Memory Gel and Shape Combined Cohort

NCT ID: NCT02919592

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

3613 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-09-01

Study Completion Date

2031-06-16

Brief Summary

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The purpose of this study is to collect additional post-approval clinical data on the long-term performance of MemoryShape and MemoryGel Breast Implants, as indicated for primary or revisional breast augmentation and primary or revisional breast reconstruction.

Detailed Description

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The post-approval study will include a maximum of 3500 women undergoing breast augmentation or reconstruction with MemoryShape or MemoryGel Breast Implants. Four cohorts will be included: primary augmentation, revision-augmentation, primary reconstruction, and revision-reconstruction. For the purpose of assessing rheumatological and neurological signs and symptoms, a control group with 300-480 women will be selected from the participating investigators' practices, who are undergoing an aesthetic surgery other than breast implant surgery. Breast implant patients and the concurrent control group patients will be followed for 10 years. Baseline and operative data will be collected at the beginning of the study, and follow-up data will be collected annually for 10 years through online questionnaires.

Conditions

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Primary Breast Augmentation Primary Breast Reconstruction Revision Breast Augmentation Revision Breast Reconstruction

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Primary Breast Augmentation

Participants who meet the requirements for primary breast augmentation (have not had previous silicone or saline breast implants) and have been implanted with Mentor MemoryGel® Breast Implants or MemoryShape® Breast Implants

Group Type EXPERIMENTAL

MemoryShape® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryShape™ Breast Implants are devices with shells constructed from medical grade silicone elastomer. The shell is filled with Mentor's proprietary formulation of medical grade silicone gel. The textured shell is constructed of successive crosslinked layers of silicone elastomer, and includes raised orientation marks on the anterior and posterior of the implant intended to help the physician orient the implant and ensure proper placement during implantation. Each MENTOR® MemoryShape™ Breast Implant is provided sterile. MemoryShape Breast Implants are available in sizes ranging from 120 cc-775 cc and 5 styles with various projection and height options.

MemoryGel® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryGel™ Breast Implants are round devices with shells constructed from medical grade silicone elastomer. The shell is filled with MemoryGel™, Mentor's proprietary formulation of medical grade silicone gel, and is constructed of successive cross-linked layers of silicone elastomer. There are two styles of shell: smooth and textured. Each MENTOR® MemoryGel™ Breast Implant is provided sterile. MemoryGel Breast Implants are available in sizes ranging from 100 cc-800 cc and 4 styles with various projection and height options.

Revision Breast Augmentation

Participants who meet the requirements for revision breast augmentation (have had previous silicone or saline breast implants) and have been implanted with Mentor MemoryGel® Breast Implants or MemoryShape® Breast implants

Group Type EXPERIMENTAL

MemoryShape® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryShape™ Breast Implants are devices with shells constructed from medical grade silicone elastomer. The shell is filled with Mentor's proprietary formulation of medical grade silicone gel. The textured shell is constructed of successive crosslinked layers of silicone elastomer, and includes raised orientation marks on the anterior and posterior of the implant intended to help the physician orient the implant and ensure proper placement during implantation. Each MENTOR® MemoryShape™ Breast Implant is provided sterile. MemoryShape Breast Implants are available in sizes ranging from 120 cc-775 cc and 5 styles with various projection and height options.

MemoryGel® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryGel™ Breast Implants are round devices with shells constructed from medical grade silicone elastomer. The shell is filled with MemoryGel™, Mentor's proprietary formulation of medical grade silicone gel, and is constructed of successive cross-linked layers of silicone elastomer. There are two styles of shell: smooth and textured. Each MENTOR® MemoryGel™ Breast Implant is provided sterile. MemoryGel Breast Implants are available in sizes ranging from 100 cc-800 cc and 4 styles with various projection and height options.

