Clinical Trials

NCT04703101 | RECRUITING | PHASE1
25 Participants

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-11
Completion: 2026-10-01
Conditions
Locally Advanced Rectal Carcinoma Rectal Adenocarcinoma Stage II Rectal Cancer AJCC v8 Stage IIA Rectal Cancer AJCC v8 Stage IIB Rectal Cancer AJCC v8 Stage IIC Rectal Cancer AJCC v8 Stage III Rectal Cancer AJCC v8 Stage IIIA Rectal Cancer AJCC v8 Stage IIIB Rectal Cancer AJCC v8 Stage IIIC Rectal Cancer AJCC v8
Interventions
DRUG RADIATION OTHER BEHAVIORAL PROCEDURE
No Results Yet
NCT04696809 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
40 Participants

A Study of Teclistamab in Japanese Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-22
Completion: 2026-04-22
Conditions
Hematologic Malignancies
Interventions
DRUG
No Results Yet
NCT04696575 | RECRUITING | PHASE2
28 Participants

Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-07-02
Completion: 2026-07-01
Conditions
Extensive Stage Lung Small Cell Carcinoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04684563 | ACTIVE_NOT_RECRUITING | PHASE1
72 Participants

huCART19-IL18 in CD19+ Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-06
Completion: 2036-05-31
Conditions
Chronic Lymphocytic Leukemia Non-hodgkin Lymphoma Acute Lymphoblastic Leukemia
Interventions
BIOLOGICAL
No Results Yet
NCT04676594 | ACTIVE_NOT_RECRUITING
400 Participants

Genentech Validation Tool for Pulmonary Fibrosis

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-04
Completion: 2026-08-31
Conditions
Interstitial Lung Disease
No Results Yet
NCT04671212 | RECRUITING
50 Participants

Discarded Bone Marrow for Hematology Research

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2022-07-26
Completion: 2030-01-31
Conditions
Hemoglobinopathies
No Results Yet
NCT04662580 | RECRUITING | PHASE1
183 Participants

ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-12-09
Completion: 2027-06-30
Conditions
Metastatic Prostate Cancer
Interventions
DRUG
No Results Yet
NCT04658862 | ACTIVE_NOT_RECRUITING | PHASE3
518 Participants

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-12-07
Completion: 2026-12-30
Conditions
Urinary Bladder Neoplasms
Interventions
BIOLOGICAL DRUG RADIATION
No Results Yet
NCT04652960 | ACTIVE_NOT_RECRUITING | PHASE1
38 Participants

Duvelisib and Nivolumab for the Treatment of Stage IIB-IVB Mycosis Fungoides and Sezary Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-10-21
Completion: 2025-12-03
Conditions
Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8 Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8 Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04644770 | RECRUITING | PHASE1
177 Participants

A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-12
Completion: 2027-10-01
Conditions
Prostatic Neoplasms Adenocarcinoma
Interventions
DRUG RADIATION
No Results Yet
NCT04641702 | RECRUITING | PHASE4
80 Participants

Comprehensive Esophageal Diagnostics Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-03-17
Completion: 2026-09-30
Conditions
Achalasia
Interventions
DRUG PROCEDURE
No Results Yet
NCT04640623 | ACTIVE_NOT_RECRUITING | PHASE2
220 Participants
NCT04634617 | ACTIVE_NOT_RECRUITING
310 Participants

Pelvic Floor Dysfunction and Quality of Life in Uterine Cancer Survivors

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-01-09
Completion: 2027-04-11
Conditions
Endometrial Carcinoma Malignant Uterine Neoplasm Uterine Corpus Cancer Uterine Corpus Sarcoma
Interventions
OTHER
No Results Yet
NCT04634552 | RECRUITING | PHASE2
510 Participants

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-01
Completion: 2026-03-31
Conditions
Hematological Malignancies
Interventions
DRUG
No Results Yet
NCT04619420 | ACTIVE_NOT_RECRUITING | PHASE2
523 Participants

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-06
Completion: 2026-02-27
Conditions
Alzheimer Disease Cognitive Dysfunction Dementia
Interventions
DRUG
No Results Yet
NCT04609566 | ACTIVE_NOT_RECRUITING | PHASE2
161 Participants

Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-26
Completion: 2026-12-31
Conditions
Melanoma Non-small Cell Lung Cancer Squamous Cell Carcinoma of the Head and Neck
Interventions
DRUG
No Results Yet
NCT04606381 | ACTIVE_NOT_RECRUITING | PHASE1
158 Participants

A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-10
Completion: 2024-07-11
Conditions
Advanced Solid Malignancies
Interventions
DRUG
No Results Yet
NCT04590326 | RECRUITING | PHASE1/PHASE2
612 Participants

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-12-08
Completion: 2027-03-25
Conditions
Ovarian Cancer Fallopian Tube Cancer Primary Peritoneal Cancer Endometrial Cancer
Interventions
DRUG
No Results Yet
NCT04586426 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
228 Participants

A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-12-15
Completion: 2025-03-18
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT04585958 | SUSPENDED | PHASE1
55 Participants

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-21
Completion: 2026-12-31
Conditions
Metastatic Malignant Solid Neoplasm Platinum-Resistant Ovarian High Grade Serous Adenocarcinoma Unresectable Malignant Solid Neoplasm
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04585685 | RECRUITING | NA
12 Participants

