Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors
NCT ID: NCT02495896
Last Updated: 2025-11-10
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
ACTIVE_NOT_RECRUITING
Clinical Phase
PHASE1
Total Enrollment
61 participants
Study Classification
INTERVENTIONAL
Study Start Date
2015-09-03
Study Completion Date
2026-04-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This pilot phase Ib trial studies the side effects and best dose of recombinant EphB4-HSA fusion protein when given together with standard chemotherapy regimens in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or have spread to other places in the body (metastatic). Drugs used in chemotherapy, such as recombinant EphB4-HSA fusion protein, paclitaxel albumin-stabilized nanoparticle formulation, gemcitabine hydrochloride, docetaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether standard chemotherapy regimens are more effective with recombinant ephB4-HSA fusion protein in treating advanced or metastatic solid tumors.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
PRIMARY OBJECTIVES:
I. To document the safety and tolerability of sEphB4-HSA (recombinant ephB4-HSA fusion protein) intravenously (IV) weekly when administered in combination with: arm A) gemcitabine (gemcitabine hydrochloride) and nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation), arm B) docetaxel, arm C) gemcitabine and cisplatin.
SECONDARY OBJECTIVES:
I. To describe the adverse event profile of sEphB4-HSA IV weekly when administered in combination with: arm A) gemcitabine and nab-paclitaxel, arm B) docetaxel, arm C) gemcitabine and cisplatin.
II. To characterize the pharmacokinetics of sEphB4-HSA when combined with: arm A) gemcitabine and nab-paclitaxel, arm B) docetaxel, arm C) gemcitabine and cisplatin.
III. To assess, in a preliminary fashion, the anti-tumor efficacy of sEphB4-HSA in combination with the various chemotherapy regimens in each of the 4 cohorts separately: Arm A cohort 1-patients with advanced pancreatic cancer; Arm B cohort 2-patients with head and neck cancer; Arm B cohort 3-patients with non-small cell lung cancer; Arm C cohort 3: patients with cholangiocarcinoma.
TERTIARY OBJECTIVES:
I. To evaluate the expression of EPH receptor B4 (EphB4) and ephrinB2 in the archival tumor samples and explore potential associations with outcome.
II. To bank specimens for future correlative biomarkers studies based on the results of ongoing biomarkers analyses in the phase I of sEphB4-HSA as a single agent.
OUTLINE: This is a dose de-escalation study of recombinant EphB4-HSA fusion protein. Patients are assigned to 1 of 3 treatment arms.
ARM A: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, 15, and 22 (beginning course 2), paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2) and docetaxel IV over 1 hour on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM C: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2), cisplatin IV over 120 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
In all arms, patients with chemotherapy related toxicity may continue treatment with recombinant EphB4-HSA fusion protein alone. Patients with toxicity related to recombinant EphB4-HSA fusion protein may continue treatment with chemotherapy at the discretion of the investigator.
After completion of study treatment, patients are followed up periodically.
I. To document the safety and tolerability of sEphB4-HSA (recombinant ephB4-HSA fusion protein) intravenously (IV) weekly when administered in combination with: arm A) gemcitabine (gemcitabine hydrochloride) and nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation), arm B) docetaxel, arm C) gemcitabine and cisplatin.
SECONDARY OBJECTIVES:
I. To describe the adverse event profile of sEphB4-HSA IV weekly when administered in combination with: arm A) gemcitabine and nab-paclitaxel, arm B) docetaxel, arm C) gemcitabine and cisplatin.
II. To characterize the pharmacokinetics of sEphB4-HSA when combined with: arm A) gemcitabine and nab-paclitaxel, arm B) docetaxel, arm C) gemcitabine and cisplatin.
III. To assess, in a preliminary fashion, the anti-tumor efficacy of sEphB4-HSA in combination with the various chemotherapy regimens in each of the 4 cohorts separately: Arm A cohort 1-patients with advanced pancreatic cancer; Arm B cohort 2-patients with head and neck cancer; Arm B cohort 3-patients with non-small cell lung cancer; Arm C cohort 3: patients with cholangiocarcinoma.
TERTIARY OBJECTIVES:
I. To evaluate the expression of EPH receptor B4 (EphB4) and ephrinB2 in the archival tumor samples and explore potential associations with outcome.