Primary Breast Reconstruction

Participants who meet the requirements for primary breast reconstruction (have not had previous silicone or saline breast implants, not including tissue expanders) and have been implanted with Mentor MemoryGel® Breast Implants or MemoryShape® Breast Implants

Group Type EXPERIMENTAL

MemoryShape® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryShape™ Breast Implants are devices with shells constructed from medical grade silicone elastomer. The shell is filled with Mentor's proprietary formulation of medical grade silicone gel. The textured shell is constructed of successive crosslinked layers of silicone elastomer, and includes raised orientation marks on the anterior and posterior of the implant intended to help the physician orient the implant and ensure proper placement during implantation. Each MENTOR® MemoryShape™ Breast Implant is provided sterile. MemoryShape Breast Implants are available in sizes ranging from 120 cc-775 cc and 5 styles with various projection and height options.

MemoryGel® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryGel™ Breast Implants are round devices with shells constructed from medical grade silicone elastomer. The shell is filled with MemoryGel™, Mentor's proprietary formulation of medical grade silicone gel, and is constructed of successive cross-linked layers of silicone elastomer. There are two styles of shell: smooth and textured. Each MENTOR® MemoryGel™ Breast Implant is provided sterile. MemoryGel Breast Implants are available in sizes ranging from 100 cc-800 cc and 4 styles with various projection and height options.

Revision Breast Reconstruction

Participants who meet the requirements for revision breast reconstruction (have had previous silicone or saline breast implants) and have been implanted with Mentor MemoryGel® Breast Implants or MemoryShape® Breast Implants

Group Type EXPERIMENTAL

MemoryShape® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryShape™ Breast Implants are devices with shells constructed from medical grade silicone elastomer. The shell is filled with Mentor's proprietary formulation of medical grade silicone gel. The textured shell is constructed of successive crosslinked layers of silicone elastomer, and includes raised orientation marks on the anterior and posterior of the implant intended to help the physician orient the implant and ensure proper placement during implantation. Each MENTOR® MemoryShape™ Breast Implant is provided sterile. MemoryShape Breast Implants are available in sizes ranging from 120 cc-775 cc and 5 styles with various projection and height options.

MemoryGel® Breast Implants

Intervention Type DEVICE

MENTOR® MemoryGel™ Breast Implants are round devices with shells constructed from medical grade silicone elastomer. The shell is filled with MemoryGel™, Mentor's proprietary formulation of medical grade silicone gel, and is constructed of successive cross-linked layers of silicone elastomer. There are two styles of shell: smooth and textured. Each MENTOR® MemoryGel™ Breast Implant is provided sterile. MemoryGel Breast Implants are available in sizes ranging from 100 cc-800 cc and 4 styles with various projection and height options.

Other Aesthetic Surgery

Participants who meet the requirements for other aesthetic surgery procedures, which may not include silicone implants (breast or otherwise)

Group Type ACTIVE_COMPARATOR

Other Aesthetic Surgery

Intervention Type PROCEDURE

Other aesthetic surgery procedures (for example, liposuction, rhinoplasty, brow lift, rhytidectomy, mentoplasty/genioplasty, otoplasty, or blepharoplasty; may not include silicone implants)

Interventions

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MemoryShape® Breast Implants

MENTOR® MemoryShape™ Breast Implants are devices with shells constructed from medical grade silicone elastomer. The shell is filled with Mentor's proprietary formulation of medical grade silicone gel. The textured shell is constructed of successive crosslinked layers of silicone elastomer, and includes raised orientation marks on the anterior and posterior of the implant intended to help the physician orient the implant and ensure proper placement during implantation. Each MENTOR® MemoryShape™ Breast Implant is provided sterile. MemoryShape Breast Implants are available in sizes ranging from 120 cc-775 cc and 5 styles with various projection and height options.

Intervention Type DEVICE

MemoryGel® Breast Implants

MENTOR® MemoryGel™ Breast Implants are round devices with shells constructed from medical grade silicone elastomer. The shell is filled with MemoryGel™, Mentor's proprietary formulation of medical grade silicone gel, and is constructed of successive cross-linked layers of silicone elastomer. There are two styles of shell: smooth and textured. Each MENTOR® MemoryGel™ Breast Implant is provided sterile. MemoryGel Breast Implants are available in sizes ranging from 100 cc-800 cc and 4 styles with various projection and height options.

