Trial Outcomes & Findings for Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design (NCT NCT04583891)

NCT ID: NCT04583891

Last Updated: 2025-11-10

Results Overview

8 item scale that measures depression symptoms on a continuous scale. Scores range from 0-24, with a higher score indicating greater severity of symptoms of depression.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 313 participants
• Primary outcome timeframe: Baseline
• Results posted on: 2025-11-10

Participant Flow

3 participants withdrew from the study shortly after being randomized to IntelliCare and never accessed the program. They are therefore not included in any IntelliCare subgroups (i.e., IntelliCare - High Engager, No Coaching; IntelliCare - Low Engager, No Coaching; IntelliCare - Low Engager, Coaching). Subgroup assignment is based on participant engagement with IntelliCare, and because these participants withdrew before engaging with the program, they do not fit into any IntelliCare subgroup.

Participant milestones

Measure	IntelliCare - Low Engager, No Coaching This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - High Engager, No Coaching This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Overall Study STARTED	38	134	34	104
Overall Study COMPLETED	33	130	32	94
Overall Study NOT COMPLETED	5	4	2	10

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design

Baseline characteristics by cohort

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.	Total n=310 Participants Total of all reporting groups
Age, Continuous	51.4 years STANDARD_DEVIATION 10.7 • n=5 Participants	50.0 years STANDARD_DEVIATION 10.9 • n=20 Participants	50.2 years STANDARD_DEVIATION 10.9 • n=40 Participants	52.2 years STANDARD_DEVIATION 10.2 • n=28 Participants	51.6 years STANDARD_DEVIATION 10.5 • n=46 Participants
Sex: Female, Male Female	134 Participants n=5 Participants	38 Participants n=20 Participants	34 Participants n=40 Participants	104 Participants n=28 Participants	310 Participants n=46 Participants
Sex: Female, Male Male	0 Participants n=5 Participants	0 Participants n=20 Participants	0 Participants n=40 Participants	0 Participants n=28 Participants	0 Participants n=46 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	10 Participants n=5 Participants	2 Participants n=20 Participants	2 Participants n=40 Participants	5 Participants n=28 Participants	19 Participants n=46 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	124 Participants n=5 Participants	36 Participants n=20 Participants	32 Participants n=40 Participants	96 Participants n=28 Participants	288 Participants n=46 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=20 Participants	0 Participants n=40 Participants	3 Participants n=28 Participants	3 Participants n=46 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=20 Participants	0 Participants n=40 Participants	0 Participants n=28 Participants	0 Participants n=46 Participants
Race (NIH/OMB) Asian	2 Participants n=5 Participants	1 Participants n=20 Participants	1 Participants n=40 Participants	0 Participants n=28 Participants	4 Participants n=46 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	1 Participants n=5 Participants	0 Participants n=20 Participants	0 Participants n=40 Participants	0 Participants n=28 Participants	1 Participants n=46 Participants
Race (NIH/OMB) Black or African American	9 Participants n=5 Participants	5 Participants n=20 Participants	4 Participants n=40 Participants	7 Participants n=28 Participants	25 Participants n=46 Participants
Race (NIH/OMB) White	120 Participants n=5 Participants	32 Participants n=20 Participants	28 Participants n=40 Participants	91 Participants n=28 Participants	271 Participants n=46 Participants
Race (NIH/OMB) More than one race	2 Participants n=5 Participants	0 Participants n=20 Participants	1 Participants n=40 Participants	5 Participants n=28 Participants	8 Participants n=46 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=20 Participants	0 Participants n=40 Participants	1 Participants n=28 Participants	1 Participants n=46 Participants

PRIMARY outcome

Timeframe: Baseline

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

8 item scale that measures depression symptoms on a continuous scale. Scores range from 0-24, with a higher score indicating greater severity of symptoms of depression.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Patient Health Questionnaire-8	12.1 score on a scale Standard Deviation 4.6	11.8 score on a scale Standard Deviation 4.1	12.5 score on a scale Standard Deviation 4.5	12.7 score on a scale Standard Deviation 4.4

PRIMARY outcome

Timeframe: Post 8 weeks

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

8 item scale that measures depression symptoms on a continuous scale. Scores range from 0-24, with a higher score indicating greater severity of symptoms of depression.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=122 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Patient Health Questionnaire-8	8.1 score on a scale Standard Deviation 5.1	10.5 score on a scale Standard Deviation 5.8	7.2 score on a scale Standard Deviation 4.4	9.4 score on a scale Standard Deviation 4.9

PRIMARY outcome

Timeframe: 6 month follow up

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

8 item scale that measures depression symptoms on a continuous scale. Scores range from 0-24, with a higher score indicating greater severity of symptoms of depression.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=121 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=93 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Patient Health Questionnaire-8	7.2 score on a scale Standard Deviation 4.9	7.4 score on a scale Standard Deviation 4.3	7.2 score on a scale Standard Deviation 5.1	8.8 score on a scale Standard Deviation 5.5

PRIMARY outcome

Timeframe: 12 month follow up

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

8 item scale that measures depression symptoms on a continuous scale. Scores range from 0-24, with a higher score indicating greater severity of symptoms of depression.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=120 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=90 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Patient Health Questionnaire-8	6.7 score on a scale Standard Deviation 4.9	7.4 score on a scale Standard Deviation 3.9	6.6 score on a scale Standard Deviation 5.6	8.3 score on a scale Standard Deviation 5.9

PRIMARY outcome

Timeframe: Baseline

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

7 item scale that measures anxiety symptoms on a continuous scale. Scores range from 0-21, with a higher score indicating greater severity of symptoms of anxiety.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Generalized Anxiety Disorder-7	11.4 score on a scale Standard Deviation 4.0	12.2 score on a scale Standard Deviation 5.0	12.4 score on a scale Standard Deviation 5.2	12.6 score on a scale Standard Deviation 4.7