II. To bank specimens for future correlative biomarkers studies based on the results of ongoing biomarkers analyses in the phase I of sEphB4-HSA as a single agent.
OUTLINE: This is a dose de-escalation study of recombinant EphB4-HSA fusion protein. Patients are assigned to 1 of 3 treatment arms.
ARM A: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, 15, and 22 (beginning course 2), paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2) and docetaxel IV over 1 hour on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM C: Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2), cisplatin IV over 120 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
In all arms, patients with chemotherapy related toxicity may continue treatment with recombinant EphB4-HSA fusion protein alone. Patients with toxicity related to recombinant EphB4-HSA fusion protein may continue treatment with chemotherapy at the discretion of the investigator.
After completion of study treatment, patients are followed up periodically.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Head and Neck Squamous Cell Carcinoma
Metastatic Pancreatic Adenocarcinoma
Non-Resectable Cholangiocarcinoma
Pancreatic Adenocarcinoma
Recurrent Gallbladder Carcinoma
Recurrent Non-Small Cell Lung Carcinoma
Stage III Pancreatic Cancer
Stage IIIA Gallbladder Cancer
Stage IIIA Non-Small Cell Lung Cancer
Stage IIIB Gallbladder Cancer
Stage IIIB Non-Small Cell Lung Cancer
Stage IV Gallbladder Cancer
Stage IV Non-Small Cell Lung Cancer
Stage IV Pancreatic Cancer
Unresectable Gallbladder Carcinoma
Unresectable Pancreatic Cancer
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
NON_RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Arm A (sEphB4-HSA, nab-paclitaxel, gemcitabine hydrochloride)
Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, 15, and 22 (beginning course 2), paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Group Type
EXPERIMENTAL
Gemcitabine Hydrochloride
Intervention Type
DRUG
Given IV
Laboratory Biomarker Analysis
Intervention Type
OTHER
Correlative studies
Paclitaxel Albumin-Stabilized Nanoparticle Formulation
Intervention Type
DRUG
Given IV
Pharmacological Study
Intervention Type
OTHER
Correlative studies
Recombinant EphB4-HSA Fusion Protein
Intervention Type
BIOLOGICAL
Given IV
Arm B (sEphB4-HSA, docetaxel)
Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2) and docetaxel IV over 1 hour on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Group Type
EXPERIMENTAL
Docetaxel
Intervention Type
DRUG
Given IV
Laboratory Biomarker Analysis
Intervention Type
OTHER
Correlative studies
Pharmacological Study
Intervention Type
OTHER
Correlative studies
Recombinant EphB4-HSA Fusion Protein
Intervention Type
BIOLOGICAL
Given IV
Arm C (sEphB4-HSA, cisplatin, gemcitabine hydrochloride)
Patients receive recombinant EphB4-HSA fusion protein IV over 1 hour on days 1, 8, and 15 (beginning course 2), cisplatin IV over 120 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Group Type
EXPERIMENTAL
Cisplatin
Intervention Type
DRUG
Given IV
Gemcitabine Hydrochloride
Intervention Type
DRUG
Given IV
Laboratory Biomarker Analysis
Intervention Type
OTHER
Correlative studies
Pharmacological Study
Intervention Type
OTHER
Correlative studies
Recombinant EphB4-HSA Fusion Protein
Intervention Type
BIOLOGICAL
Given IV
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Cisplatin
Given IV
Intervention Type
DRUG
Docetaxel
Given IV
Intervention Type
DRUG
Gemcitabine Hydrochloride
Given IV
Intervention Type
DRUG
Laboratory Biomarker Analysis
Correlative studies
Intervention Type
OTHER
Paclitaxel Albumin-Stabilized Nanoparticle Formulation
Given IV
Intervention Type
DRUG
Pharmacological Study
Correlative studies
Intervention Type
OTHER
Recombinant EphB4-HSA Fusion Protein
Given IV
Intervention Type
BIOLOGICAL
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Abiplatin
Blastolem
Briplatin
CDDP
Cis-diammine-dichloroplatinum
Cis-diamminedichloridoplatinum
Cis-diamminedichloro Platinum (II)
Cis-diamminedichloroplatinum
Cis-dichloroammine Platinum (II)
Cis-platinous Diamine Dichloride
Cis-platinum
Cis-platinum II
Cis-platinum II Diamine Dichloride
Cismaplat
Cisplatina
Cisplatinum
Cisplatyl
Citoplatino
Citosin
Cysplatyna
DDP
Lederplatin
Metaplatin
Neoplatin
Peyrone's Chloride
Peyrone's Salt
Placis
Plastistil
Platamine
Platiblastin
Platiblastin-S
Platinex
Platinol
Platinol- AQ
Platinol-AQ
Platinol-AQ VHA Plus