Intervention Type DEVICE

Other Aesthetic Surgery

Other aesthetic surgery procedures (for example, liposuction, rhinoplasty, brow lift, rhytidectomy, mentoplasty/genioplasty, otoplasty, or blepharoplasty; may not include silicone implants)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Is a candidate for breast augmentation with MemoryShape or MemoryGel Breast Implants and is at least 22 years old (primary or revision) OR is a candidate for breast reconstruction (primary or revision) with MemoryShape or MemoryGel Breast Implants and is at least 18 years old;
2. Signs an Acknowledgement of Informed Decision from the patient brochure, or equivalent documentation of discussion and acknowledgement;
3. Signs an Informed Consent Form, including an Authorization to Disclose Health Information and Release Medical Records;
4. Agrees to answer baseline questions;
5. Agrees to authorize return of the device(s) to Mentor if the device is explanted during study participation;
6. Agrees via Informed Consent to comply with study follow-up, including following the surgeon's standard of care for office visits and responding to questionnaires in their entirety; and
7. Has a valid e-mail address and access to the internet to complete online questionnaires.


1. Is a candidate for aesthetic surgery (for example, liposuction, rhinoplasty, brow lift, autoplasty, rhytidectomy, mentoplasty/genioplasty, otoplasty, or blepharoplasty; may not include silicone or saline implants) and is at least 22 years of age;
2. Signs an Informed Consent Form, including an Authorization to Disclose Health Information and Release Medical Records;
3. Agrees to answer baseline questions;
4. Agrees via Informed Consent to comply with study follow-up, including responding to questionnaires in their entirety; and
5. Has a valid e-mail address and access to the internet to complete online questionnaires.


1. Received MemoryShape Breast Implants for breast augmenation after January 01, 2015 and was at least 22 years old (primary or revision) at the time of surgery OR underwent breast reconstruction (primary or revision) with MemoryShape Breast Implants after January 01, 2015. A women who has since had her MemoryShape Breast Implants explanted may still be enrolled in the study.
2. Signed an Acknowledgement of Informed Decision from the patient brochure, or equivalent documentation of discussion and acknowledgement is available from the time of surgery;
3. Signs an Informed Consent Form, including an Authorization to Disclose Health Information and Release Medical Records;
4. Agrees to answer baseline questions;
5. Agrees to authorize return of the device(s) to Mentor if the device is explanted during study participation;
6. Agrees via Informed Consent to comply with study follow-up, including following the surgeon's standard of care for office visits and responding to questionnaires in their entirety; and
7. Has a valid e-mail address and access to the internet to complete online questionnaires.

Exclusion Criteria

1. Has active infection anywhere in her body;
2. For augmentation patients, has a history of cancer of any kind, except non-melanoma skin cancer; for reconstruction patients, has a history of cancer of any kind, except non melanoma skin cancer or adequately treated breast cancer;
3. Has a confirmed diagnosis of connective tissue disease or neurological disease OR is currently being evaluated for symptoms suggestive of connective tissue disease or neurological disease;
4. Is currently pregnant or nursing;
5. Is planning on undergoing or has undergone bariatric surgery; or
6. Is planning on undergoing experimental procedures or procedures with investigational products/devices during the study period that in the opinion of the investigator could compromise the results of this study.


1. Has ever had unilateral or bilateral breast implants (including breast tissue expanders);
2. Expects to undergo breast implant surgery during the study period;
3. Has ever had silicone implants anywhere in her body;
4. Has active infection anywhere in her body;
5. Has a history of cancer of any kind, except non-melanoma skin cancer;
6. Has a confirmed diagnosis of connective tissue disease or neurological disease OR is currently being evaluated for symptoms suggestive of connective tissue disease or neurological disease;
7. Is currently pregnant or nursing;
8. Is planning on undergoing or has undergone bariatric surgery; or
9. Is planning on undergoing experimental procedures or procedures with investigational products/devices during the study period that in the opinion of the investigator could compromise the results of this study.


