Preoperative Hemodialysis Timing in Patients With End-Stage Kidney Disease: The POD-ESKD Pilot Trial

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-02-28

Study Completion Date

2027-09-30

Brief Summary

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The goal of this clinical trial is to evaluate the feasibility of two different preoperative hemodialysis schedules for people with end-stage kidney disease (ESKD) who undergo surgical procedures. The main questions it aims to answer are:

Is it feasible to randomize participants with ESKD undergoing nonemergent surgical procedures to same-day hemodialysis versus no same-day hemodialysis?

Is it safe to randomize participants with ESKD undergoing nonemergent surgical procedures to same-day hemodialysis versus no same-day hemodialysis?

Researchers will compare the two hemodialysis schedules to see if the scheduling and safety profiles are the same.

Participants will:

Answer questions about their health up to 4 weeks before and 4 weeks after the surgical procedure.

Receive hemodialysis on the day of the surgical procedure or not, depending on the study treatment assignment.

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Detailed Description

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Participants will participate in the study for approximately 2 months, including assessment of 30-day postoperative outcomes.

Conditions

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Perioperative Management End Stage Kidney Disease (ESRD) Hemodialysis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Same-Day Hemodialysis

Participants will receive same-day hemodialysis, defined as a hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure (typically in the morning prior to the procedure).

Group Type EXPERIMENTAL

Same-Day Hemodialysis

Intervention Type PROCEDURE

Hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure (typically in the morning prior to the procedure).

No Same-Day Hemodialysis

Participants will not receive same-day hemodialysis, defined as a hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure.

Group Type ACTIVE_COMPARATOR

No Same-Day Hemodialysis

Intervention Type PROCEDURE

No hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure.

Interventions

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Same-Day Hemodialysis

Hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure (typically in the morning prior to the procedure).

Intervention Type PROCEDURE

No Same-Day Hemodialysis

No hemodialysis treatment prior to the surgical procedure but on the same calendar day as the surgical procedure.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Patient is willing to comply with all study procedures for the duration of the study
2. Patient has a diagnosis of ESKD
3. Patient initiated hemodialysis at least 90 days prior to the planned surgical procedure
4. Patient is treated with a stable hemodialysis schedule, defined as an average of 2.5- 3.5 hemodialysis sessions per week in the preceding 4 weeks prior to surgery
5. Patient is scheduled to undergo nonemergent surgical procedures in the Stanford Health Care system. This includes (but is not limited to):

* Fistula or graft creation, revision, or removal
* Fistulogram
* Peritoneal dialysis catheter placement or revision
* Lower extremity angiogram (including femoral and iliac vessels)
* Lower extremity bypass (including femoral and iliac vessels)
* Lower extremity amputation

Exclusion Criteria

1. Patient is pregnant
2. Patient is a prisoner
3. Patient is \< 18 years old
4. The treating clinicians determine that the patient's clinical condition necessitate a specific approach to surgical scheduling or preoperative hemodialysis

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No