17
Completion: 2028-11-30
Conditions
Non-muscle-invasive Bladder Cancer
Interventions
PROCEDURE DIAGNOSTIC_TEST
No Results Yet
NCT05794997 | COMPLETED
817337 Participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2022-11-30
Completion: 2023-01-01
Conditions
Hypertension
Interventions
DRUG
Results Available
NCT05789082 | RECRUITING | PHASE1/PHASE2
240 Participants

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-20
Completion: 2032-01-29
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05784441 | RECRUITING | PHASE1
20 Participants

A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/r B-NHL)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-11-06
Completion: 2037-10-30
Conditions
Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
NCT05776030 | RECRUITING | NA
30 Participants

Multi-speed Ergonomic Wheelchair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-18
Completion: 2026-02-27
Conditions
Spinal Cord Diseases Spinal Cord Injuries
Interventions
DEVICE
No Results Yet
NCT05773040 | RECRUITING | PHASE1
33 Participants

A Phase 1 Study of JV-213 Autologous CD79b-targeting Chimeric Antigen Receptor T-cell Therapy in Adults With Relapsed or Refractory B-cell Lymphomas

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-14
Completion: 2025-12-31
Conditions
Lymphomas B-cell Lymphomas
Interventions
DRUG PROCEDURE
No Results Yet
NCT05768945 | COMPLETED
742670 Participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2022-11-30
Completion: 2023-07-07
Conditions
Diabetes
Interventions
DRUG
Results Available
NCT05766852 | COMPLETED | NA
31 Participants

Potential Benefits of the Somatic Psychoeducational Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-10-23
Completion: 2024-04-11
Conditions
Work Related Stress
Interventions
BEHAVIORAL
No Results Yet
NCT05764135 | COMPLETED | NA
33 Participants

SCI-Lynx: A Mobile Platform for Physical Activity Social Support for People With SCI Pilot Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-14
Completion: 2024-10-01
Conditions
Spinal Cord Injuries
Interventions
BEHAVIORAL
No Results Yet
NCT05761951 | ACTIVE_NOT_RECRUITING | PHASE2
8 Participants

Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-29
Completion: 2027-01-31
Conditions
Endometrial Cancer
Interventions
DRUG
No Results Yet
NCT05757869 | ACTIVE_NOT_RECRUITING | PHASE3
20296 Participants

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-11
Completion: 2026-10-31
Conditions
Atrial Fibrillation
Interventions
DRUG
No Results Yet
NCT05754957 | RECRUITING | PHASE3
16000 Participants

A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-07
Completion: 2026-09-07
Conditions
Acute Coronary Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT05742802 | RECRUITING | PHASE3
1869 Participants

Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-06
Completion: 2026-06-16
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05739981 | RECRUITING | PHASE1/PHASE2
50 Participants

Phase II IMNN-001 (Also Known as GEN-1) on SLL With BEV and NACT, Newly Diagnosed Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-02-10
Completion: 2026-08-30
Conditions
Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer
Interventions
DRUG
No Results Yet
NCT05731544 | COMPLETED | PHASE1/PHASE2
443 Participants

Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-08-17
Completion: 2024-11-18
Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG
No Results Yet
NCT05724121 | RECRUITING
135 Participants

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-01
Completion: 2027-04-08
Conditions
Chronic Lymphocytic Leukemia (CLL) Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia Mantle Cell Lymphoma Sudden Cardiac Death Cardiac Arrhythmias Hematologic Malignancies
No Results Yet
NCT05715281 | ACTIVE_NOT_RECRUITING | PHASE2
15 Participants

Testing the Combination of Anti-cancer Drugs Atezolizumab and Tiragolumab in People With Advanced Stage Rare Cancers, RARE3 Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-26
Completion: 2026-10-15
Conditions
Advanced Rare Malignant Solid Neoplasm Rare Malignant Solid Neoplasm Refractory Rare Malignant Solid Neoplasm
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT05714202 | ACTIVE_NOT_RECRUITING | PHASE3
1135 Participants

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guรฉrin (BCG) in Participants With BCG-naรฏve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-23
Completion: 2029-09-18
Conditions
Bladder Cancer
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05711940 | ACTIVE_NOT_RECRUITING | PHASE3
572 Participants

Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-02-14
Completion: 2026-02-28
Conditions
Treatment Resistant Depression
Interventions
DRUG
No Results Yet
NCT05707377 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
178 Participants