1. Had an active infection anywhere in her body at the time of surgery;
2. For augmentation patients, had a history of cancer (prior to implantation) of any kind, except non-melanoma skin cancer; for reconstruction patients, had a history of cancer (prior to implantation) of any kind, except non melanoma skin cancer or adequately treated breast cancer;
3. Had a confirmed diagnosis of connective tissue disease or neurological disease prior to implantation OR was being evaluated for symptoms suggestive of connective tissue disease or neurological disease;
4. Was pregnant or nursing at the time of surgery;
5. Was planning on undergoing bariatric surgery at the time of breast implant surgery or has undergone bariatric surgery since breast implant surgery; or
6. Is planning on undergoing experimental procedures or procedures with investigational products/devices during the study period that in the opinion of the investigator could compromise the results of this study.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Mentor Worldwide, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Mentor Worldwide, LLC

Locations

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Hedden Plastic Surgery Center

Birmingham, Alabama, United States

Site Status

Plastic Surgery of Tuscaloosa

Tuscaloosa, Alabama, United States

Site Status

Advanced Plastic Surgery Institute

Gilbert, Arizona, United States

Site Status

Advanced Surgical Associates

Mesa, Arizona, United States

Site Status

Robles Plastic Surgery

Phoenix, Arizona, United States

Site Status

Berardi Aesthetics and Plastic Surgery

Scottsdale, Arizona, United States

Site Status

Guerra Plastic Surgery Center

Scottsdale, Arizona, United States

Site Status

Mark Malek, MD Plastic Surgery

Scottsdale, Arizona, United States

Site Status

Vanderpool Cosmetic Plastic Surgery

Fayetteville, Arkansas, United States

Site Status

Jaime Schwartz, MD

Beverly Hills, California, United States

Site Status

Susan E. Downey, MD Inc

Burbank, California, United States

Site Status

Mohebali Plastic Surgery

Corte Madera, California, United States

Site Status

Institute of Cosmetic and Reconstructive Surgery

Fountain Valley, California, United States

Site Status

Newport Beach Center for Plastic Surgery

Newport Beach, California, United States

Site Status

Newport Center for Special Surgery

Newport Beach, California, United States

Site Status

North Coast Plastic Surgery

Oceanside, California, United States

Site Status

Li Plastic Surgery

Ontario, California, United States

Site Status

Summit Plastic Surgery

Redding, California, United States

Site Status

Verve Plastic Surgery

Solana Beach, California, United States

Site Status

Kaweah Delta Health Care District

Visalia, California, United States

Site Status

Park Meadows Cosmetic Surgery

Lone Tree, Colorado, United States

Site Status

David Bogue MD, Plastic Surgery, PL

Boca Raton, Florida, United States

Site Status

The Plastic Surgery Institute of Miami

Coral Gables, Florida, United States

Site Status

University of Miami / Sylvester Comp Cancer Ctr

Coral Gables, Florida, United States

Site Status

South Florida Plastic Surgery

Fort Lauderdale, Florida, United States

Site Status

First Coast Plastic Surgery

Jacksonville, Florida, United States

Site Status

Sean A. Simon, MD

Miami, Florida, United States

Site Status

Pierini Esthetic Surgery

Miami, Florida, United States

Site Status

Imagos Plastic Surgery

Miami, Florida, United States

Site Status

Christopher Craft Cosmetic Surgery

Miami, Florida, United States

Site Status

Southeastern Plastic Surgery

Tallahassee, Florida, United States

Site Status

Dr. Joshua Halpern MD, PA

Tampa, Florida, United States

Site Status

The Swan Center for Plastic Surgery

Alpharetta, Georgia, United States

Site Status

