Clinical Trials

NCT02996773 | COMPLETED | PHASE1
50 Participants

Haploidentical BMT With Post-Transplant Cyclophosphamide and Bendamustine

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-11-29
Completion: 2025-08-01
Conditions
Acute Lymphoblastic Leukemia Acute Myelogenous Leukemia Myelodysplastic Syndromes Chronic Myelogenous Leukemia Lymphoma,Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Follicular Marginal Zone Lymphoma Large Cell Lymphoma Mantle-Cell Lymphoma Gray Zone Lymphoma Burkitt Lymphoma High Risk Undifferentiated Acute Leukemia
Interventions
DRUG
No Results Yet
NCT02990819 | ACTIVE_NOT_RECRUITING | PHASE2
60 Participants

Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-31
Completion: 2026-11-30
Conditions
Immunodeficiencies Immune Dysregulation Syndromes
Interventions
DEVICE
No Results Yet
NCT02979522 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
59 Participants

A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2017-09-06
Completion: 2020-05-05
Conditions
Hodgkin Disease
Interventions
DRUG
NCT02977780 | RECRUITING | PHASE2
460 Participants

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2017-02-09
Completion: 2028-02-01
Conditions
Glioblastoma
Interventions
DRUG
No Results Yet
NCT02955290 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
51 Participants

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-22
Completion: 2025-05-23
Conditions
Advanced Head and Neck Squamous Cell Carcinoma Lung Non-Small Cell Carcinoma Metastatic Lung Non-Small Cell Carcinoma PD-L1 Positive Recurrent Head and Neck Squamous Cell Carcinoma Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage III Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage IV Lung Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8 Unresectable Lung Non-Small Cell Carcinoma Advanced Squamous Non-Small Cell Lung Carcinoma
Interventions
OTHER BIOLOGICAL
No Results Yet
NCT02926690 | RECRUITING | PHASE1
70 Participants

Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2017-05-29
Completion: 2027-09-30
Conditions
Relapsed/Refractory Locally Advanced or Metastatic Breast Cancer and Triple Negative Breast Cancer
Interventions
DRUG
No Results Yet
NCT02920788 | ACTIVE_NOT_RECRUITING | NA
63 Participants

Mild TBI Assessment & Rehabilitation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2017-03-09
Completion: 2025-10-31
Conditions
Brain Injuries, Traumatic
Interventions
BEHAVIORAL OTHER DEVICE
No Results Yet
NCT02919592 | ACTIVE_NOT_RECRUITING | NA
3613 Participants

Memory Gel and Shape Combined Cohort

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-09-01
Completion: 2031-06-16
Conditions
Primary Breast Augmentation Primary Breast Reconstruction Revision Breast Augmentation Revision Breast Reconstruction
Interventions
DEVICE PROCEDURE
No Results Yet
NCT02916862 | COMPLETED | PHASE2
177 Participants

Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-02-10
Completion: 2025-04-30
Conditions
Osteoporosis
Interventions
DIETARY_SUPPLEMENT COMBINATION_PRODUCT
NCT02908906 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
413 Participants

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-11-21
Completion: 2023-11-17
Conditions
Neoplasms
Interventions
DRUG
No Results Yet
NCT02890355 | ACTIVE_NOT_RECRUITING | PHASE2
123 Participants

FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-09-01
Completion: 2019-05-01
Conditions
Metastatic Pancreatic Adenocarcinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions
DRUG OTHER
NCT02880163 | RECRUITING | NA
40 Participants

REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2025-08-07
Completion: 2026-10-31
Conditions
Hemorrhagic Shock Trauma Exsanguinating Hemorrhage Shock; Traumatic
Interventions
DEVICE
No Results Yet
NCT02861573 | RECRUITING | PHASE1/PHASE2
1200 Participants

Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-11-17
Completion: 2027-10-22
Conditions
Metastatic Castration-Resistant Prostate Cancer
Interventions
BIOLOGICAL DRUG OTHER
No Results Yet
NCT02839850 | ACTIVE_NOT_RECRUITING | NA
540 Participants

14022 ATTUNE Cementless RP Clinical Performance Evaluation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-09-01
Completion: 2027-09-01
Conditions
Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT02839707 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
444 Participants

Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2017-06-23
Completion: 2023-05-09
Conditions
Fallopian Tube High Grade Serous Adenocarcinoma Ovarian High Grade Serous Adenocarcinoma Ovarian Seromucinous Carcinoma Primary Peritoneal High Grade Serous Adenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Fallopian Tube Clear Cell Adenocarcinoma Recurrent Fallopian Tube Endometrioid Adenocarcinoma Recurrent Fallopian Tube Undifferentiated Carcinoma Recurrent Ovarian Carcinoma Recurrent Ovarian Clear Cell Adenocarcinoma Recurrent Ovarian Endometrioid Adenocarcinoma Recurrent Ovarian Undifferentiated Carcinoma Recurrent Platinum-Resistant Fallopian Tube Carcinoma Recurrent Platinum-Resistant Ovarian Carcinoma Recurrent Platinum-Resistant Primary Peritoneal Carcinoma Recurrent Primary Peritoneal Carcinoma Recurrent Primary Peritoneal Clear Cell Adenocarcinoma Recurrent Primary Peritoneal Endometrioid Adenocarcinoma Recurrent Primary Peritoneal Undifferentiated Carcinoma
Interventions
DRUG BIOLOGICAL PROCEDURE OTHER
NCT02830451 | ACTIVE_NOT_RECRUITING
960 Participants