A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-17
Completion: 2027-10-31
Conditions
Primary Membranous Nephropathy
Interventions
DRUG
No Results Yet
NCT05704361 | RECRUITING | PHASE1
129 Participants

A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-08-11
Completion: 2027-07-08
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05702034 | RECRUITING | PHASE3
15000 Participants

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-02-15
Completion: 2026-11-11
Conditions
Ischemic Stroke; Ischemic Attack, Transient
Interventions
DRUG
No Results Yet
NCT05693142 | RECRUITING | PHASE2/PHASE3
65 Participants

AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-01-04
Completion: 2026-02-28
Conditions
Duchenne Muscular Dystrophy
Interventions
GENETIC
No Results Yet
NCT05691270 | COMPLETED | NA
35 Participants

Contraception Navigator Program

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-28
Completion: 2025-09-01
Conditions
Contraception Contraceptive Usage Health Care Utilization
Interventions
BEHAVIORAL
No Results Yet
NCT05682326 | COMPLETED | PHASE3
4 Participants

Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-06
Completion: 2024-10-18
Conditions
Anaemia
Interventions
DRUG
Results Available
NCT05675410 | RECRUITING | PHASE3
1875 Participants

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-05-11
Completion: 2031-04-28
Conditions
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Interventions
PROCEDURE BIOLOGICAL DRUG OTHER RADIATION
No Results Yet
NCT05674799 | RECRUITING | NA
403 Participants

NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-08
Completion: 2027-05-31
Conditions
Overweight or Obesity
Interventions
BEHAVIORAL
No Results Yet
NCT05669664 | ACTIVE_NOT_RECRUITING | PHASE2
21 Participants

Testing the Anti-cancer Drug Darolutamide in Patients With Testosterone-Driven Salivary Gland Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-20
Completion: 2027-04-11
Conditions
Locally Advanced Salivary Gland Carcinoma Metastatic Salivary Gland Carcinoma Recurrent Salivary Gland Carcinoma Unresectable Salivary Gland Carcinoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT05661942 | COMPLETED | PHASE4
92 Participants

Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-11-30
Completion: 2024-11-20
Conditions
Atrial Fibrillation With Rapid Ventricular Response Hypotension Drug-Induced
Interventions
DRUG OTHER
Results Available
NCT05652335 | RECRUITING | PHASE1
180 Participants

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-11-22
Completion: 2027-04-19
Conditions
Relapsed or Refractory Multiple Myeloma Previously Treated Amyloid Light-chain (AL) Amyloidosis
Interventions
DRUG
No Results Yet
NCT05648630 | WITHDRAWN | NA
0 Participants

Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-03
Completion: 2025-10-01
Conditions
Peripheral Artery Disease (D058729) Oxidative Stress (D018384) Inflammation (D007249)
Interventions
DIETARY_SUPPLEMENT BEHAVIORAL
No Results Yet
NCT05647122 | RECRUITING | PHASE1
403 Participants

First in Human Study of AZD9592 in Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-12-22
Completion: 2027-10-06
Conditions
Advanced Solid Tumours Carcinoma Non-small Cell Lung Head and Neck Neoplasms Colorectal Neoplasms
Interventions
DRUG
No Results Yet
NCT05645406 | COMPLETED | EARLY_PHASE1
8 Participants

Estrogen Hormone Products

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-05-14
Completion: 2025-06-12
Conditions
Menopause
Interventions
DRUG
No Results Yet
NCT05632809 | RECRUITING | PHASE2
39 Participants

REStoring lymphoCytes Using NKTR-255* After chemoradiothErapy in Solid Tumors (RESCUE)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-01-10
Completion: 2025-12-31
Conditions
Lung Cancer
Interventions
DRUG
No Results Yet
NCT05627635 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
20 Participants

FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-05-03
Completion: 2026-06-23
Conditions
Metastatic Colon Adenocarcinoma Metastatic Colorectal Adenocarcinoma Metastatic Microsatellite Stable Colorectal Carcinoma Metastatic Rectal Adenocarcinoma Stage IV Colon Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Rectal Cancer AJCC v8
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT05624996 | RECRUITING | PHASE3
474 Participants

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-12
Completion: 2031-10-15
Conditions
Locally Advanced Lung Non-Small Cell Carcinoma Stage IIB Lung Cancer AJCC v8 Stage III Lung Cancer AJCC v8
Interventions
DRUG PROCEDURE BIOLOGICAL RADIATION OTHER
No Results Yet
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