Platinoxan
Platinum
Platinum Diamminodichloride
Platiran
Platistin
Platosin
RP56976
Taxotere
Taxotere Injection Concentrate
dFdCyd
Difluorodeoxycytidine Hydrochloride
Gemzar
LY-188011
ABI 007
ABI-007
Abraxane
Albumin-bound Paclitaxel
Albumin-Stabilized Nanoparticle Paclitaxel
nab-paclitaxel
Nanoparticle Albumin-bound Paclitaxel
Nanoparticle Paclitaxel
protein-bound paclitaxel
sEphB4-HSA
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1
* Patients must have a life expectancy of at least 12 weeks
* Patients must be able to comprehend and provide written informed consent
* Women of childbearing potential (WOCBP) and male patients with WOCBP partner must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 12 weeks after the last dose of investigational product in such a manner that the risk of pregnancy is minimized; WOCBP include any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal; post menopause is defined as:
* Amenorrhea \>= 12 consecutive months without another cause or
* For women with irregular menstrual periods and on hormone replacement therapy (HRT), a documented serum follicle stimulating hormone (FSH) level \> 35 mIU/mL
* Women who are using oral contraceptives, other hormonal contraceptives (vagina products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential
* WOCBP must have a negative serum test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin \[HCG\]) within 72 hours prior to the start of investigational product
* Patients with hepatitis B infection must be on appropriate antiviral therapy
* ARM A COHORT 1: Patients must have advanced pancreatic adenocarcinoma (unresectable or metastatic)
* ARM A COHORT 1: Patients must not have received prior therapy for metastatic or advanced disease; adjuvant therapy that is gemcitabine based is allowed as long as the adjuvant treatment was completed \>= 6 months before the diagnosis of recurrent disease
* ARM A COHORT 1: Absolute neutrophil count \>= 1,500/ul
* ARM A COHORT 1: Platelet count \>= 100,000/ul
* ARM A COHORT 1: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2 x upper limit of normal (ULN); if liver metastases are present then must be \< 5 X the ULN
* ARM A COHORT 1: Total bilirubin =\< 1.5 x ULN
* ARM A COHORT 1: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM A COHORT 1: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 2: Patients must have a histologically confirmed diagnosis of head and neck (squamous cell) carcinoma
* ARM B COHORT 2: Patients must have failed treatment with platinum based therapy with or without cetuximab; previous therapy with a platinum concurrent with radiation followed by progression of disease within 6 months will count as failure of one prior line of cisplatin based therapy
* ARM B COHORT 2: Absolute neutrophil count \>= 1,500/ul
* ARM B COHORT 2: Platelet count \>= 100,000/ul
* ARM B COHORT 2: AST and ALT =\< 2 X ULN; if liver metastases are present then must be \< 5 X the ULN
* ARM B COHORT 2: Total bilirubin =\< 1.5 x institutional upper limit of normal (IULN)
* ARM B COHORT 2: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 2: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM B COHORT 3: Patients must have a histologically confirmed diagnosis of non-small cell lung cancer
* ARM B COHORT 3: Patients must have failed one prior line of systemic therapy for the treatment of advanced non-small cell lung cancer; prior adjuvant therapy with subsequent recurrence within 6 months of completion of therapy will count as one prior line of systemic therapy and such patients will be eligible
* ARM B COHORT 3: Absolute neutrophil count \>= 1,500/ul
* ARM B COHORT 3: Platelet count \>= 100,000/ul
* ARM B COHORT 3: AST and ALT =\< 2 X ULN; if liver metastases are present then must be \< 5 X the ULN
* ARM B COHORT 3: Total bilirubin =\< 1.5 x IULN
* ARM B COHORT 3: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 3: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM C COHORT 4: Patients must have a histologically or cytologically proven diagnosis of advanced (unresectable or metastatic) gallbladder cancer or cholangiocarcinoma and be candidates for first line therapy with gemcitabine and cisplatin
* ARM C COHORT 4: Patients must not have received prior systemic chemotherapy for advanced or metastatic disease; prior adjuvant chemotherapy or concurrent chemotherapy and radiation are allowed if they were completed \>= 6 months prior to the diagnosis of recurrent disease