PRIMARY outcome

Timeframe: Post 8 weeks

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

7 item scale that measures anxiety symptoms on a continuous scale. Scores range from 0-21, with a higher score indicating greater severity of symptoms of anxiety.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=94 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Generalized Anxiety Disorder-7	6.9 score on a scale Standard Deviation 4.6	7.6 score on a scale Standard Deviation 4.5	7.7 score on a scale Standard Deviation 5.1	8.9 score on a scale Standard Deviation 5.5

PRIMARY outcome

Timeframe: 6 month follow up

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

7 item scale that measures anxiety symptoms on a continuous scale. Scores range from 0-21, with a higher score indicating greater severity of symptoms of anxiety.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=127 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=94 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Generalized Anxiety Disorder-7	6.3 score on a scale Standard Deviation 5.0	7.0 score on a scale Standard Deviation 4.6	7.3 score on a scale Standard Deviation 5.7	8.0 score on a scale Standard Deviation 5.5

PRIMARY outcome

Timeframe: 12 month follow up

Population: Breast Cancer Survivors who were classified as high or low engagers and who completed every item of this measure

7 item scale that measures anxiety symptoms on a continuous scale. Scores range from 0-21, with a higher score indicating greater severity of symptoms of anxiety.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=123 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=89 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Generalized Anxiety Disorder-7	5.7 score on a scale Standard Deviation 5.1	6.0 score on a scale Standard Deviation 4.2	7.2 score on a scale Standard Deviation 5.6	7.5 score on a scale Standard Deviation 5.8

SECONDARY outcome

Timeframe: Frequency of unique app sessions from Baseline through 8 weeks

Population: Includes only participants who downloaded their assigned app or intervention.

Frequency of unique app sessions from Baseline through 8 weeks based on median number of app sessions

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=102 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
App Engagement From App Sessions Week 1	12 app sessions Interval 8.5 to 15.5	6 app sessions Interval 3.5 to 8.5	7 app sessions Interval 5.0 to 9.0	2 app sessions Interval 1.0 to 3.0
App Engagement From App Sessions Week 2	9 app sessions Interval 5.0 to 13.0	4 app sessions Interval 2.0 to 6.0	4.5 app sessions Interval 2.0 to 7.0	0 app sessions Interval 0.0 to 1.0
App Engagement From App Sessions Week 3	8 app sessions Interval 4.5 to 11.5	2.5 app sessions Interval 1.0 to 4.0	5 app sessions Interval 2.5 to 7.5	0 app sessions Interval 0.0 to 0.0
App Engagement From App Sessions Week 4	7 app sessions Interval 3.5 to 10.5	1 app sessions Interval 0.0 to 4.0	5 app sessions Interval 2.0 to 8.0	0 app sessions Interval 0.0 to 0.0
App Engagement From App Sessions Week 5	6 app sessions Interval 3.0 to 9.0	2 app sessions Interval 0.5 to 3.5	3.5 app sessions Interval 1.5 to 5.5	0 app sessions Interval 0.0 to 0.0
App Engagement From App Sessions Week 6	5 app sessions Interval 2.5 to 7.5	1 app sessions Interval 0.0 to 3.0	4 app sessions Interval 2.0 to 6.0	0 app sessions Interval 0.0 to 0.0
App Engagement From App Sessions Week 7	5 app sessions Interval 2.0 to 8.0	0.5 app sessions Interval 0.0 to 4.0	4.5 app sessions Interval 2.5 to 6.5	0 app sessions Interval 0.0 to 0.0
App Engagement From App Sessions Week 8	4 app sessions Interval 0.5 to 7.5	0.5 app sessions Interval 0.0 to 3.0	3.5 app sessions Interval 1.5 to 5.5	0 app sessions Interval 0.0 to 0.0

SECONDARY outcome

Timeframe: Duration in seconds of app sessions from Baseline through 8 weeks

Population: Technical problems led to not being able to extract app engagement based on app session duration from any participants. Data related to the gold standard metric of number of app sessions was captured and reported.

Duration in seconds of app sessions from Baseline through 8 weeks

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Number of apps downloaded from Baseline through 8 weeks

Population: Technical problems led to not being able to extract app engagement based on number of app downloads from any participants. Data related to the gold standard metric of number of app sessions was captured and reported.

Number of apps downloaded from Baseline through 8 weeks

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Baseline

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Physical Health	35.5 score on a scale Standard Deviation 40.9	41.4 score on a scale Standard Deviation 36.9	39.7 score on a scale Standard Deviation 42.2	35.7 score on a scale Standard Deviation 39.4

SECONDARY outcome

Timeframe: 8 week

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=129 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Physical Health	44.7 score on a scale Standard Deviation 41.9	45.8 score on a scale Standard Deviation 36.6	53.8 score on a scale Standard Deviation 41.5	44.5 score on a scale Standard Deviation 40.2

SECONDARY outcome

Timeframe: 6 months

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=127 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Physical Health	60.3 score on a scale Standard Deviation 42.1	51.5 score on a scale Standard Deviation 41.0	56.5 score on a scale Standard Deviation 45.2	49.0 score on a scale Standard Deviation 40.1

SECONDARY outcome

Timeframe: 12 months

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=92 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Physical Health	65.9 score on a scale Standard Deviation 41.3	52.3 score on a scale Standard Deviation 41.6	56.0 score on a scale Standard Deviation 42.5	56.8 score on a scale Standard Deviation 41.8

SECONDARY outcome

Timeframe: Baseline

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Mental Health	54.2 score on a scale Standard Deviation 16.3	47.9 score on a scale Standard Deviation 16.8	48.2 score on a scale Standard Deviation 14.6	48.6 score on a scale Standard Deviation 16.9