Artisan Plastic Surgery

Atlanta, Georgia, United States

Site Status

North Atlanta Plastic Surgery

Atlanta, Georgia, United States

Site Status

Advanced Aesthetics

Fayetteville, Georgia, United States

Site Status

Marietta Plastic Surgery

Marietta, Georgia, United States

Site Status

Snodgrass and Robinson Plastic Surgery Specialists

Rome, Georgia, United States

Site Status

The Georgia Institute for Plastic Surgery

Savannah, Georgia, United States

Site Status

Barrington Plastic Surgery

Inverness, Illinois, United States

Site Status

MAE Plastic Surgery

Northbrook, Illinois, United States

Site Status

A New You Plastic Surgery & Laser Center

Oak Lawn, Illinois, United States

Site Status

Iowa Plastic Surgery

Davenport, Iowa, United States

Site Status

AMAE Plastic & Reconstructive Surgery

Birmingham, Michigan, United States

Site Status

Ellen A. Janetzke, MD

Bloomfield, Michigan, United States

Site Status

Partners in Plastic Surgery

Grand Rapids, Michigan, United States

Site Status

The Center for You

Traverse City, Michigan, United States

Site Status

Spa Renaissance & Renaissance Plastic Surgery

Troy, Michigan, United States

Site Status

Danielle DeLuca-Pytell, MD, PC

Troy, Michigan, United States

Site Status

Gryskiewicz Twin Cities Cosmetic Surgery

Burnsville, Minnesota, United States

Site Status

Parkcrest Plastic Surgery

St Louis, Missouri, United States

Site Status

Hankins and Sohn Plastic Surgery

Henderson, Nevada, United States

Site Status

Atlantic Plastic Surgery

Portsmouth, New Hampshire, United States

Site Status

Summit Medical Group

Berkeley Heights, New Jersey, United States

Site Status

Doctors Plastic Surgery

Long Island City, New York, United States

Site Status

Piedmont Plastic Surgery & Dermatology - Blakeney

Charlotte, North Carolina, United States

Site Status

Providence Plastic Surgery & Skin Center

Charlotte, North Carolina, United States

Site Status

Piedmont Plastic Surgery & Dermatology - Cox Road

Gastonia, North Carolina, United States

Site Status

Piedmont Plastic Surgery & Dermatology Center - New Hope

Gastonia, North Carolina, United States

Site Status

Piedmont Plastic Surgery & Dermatology - Hickory

Hickory, North Carolina, United States

Site Status

Forsyth Plastic Surgery

Winston-Salem, North Carolina, United States

Site Status

Advanced Surgical Arts Center

Bismarck, North Dakota, United States

Site Status

The Columbus Institute for Plastic Surgery

Columbus, Ohio, United States

Site Status

Carp Cosmetic Surgery

Uniontown, Ohio, United States

Site Status

Tim R. Love, M.D., P.C.

Oklahoma City, Oklahoma, United States

Site Status

Paul Glat, MD, PC

Bala-Cynwyd, Pennsylvania, United States

Site Status

Upstate Plastic Surgery

Greer, South Carolina, United States

Site Status

The Center for Dermatology and Plastic Surgery

Alcoa, Tennessee, United States

Site Status

Plastic Surgery Group

Chattanooga, Tennessee, United States

Site Status

Music City Plastic Surgery

Nashville, Tennessee, United States

Site Status

Ciaravino Plastic Surgery

Houston, Texas, United States

Site Status

Premier Plastic Surgery

Draper, Utah, United States

Site Status

Michael D. Marion Plastic Surgery

Lehi, Utah, United States

Site Status

Plastic Surgery of Fredericksburg

Fredericksburg, Virginia, United States

Site Status

Plastic Surgery Center of Hampton Roads

Newport News, Virginia, United States

Site Status

The Hague Center for Cosmetic and Plastic Surgery

Norfolk, Virginia, United States

Site Status

Richmond Plastic Surgeons

Richmond, Virginia, United States

Site Status

Kai Morimoto MD PLLC

Spokane Valley, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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MEN-15-003

Identifier Type: -

Identifier Source: org_study_id