Healthy Recovery After Trauma Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-10
Completion: 2026-11-30
Conditions
Stress Disorders, Post-Traumatic Shame Guilt Sexual Assault and Rape
Interventions
BEHAVIORAL
No Results Yet
NCT04583891 | COMPLETED | NA
313 Participants

Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-09-27
Completion: 2024-01-16
Conditions
Depression, Anxiety Engagement, Patient
Interventions
BEHAVIORAL
NCT04577833 | ACTIVE_NOT_RECRUITING | PHASE1
136 Participants

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-13
Completion: 2021-10-15
Conditions
Prostatic Neoplasms
Interventions
DRUG
No Results Yet
NCT04569240 | COMPLETED | NA
40 Participants

Accuracy of the Dexcom G6 Continuous Glucose Monitoring System Following Cardiac Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-01
Completion: 2024-01-20
Conditions
Surgery--Complications
Interventions
DEVICE
NCT04560972 | ACTIVE_NOT_RECRUITING | PHASE1
3 Participants

LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-05-28
Completion: 2026-03-09
Conditions
Extensive Stage Lung Small Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT04557098 | ACTIVE_NOT_RECRUITING | PHASE2
194 Participants

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-17
Completion: 2025-11-30
Conditions
Hematological Malignancies
Interventions
DRUG
No Results Yet
NCT04557059 | ACTIVE_NOT_RECRUITING | PHASE3
694 Participants

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-12
Completion: 2029-08-27
Conditions
Prostatic Neoplasms
Interventions
RADIATION DRUG
No Results Yet
NCT04553770 | RECRUITING | PHASE2
88 Participants

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-09
Completion: 2026-12-31
Conditions
Early-stage Breast Cancer Hormone Receptor Positive Breast Carcinoma Invasive Breast Cancer Stage II Breast Cancer Stage IIA Breast Cancer Stage IIB Breast Cancer Stage III Breast Cancer
Interventions
DRUG PROCEDURE BIOLOGICAL
No Results Yet
NCT04551222 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
99 Participants

The Re-Prosper HF Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-09
Completion: 2025-12-31
Conditions
Heart Failure
Interventions
DRUG
No Results Yet
NCT04551092 | TERMINATED | NA
11 Participants

Neurofeedback-EEG-VR System for Non-opioid Pain Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-07
Completion: 2022-03-31
Conditions
Pain Management
Interventions
DEVICE
NCT04545866 | ACTIVE_NOT_RECRUITING | PHASE3
642 Participants

The Budesonide in Babies (BiB) Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-04-01
Completion: 2024-09-05
Conditions
Bronchopulmonary Dysplasia (BPD) Respiratory Distress Syndrome Prematurity; Extreme Neonatal
Interventions
DRUG
NCT04545424 | RECRUITING | PHASE2
340 Participants

Trial of Therapeutic Hypothermia in Patients With ARDS

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-29
Completion: 2026-08-31
Conditions
Respiratory Distress Syndrome, Adult
Interventions
DEVICE DRUG
No Results Yet
NCT04513717 | ACTIVE_NOT_RECRUITING | PHASE3
2753 Participants

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-21
Completion: 2033-12-31
Conditions
Prostate Adenocarcinoma Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8
Interventions
DRUG PROCEDURE OTHER RADIATION
No Results Yet
NCT04505267 | ACTIVE_NOT_RECRUITING | PHASE1
34 Participants

NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-10
Completion: 2026-03-31
Conditions
Recurrent Lung Non-Small Cell Carcinoma Stage I Lung Cancer AJCC v8 Stage IA1 Lung Cancer AJCC v8 Stage IA2 Lung Cancer AJCC v8 Stage IA3 Lung Cancer AJCC v8 Stage IB Lung Cancer AJCC v8 Stage II Lung Cancer AJCC v8 Stage IIA Lung Cancer AJCC v8 Stage IIB Lung Cancer AJCC v8 Stage III Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Unresectable Lung Non-Small Cell Carcinoma
Interventions
OTHER RADIATION
No Results Yet
NCT04504916 | TERMINATED | PHASE2
102 Participants

A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-07
Completion: 2023-06-12
Conditions
Triple-negative Breast Cancer Non-squamous Non-small-cell Lung Cancer NSCLC Estrogen-receptor-positive Breast Cancer Progesterone-receptor-positive Breast Cancer Estrogen-receptor-negative Breast Cancer ER-negative Breast Cancer Progesterone-receptor Negative Breast Cancer PR-negative Breast Cancer HER2-negative Breast Cancer ER-positive Breast Cancer PR-positive Breast Cancer Platinum-resistant Ovarian Cancer Gastric Cancer Pancreatic Cancer
Interventions
DRUG
NCT04499248 | RECRUITING | PHASE1/PHASE2
96 Participants

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-11-16
Completion: 2029-02-28
Conditions
Open-angle Glaucoma Ocular Hypertension
Interventions
DRUG OTHER
No Results Yet
NCT04497844 | ACTIVE_NOT_RECRUITING | PHASE3
696 Participants
NCT04485546 | COMPLETED | PHASE4
37 Participants

Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-09
Completion: 2021-09-30
Conditions
Neurotrophic Keratitis
Interventions
DRUG
NCT04484142 | ACTIVE_NOT_RECRUITING | PHASE2
137 Participants

Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-03-30
Completion: 2023-03-10
Conditions
Non-small Cell Lung Cancer
Interventions
DRUG
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