SECONDARY outcome

Timeframe: 8 weeks

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=129 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Mental Health	62.7 score on a scale Standard Deviation 17.5	59.3 score on a scale Standard Deviation 18.2	57.8 score on a scale Standard Deviation 19.5	55.3 score on a scale Standard Deviation 18.3

SECONDARY outcome

Timeframe: 6 months

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Mental Health	69.6 score on a scale Standard Deviation 16.4	60.7 score on a scale Standard Deviation 19.0	60.3 score on a scale Standard Deviation 20.9	61.3 score on a scale Standard Deviation 17.4

SECONDARY outcome

Timeframe: 12 months

The SF-36 is a 36 item scale that is composed of 2 summary scores that measure health status related to both physical and mental health. Scores for each domain range from 0-100, with higher scores indicating better health status.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=92 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
36-Item Short Form Survey - Mental Health	68.7 score on a scale Standard Deviation 16.9	66.2 score on a scale Standard Deviation 14.6	64.5 score on a scale Standard Deviation 18.7	63.1 score on a scale Standard Deviation 19.6

SECONDARY outcome

Timeframe: Baseline

Fatigue will be measured using the MFSI-SF, which is a 30 item self-report measure comprised of five subscales (general, emotional, physical, mental, vigor) and a total fatigue score. Each subscale score ranges from 0 to 24. The Total MSFI-SF score is calculated by adding the general, physical, emotional and mental subscale scores and subtracting vigor subscale score. Total MFSI-SF score ranges from 0 to 96 with a higher score indicating higher levels of cancer-related fatigue experienced by the patient.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=35 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Multidimensional Fatigue Symptom Inventory-Short Form	35.4 score on a scale Standard Deviation 19.5	38.8 score on a scale Standard Deviation 16.4	42.9 score on a scale Standard Deviation 17.4	42.0 score on a scale Standard Deviation 19.8

SECONDARY outcome

Timeframe: 8 weeks

Fatigue will be measured using the MFSI-SF, which is a 30 item self-report measure comprised of five subscales (general, emotional, physical, mental, vigor) and a total fatigue score. Each subscale score ranges from 0 to 24. The Total MSFI-SF score is calculated by adding the general, physical, emotional and mental subscale scores and subtracting vigor subscale score. Total MFSI-SF score ranges from 0 to 96 with a higher score indicating higher levels of cancer-related fatigue experienced by the patient.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=120 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=35 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=88 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Multidimensional Fatigue Symptom Inventory-Short Form	25.3 score on a scale Standard Deviation 20.1	29.5 score on a scale Standard Deviation 19.3	27.2 score on a scale Standard Deviation 20.1	31.3 score on a scale Standard Deviation 22.5

SECONDARY outcome

Timeframe: 6 months

Fatigue will be measured using the MFSI-SF, which is a 30 item self-report measure comprised of five subscales (general, emotional, physical, mental, vigor) and a total fatigue score. Each subscale score ranges from 0 to 24. The Total MSFI-SF score is calculated by adding the general, physical, emotional and mental subscale scores and subtracting vigor subscale score. Total MFSI-SF score ranges from 0 to 96 with a higher score indicating higher levels of cancer-related fatigue experienced by the patient.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=118 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=25 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=87 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Multidimensional Fatigue Symptom Inventory-Short Form	21.1 score on a scale Standard Deviation 21.1	26.8 score on a scale Standard Deviation 19.2	24.6 score on a scale Standard Deviation 19.4	29.5 score on a scale Standard Deviation 24.3

SECONDARY outcome

Timeframe: 12 months

Fatigue will be measured using the MFSI-SF, which is a 30 item self-report measure comprised of five subscales (general, emotional, physical, mental, vigor) and a total fatigue score. Each subscale score ranges from 0 to 24. The Total MSFI-SF score is calculated by adding the general, physical, emotional and mental subscale scores and subtracting vigor subscale score. Total MFSI-SF score ranges from 0 to 96 with a higher score indicating higher levels of cancer-related fatigue experienced by the patient.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=117 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=85 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Multidimensional Fatigue Symptom Inventory-Short Form	19.7 score on a scale Standard Deviation 22.7	24.0 score on a scale Standard Deviation 18.1	20.5 score on a scale Standard Deviation 22.2	25.8 score on a scale Standard Deviation 23.2

SECONDARY outcome

Timeframe: Baseline

The Pittsburgh Sleep Quality Index contains 19 self-rated questions that assesses sleep quality and disturbances. Global scores range from 0-21, with a score of 5 or more indicating poor sleep quality. The higher the score, the worse the sleep quality.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=123 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=100 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Pittsburgh Sleep Quality Index	10.7 score on a scale Standard Deviation 4.1	10.8 score on a scale Standard Deviation 3.5	10.2 score on a scale Standard Deviation 4.0	11.1 score on a scale Standard Deviation 4.3

SECONDARY outcome

Timeframe: 8 weeks

The Pittsburgh Sleep Quality Index contains 19 self-rated questions that assesses sleep quality and disturbances. Global scores range from 0-21, with a score of 5 or more indicating poor sleep quality. The higher the score, the worse the sleep quality.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=118 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=85 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Pittsburgh Sleep Quality Index	9.8 score on a scale Standard Deviation 4.0	9.3 score on a scale Standard Deviation 3.4	8.5 score on a scale Standard Deviation 4.2	9.9 score on a scale Standard Deviation 4.3