* ARM C COHORT 4: Absolute neutrophil count \>= 1,500/ul
* ARM C COHORT 4: Platelet count \>= 100,000/ul
* ARM C COHORT 4: AST and ALT =\< 5 x ULN
* ARM C COHORT 4: Total bilirubin =\< 2 X IULN
* ARM C COHORT 4: Serum albumin \>= 2.5 g/dL
* ARM C COHORT 4: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM C COHORT 4: Patients who have had decompression of the biliary tree within the last 14 days, must have a stable bilirubin level as confirmed by two measurements that are within 5 to 7 days of each other; (the second measurement must be obtained within 7 days prior to registration); both the first and second measurement must be =\< 2 X IULN; stability is defined as the second measurement being no more than one point higher than the first
* Patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1
* Patients must have a life expectancy of at least 12 weeks
* Patients must be able to comprehend and provide written informed consent
* Women of childbearing potential (WOCBP) and male patients with WOCBP partner must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 12 weeks after the last dose of investigational product in such a manner that the risk of pregnancy is minimized; WOCBP include any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal; post menopause is defined as:
* Amenorrhea \>= 12 consecutive months without another cause or
* For women with irregular menstrual periods and on hormone replacement therapy (HRT), a documented serum follicle stimulating hormone (FSH) level \> 35 mIU/mL
* Women who are using oral contraceptives, other hormonal contraceptives (vagina products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential
* WOCBP must have a negative serum test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin \[HCG\]) within 72 hours prior to the start of investigational product
* Patients with hepatitis B infection must be on appropriate antiviral therapy
* ARM A COHORT 1: Patients must have advanced pancreatic adenocarcinoma (unresectable or metastatic)
* ARM A COHORT 1: Patients must not have received prior therapy for metastatic or advanced disease; adjuvant therapy that is gemcitabine based is allowed as long as the adjuvant treatment was completed \>= 6 months before the diagnosis of recurrent disease
* ARM A COHORT 1: Absolute neutrophil count \>= 1,500/ul
* ARM A COHORT 1: Platelet count \>= 100,000/ul
* ARM A COHORT 1: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2 x upper limit of normal (ULN); if liver metastases are present then must be \< 5 X the ULN
* ARM A COHORT 1: Total bilirubin =\< 1.5 x ULN
* ARM A COHORT 1: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM A COHORT 1: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 2: Patients must have a histologically confirmed diagnosis of head and neck (squamous cell) carcinoma
* ARM B COHORT 2: Patients must have failed treatment with platinum based therapy with or without cetuximab; previous therapy with a platinum concurrent with radiation followed by progression of disease within 6 months will count as failure of one prior line of cisplatin based therapy
* ARM B COHORT 2: Absolute neutrophil count \>= 1,500/ul
* ARM B COHORT 2: Platelet count \>= 100,000/ul
* ARM B COHORT 2: AST and ALT =\< 2 X ULN; if liver metastases are present then must be \< 5 X the ULN
* ARM B COHORT 2: Total bilirubin =\< 1.5 x institutional upper limit of normal (IULN)
* ARM B COHORT 2: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 2: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM B COHORT 3: Patients must have a histologically confirmed diagnosis of non-small cell lung cancer
* ARM B COHORT 3: Patients must have failed one prior line of systemic therapy for the treatment of advanced non-small cell lung cancer; prior adjuvant therapy with subsequent recurrence within 6 months of completion of therapy will count as one prior line of systemic therapy and such patients will be eligible
* ARM B COHORT 3: Absolute neutrophil count \>= 1,500/ul
* ARM B COHORT 3: Platelet count \>= 100,000/ul
* ARM B COHORT 3: AST and ALT =\< 2 X ULN; if liver metastases are present then must be \< 5 X the ULN
* ARM B COHORT 3: Total bilirubin =\< 1.5 x IULN
* ARM B COHORT 3: Serum albumin \>= 2.5 g/dL
* ARM B COHORT 3: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM C COHORT 4: Patients must have a histologically or cytologically proven diagnosis of advanced (unresectable or metastatic) gallbladder cancer or cholangiocarcinoma and be candidates for first line therapy with gemcitabine and cisplatin