Metastatic Tumor Research and Outcomes Network

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2017-11-15
Completion: 2025-12-31
Conditions
Metastatic Spine Tumor
No Results Yet
NCT02823990 | COMPLETED | PHASE2
13 Participants

TG4010 and Nivolumab in Patients With Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-14
Completion: 2021-02-24
Conditions
Recurrent Non-Small Cell Lung Carcinoma Stage I Non-Small Cell Lung Cancer Stage II Non-Small Cell Lung Cancer Stage IIIA Non-Small Cell Lung Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IV Non-Small Cell Lung Cancer
Interventions
BIOLOGICAL
NCT02808780 | ACTIVE_NOT_RECRUITING
537 Participants

An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-16
Completion: 2026-12-10
Conditions
Ulcerative Colitis
No Results Yet
NCT02790983 | RECRUITING
1350 Participants

Primary Tumor Research and Outcomes Network

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2016-10-31
Completion: 2025-12-31
Conditions
Spinal Column Tumor
No Results Yet
NCT02775643 | RECRUITING
500 Participants

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2016-05-31
Completion: 2031-05-31
Conditions
Melanoma
No Results Yet
NCT02726997 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
18 Participants

Matched Paired Pharmacodynamics and Feasibility Study of Durvalumab in Combination With Chemotherapy in Frontline Ovarian Cancer (N-Dur)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-07-06
Completion: 2025-12-31
Conditions
Stage III Fallopian Tube Cancer AJCC v7 Stage III Ovarian Cancer AJCC v6 and v7 Stage III Primary Peritoneal Cancer AJCC v7 Stage IIIA Fallopian Tube Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIA Primary Peritoneal Cancer AJCC v7 Stage IIIB Fallopian Tube Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIB Primary Peritoneal Cancer AJCC v7 Stage IIIC Fallopian Tube Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IIIC Primary Peritoneal Cancer AJCC v7 Stage IV Fallopian Tube Cancer AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7
Interventions
DRUG BIOLOGICAL OTHER
No Results Yet
NCT02724371 | ACTIVE_NOT_RECRUITING | NA
400 Participants

A Study of the Safety and Effectiveness of the Mentor Larger Size MemoryGel Ultra High Profile Breast Implants in Subjects Who Are Undergoing Primary Breast Reconstruction or Revision Reconstruction

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-04-01
Completion: 2029-01-31
Conditions
Breast Reconstruction, Revision Breast Reconstruction
Interventions
DEVICE
No Results Yet
NCT02710253 | RECRUITING | PHASE2
230 Participants

Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-05-25
Completion: 2026-05-30
Conditions
Hematopoietic and Lymphoid Cell Neoplasm Metastatic Malignant Solid Neoplasm
Interventions
RADIATION OTHER
No Results Yet
NCT02704975 | COMPLETED | NA
39 Participants

Effectiveness of Dry Needling and Physical Therapy Versus Physical Therapy Alone Following Shoulder Stabilization Repair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-03-31
Completion: 2017-12-31
Conditions
Shoulder Pain
Interventions
DEVICE
NCT02703623 | ACTIVE_NOT_RECRUITING | PHASE2
196 Participants

Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-05-18
Completion: 2026-03-31
Conditions
Castration Levels of Testosterone Castration-Resistant Prostate Carcinoma Metastatic Prostate Carcinoma PSA Progression Stage IV Prostate Adenocarcinoma AJCC v7
Interventions
DRUG BIOLOGICAL OTHER
No Results Yet
NCT02699190 | COMPLETED
236 Participants

LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2017-01-06
Completion: 2023-10-31
Conditions
Leukodystrophy White Matter Disease 4H Syndrome Adrenoleukodystrophy AMN ALD ALD (Adrenoleukodystrophy) X-linked Adrenoleukodystrophy X-ALD Adrenomyeloneuropathy Aicardi Goutieres Syndrome AGS Alexander Disease Alexanders Leukodystrophy AxD ADLD Canavan Disease CTX Cerebrotendinous Xanthomatoses Krabbe Disease GALC Deficiency Globoid Leukodystrophy TUBB4A-Related Leukodystrophy H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum HBSL HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity LBSL Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder) Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation ALSP CSF1R Gene Mutation HCC - Hypomyelination and Congenital Cataract MLC1 Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 MLD Metachromatic Leukodystrophy PMD Pelizaeus-Merzbacher Disease PLP1 Null Syndrome PLP1 Gene Duplication | Blood or Tissue | Mutations Pelizaeus-Merzbacher-Like Disease, 1 Peroxisomal Biogenesis Disorder Zellweger Syndrome Refsum Disease Salla Disease Sialic Storage Disease Sjรถgren Sjogren-Larsson Syndrome Van Der Knapp Disease Vanishing White Matter Disease Charcot-Marie-Tooth CMT Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency Allan-Herndon-Dudley Syndrome Cadasil Cockayne Syndrome Multiple Sulfatase Deficiency Gangliosidoses GM2 Gangliosidosis BPAN Labrune Syndrome LCC Mucopolysaccharidoses TBCK-Related Intellectual Disability Syndrome
NCT02697227 | ACTIVE_NOT_RECRUITING | NA
85 Participants