SECONDARY outcome

Timeframe: 6 months

The Pittsburgh Sleep Quality Index contains 19 self-rated questions that assesses sleep quality and disturbances. Global scores range from 0-21, with a score of 5 or more indicating poor sleep quality. The higher the score, the worse the sleep quality.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=112 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=28 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=84 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Pittsburgh Sleep Quality Index	8.9 score on a scale Standard Deviation 3.8	10.1 score on a scale Standard Deviation 3.5	8.5 score on a scale Standard Deviation 4.0	9.8 score on a scale Standard Deviation 4.6

SECONDARY outcome

Timeframe: 12 months

The Pittsburgh Sleep Quality Index contains 19 self-rated questions that assesses sleep quality and disturbances. Global scores range from 0-21, with a score of 5 or more indicating poor sleep quality. The higher the score, the worse the sleep quality.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=110 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=80 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Pittsburgh Sleep Quality Index	8.7 score on a scale Standard Deviation 4.0	9.6 score on a scale Standard Deviation 3.6	8.0 score on a scale Standard Deviation 3.5	9.5 score on a scale Standard Deviation 4.2

SECONDARY outcome

Timeframe: Baseline

The Alcohol Use Disorders Identification Test contains 10 questions (each question is scored 0-4). The range of possible scores is from 0 to 40 where 0 indicates an abstainer who has never had any problems from alcohol. A score of 1 to 7 suggests low-risk consumption according to World Health Organization (WHO) guidelines. Scores from 8 to 14 suggest hazardous or harmful alcohol consumption and a score of 15 or more indicates the likelihood of alcohol dependence (moderate-severe alcohol use disorder).

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=132 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=101 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Alcohol Use Disorders Identification Test	2.3 score on a scale Standard Deviation 3.4	4.0 score on a scale Standard Deviation 5.4	2.2 score on a scale Standard Deviation 2.9	1.7 score on a scale Standard Deviation 2.8

SECONDARY outcome

Timeframe: 8 weeks

The Alcohol Use Disorders Identification Test contains 10 questions (each question is scored 0-4). The range of possible scores is from 0 to 40 where 0 indicates an abstainer who has never had any problems from alcohol. A score of 1 to 7 suggests low-risk consumption according to World Health Organization (WHO) guidelines. Scores from 8 to 14 suggest hazardous or harmful alcohol consumption and a score of 15 or more indicates the likelihood of alcohol dependence (moderate-severe alcohol use disorder).

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Alcohol Use Disorders Identification Test	2.0 score on a scale Standard Deviation 3.4	3.5 score on a scale Standard Deviation 5.1	1.9 score on a scale Standard Deviation 2.6	1.5 score on a scale Standard Deviation 2.7

SECONDARY outcome

Timeframe: 6 months

The Alcohol Use Disorders Identification Test contains 10 questions (each question is scored 0-4). The range of possible scores is from 0 to 40 where 0 indicates an abstainer who has never had any problems from alcohol. A score of 1 to 7 suggests low-risk consumption according to World Health Organization (WHO) guidelines. Scores from 8 to 14 suggest hazardous or harmful alcohol consumption and a score of 15 or more indicates the likelihood of alcohol dependence (moderate-severe alcohol use disorder).

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=29 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Alcohol Use Disorders Identification Test	1.7 score on a scale Standard Deviation 2.9	3.3 score on a scale Standard Deviation 5.3	1.6 score on a scale Standard Deviation 2.6	1.5 score on a scale Standard Deviation 2.6

SECONDARY outcome

Timeframe: 12 months

The Alcohol Use Disorders Identification Test contains 10 questions (each question is scored 0-4). The range of possible scores is from 0 to 40 where 0 indicates an abstainer who has never had any problems from alcohol. A score of 1 to 7 suggests low-risk consumption according to World Health Organization (WHO) guidelines. Scores from 8 to 14 suggest hazardous or harmful alcohol consumption and a score of 15 or more indicates the likelihood of alcohol dependence (moderate-severe alcohol use disorder).

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Alcohol Use Disorders Identification Test	2.0 score on a scale Standard Deviation 3.2	3.7 score on a scale Standard Deviation 5.9	1.7 score on a scale Standard Deviation 3.0	1.7 score on a scale Standard Deviation 3.1

SECONDARY outcome

Timeframe: Baseline

The PROMIS Global Mental Health scale v1.2 contains 4 items that measure mental health. Each question is scored on a 1-5 scale with a raw score total range of 4-20. The raw scores are then transformed into a T-score where higher scores indicate better overall health. PROMIS uses T-scores to standardize results, with a mean of 50 and a standard deviation (SD) of 10 for the general U.S. population. A higher T-score for mental health indicates a better outcome.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=131 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=37 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=101 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Global Mental Health v1.2	39.5 T-score Standard Deviation 6.3	38.8 T-score Standard Deviation 6.1	37.6 T-score Standard Deviation 5.6	38.4 T-score Standard Deviation 7.0

SECONDARY outcome

Timeframe: 8 weeks

The PROMIS Global Mental Health scale v1.2 contains 4 items that measure mental health. Each question is scored on a 1-5 scale with a raw score total range of 4-20. The raw scores are then transformed into a T-score where higher scores indicate better overall health. PROMIS uses T-scores to standardize results, with a mean of 50 and a standard deviation (SD) of 10 for the general U.S. population. A higher T-score for mental health indicates a better outcome.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Global Mental Health v1.2	42.6 T-score Standard Deviation 7.1	41.5 T-score Standard Deviation 6.0	42.4 T-score Standard Deviation 5.6	40.3 T-score Standard Deviation 7.0

SECONDARY outcome

Timeframe: 6 months

The PROMIS Global Mental Health scale v1.2 contains 4 items that measure mental health. Each question is scored on a 1-5 scale with a raw score total range of 4-20. The raw scores are then transformed into a T-score where higher scores indicate better overall health. PROMIS uses T-scores to standardize results, with a mean of 50 and a standard deviation (SD) of 10 for the general U.S. population. A higher T-score for mental health indicates a better outcome.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Global Mental Health v1.2	45.2 T-score Standard Deviation 8.6	43.7 T-score Standard Deviation 6.6	43.0 T-score Standard Deviation 6.6	41.4 T-score Standard Deviation 7.9

