Metastatic Tumor Research and Outcomes Network

NCT ID: NCT02830451

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

960 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-15

Study Completion Date

2025-12-31

Brief Summary

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The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).

Detailed Description

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To prospectively determine the prognostic variables (clinical, diagnostic, and therapeutic) within patients diagnosed with metastatic spine tumor(s) that are associated with:

* patient reported outcomes (HRQOL)
* morbidity data
* local tumor control
* survival

Outcome measures:

Variables which will be collected in the registry that are applicable to patients with metastatic spine tumor include:

* • Patient details
* Details of previous treatment
* Diagnosis
* Symptoms
* Treatment details for the index target
* Imaging information

The following outcome measures will be collected:

* Patient reported outcomes:

* Euroqol EQ-5D-3L
* Euroqol EQ-5D VAS - Quality of Life
* Neck Pain Numeric Rating Scale (NRS)
* Arm Pain NRS
* Back Pain NRS
* Leg Pain NRS
* SOSGOQ
* Patient assessment
* Ambulation
* Pain medication
* Nutritional Status Tool (PG-SGA©)
* Morbidity data
* Local disease recurrence data
* Overall survival data

Conditions

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Metastatic Spine Tumor

Keywords

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Registry Spine Surgery Medical Oncology Radiation Oncology Neoplasms Metastasis Chemotherapy Radiation Therapy Tumor Markers

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient 18 or older.
* Patient diagnosed with a metastatic tumor of the spine
* Informed consent obtained, i.e.:

* Ability to understand the content of the patient information/ICF
* Willingness and ability to participate in the registry according to the Registry Plan
* Signed and dated EC/IRB approved written informed consent (if consent is required by the EC/ IRB at the registry site)

Exclusion Criteria

• Patient diagnosed with a primary tumor of the spine.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AO Foundation, AO Spine

OTHER

Sponsor Role collaborator

AO Innovation Translation Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Charles G. Fisher, MD

Role: PRINCIPAL_INVESTIGATOR

Vancouver General Hospital and the University of British Columbia

Locations

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University of California The UCSF Spine Center Department of Neurological Surgery

San Francisco, California, United States

Site Status

Rush University Medical Center University Neurosurgery

Chicago, Illinois, United States

Site Status

Johns Hopkins University Department of Neurosurgery / Spine Division

Baltimore, Maryland, United States

Site Status

Harvard Medical School Department of Neurosurgery

Boston, Massachusetts, United States

Site Status

Mayo Clinic Department of Neurosurgery

Rochester, Minnesota, United States

Site Status

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

Site Status

University of Rochester School of Medicine and Dentistry Department of Orthopaedic Surgery and Neurosurgery

Rochester, New York, United States

Site Status

Westchester Medical Center Department of Neurosurgery

Valhalla, New York, United States

Site Status

Penn Presbyterian Medical Center Department of Neurosurgery

Philadelphia, Pennsylvania, United States

Site Status

The Warren Alpert Medical School of Brown university Department of Neurosurgery

Providence, Rhode Island, United States

Site Status

The University of Texas MD Anderson Cancer Center Department of Neurosurgery

Houston, Texas, United States

Site Status

Monash University Melbourne

Clayton, Victoria, Australia

Site Status

Vancouver General Hospital and the University of British Columbia

Vancouver, British Columbia, Canada

Site Status

Winnipeg Spine Program University of Manitoba Department of Surgery

Winnipeg, Manitoba, Canada

Site Status

Toronto Western Hospital Department of Neurosurgery Division of Surgery

Toronto, Ontario, Canada

Site Status

University of Toronto Odette Cancer Centre - T2 158 Sunnybrook Health Sciences Ccenter

Toronto, Ontario, Canada

Site Status

McGill University Health Centre

Montreal, Quebec, Canada

Site Status

Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden

Dresden, Saxony, Germany

Site Status

National Center for Spinal Disorders and Buda Health Center

Budapest, , Hungary

Site Status

Instituto Ortopedico Rizzoli Department of Oncologic and Degenerative Spine Surgery

Bologna, Emilia-Romagna, Italy

Site Status

IRCCS Istituto Ortopedico Galeazzi Centro die Chirurgia Ortopedica Oncologica e Ricostr

Milan, Lombardy, Italy

Site Status

Kanazawa Medical University Hospital Department of Orthopaedic Surgery

Uchinoda, Ishikawa-ken, Japan

Site Status

Universitair Medisch Centrum Utrecht

Utrecht, , Netherlands

Site Status

National University of Singapore Department of Orthopaedic Surgery

Singapore, , Singapore

Site Status

Universitätsspital Basel Wirbelsäulenzentrum

Basel, Basel, Switzerland

Site Status

Countries

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United Kingdom United States Australia Canada Germany Hungary Italy Japan Netherlands Singapore Switzerland

Other Identifiers

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MTRON

Identifier Type: -

Identifier Source: org_study_id