Peritoneal Dialysis Daily Versus Six Days Per Week

NCT ID: NCT06399848

Last Updated: 2025-05-22

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-07-31
• Study Completion Date: 2025-06-30

Brief Summary

The study will enroll patients receiving daily peritoneal dialysis who have significant residual native kidney function. The investiators will visit the patients at a routinely scheduled clinic visit and again at a non-routine visit after the patients skip a single day of dialysis. Blood samples will be obtained and a quality of life questionnaire will be administered at both visits.

The primary aim will be to determine whether the patients would prefer daily treatment or being allowed to skip one day per week.

Other aims will be to determine the effect of skipping a day on plasma levels of urea nitrogen and creatinine.

Detailed Description

The patients' preference will be assessed by asking the simple question would you prefer to perform peritoneal dialysis daily of six days per week.

The quality of life questionnaire to be used will be the Dialysis Symptom Index (DSI) which has a range of 0 to 150 with a high score reflecting worse quality of life.

The chemical to be measured will be the plasma urea nitrogen in mg/dl and the plasma creatinine in mg/dl as measured by the clinical laboratory.

Conditions

Peritoneal Dialysis

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Peritoneal Dialysis Daily

Each patient will compare their regular daily treatment with the effect of skipping a single day of treatment. There will be no other intervention.

Group Type: OTHER

Skip one day of peritoneal dialysis treatment

Intervention Type: OTHER

Skip one day of peritoneal dialysis treatment

Interventions

Skip one day of peritoneal dialysis treatment

Skip one day of peritoneal dialysis treatment

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Daily treament with peritoneal dialysis and residual native kidney funciton with residual urea clearance greater than 2 ml/min.

Exclusion Criteria

• less than 3 months on peritoneal dialysis
• recent change in the dialysis prescriptoin
• recent peritonitis

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Stanford University

OTHER

Sponsor Role: lead

Responsible Party

Timothy Meyer

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

75365

Identifier Type: -

Identifier Source: org_study_id