SECONDARY outcome

Timeframe: 12 months

The PROMIS Global Mental Health scale v1.2 contains 4 items that measure mental health. Each question is scored on a 1-5 scale with a raw score total range of 4-20. The raw scores are then transformed into a T-score where higher scores indicate better overall health. PROMIS uses T-scores to standardize results, with a mean of 50 and a standard deviation (SD) of 10 for the general U.S. population. A higher T-score for mental health indicates a better outcome.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Global Mental Health v1.2	45.5 T-score Standard Deviation 8.5	45.2 T-score Standard Deviation 6.0	44.8 T-score Standard Deviation 6.6	42.6 T-score Standard Deviation 8.3

SECONDARY outcome

Timeframe: Baseline

The PROMIS Satisfaction with Sex Life scale v.20 contains 5 items that measure satisfaction with one's sex life. Each question is scored on a 1-5 scale with a total score range of 5-25. Higher scores indicate higher satisfaction with one's sex life.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=127 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=35 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=101 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Satisfaction With Sex Life	9.4 score on a scale Standard Deviation 5.0	8.9 score on a scale Standard Deviation 4.6	10.6 score on a scale Standard Deviation 6.5	9.2 score on a scale Standard Deviation 5.0

SECONDARY outcome

Timeframe: 8 weeks

The PROMIS Satisfaction with Sex Life scale v.20 contains 5 items that measure satisfaction with one's sex life. Each question is scored on a 1-5 scale with a total score range of 5-25. Higher scores indicate higher satisfaction with one's sex life.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=119 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=35 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Satisfaction With Sex Life	9.3 score on a scale Standard Deviation 5.1	9.1 score on a scale Standard Deviation 5.1	11.7 score on a scale Standard Deviation 6.3	9.9 score on a scale Standard Deviation 5.1

SECONDARY outcome

Timeframe: 6 months

The PROMIS Satisfaction with Sex Life scale v.20 contains 5 items that measure satisfaction with one's sex life. Each question is scored on a 1-5 scale with a total score range of 5-25. Higher scores indicate higher satisfaction with one's sex life.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=123 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Satisfaction With Sex Life	10.5 score on a scale Standard Deviation 5.9	9.7 score on a scale Standard Deviation 5.6	11.6 score on a scale Standard Deviation 5.9	10.2 score on a scale Standard Deviation 5.7

SECONDARY outcome

Timeframe: 12 months

The PROMIS Satisfaction with Sex Life scale v.20 contains 5 items that measure satisfaction with one's sex life. Each question is scored on a 1-5 scale with a total score range of 5-25. Higher scores indicate higher satisfaction with one's sex life.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=121 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=90 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
PROMIS Satisfaction With Sex Life	10.6 score on a scale Standard Deviation 6.1	10.4 score on a scale Standard Deviation 6.0	12.0 score on a scale Standard Deviation 6.5	10.5 score on a scale Standard Deviation 5.9

SECONDARY outcome

Timeframe: Baseline

The UAMS Health Literacy measure consists of 3 items that assess health literacy. Each question is scored on a 1-5 scale, with a possible total score range of 3-15. Higher scores indicate worse health literacy.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=133 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=104 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
UAMS Health Literacy Measure	10.3 score on a scale Standard Deviation 1.2	10.7 score on a scale Standard Deviation 1.0	10.3 score on a scale Standard Deviation 1.3	10.4 score on a scale Standard Deviation 1.1

SECONDARY outcome

Timeframe: 8 weeks

The UAMS Health Literacy measure consists of 3 items that assess health literacy. Each question is scored on a 1-5 scale, with a possible total score range of 3-15. Higher scores indicate worse health literacy.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
UAMS Health Literacy Measure	10.5 score on a scale Standard Deviation 1.1	10.4 score on a scale Standard Deviation 1.3	10.0 score on a scale Standard Deviation 1.7	10.5 score on a scale Standard Deviation 1.2

SECONDARY outcome

Timeframe: 6 months

The UAMS Health Literacy measure consists of 3 items that assess health literacy. Each question is scored on a 1-5 scale, with a possible total score range of 3-15. Higher scores indicate worse health literacy.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=127 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
UAMS Health Literacy Measure	10.5 score on a scale Standard Deviation 1.1	10.7 score on a scale Standard Deviation 1.0	10.7 score on a scale Standard Deviation 0.8	10.7 score on a scale Standard Deviation 1.2

SECONDARY outcome

Timeframe: 12 months

The UAMS Health Literacy measure consists of 3 items that assess health literacy. Each question is scored on a 1-5 scale, with a possible total score range of 3-15. Higher scores indicate worse health literacy.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=92 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
UAMS Health Literacy Measure	10.6 score on a scale Standard Deviation 1.1	10.6 score on a scale Standard Deviation 0.8	10.4 score on a scale Standard Deviation 1.2	10.7 score on a scale Standard Deviation 0.9

SECONDARY outcome

Timeframe: Baseline

The Penn State Worry Questionnaire consists of 16 items that assess the trait of worry. Each question is scored on a 1-5 scale with a possible total score range of 16-80. Higher scores indicate higher levels of trait worry.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=124 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=97 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Penn State Worry Questionnaire	56.8 score on a scale Standard Deviation 12.7	57.8 score on a scale Standard Deviation 13.7	61.3 score on a scale Standard Deviation 14.1	59.5 score on a scale Standard Deviation 12.7