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-08-05
Completion: 2025-12-31
Conditions
Cigarette Smoker Tobacco Use Disorder
Interventions
BEHAVIORAL OTHER DRUG
No Results Yet
NCT02696993 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
80 Participants

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-16
Completion: 2027-12-31
Conditions
Metastatic Malignant Neoplasm in the Brain Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions
PROCEDURE BIOLOGICAL OTHER RADIATION
No Results Yet
NCT02684838 | COMPLETED
272 Participants

Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2016-04-26
Completion: 2025-06-23
Conditions
CNS Tumor
No Results Yet
NCT02683993 | COMPLETED | NA
20 Participants

Utilizing Holmium Laser for FURS Renal Stone Lithotripsy Comparing Stone Breaking vs. Stone Dusting Settings

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-02-29
Completion: 2017-01-31
Conditions
Stone Clearance
Interventions
DEVICE
NCT02642042 | ACTIVE_NOT_RECRUITING | PHASE2
60 Participants

Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-07-18
Completion: 2019-05-15
Conditions
KRAS Gene Mutation Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions
DRUG OTHER
NCT02623439 | TERMINATED | PHASE2
10 Participants

A Study of Haploidentical Bone Marrow Transplant for Patients With Hematologic Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2012-09-21
Completion: 2016-05-12
Conditions
Hematologic Malignancies
Interventions
DRUG
NCT02609776 | ACTIVE_NOT_RECRUITING | PHASE1
751 Participants

Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-05-24
Completion: 2026-12-31
Conditions
Non-Small-Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT02567435 | ACTIVE_NOT_RECRUITING | PHASE3
325 Participants

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-06-01
Completion: 2023-06-30
Conditions
Alveolar Rhabdomyosarcoma Botryoid-Type Embryonal Rhabdomyosarcoma Embryonal Rhabdomyosarcoma Rhabdomyosarcoma Sclerosing Rhabdomyosarcoma Spindle Cell Rhabdomyosarcoma
Interventions
DRUG BIOLOGICAL OTHER RADIATION
NCT02546661 | ACTIVE_NOT_RECRUITING | PHASE1
117 Participants

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2016-12-28
Completion: 2020-03-18
Conditions
Muscle Invasive Bladder Cancer
Interventions
DRUG
No Results Yet
NCT02531516 | ACTIVE_NOT_RECRUITING | PHASE3
1503 Participants

An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2015-11-19
Completion: 2026-06-30
Conditions
Prostatic Neoplasms
Interventions
DRUG RADIATION
No Results Yet
NCT02506153 | ACTIVE_NOT_RECRUITING | PHASE3
1301 Participants

Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2015-11-10
Completion: 2023-09-15
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Metastatic Cutaneous Melanoma Metastatic Mucosal Melanoma Metastatic Non-Cutaneous Melanoma Non-Cutaneous Melanoma Recurrent Cutaneous Melanoma Recurrent Mucosal Melanoma Recurrent Non-Cutaneous Melanoma
Interventions
PROCEDURE BIOLOGICAL OTHER
NCT02495896 | ACTIVE_NOT_RECRUITING | PHASE1
61 Participants

Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2015-09-03
Completion: 2021-04-01
Conditions
Head and Neck Squamous Cell Carcinoma Metastatic Pancreatic Adenocarcinoma Non-Resectable Cholangiocarcinoma Pancreatic Adenocarcinoma Recurrent Gallbladder Carcinoma Recurrent Non-Small Cell Lung Carcinoma Stage III Pancreatic Cancer Stage IIIA Gallbladder Cancer Stage IIIA Non-Small Cell Lung Cancer Stage IIIB Gallbladder Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IV Gallbladder Cancer Stage IV Non-Small Cell Lung Cancer Stage IV Pancreatic Cancer Unresectable Gallbladder Carcinoma Unresectable Pancreatic Cancer
Interventions
DRUG OTHER BIOLOGICAL
No Results Yet
NCT02455531 | ACTIVE_NOT_RECRUITING
237 Participants

Long-term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2015-06-30
Completion: 2020-10-31
Conditions
Heart Defects
NCT02445781 | RECRUITING | EARLY_PHASE1
32 Participants

Differing Levels of Hypoglycemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2015-07-31
Completion: 2026-09-30
Conditions
Hypoglycemia
Interventions
DEVICE
No Results Yet
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