* ARM C COHORT 4: Patients must not have received prior systemic chemotherapy for advanced or metastatic disease; prior adjuvant chemotherapy or concurrent chemotherapy and radiation are allowed if they were completed \>= 6 months prior to the diagnosis of recurrent disease
* ARM C COHORT 4: Absolute neutrophil count \>= 1,500/ul
* ARM C COHORT 4: Platelet count \>= 100,000/ul
* ARM C COHORT 4: AST and ALT =\< 5 x ULN
* ARM C COHORT 4: Total bilirubin =\< 2 X IULN
* ARM C COHORT 4: Serum albumin \>= 2.5 g/dL
* ARM C COHORT 4: Creatinine =\< 1.5 x institutional ULN, or creatinine clearance \>= 50 mL/min (calculated with the Cockcroft-Gault formula)
* ARM C COHORT 4: Patients who have had decompression of the biliary tree within the last 14 days, must have a stable bilirubin level as confirmed by two measurements that are within 5 to 7 days of each other; (the second measurement must be obtained within 7 days prior to registration); both the first and second measurement must be =\< 2 X IULN; stability is defined as the second measurement being no more than one point higher than the first
Exclusion Criteria
* Patients must not have received any anti-cancer therapy (cytotoxic chemotherapy, targeted therapy or radiation) within the past 28 days prior to initiation of study therapy
* Patients must not have an active major systemic infection requiring systemic antibiotics 72 hours or less prior to the first dose of study drug
* Patients must not have untreated central nervous system (CNS) metastases; patients whose CNS metastases have been treated by surgery or radiotherapy, who are no longer on corticosteroids, and who are neurologically stable may be enrolled
* Patients must not have any of the following: New York Heart Association (NYHA) class 3 or 4 congestive heart failure; myocardial infarction within the past 12 months, acute coronary syndrome, diabetes mellitus with ketoacidosis or chronic obstructive pulmonary disease (COPD) requiring hospitalization in the preceding 6 months; or any other intercurrent medical condition that contra-indicates treatment with sEphB4HSA or places the patient at undue risk for treatment related complications
* Patients must not have any other condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interferes with the interpretation of the results
* Patients must not be pregnant of lactating
* Patients must not be on any dose of warfarin or are on full dose anticoagulation with other agents, including low molecular weight heparin, antithrombin agents, anti-platelet agents and full dose aspirin within 7 days prior to first dose of study drug; patients on prophylactic doses of low-molecular weight heparin are allowed
* Patients must not have had any active bleeding in the last =\< 4 weeks or have an otherwise known bleeding diathesis
* Patients must not have corrected QT (QTc)F (Fridericia Correction Formula) \> 480 on 2 out of 3 electrocardiograms (EKG's) (if first EKG is =\< 480, no need to repeat, if first EKG is \> 480 repeat twice for a total of 3 EKG's)
* Patients must not have uncontrolled hypertension as defined by systolic blood pressure (SBP) \>= 160 mmHg or diastolic blood pressure (DBP) \>= 90 mmHg; patients whose blood pressure can be controlled medically are allowed to be rescreened once blood pressure (BP) is under control
* Patients must not have \> grade sensory neuropathy
* Patients must not have known human immunodeficiency virus (HIV) infection
* ARM A COHORT 1: Patients must not have prior nab-paclitaxel exposure
* ARM A COHORT 1: Patients must not have a history of slowly progressive dyspnea and unproductive cough, or of conditions such as sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis, or multiple allergies
* ARM B COHORT 2: Patients must not have prior exposure to docetaxel
* ARM B COHORT 2: Patients with head and neck cancer must not have radiologic evidence of major arterial involvement
* ARM B COHORT 3: Patients must not have prior exposure to docetaxel
* ARM B COHORT 3: Patients must not have had more than one prior line of systemic therapy for advanced non-small cell lung cancer (including treatment with a targeted agent); prior adjuvant therapy completed more than 6 months prior to disease recurrence will not count as a prior line of systemic therapy for advanced disease