SECONDARY outcome

Timeframe: 8 weeks

The Penn State Worry Questionnaire consists of 16 items that assess the trait of worry. Each question is scored on a 1-5 scale with a possible total score range of 16-80. Higher scores indicate higher levels of trait worry.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=120 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Penn State Worry Questionnaire	53.1 score on a scale Standard Deviation 12.9	54.0 score on a scale Standard Deviation 12.8	54.2 score on a scale Standard Deviation 14.3	55.0 score on a scale Standard Deviation 12.4

SECONDARY outcome

Timeframe: 6 months

The Penn State Worry Questionnaire consists of 16 items that assess the trait of worry. Each question is scored on a 1-5 scale with a possible total score range of 16-80. Higher scores indicate higher levels of trait worry.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=122 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=27 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Penn State Worry Questionnaire	50.1 score on a scale Standard Deviation 13.9	50.8 score on a scale Standard Deviation 10.2	55.9 score on a scale Standard Deviation 15.5	55.0 score on a scale Standard Deviation 13.5

SECONDARY outcome

Timeframe: 12 months

The Penn State Worry Questionnaire consists of 16 items that assess the trait of worry. Each question is scored on a 1-5 scale with a possible total score range of 16-80. Higher scores indicate higher levels of trait worry.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=118 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Penn State Worry Questionnaire	48.8 score on a scale Standard Deviation 13.0	49.4 score on a scale Standard Deviation 12.3	51.9 score on a scale Standard Deviation 14.6	54.4 score on a scale Standard Deviation 14.4

SECONDARY outcome

Timeframe: Baseline

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Extraversion is assessed by 2 items, each of which is scored on a 1-7 scale and the responses are summed for a total Extraversion score. Therefore, scores for Extraversion range from 2-14. Higher scores indicates higher levels of Extraversion.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=134 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=100 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory- Extraversion	8.0 score on a scale Standard Deviation 3.5	8.1 score on a scale Standard Deviation 3.5	8.8 score on a scale Standard Deviation 3.7	7.4 score on a scale Standard Deviation 3.3

SECONDARY outcome

Timeframe: 8 weeks

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Extraversion is assessed by 2 items, each of which is scored on a 1-7 scale and the responses are summed for a total Extraversion score. Therefore, scores for Extraversion range from 2-14. Higher scores indicates higher levels of Extraversion.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Extraversion	8.1 score on a scale Standard Deviation 3.2	8.2 score on a scale Standard Deviation 3.4	8.7 score on a scale Standard Deviation 3.9	7.3 score on a scale Standard Deviation 3.3

SECONDARY outcome

Timeframe: 6 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Extraversion is assessed by 2 items, each of which is scored on a 1-7 scale and the responses are summed for a total Extraversion score. Therefore, scores for Extraversion range from 2-14. Higher scores indicates higher levels of Extraversion.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=95 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Extraversion	8.2 score on a scale Standard Deviation 3.3	8.1 score on a scale Standard Deviation 3.3	8.4 score on a scale Standard Deviation 3.2	7.8 score on a scale Standard Deviation 3.1

SECONDARY outcome

Timeframe: 12 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Extraversion is assessed by 2 items, each of which is scored on a 1-7 scale and the responses are summed for a total Extraversion score. Therefore, scores for Extraversion range from 2-14. Higher scores indicates higher levels of Extraversion.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Extraversion	8.3 score on a scale Standard Deviation 3.1	7.9 score on a scale Standard Deviation 3.2	8.8 score on a scale Standard Deviation 3.5	8.0 score on a scale Standard Deviation 3.3

SECONDARY outcome

Timeframe: Baseline

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Agreeableness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Agreeableness score. Therefore, scores for Agreeableness range from 2-14. Higher scores indicates higher levels of Agreeableness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=133 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=101 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Agreeableness	10.9 score on a scale Standard Deviation 2.2	10.2 score on a scale Standard Deviation 2.3	10.3 score on a scale Standard Deviation 2.0	10.2 score on a scale Standard Deviation 2.6

SECONDARY outcome

Timeframe: 8 weeks

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Agreeableness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Agreeableness score. Therefore, scores for Agreeableness range from 2-14. Higher scores indicates higher levels of Agreeableness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=129 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Agreeableness	11.1 score on a scale Standard Deviation 2.3	10.9 score on a scale Standard Deviation 2.3	11.0 score on a scale Standard Deviation 2.4	10.7 score on a scale Standard Deviation 2.6

SECONDARY outcome

Timeframe: 6 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Agreeableness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Agreeableness score. Therefore, scores for Agreeableness range from 2-14. Higher scores indicates higher levels of Agreeableness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=127 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=29 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Agreeableness	11.2 score on a scale Standard Deviation 2.3	10.8 score on a scale Standard Deviation 2.2	11.1 score on a scale Standard Deviation 2.1	10.7 score on a scale Standard Deviation 2.5

SECONDARY outcome

Timeframe: 12 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Agreeableness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Agreeableness score. Therefore, scores for Agreeableness range from 2-14. Higher scores indicates higher levels of Agreeableness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Agreeableness	11.2 score on a scale Standard Deviation 2.5	10.7 score on a scale Standard Deviation 2.2	10.6 score on a scale Standard Deviation 2.3	11.0 score on a scale Standard Deviation 2.3

SECONDARY outcome

Timeframe: Baseline

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Conscientiousness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Conscientiousness score. Therefore, scores for Conscientiousness range from 2-14. Higher scores indicates higher levels of Conscientiousness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=132 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=102 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Conscientiousness	11.0 score on a scale Standard Deviation 2.6	10.8 score on a scale Standard Deviation 2.6	10.5 score on a scale Standard Deviation 2.6	10.9 score on a scale Standard Deviation 2.6

SECONDARY outcome

Timeframe: 8 weeks

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Conscientiousness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Conscientiousness score. Therefore, scores for Conscientiousness range from 2-14. Higher scores indicates higher levels of Conscientiousness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=31 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Conscientiousness	11.2 score on a scale Standard Deviation 2.2	10.4 score on a scale Standard Deviation 3.0	11.0 score on a scale Standard Deviation 2.8	10.7 score on a scale Standard Deviation 2.7

SECONDARY outcome

Timeframe: 6 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Conscientiousness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Conscientiousness score. Therefore, scores for Conscientiousness range from 2-14. Higher scores indicates higher levels of Conscientiousness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Conscientiousness	11.3 score on a scale Standard Deviation 2.5	10.8 score on a scale Standard Deviation 2.7	10.9 score on a scale Standard Deviation 2.7	10.7 score on a scale Standard Deviation 2.7

SECONDARY outcome

Timeframe: 12 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Conscientiousness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Conscientiousness score. Therefore, scores for Conscientiousness range from 2-14. Higher scores indicates higher levels of Conscientiousness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=88 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Conscientiousness	11.2 score on a scale Standard Deviation 2.4	11.0 score on a scale Standard Deviation 2.7	10.0 score on a scale Standard Deviation 2.8	11.1 score on a scale Standard Deviation 2.5

SECONDARY outcome

Timeframe: Baseline

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Neuroticism is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Neuroticism score. Therefore, scores for Neuroticism range from 2-14. Higher scores indicates higher levels of Neuroticism.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=132 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=103 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Neuroticism	7.6 score on a scale Standard Deviation 2.7	7.7 score on a scale Standard Deviation 2.6	6.6 score on a scale Standard Deviation 2.7	7.3 score on a scale Standard Deviation 2.8

SECONDARY outcome

Timeframe: 8 weeks

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Neuroticism is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Neuroticism score. Therefore, scores for Neuroticism range from 2-14. Higher scores indicates higher levels of Neuroticism.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=35 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=97 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Neuroticism	8.5 score on a scale Standard Deviation 2.7	8.5 score on a scale Standard Deviation 2.5	8.3 score on a scale Standard Deviation 2.8	7.9 score on a scale Standard Deviation 2.8

SECONDARY outcome

Timeframe: 6 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Neuroticism is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Neuroticism score. Therefore, scores for Neuroticism range from 2-14. Higher scores indicates higher levels of Neuroticism.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Neuroticism	8.9 score on a scale Standard Deviation 3.0	8.5 score on a scale Standard Deviation 2.5	8.4 score on a scale Standard Deviation 2.5	8.2 score on a scale Standard Deviation 2.8

SECONDARY outcome

Timeframe: 12 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Neuroticism is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Neuroticism score. Therefore, scores for Neuroticism range from 2-14. Higher scores indicates higher levels of Neuroticism.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=125 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=91 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Neuroticism	9.5 score on a scale Standard Deviation 2.7	8.9 score on a scale Standard Deviation 2.6	8.3 score on a scale Standard Deviation 2.8	8.4 score on a scale Standard Deviation 2.9

SECONDARY outcome

Timeframe: Baseline

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Openness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Openness score. Therefore, scores for Openness range from 2-14. Higher scores indicates higher levels of Openness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=133 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=38 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=34 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=102 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Openness	10.1 score on a scale Standard Deviation 2.5	9.7 score on a scale Standard Deviation 2.3	10.8 score on a scale Standard Deviation 2.0	9.6 score on a scale Standard Deviation 2.5

SECONDARY outcome

Timeframe: 8 weeks

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Openness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Openness score. Therefore, scores for Openness range from 2-14. Higher scores indicates higher levels of Openness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=128 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=98 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Openness	10.2 score on a scale Standard Deviation 2.3	10.2 score on a scale Standard Deviation 2.5	10.5 score on a scale Standard Deviation 2.0	9.6 score on a scale Standard Deviation 2.7

SECONDARY outcome

Timeframe: 6 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Openness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Openness score. Therefore, scores for Openness range from 2-14. Higher scores indicates higher levels of Openness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=30 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=96 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Openness	10.2 score on a scale Standard Deviation 2.5	10.6 score on a scale Standard Deviation 2.7	10.5 score on a scale Standard Deviation 2.1	10.2 score on a scale Standard Deviation 2.3

SECONDARY outcome

Timeframe: 12 months

The Ten Item Personality Inventory consists of 10 items that assess the Big 5 personality domains (i.e., conscientiousness, openness, agreeableness, extraversion, neuroticism). Openness is assessed by 2 of the items, each of which is scored on a 1-7 scale and the responses are summed for a total Openness score. Therefore, scores for Openness range from 2-14. Higher scores indicates higher levels of Openness.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=126 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=32 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=90 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Ten Item Personality Inventory - Openness	10.4 score on a scale Standard Deviation 2.4	10.0 score on a scale Standard Deviation 2.6	10.2 score on a scale Standard Deviation 2.5	10.2 score on a scale Standard Deviation 2.7

SECONDARY outcome

Timeframe: Baseline

Population: This measure was not administered because it was deemed to be redundant with the other intervention engagement and adherence measures. It was omitted to reduce participant burden.

The TWEETS scale consists of 9 items on a 5-point Likert scale (0-4). Of the 9 items, 3 are aimed at assessing behavioral engagement, 3 on cognitive engagement, and 3 of affective engagement. Higher scores indicate higher levels on each of the engagement domains.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 8 weeks

Population: This measure was not administered because it was deemed to be redundant with the other intervention engagement and adherence measures. It was omitted to reduce participant burden.