* ARM B COHORT 3: Patients must not have active clinically significant hemoptysis
* ARM B COHORT 3: Patients must not have a central lesion with radiologic evidence of arterial involvement
* ARM C COHORT 4: Patients must not have prior cisplatin exposure
* Patients must not have an active major systemic infection requiring systemic antibiotics 72 hours or less prior to the first dose of study drug
* Patients must not have untreated central nervous system (CNS) metastases; patients whose CNS metastases have been treated by surgery or radiotherapy, who are no longer on corticosteroids, and who are neurologically stable may be enrolled
* Patients must not have any of the following: New York Heart Association (NYHA) class 3 or 4 congestive heart failure; myocardial infarction within the past 12 months, acute coronary syndrome, diabetes mellitus with ketoacidosis or chronic obstructive pulmonary disease (COPD) requiring hospitalization in the preceding 6 months; or any other intercurrent medical condition that contra-indicates treatment with sEphB4HSA or places the patient at undue risk for treatment related complications
* Patients must not have any other condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interferes with the interpretation of the results
* Patients must not be pregnant of lactating
* Patients must not be on any dose of warfarin or are on full dose anticoagulation with other agents, including low molecular weight heparin, antithrombin agents, anti-platelet agents and full dose aspirin within 7 days prior to first dose of study drug; patients on prophylactic doses of low-molecular weight heparin are allowed
* Patients must not have had any active bleeding in the last =\< 4 weeks or have an otherwise known bleeding diathesis
* Patients must not have corrected QT (QTc)F (Fridericia Correction Formula) \> 480 on 2 out of 3 electrocardiograms (EKG's) (if first EKG is =\< 480, no need to repeat, if first EKG is \> 480 repeat twice for a total of 3 EKG's)
* Patients must not have uncontrolled hypertension as defined by systolic blood pressure (SBP) \>= 160 mmHg or diastolic blood pressure (DBP) \>= 90 mmHg; patients whose blood pressure can be controlled medically are allowed to be rescreened once blood pressure (BP) is under control
* Patients must not have \> grade sensory neuropathy
* Patients must not have known human immunodeficiency virus (HIV) infection
* ARM A COHORT 1: Patients must not have prior nab-paclitaxel exposure
* ARM A COHORT 1: Patients must not have a history of slowly progressive dyspnea and unproductive cough, or of conditions such as sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis, or multiple allergies
* ARM B COHORT 2: Patients must not have prior exposure to docetaxel
* ARM B COHORT 2: Patients with head and neck cancer must not have radiologic evidence of major arterial involvement
* ARM B COHORT 3: Patients must not have prior exposure to docetaxel
* ARM B COHORT 3: Patients must not have had more than one prior line of systemic therapy for advanced non-small cell lung cancer (including treatment with a targeted agent); prior adjuvant therapy completed more than 6 months prior to disease recurrence will not count as a prior line of systemic therapy for advanced disease
* ARM B COHORT 3: Patients must not have active clinically significant hemoptysis
* ARM B COHORT 3: Patients must not have a central lesion with radiologic evidence of arterial involvement
* ARM C COHORT 4: Patients must not have prior cisplatin exposure
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Cancer Institute (NCI)
NIH
Sponsor Role
collaborator
Vasgene Therapeutics, Inc
INDUSTRY
Sponsor Role
collaborator
University of Southern California
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Responsibility Role
SPONSOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Anthony El-Khoueiry
Role: PRINCIPAL_INVESTIGATOR
University of Southern California
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Site Status
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
Site Status
Countries
Review the countries where the study has at least one active or historical site.
United States
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
0S-15-5
Identifier Type: -
Identifier Source: org_study_id
NCI-2015-00987
Identifier Type: REGISTRY
Identifier Source: secondary_id
0S-15-5
Identifier Type: OTHER
Identifier Source: secondary_id