The TWEETS scale consists of 9 items on a 5-point Likert scale (0-4). Of the 9 items, 3 are aimed at assessing behavioral engagement, 3 on cognitive engagement, and 3 of affective engagement. Higher scores indicate higher levels on each of the engagement domains.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 6 months

Population: This measure was not administered because it was deemed to be redundant with the other intervention engagement and adherence measures. It was omitted to reduce participant burden.

The TWEETS scale consists of 9 items on a 5-point Likert scale (0-4). Of the 9 items, 3 are aimed at assessing behavioral engagement, 3 on cognitive engagement, and 3 of affective engagement. Higher scores indicate higher levels on each of the engagement domains.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 12 months

Population: This measure was not administered because it was deemed to be redundant with the other intervention engagement and adherence measures. It was omitted to reduce participant burden.

The TWEETS scale consists of 9 items on a 5-point Likert scale (0-4). Of the 9 items, 3 are aimed at assessing behavioral engagement, 3 on cognitive engagement, and 3 of affective engagement. Higher scores indicate higher levels on each of the engagement domains.

Outcome measures

Outcome data not reported

OTHER_PRE_SPECIFIED outcome

Timeframe: 8 weeks

A 12-item questionnaire with subscales of perceived utility and perceived impact of digital interventions. Each item is rated on a 0 (not at all) to 5 (very) scale and the items are summed to compute a total score ranging from 0-60. Higher scores indicate higher perceived utility and impact of a digital intervention.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=132 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=100 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Digital Intervention Evaluation Questionnaire	27.8 score on a scale Standard Deviation 10.5	25.7 score on a scale Standard Deviation 10.4	30.4 score on a scale Standard Deviation 9.7	23.5 score on a scale Standard Deviation 10.7

OTHER_PRE_SPECIFIED outcome

Timeframe: 8 weeks

A 26 item questionnaire that assesses perceived adherence to a digital intervention due to barriers to use. Each item is scored on a 0 (not at all) to 2 (very) scale and the items are summed to compute a total score ranging from 0-52. Higher scores indicate lower perceived adherence to a digital intervention due to barriers to use.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=132 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=36 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=33 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education n=100 Participants The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Digital Intervention Adherence Questionnaire	7.6 score on a scale Standard Deviation 7.1	10.6 score on a scale Standard Deviation 9.3	7.3 score on a scale Standard Deviation 6.0	5.1 score on a scale Standard Deviation 5.9

POST_HOC outcome

Timeframe: 8 weeks

Population: The data collected were qualitative based on interviews with participants who received IntelliCare. The "Patient Education" participants did not receive the Intellicare App. The count of participants that endorsed each theme is provided, however, it is important to stress that the goal was to identify meaningful patterns and concepts within the data, not just count how many people mention a theme.

The purpose of collecting this data was to explore how the intervention could be improved upon in future trials. Only those that receive the IntelliCare apps will be administered a qualitative interview that contains items assessing how the app intervention met their needs as a breast cancer survivor and possible changes to improve fit. Study staff will administer this interview on the phone and manually type in the participant responses during the interview. 10 questions will assess overall impressions of the IntelliCare app program to inform how it could be improved upon for future trials. When new data no longer adds new information or a new theme to the analysis, the theme is considered sufficiently explored and important. A numerical threshold for theme importance in qualitative analysis is not important, as this can lead to losing valuable, nuanced insights.

Outcome measures

Measure	IntelliCare - High Engager, No Coaching n=44 Participants This arm included participants who received IntelliCare and displayed optimal levels of engagement to the intervention in the first week. These participants were not eligible to receive added coaching after week two. They continued to use IntelliCare as usual.	IntelliCare - Low Engager, No Coaching n=23 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive no added coaching and continued to use IntelliCare as usual.	IntelliCare - Low Engager, Coaching n=19 Participants This arm included participants who received IntelliCare and displayed suboptimal levels of engagement to the intervention in the first week. These participants were eligible to receive added coaching after week two. They were randomized to receive added coaching which consisted of an initial phone call with a human coach, a midpoint check-in, and regular messaging with their coach.	Patient Education The patient education app will contain psychoeducational information about distress prevalence and distress management. It will serve as an active control condition to compare with the IntelliCare apps. Psychoeducation: The Patient Education app will contain content relevant for general distress management. This includes information about thoughts/worries, prevalence of mood symptoms, CBT strategies for coping with negative affect, and other information typical of education-based mental health apps. The structure of this app will closely mirror patient education websites and apps which mimic the form and structure of apps that target cancer survivors and that primarily provide educational information about cancer and related symptoms.
Limited List of Questions for Exit Interview More variety of activities in the behavioral activation portion of the intervention	3 Participants	4 Participants	4 Participants	0 Participants
Limited List of Questions for Exit Interview Create a progress report for users as they use the app over time	4 Participants	1 Participants	0 Participants	0 Participants
Limited List of Questions for Exit Interview Include cancer related examples in the activities in the app to make them more relatable	17 Participants	8 Participants	9 Participants	0 Participants
Limited List of Questions for Exit Interview Make loading pictures easier	2 Participants	3 Participants	3 Participants	0 Participants
Limited List of Questions for Exit Interview Have a way for users to connect with one another directly to provide emotional support	8 Participants	1 Participants	0 Participants	0 Participants
Limited List of Questions for Exit Interview Want more variety of activities and exercises to choose from to learn additional skills	10 Participants	6 Participants	3 Participants	0 Participants

Adverse Events

IntelliCare - High Engager, No Coaching

Serious events: 0 serious events

Other events: 0 other events

Deaths: 1 deaths

IntelliCare - Low Engager, No Coaching

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

IntelliCare - Low Engager, Coaching

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Patient Education

Serious events: 0 serious events

Other events: 0 other events

Deaths: 2 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Philip Chow

University of Virginia

Phone: 9146453458

Email: pic2u@virginia.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place